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| 1 | Osteoporosis:A Silent Disease with Complex Genetic Contribution显示文摘Osteoporosis is the most common multifactorial metabolic bone disorder worldwide with a strong genetic component. In this review, the evidence for a genetic contribution to osteoporosis and related phenotypes is summarized alongside with methods used to identify osteoporosis susceptibility genes. The key biological pathways involved in the skeleton and bone development are discussed with a particular focus on master genes clustered in these pathways and their mode of action. Furthermore, the most studied single nucleotide polymorphisms(SNPs) analyzed for their importance as genetic markers of the disease are presented. New data generated by nextgeneration sequencing in conjunction with extensive meta-analyses should contribute to a better understanding of the genetic basis of osteoporosis and related phenotype variability. These data could be ultimately used for identifying at-risk patients for disease prevention by both controlling environmental factors and providing possible therapeutic targets. | Maryam Marl Golchin Laleh Heidari Seyyed Mohammad Hossein Ghaderian Haleh Akhavan-Niaki | 2016 | Journal of Genetics and Genomics2016，43，2： | 15 |
| 2 | Effects of maternal diabetes on trophoblast cells显示文摘Diabetes mellitus(DM)is a health condition characterized by hyperglycemia over a prolonged period.There are three main types of DM:DM type 1(DM1),DM2 and gestational DM(GDM).Maternal diabetes,which includes the occurrence of DM1 and DM2 during pregnancy or GDM,increases the occurrence of gesttional complications and adverse fetal outcomes.The hyperglycemic intrauterine environment affects not only the fetus but also the placental development and function in humans and experimental rodents.The underlying mechanisms are still unclear,but some evidence indicates alterations in trophoblast proliferation,apoptosis and cell cycle control in diabetes.A proper coordination of trophoblast proliferation,differentiation and invasion is required for placental development.Initially,increased expression of proliferative markers in junctional and labyrinth zones of rat placentas and villous cytotrophoblast,syncytiotrophoblast,stromal cells and fetal endothelial cells in human placentas is reported among diabetics.Moreover,reduced apoptotic index and expression of some apoptotic genes are described in placentas of GDM women.In addition,cell cycle regulators including cyclins and cyclin-dependent kinase inhibitors seem to be affected by the hyperglycemic environment.More studies are necessary to check the balance between proliferation,apoptosis and differentiation in trophoblast cells during maternal diabetes. | Marlúcia Bastos Aires Anne Carolline Veríssimo dos Santos | 2015 | World Journal of Diabetes2015，6，2： | 9 |
| 3 | MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer显示文摘Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. | Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 4 | Changing human-environment interactions in medium mountains:the Apuseni Mts(Romania)as a case study显示文摘The study of human-environment relationships in mountain areas is important for both theoretical and practical reasons, as many mountain areas suffer similar problems, such as depopulation, unemployment and natural hazards. Medium mountains constitute a special case within mountains, because they are more populated but less attractive as tourist destinations than high mountains. In this context, the Apuseni Mts(Romania) are considered as a case study. In this paper, we apply GIS-based, quantitative methods to characterize the strength and dynamics of human-environment interactions, taking into consideration some environmental factors(elevation, relative height, slope, river distance, lithology, land cover, natural attractions) as well as historical population and recent tourism data. We found that population density has strong(r2>0.8) relationships with all relief factors(elevation, relative height, slope, river distance), and that best-fit functions are nonlinear. We outlined the varying demographic scenarios by elevation zones and interpreted the historically switching sign of population change versus elevation relationship. We demonstrated that lithology also has an impact on the spatial distribution of population, although it is notindependent from the relief effect. The land cover of the mainly cultural landscape is very strongly correlated with relief parameters(especially slope), which suggests good adaptation. We pointed out the dominance of karst objects in the natural tourism potential of the Apuseni Mts and also explored further components of real tourism(spas, heritage, towns). Finally, we concluded that the environmental settings investigated do in fact constrain the spatial framework of society, but socio-economic changes in history can be explained from the side of society, which conforms to the theory of cultural possibilism. | TELBISZ Tamas IMECS Zoltan MARl Laszlo BOTTLIK Zsolt | 2016 | Journal of Mountain Science2016，13，9： | 4 |
