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| 1 | 比利时高放废物处置库设计及与基岩和工程屏障体系的热–水–力性状的相关研究(英文)显示文摘在比利时,泥岩中地质处置是高放废物最终处置的首选。处置库在高放废物与生物圈之间的多重屏障基础上设计的,而 Boom 泥岩作为基岩的研究已有 20 多年历史。1980 年比利时做出重大决定,建立名为 HADES 的地下研究机构,以研究 Boom 泥岩在地下 223 m 处的力学性质,并调查和论证处置的可行性,为处置库屏障(天然和人工)提供可靠数据。在 HADES 的众多现场试验中,很多试验用来对基岩和工程屏障体系(包括封口和回填的可行性)的热–水–力性状进行研究,包括 CACTUS,ATLAS,BACCHUS 和 RESEAL 等项目。自 1995 年以来,研究开发计划向大型和示范性试验方向发展。最主要成果是运用工业技术建立地下研究设施(竖井和井巷)可行性得到了验证,且这种工业技术给研究提供一个较好机会,便于进一步认识基岩泥岩(CLIPEX 方案)的水–力性状及了解隧道开挖工程(SELFRAC 课题)对挖掘破坏区的影响。另一个重大成果是成功地实现对一种称为“OPHELE”的预制膨润土(人工屏障材料)加热和水化地面大型试验。下一步工作内容包括实现大尺寸现场加热器试验(PRACLAY 试验),此试验预计于 2006 年开始,并可持续 10 a 之久。据此,首先简要描述比利时高放废物处置库设计,然后回顾 Boom 泥岩和工程屏障体系的热–水–力性状相关试验,最后介绍下一步大规模 PRACLAY 试验。 | 李香绫 Bernier Frédéric Bel Johan | 2006 | 岩石力学与工程学报2006，25，4： | 20 |
| 2 | Watt-level and spectrally flat mid-infrared supercontinuum in fluoroindate fibers显示文摘We report on infrared supercontinuum(SC) generation in step-index fluoroindate-based fiber by using an all-fiber laser source. In comparison to widely used ZBLAN fibers for high-power mid-infrared(MIR) SC generation, fluoroindate fibers have multiphoton absorption edges at significantly longer wavelengths and can sustain similar intensities. Recent developments highlighted in the present study allowed the production of fluoroindate fibers with MIR background loss of 2 dB/km, which is similar to or even better than ZBLAN fibers.By using an all-fiber picosecond laser source based on an erbium amplifier followed by a thulium power amplifier,we demonstrate the generation of 1.0 W infrared SC spanning over 2.25 octaves from 1 μm to 5 μm. The generated MIR SC also exhibits high spectral flatness with a 6 dB spectral bandwidth from 1.91 μm to 4.77 μm and an average power two orders of magnitude greater than in previous demonstrations with a similar spectral distribution. | FRANCIS THEBERGE NANCY BERUBE SAMUEL POULAIN SOLENN COXIC LOUIS-RAFAEL ROBICHAUD MARTIN BERNIER REAL VALLEE | 2018 | Photonics Research2018，6，6： | 5 |
| 3 | Geohydromechanical processes in the Excavation Damaged Zone in crystalline rock, rock salt, and indurated and plastic clays—in the context of radioactive waste disposal显示文摘 | Chin-Fu Tsang F. Bernier C. Davies | 2004 | International Journal of Rock Mechanics and Mining Sciences2004，，1： | 3 |
| 4 | Implications of safety requirements for the treatment of THMC processes in geological disposal systems for radioactive waste显示文摘The mission of nuclear safety authorities in national radioactive waste disposal programmes is to ensure that people and the environment are protected against the hazards of ionising radiations emitted by the waste.It implies the establishment of safety requirements and the oversight of the activities of the waste management organisation in charge of implementing the programme.In Belgium,the safety requirements for geological disposal rest on the following principles:defence-in-depth,demonstrability and the radiation protection principles elaborated by the International Commission on Radiological Protection(ICRP).Applying these principles requires notably an appropriate identification and characterisation of the processes upon which the safety functions fulfilled by the disposal system rely and of the processes that may affect the system performance.Therefore,research and development(R&D)on safety-relevant thermo-hydro-mechanical-chemical(THMC)issues is important to build confidence in the safety assessment.This paper points out the key THMC processes that might influence radionuclide transport in a disposal system and its surrounding environment,considering the dynamic nature of these processes.Their nature and significance are expected to change according to prevailing internal and external conditions,which evolve from the repository construction phase to the whole heatingecooling cycle of decaying waste after closure.As these processes have a potential impact on safety,it is essential to identify and to understand them properly when developing a disposal concept to ensure compliance with relevant safety requirements.In particular,the investigation of THMC processes is needed to manage uncertainties.This includes the identification and characterisation of uncertainties as well as for the understanding of their safety-relevance.R&D may also be necessary to reduce uncertainties of which the magnitude does not allow demonstrating the safety of the disposal system. | Frédéric Bernier Frank Lemy Pierre De Cannière Valéry Detilleux | 2017 | Journal of Rock Mechanics and Geotechnical Engineering2017，9，3： | 3 |
