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| 1 | Characterization of bbtTICAM from amphioxus suggests the emergence of a MyD88-independent pathway in basal chordates显示文摘MyD88 独立的小径,发信号的二关键 TLR 之一发送,被认为是脊椎动物革新。然而,一个新奇 Toll/interleukin-1 受体(TIR ) 适配器,指明的 bbtTICAM,在基础脊索动物文昌鱼被识别,连接这条小径到无脊椎动物。bbtTICAM 的蛋白质建筑学类似于脊椎动物 TICAM1 的(包含 TIR 适配器 molecule-1,也作为 TRIF 知道) 当种系发生的分析基于 TIR 领域显示了那时, bbtTICAM 是脊椎动物 TICAM1 和 TICAM2 的最旧的 ortholog (包含 TIR 适配器 molecule-2,是也知道电车) 。类似于人的 TICAM1, bbtTICAM 激活 NF-κ以由与受体交往蛋白质交往的一种 MyD88 独立的方式的 B (裂开) 经由它的 RHIM 主题。如此的激活要求 bbtTICAM 形成 homodimers 在里面内涵体,和它可以被文昌鱼 SARM 否定地调整(无菌的 α并且犰狳包含主题的蛋白质) 并且 TRAF2。然而, bbtTICAM 没导致类型的生产我干扰素。因此,我们的学习不仅介绍脊椎动物 TICAM1 和 TICAM2 的祖先的特征,而且从基础脊索动物揭示 MyD88 独立的小径的进化起源,它将帮助理解脊椎动物 TLR 网络的开发。 | Manyi Yang Shaochun Yuan Shengfeng Huang Jun Li Liqun Xu Huiqing Huang Xin Tao Jian Peng Anlong Xu | 2011 | Cell Research2011，21，10： | 5 |
| 2 | Selective dopamine D3 receptor antagonist YQA14 inhibits morphine-induced behavioral sensitization in wild type,but not in dopamine D3 receptor knockout mice显示文摘Increasing preclinical evidence demonstrates that dopamine D3 receptor (D3R) antagonists are a potential option for the treatment of drug addiction. The reinstatement of the addiction can be triggered by environmental stimuli that acquire motivational salience through repeated associations with the drug’s effects. YQA14 is a novel D3R antagonist that has exhibited pharmacotherapeutic efficacy in reducing cocaine and amphetamine reward and relapse to drug seeking in mice. In this study we investigated the effects of YQA14 on morphine-induced context-specific locomotor sensitization in mice. We showed that repeated injection of YQA14 (6.25–25mg/kg every day ip) prior to morphine (10mg/kg every day sc) not only inhibited the acquisition, but also significantly attenuated the expression of morphine-induced locomotor sensitization. Furthermore, in the expression phase, one single injection of YQA14 (6.25-25mg/kg, ip) dose-dependently inhibited the expression of morphine-induced behavioral sensitization. Moreover, YQA14 inhibited the expression of morphine-induced behavioral sensitization in wild mice (WT), but not in D3R knockout (D3R^-/-) mice in the expression phase. In addition, D3R^-/- mice also displayed the reduction in the expression phase compared with WT mice. In summary, this study demonstrates that blockade or knockout of the D3R inhibits morphine-induced behavior sensitization, suggesting that D3R plays an important role in the pathogenesis and etiology of morphine addiction, and it might be a potential target for clinical management of opioid addiction. | Yang Lv Rong-rong Hu Manyi Jing Tai-yun Zhao Ning Wu Rui Song Jin Li Gang Hu | 2019 | Acta Pharmacologica Sinica2019，40，5： | 4 |
| 3 | Swarming Responsive Photonic Nanorobots for Motile-Targeting Microenvironmental Mapping and Mapping-Guided Photothermal Treatment显示文摘Micro/nanorobots can propel and navigate in many hard-to-reach biological environments,and thus may bring revolutionary changes to biomedical research and applications.However,current MNRs lack the capability to collectively perceive and report physicochemical changes in unknown microenvironments.Here we propose to develop swarming responsive photonic nanorobots that can map local physicochemical conditions on the fly and further guide localized photothermal treatment.The RPNRs consist of a photonic nanochain of periodically-assembled magnetic Fe_(3)O_(4)nanoparticles encapsulated in a responsive hydrogel shell,and show multiple integrated functions,including energetic magnetically-driven swarming motions,bright stimuli-responsive structural colors,and photothermal conversion.Thus,they can actively navigate in complex environments utilizing their controllable swarming motions,then visualize unknown targets(e.g.,tumor lesion)by collectively mapping out local abnormal physicochemical conditions(e.g.,pH,temperature,or glucose concentra-tion)via their responsive structural colors,and further guide external light irradiation to initiate localized photothermal treatment.This work facilitates the development of intelligent motile nanosensors and versatile multifunctional nanotheranostics for cancer and inflam-matory diseases. | Luolin Li Zheng Yu Jianfeng Liu Manyi Yang Gongpu Shi Ziqi Feng Wei Luo Huiru Ma Jianguo Guan Fangzhi Mou | 2023 | Nano-Micro Letters2023，15，9： | 3 |