| 5 | Immunotoxic potential of aeration lagoon effluents for the treatment of domestic and hospital wastewaters in the freshwater mussel Elliptio complanata显示文摘Municipal wastewaters are major sources of pollution for the aquatic biota. The purpose of this study was to determine the levels of some pharmaceutical products and the immunotoxic potential of a municipal wastewater aeration lagoon for the treatment of the domestic wastewaters of a small town with wastewater inputs from a 400-bed hospital complex. Endemic mussels were collected, caged and placed in the final aeration lagoon and at sites 1 km upstream and 1 km downstream of the effluent outfall in the receiving river for a period of 14 days. The results showed that the final aeration lagoon contained high levels of total coliforms, conductivity and low dissolved oxygen (2.9 mg/L) as well as detectable amounts of trimethoprim, carbamazepine, gemfibrozil, and norfloxacin at concentrations exceeding 50 ng/L. The lagoon effluent was indeed toxic to the mussel specimens, as evidenced by the appearance of mortality after 14 days (10% mortality), decreased mussel weight-to-shell-length ratio and loss of hemocyte viability. The number of adhering hemocytes, phagocytic activity, total nitrite levels and arachidonic cyclooxygenase activity were significantly higher in mussels placed in the final aeration lagoon. A multivariate analysis also revealed that water pH, conductivity, total coliforms and dissolved oxygen were the endpoints most closely linked with phagocytic activity, the amount of adhering hemocytes and loss of hemocyte viability. In conclusion, exposure of mussels to treated aerated lagoon wastewater is deleterious to freshwater mussels where the immune system is compromised. | Francois Gagné Chantale André Marlène Fortier Michel Fournier | 2012 | Journal of Environmental Sciences2012，24，5： | 4 |
| 6 | Safety of Green Tea Extracts: A Systematic Review by the US Pharmacopeia显示文摘 | Sarma Dandapantula N Barrett Marilyn L Chavez Mary L Gardiner Paula Ko Richard Mahady Gail B Marles Robin J Pellicore Linda S Giancaspro Gabriel I Dog Tieraona Low | 2008 | Drug Safety2008，，6： | 2 |
| 7 | Using a Delphi process and the Analytic Hierarchy Process (AHP) to evaluate the complexity of projects显示文摘 | Ludovic-Alexandre Vidal Franck Marle Jean-Claude Bocquet | 2010 | Expert Systems With Applications2010，，5： | 2 |
| 8 | Using a Delphi process and the Analytic Hierarchy Process (AHP) to evaluate the complexity of projects显示文摘 | Ludovic-Alexandre Vidal Franck Marle Jean-Claude Bocquet | 2010 | Expert Systems With Applications2010，，5： | 2 |
| 9 | Characterization of Hepatitis C Virus Particle Subpopulations Reveals Multiple Usage of the Scavenger Receptor BI for Entry Steps显示文摘 | Viet Loan Dao Thi Christelle Granier Mirjam B. Zeisel Maryse Guérin Jimmy Mancip Ophélia Granio Fran?ois Penin Dimitri Lavillette Ralf Bartenschlager Thomas F. Baumert Fran?ois-Lo?c Cosset Marlène Dreux | 2012 | Journal of Biological Chemistry2012，，37： | 2 |
| 10 | SSJD15011600007878显示文摘 | María A. Mejía-Benítez Amélie Bonnefond Lo?c Yengo Marlène Huyvaert Aurélie Dechaume Jesús Peralta-Romero Miguel Klünder-Klünder Jaime García Mena Julia S. El-Sayed Moustafa Mario Falchi Miguel Cruz Philippe Froguel | 2015 | Diabetologia2015，，2： | 2 |
| 11 | Assessment of herbal medicinal products: Challenges, and opportunities to increase the knowledge base for safety assessment显示文摘 | Scott A. Jordan David G. Cunningham Robin J. Marles | 2009 | Toxicology and Applied Pharmacology2009，，2： | 2 |
| 12 | Mutations and polymorphisms of the FSH receptor (FSHR) gene: clinical implications in female fecundity and molecular biology of FSHR protein and gene显示文摘 | Lussiana C Guani B Marl C | 2008 | Obstet Gynecol Surv2008，63，12： | 1 |
| 13 | Postinjury niches induce tem- poral shifts in progenitor fates to direct lesion repair after spinal cord injury显示文摘 | Sellers DL Marls DO Homer PJ | 2009 | J Neurosci2009，29，20： | 1 |
| 14 | Nonlinear analysis of reinforced concrete cross-sections exposed to fire显示文摘 | CAPUA D D MARl A R | 2007 | Fire Safety Journal2007，42，2： | 1 |
| 15 | C-reactive protein and mor- tality in mild to moderate chronic obstructive pulmonary disease 显示文摘 | Marl SF Connett JE Anthanisen NR | 2006 | Thorax2006，61，10： | 1 |
| 16 | Conofocal microscopy study of undisturbed and chlorhexidine-treated dental biofilm显示文摘 | Zaura-Arite E van Marle J ten Cate JM | 2001 | J Dent Res2001，80，5： | 1 |
| 17 | Incidence of pertussis in persons < 15 years of age in Valencia, Spain: seroprevalence of antibodies to pertussis toxin (PT) in children, adolescents and adults 显示文摘 | Javier Diez-Domingo Alfredo Ballester Jose'-Marl'a Baldo | 2004 | Journal of Infection2004，49，3： | 1 |
| 18 | Thioglycoligases:mutant glycosidases for thioglycoside synthesis显示文摘 | Jahn M Marles J Warren R | 2003 | Angew Chem Int Ed2003，42，： | 1 |
| 19 | Experimental study on high-strength concrete beams failing in shear 显示文摘 | Cladera Marl | 2005 | Engineering Structures2005，27，： | 1 |
| 20 | Liquid chromatographic de- tenination of ampicillin residues in porcine muscle tissue by a multipenicilin analytical method: european collaborative study 显示文摘 | Verdon E Couedor P Marls P | 2002 | JAOACInt2002，85，4： | 1 |
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