| 5 | Autoregressive neural networks with exogenous variables for indoor temperature prediction in buildings显示文摘Thermal models of buildings are helpful to forecast their energy use and to enhance the control of their mechanical systems.However,these models are building-specific and require a tedious,error-prone and time-consuming development effort relying on skilled building energy modelers.Compared to white-box and gray-box models,data-driven(black-box)models require less development time and a minimal amount of information about the building characteristics.In this paper,autoregressive neural network models are compared to gray-box and black-box linear models to simulate indoor temperatures.These models are trained,validated and compared to actual experimental data obtained for an existing commercial building in Montreal(QC,Canada)equipped with roof top units for air conditioning.Results show that neural networks mimic more accurately the thermal behavior of the building when limited information is available,compared to gray-box and black-box linear models.The gray-box model does not perform adequately due to its under-parameterized nature,while the linear models cannot capture non-linear phenomena such as radiative heat transfer and occupancy.Therefore,the neural network models outperform the alternative models in the presented application,reaching a coefficient of determination R2 up to 0.824 and a root mean square error down to 1.11℃,including the error propagation over time for a 1-week period with a 5-minute time-step.When considering a 50-hour time horizon,the best neural networks reach a much lower root mean square error of around 0.6℃,which is suitable for applications such as model predictive control. | Benoit Delcroix Jérôme Le Ny Michel Bernier Muhammad Azam Bingrui Qu Jean-Simon Venne | 2021 | Building Simulation2021，14，1： | 3 |
| 6 | Outcome and prognostic factors in 110 consecutive patients with primary uterine leiomyosarcoma:A Rare Cancer Network study显示文摘Objective: Primary uterine leiomyosarcomas(ULMS) are rare,and the optimal treatment is controversial.We aimed to assess the outcome and prognostic factors in a multicenter population of women treated for primary ULMS.Methods: We retrospectively collected data of 110 women treated in 19 institutions of the Rare Cancer Network(RCN).Inclusion criteria consisted of a pathology report confirming the diagnosis of ULMS,aged 18–80 years,complete International Federation of Gynecology and Obstetrics(FIGO) stage information,complete information on treatment,and a minimum follow-up of 6 months.Local control(LC) and locoregional control(LRC),overall survival(OS) and disease-free survival(DFS) rates were computed using the Kaplan-Meier method.Univariate analysis was implemented using the log rank test,and multivariate analysis using the Cox model.Results: All patients underwent surgery.Seventy-five patients(68%) received adjuvant radiotherapy(RT),including brachytherapy in 18(16%).Seventeen patients(15%) received adjuvant chemotherapy.Median follow-up was 58(range,6–240) months.Five-year OS and DFS rates were 50% and 34%,and LC and LRC rates were 88%and 72%,respectively.On multivariate analysis,independent favorable prognostic factors were younger age,FIGO stage I,small tumor size,previous uterine disease,and no vascular invasion for OS and DFS.FIGO stage was the only favorable factor influencing LRC.Adjuvant local or systemic treatments did not improve the outcomes.Eight patients treated with RT presented a grade 3 acute toxicity,and only one patient with grade 3 late toxicity.Conclusions: In this large population of primary ULMS patients,we found good results in terms of LC and LRC.Nevertheless,OS remains poor,mainly due to the occurrence of distant metastases.An early diagnosis seemed to improve the prognosis of the patients.Adjuvant local or systemic treatments,or more aggressive surgicalprocedures such as the Wertheim procedure,did not seem to impact the outcome. | Alessandra Franzetti Pellanda Berardino De Bari Elisabeth Deniaud-Alexandre MarcoKrengli Paul Van Houtte Antonella Riehetti Salvador Villa Hadassah Goldberg EwaSzutowiez-Zielifiska Michel Bolla Heidi Rutten Marc Van Eijkeren Philip Poortmans Guido Henke Yavuz Anaeak Steve Chan Christine Landmann Carine Kirkove LueianoScandolaro Jacques Bernier Rene-Olivier Mirimanof Mahmut Ozsahin | 2017 | Chinese Journal of Cancer Research2017，29，6： | 2 |