| 4 | Protective effects of sodium butyrate on rotavirus inducing endoplasmic reticulum stress-mediated apoptosis via PERK-eIF2αsignaling pathway in IPEC-J2 cells显示文摘Background:Rotavirus(RV)is a major pathogen that causes severe gastroenteritis in infants and young animals.Endoplasmic reticulum(ER)stress and subsequent apoptosis play pivotal role in virus infection.However,the protective mechanisms of intestinal damage caused by RV are poorly defined,especially the molecular pathways related to enterocytes apoptosis.Thus,the aim of this study was to investigate the protective effect and mechanism of sodium butyrate(SB)on RV-induced apoptosis of IPEC-J2 cells.Results:The RV infection led to significant cell apoptosis,increased the expression levels of ER stress(ERS)markers,phosphorylated protein kinase-like ER kinase(PERK),eukaryotic initiation factor 2 alpha(eIF2α),caspase9,and caspase3.Blocking PERK pathway using specific inhibitor GSK subsequently reversed RV-induced cell apoptosis.The SB treatment significantly inhibited RV-induced ERS by decreasing the expression of glucose regulated protein 78(GRP78),PERK,and eIF2α.In addition,SB treatment restrained the ERS-mediated apoptotic pathway,as indicated by downregulation of C/EBP homologous protein(CHOP)mRNA level,as well as decreased cleaved caspase9 and caspase3 protein levels.Furthermore,siRNA-induced GPR109a knockdown significantly suppressed the protective effect of SB on RV-induced cell apoptosis.Conclusions:These results indicate that SB exerts protective effects against RV-induced cell apoptosis through inhibiting ERS mediated apoptosis by regulating PERK-eIF2αsignaling pathway via GPR109a,which provide new ideas for the prevention and control of RV. | Ye Zhao Ningming Hu Qin Jiang Li Zhu Ming Zhang Jun Jiang Manyi Xiong Mingxian Yang Jiandong Yang Linyuan Shen Shunhua Zhang Lili Niu Lei Chen Daiwen Chen | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 2 |
| 5 | Comparison study of two surgical options for distal tibia fracture-minimally invasive plate osteosynthesis vs open reduction and internal fixa- tion显示文摘 | CHENG W LI Y MANYI W | 2011 | Int Orthop2011，35，5： | 1 |
| 6 | Comparison study of two surgical options for disal tibia fractures-minimally invasive plate osteosyuthesis vs 显示文摘 | Cheng W Li Y Manyi W | 2011 | Open Reduct Inter Fixat Orth2011，35，5： | 1 |
| 7 | Enhanced electrochemical performance of La_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3−δ)cathode via Ba-doping for intermediate-temperature solid oxide fuel cells显示文摘La_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3-δ)(LSCF)is recognized as one of the most promising cathode materials for the highly-desired intermediatetemperature solid oxide fuel cell(IT-SOFC)technology.However,it is still challenged by polarization losses due to reduced operation temperatures.In this work,a series of Ba^(2+)-doped La0.6-xBaxSr0.4Co0.2Fe0.8O3-δ(LBSCFx,x=0.05,0.10,0.15,and 0.20)materials are successfully synthesized and their electrochemical performances are evaluated as a cathode for IT-SOFC technology.The study shows that,compared to the un-doped LSCF,the Ba^(2+)-doped LBSCF possess higher electrical conductivities at 500-800℃ and display lower polarization resistances to oxygen adsorption/dissociation.As a result,the Ni-SDC|SDC|LBSCF0.20 cell(SDC=samarium-doped cerium,Sm_(0.2)Ce_(0.8)O_(1.9))delivers a high maximum power density of 0.704 W/cm^(2)at 750℃,which is>30%higher than the Ni-SDC|SDC|LSCF cell.This work reveals that Ba^(2+)-doping is effective in enhancing oxygen catalytic activity of LSCF-based cathode materials,demonstrating a new and commercial-feasible strategy in developing high performance cathode materials for the IT-SOFC technology. | Changkun Cai Manyi Xie Ke Xue Yu Shi Shuting Li Yuanyuan Liu Shengli An Hong Yang | 2022 | Nano Research2022，15，4： | 1 |