| 7 | Alzheimer’s disease:a tale of two diseases?显示文摘Sporadic late-onset Alzheimer’s disease(SLOAD)and familial early-onset Alzheimer’s disease(FEOAD)associated with dominant mutations in APP,PSEN1 and PSEN2,are thought to represent a spectrum of the same disorder based on near identical behavioral and histopathological features.Hence,FEOAD transgenic mouse models have been used in past decades as a surrogate to study SLOAD pathogenic mechanisms and as the gold standard to validate drugs used in clinical trials.Unfortunately,such research has yielded little output in terms of therapeutics targeting the disease’s development and progression.In this short review,we interrogate the widely accepted view of one,dimorphic disease through the prism of the Bmi1+/–mouse model and the distinct chromatin signatures observed between SLOAD and FEOAD brains. | Eleonora Nardini Ryan Hogan Anthony Flamier Gilbert Bernier | 2021 | Neural Regeneration Research2021，16，10： | 2 |
| 8 | Stability of fruit quality traits in diverse watermelon cultivars tested in multiple environments显示文摘Lycopene is a naturally occurring red carotenoid compound that is found in watermelon.Lycopene has antioxidant properties.Lycopene content,sugar content and hollowheart resistance are subject to significant genotype×environment interaction(G×E),which makes breeding for these fruit quality traits difficult.The objectives of this study were to(i)evaluate the influence of years and locations on lycopene content,sugar content and hollowheart resistance for a set of watermelon genotypes,and(ii)identify genotypes with high stability for lycopene,sugar,and hollowheart resistance.A diverse set of 40 genotypes was tested over 3 years and 8 locations across the southern United States in replicated,multi-harvest trials.Lycopene was tested in a subset of 10 genotypes.Data were analyzed using univariate and multivariate stability statistics(BLUP-GGE biplot)using SASGxE and RGxE programs.There were strong effects of environment as well as G×E interaction on watermelon quality traits.On the basis of stability measures,genotypes were classified as stable or unstable for each quality trait.'Crimson Sweet'is an inbred line with high quality trait performance as well as trait stability.'Stone Mountain','Tom Watson','Crimson Sweet'and'Minilee'were among the best genotypes for lycopene content,sugar content and hollowheart resistance.We developed a stability chart based on marketable yield and average ranking generated from different stability measures for yield attributes and quality traits.The chart will assist in choosing parents for improvement of watermelon cultivars.See http://gffzz783b6e01a04243c3h669vbbxvu9o56buk.ffgz.tsg.suse.edu.cn/cucurbit/wmelon/wmelonmain.html. | Mahendra Dia Todd C Wehner Penelope Perkins-Veazie Richard Hassell Daniel S Price George E Boyhan Stephen M Olson Stephen R King Angela R Davis Gregory E Tolla Jerome Bernier Benito Juarez | 2016 | Horticulture Research2016，3，1： | 2 |
| 9 | Pumping energy and variable frequency drives显示文摘 | Bernier M A Bourret B | 1999 | ASHRAE Journal1999，41，12： | 1 |
| 10 | Cetuximab combined with radiotherapy: an alternative to chemoradiotherapy for pa- tients with locally advanced squamous cell carcinomas of the head and neck显示文摘 | BERNIER J SCHNEIDER D | 2007 | Eur J Cancer2007，43，1： | 1 |
| 11 | Mitochondrial iron sequestration in dopamine-challeged astroglia: role of heine oxygenase-1 and the permeability transition pore 显示文摘 | Schipper H Bernier L Mehindate K | 1999 | Neurochem1999，72，5： | 1 |
| 12 | The production of polysaccharides by fungi active in the decomp-osition of wood and forest litter显示文摘 | Bernier B | 1958 | Can J Microbiol1958，4，： | 1 |
| 13 | Antioxidant properties of hydroxy-flavones 显示文摘 | Cotelle Nicole Bernier Jean-Luc Catteau Jean-Pierre | 1996 | Free Radical Biology & Medicine1996，，： | 1 |
| 14 | Elastic properties of C and BxCyNz composite nanotubes显示文摘 | Hernandez E Goze C Bernier P | 1998 | Phys Rev Lett1998，80，： | 1 |
| 15 | Bayesian POT modeling for historical data 显示文摘 | Parent E Bernier J | 2003 | Journal of Hydrology2003，274，： | 1 |
| 16 | Diagnostic accuracy of contrast echocardiography during adenosine stress for detection of abnormal myocardial perfusion:A prospective comparison with technetium-99m sestamibi single-photon emission computed tomography显示文摘 | Abdelmoneim SS Bernier M Dhoble A | | 0，，02： | 1 |
| 17 | Krüppel-like factor 4 inhibits proliferation by platelet-derived growth factor receptor β-mediated,not by retinoic acid receptor α-mediated,phosphatidylinositol 3-kinase and ERK signaling in vascular smooth muscle cells显示文摘 | Zheng B Han M Bernier M | 2009 | J Biol Chem2009，284，22： | 1 |
| 18 | Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia显示文摘 | Dubuc G Chamberland A Wassef H Davignon J Seidah NG Bernier L | 2004 | Arterioscler Thromb Vasc Biol2004，24，8： | 1 |
| 19 | Pumping energy and variable frequency drives显示文摘 | MICHEL A BERNIER BERNARD BOURRET | 1999 | ASHRAE Journal1999，，12： | 1 |
| 20 | Mechanical properties of reactive powder concrete 显示文摘 | Dugat J Roux N Bernier G | 1996 | Material Sand Structures1996，29，5： | 1 |
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