| 8 | Comparison of the Icare Tonometer and the Hand-held Goldmann Applanation Tonometer in Pediatric Aphakia显示文摘 | Yunping Li Luosheng Tang Manyi Xiao Songbai Jia Ping Liu Yi Zhou Huihui Chen Jiexi Zeng | 2013 | Journal of Glaucoma2013，，7： | 1 |
| 9 | Comparison study of twosur gicaloptions for distaltibia fracture -minimall yinvasive plateoste osynthesisvs, open reduction andintennal fixation 显示文摘 | cheng W Li Y Manyi W | 2011 | Intorthop2011，35，5： | 1 |
| 10 | Comparison study of two surgical options for distal tibia fracture-minimally invasive plate osteosynthesis open reduction and internal fixation显示文摘 | Cheng W Li Y Manyi W | 2011 | Int Orthop2011，35，5： | 1 |
| 11 | Curcumin is a biologically active copper chelator with antitumor activity显示文摘 | Wei Zhang Changmai Chen Hengfei Shi Manyi Yang Yu Liu Ping Ji Huijun Chen Ren Xiang Tan Erguang Li | 2015 | Phytomedicine2015，，： | 1 |
| 12 | Photon-counting distributed free-space spectroscopy显示文摘Spectroscopy is a well-established nonintrusive tool that has played an important role in identifying and quantifying substances,from quantum descriptions to chemical and biomedical diagnostics.Challenges exist in accurate spectrum analysis in free space,which hinders us from understanding the composition of multiple gases and the chemical processes in the atmosphere.A photon-counting distributed free-space spectroscopy is proposed and demonstrated using lidar technique,incorporating a comb-referenced frequency-scanning laser and a superconducting nanowire single-photon detector.It is suitable for remote spectrum analysis with a range resolution over a wide band.As an example,a continuous field experiment is carried out over 72 h to obtain the spectra of carbon dioxide(CO_(2))and semi-heavy water(HDO,isotopic water vapor)in 6 km,with a range resolution of 60 m and a time resolution of 10 min.Compared to the methods that obtain only column-integrated spectra over kilometer-scale,the range resolution is improved by 2-3 orders of magnitude in this work.The CO_(2)and HDO concentrations are retrieved from the spectra acquired with uncertainties as low as±1.2%and±14.3%,respectively.This method holds much promise for increasing knowledge of atmospheric environment and chemistry researches,especially in terms of the evolution of complex molecular spectra in open areas. | Saifen Yu Zhen Zhang Haiyun Xia Xiankang Dou Tengfei Wu Yihua Hu Manyi Li Mingjia Shangguan Tianwen Wei Lijie Zhao Lu Wang Pu Jiang Chengjun Zhang Lixing You Leigang Tao Jiawei Qiu | 2021 | Light(Science & Applications)2021，10，11： | 1 |
| 13 | Postoperative malrotation of humeral shaft fracture after plating compared with intramedullary nailing显示文摘 | Ying Li Cheng Wang Manyi Wang Lei Huang Qiang Huang | 2011 | Journal of Shoulder and Elbow Surgery2011，，6： | 1 |
| 14 | Comparison of the Icare Tonometer and the Hand-held Goldmann Applanation Tonometer in Pediatric Aphakia显示文摘 | Yunping Li Luosheng Tang Manyi Xiao Songbai Jia Ping Liu Yi Zhou Huihui Chen Jiexi Zeng | 2013 | Journal of Glaucoma2013，，7： | 1 |
| 15 | A Novel Pulse Density Modulation with Semi-bridgeless Active Rectifier in Inductive Power Transfer System for Rail Vehicle显示文摘In this paper,a novel pulse density modulation(PDM)with semi-bridgeless active rectifier(S-BAR)in inductive power transfer(IPT)system for rail vehicle is proposed.It is to reduce switching losses of the active rectifier in pickups.In the control method,the insulated-gate bipolar transistors(IGBTs)in the S-BAR are controlled by synchronous PDM signals,so that zero-voltage switching(ZVS)and zero-current switching(ZCS)can be achieved in the whole output power range.The output power is regulated by changing the pulse density(PD)of the S-BAR since the it is almost linear proportional with the PD in high quality factor of pickup side.The communication device between the primary side and pickup side is not necessary anymore.The detailed theoretical analyses of the PDM method are provided,and its advantages are shown in a 7.5kW IPT prototype for rail vehicle.The experimental results are presented to verify the analysis and demonstrate the performance.The overall efficiency of the system by PDM control is 74.2%which is improved by 4%compared with phase shift(PS)control at light load. | Manyi Fan Liming Shi Zhenggang Yin Yaohua Li | 2017 | CES Transactions on Electrical Machines and Systems2017，1，4： | 0 |
| 16 | Genomic selection of eight fruit traits in pear显示文摘Genomic selection (GS) has the potential to improve selection efficiency and shorten the breeding cycle in fruit tree breeding. In this study,we evaluated the effect of prediction methods, marker density and the training population (TP) size on pear GS for improving its performance and reducing cost. We evaluated GS under two scenarios:(1) five-fold cross-validation in an interspecific pear family;(2) independent validation. Based on the cross-validation scheme, the prediction accuracy (PA) of eight fruit traits varied between 0.33 (fruit core vertical diameter)and 0.65 (stone cell content). Except for single fruit weight, a slightly better prediction accuracy (PA) was observed for the five parametrical methods compared with the two non-parametrical methods. In our TP of 310 individuals, 2 000 single nucleotide polymorphism (SNP) markers were sufficient to make reasonably accurate predictions. PAs for different traits increased by 18.21%-46.98%when the TP size increased from 50to 100, but the increment was smaller (-4.13%-33.91%) when the TP size increased from 200 to 250. For independent validation, the PAs ranged from 0.11 to 0.45 using rrBLUP method. In summary, our results showed that the TP size and SNP numbers had a greater impact on the PA than prediction methods. Furthermore, relatedness among the training and validation sets, and the complexity of traits should be considered when designing a TP to predict the test panel. | Manyi Sun Mingyue Zhang Satish Kumar Mengfan Qin Yueyuan Liu Runze Wang Kaijie Qi Shaoling Zhang Wenjing Chang Jiaming Li Jun Wu | 2024 | Horticultural Plant Journal2024，10，2： | 0 |
| 17 | Swarming magnetic photonic-crystal microrobots withon-the-fly visual pH detection and self-regulated drug delivery显示文摘Swarming magnetic micro/nanorobots hold great promise for biomedical applications,but at present suffer from inferior capabilities to perceive and respond to chemical signals in local microenvironments.Here we demonstrate swarming magnetic photonic crystal microrobots(PC-bots)capable of sponta-neously performing on-the-fly visual pH detection and self regulated drug delivery by perceiving local pH changes.The magnetic PC-bots consist of pH-responsive hydrogel microspheres with encapsulated one-dimensional periodic assemblies of Fe3O4 nanoparticles.By programming extemnal rotating magnetic fields,they can self-organize into large swarms with much-enhanced collective velocity to actively find targets while shining bright“blinking”structural colors.When approaching the target with abnormal pH conditions(e.g.an ulcerated superficial tumor lesion),the PC-bots can visualize local pH changes on the fly via pH-responsive structural colors,and realize self-regulated release of the loaded drugs by recognizing local pH.This work facilita tes the develop-ment of intelligent micro/nanorobots for active“motile-targeting”tumor diag-nosis and treatment. | Zheng Yu Luolin Li Fangzhi Mou Shimin Yu Di Zhang Manyi Yang Qing Zhao Huiru Ma Wei Luo Tianlong Li Jianguo Guan | 2023 | InfoMat2023，5，10： | 0 |
| 18 | High-throughput screening of single-atom catalysts confined in monolayer black phosphorus for efficient nitrogen reduction reaction显示文摘The discovery of metal-nitrogen centers as the active sites for electrolysis has aroused significant interest in utilizing single-atom catalysts for nitrogen reduction reaction(NRR).Properly designed nanostructured catalysts that strongly interact with nitrogen molecules(N_(2))can promote adsorption and activation,thereby resulting in efficient catalysts with high stability,activity,and selectivity.In this study,using density functional theory calculations,we selected monolayer black phosphorus(BP)as the substrate and screened a series of single-atom transition metals confined in tri-coordinated and tetra-coordinated active centers(without and with N dopants)to electro-catalyze NRR.As a result,we have identified two promising candidates(Hf_(1)-N_(1)P_(2)-1 and Tc_(1)-N_(4)),which exhibit not only low overpotentials of 0.56 and 0.49 V but also high thermodynamic and electrochemical stability,as well as good selectivity towards NRR over the competing hydrogen evolution reaction.We also demonstrate the ability of Hf_(1)-N_(1)P_(2)-1 and Tc_(1)-N_(4) to activate and hydrogenate N_(2) by donating electrons and regulating charge transfer.This study not only predicts new BP-based promising catalysts but also provides guidance for the rational design of high-performance NRR electrocatalysts under ambient conditions. | Xiao-Yan Li Manyi Duan Pengfei Ou | 2024 | Nano Research2024，17，4： | 0 |
| 19 | TCP-1,a novel peptide to diagnose early colon cancer显示文摘A nine cyclic peptide(TCP-1)showed excellent specificity for colon cancer.TCP-1 binds with human tumor tissues at early stages and mice tumor with diameters of 1-4 mm,suggesting that TCP-1 may be used for early diagnosis of colon cancer.The mechanism of the targeted binding of TCP-1 to colon cancer was also studied using immunoprecipitation,LC-MS and bioinformatics.After screening and identifying of the possible binding target proteins of TCP-1,keratin,typeⅡcytoskeletal 5 was speculated to be the specific binding target protein of TCP-1 in human tumor tissue.Pharmacokinetics studies were conducted to investigate the target-mediated drug disposition of the new tumor-specific peptide by LC-MS/MS.The tissue distribution study showed that TCP-1 was found only in colon tumors(the target site)in tumor mice did not bind to any other tissues.Conjugating TCP-1 to tumor markedly increased its removal rate from blood circulation but mildly extended its staying time in vivo.In tumor mice,a lower AUC of TCP-1(reduced by almost 35%)and 2-fold higher clearance were found compared to that of normal mice.The proposed metabolic pathway of TCP-1 in the kidney was also determined using LC-MS^(n)-IT-TOF.The high specificity and low toxicity of the peptide may be caused by its extremely tight binding to the targets.Potential applications for future clinical use,including MRI and PET/CT were also explored,and this research may promote the development of colon cancer diagnostic technology research and provide new ideas and technical routes for tumor diagnostic technology. | Hang Yu Baoying Wen Min Huang Ru Feng Libin Pan Manyi Xu Hao Lin Lin Cong Sen Zhang Yan Li Chi-Hin Cho Chongjing Zhang Xiaoguang Chen Yan Wang | 2024 | Chinese Chemical Letters2024，35，3： | 0 |
| 20 | CAD-DIRECTED INSPECTION PLANNING FOR FREEFORM SURFACE USING CONTACT PROBES显示文摘A methodology for CAD-directed measurement of freeform surface using a coordinate measuring machine equipped with a touch-trigger probe is presented, mainly including adaptive sampling of measurement points and registration of freeform surface. The proposed sampling method follows four steps:Freeform surface is fitted by bi-cubic B-spline; Curvedness measure of the surface is computed; Given a number of sampling points, an iterative algorithm is constructed for selecting a set of measurement points by employing the curvedness information; The measurement points is regularized for tradeoffbetween maximizing the measurement accuracy and minimizing the sampling time and cost. The aforesaid algorithm is demonstrated in term of a marine propeller blade. An offset surface registration method is presented to improve alignment accuracy of freeform objects, and Monte Carlo simulation is conducted to verify the effectiveness of the method. | Chen Manyi Li Bin Duan Zhengcheng | 2005 | Chinese Journal of Mechanical Engineering2005，18，4： | 0 |
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