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| 1 | Characterization of bbtTICAM from amphioxus suggests the emergence of a MyD88-independent pathway in basal chordates显示文摘MyD88 独立的小径,发信号的二关键 TLR 之一发送,被认为是脊椎动物革新。然而,一个新奇 Toll/interleukin-1 受体(TIR ) 适配器,指明的 bbtTICAM,在基础脊索动物文昌鱼被识别,连接这条小径到无脊椎动物。bbtTICAM 的蛋白质建筑学类似于脊椎动物 TICAM1 的(包含 TIR 适配器 molecule-1,也作为 TRIF 知道) 当种系发生的分析基于 TIR 领域显示了那时, bbtTICAM 是脊椎动物 TICAM1 和 TICAM2 的最旧的 ortholog (包含 TIR 适配器 molecule-2,是也知道电车) 。类似于人的 TICAM1, bbtTICAM 激活 NF-κ以由与受体交往蛋白质交往的一种 MyD88 独立的方式的 B (裂开) 经由它的 RHIM 主题。如此的激活要求 bbtTICAM 形成 homodimers 在里面内涵体,和它可以被文昌鱼 SARM 否定地调整(无菌的 α并且犰狳包含主题的蛋白质) 并且 TRAF2。然而, bbtTICAM 没导致类型的生产我干扰素。因此,我们的学习不仅介绍脊椎动物 TICAM1 和 TICAM2 的祖先的特征,而且从基础脊索动物揭示 MyD88 独立的小径的进化起源,它将帮助理解脊椎动物 TLR 网络的开发。 | Manyi Yang Shaochun Yuan Shengfeng Huang Jun Li Liqun Xu Huiqing Huang Xin Tao Jian Peng Anlong Xu | 2011 | Cell Research2011，21，10： | 5 |
| 2 | Selective dopamine D3 receptor antagonist YQA14 inhibits morphine-induced behavioral sensitization in wild type,but not in dopamine D3 receptor knockout mice显示文摘Increasing preclinical evidence demonstrates that dopamine D3 receptor (D3R) antagonists are a potential option for the treatment of drug addiction. The reinstatement of the addiction can be triggered by environmental stimuli that acquire motivational salience through repeated associations with the drug’s effects. YQA14 is a novel D3R antagonist that has exhibited pharmacotherapeutic efficacy in reducing cocaine and amphetamine reward and relapse to drug seeking in mice. In this study we investigated the effects of YQA14 on morphine-induced context-specific locomotor sensitization in mice. We showed that repeated injection of YQA14 (6.25–25mg/kg every day ip) prior to morphine (10mg/kg every day sc) not only inhibited the acquisition, but also significantly attenuated the expression of morphine-induced locomotor sensitization. Furthermore, in the expression phase, one single injection of YQA14 (6.25-25mg/kg, ip) dose-dependently inhibited the expression of morphine-induced behavioral sensitization. Moreover, YQA14 inhibited the expression of morphine-induced behavioral sensitization in wild mice (WT), but not in D3R knockout (D3R^-/-) mice in the expression phase. In addition, D3R^-/- mice also displayed the reduction in the expression phase compared with WT mice. In summary, this study demonstrates that blockade or knockout of the D3R inhibits morphine-induced behavior sensitization, suggesting that D3R plays an important role in the pathogenesis and etiology of morphine addiction, and it might be a potential target for clinical management of opioid addiction. | Yang Lv Rong-rong Hu Manyi Jing Tai-yun Zhao Ning Wu Rui Song Jin Li Gang Hu | 2019 | Acta Pharmacologica Sinica2019，40，5： | 4 |
| 3 | Swarming Responsive Photonic Nanorobots for Motile-Targeting Microenvironmental Mapping and Mapping-Guided Photothermal Treatment显示文摘Micro/nanorobots can propel and navigate in many hard-to-reach biological environments,and thus may bring revolutionary changes to biomedical research and applications.However,current MNRs lack the capability to collectively perceive and report physicochemical changes in unknown microenvironments.Here we propose to develop swarming responsive photonic nanorobots that can map local physicochemical conditions on the fly and further guide localized photothermal treatment.The RPNRs consist of a photonic nanochain of periodically-assembled magnetic Fe_(3)O_(4)nanoparticles encapsulated in a responsive hydrogel shell,and show multiple integrated functions,including energetic magnetically-driven swarming motions,bright stimuli-responsive structural colors,and photothermal conversion.Thus,they can actively navigate in complex environments utilizing their controllable swarming motions,then visualize unknown targets(e.g.,tumor lesion)by collectively mapping out local abnormal physicochemical conditions(e.g.,pH,temperature,or glucose concentra-tion)via their responsive structural colors,and further guide external light irradiation to initiate localized photothermal treatment.This work facilitates the development of intelligent motile nanosensors and versatile multifunctional nanotheranostics for cancer and inflam-matory diseases. | Luolin Li Zheng Yu Jianfeng Liu Manyi Yang Gongpu Shi Ziqi Feng Wei Luo Huiru Ma Jianguo Guan Fangzhi Mou | 2023 | Nano-Micro Letters2023，15，9： | 3 |
| 4 | Improved Plasmonic Hot‑Electron Capture in Au Nanoparticle/Polymeric Carbon Nitride by Pt Single Atoms for Broad‑Spectrum Photocatalytic H_(2)Evolution显示文摘ABSTRACT Rationally designing broad-spectrum photocatalysts to harvest whole visible-light region photons and enhance solar energy conversion is a“holy grail”for researchers,but is still a challenging issue.Herein,based on the common polymeric carbon nitride(PCN),a hybrid co-catalysts system comprising plasmonic Au nanoparticles(NPs)and atomically dispersed Pt single atoms(PtSAs)with different functions was constructed to address this challenge.For the dual co-catalysts decorated PCN(PtSAs–Au_(2.5)/PCN),the PCN is photoexcited to generate electrons under UV and short-wavelength visible light,and the synergetic Au NPs and PtSAs not only accelerate charge separation and transfer though Schottky junctions and metal-support bond but also act as the co-catalysts for H_(2) evolution.Furthermore,the Au NPs absorb long-wavelength visible light owing to its localized surface plasmon resonance,and the adjacent PtSAs trap the plasmonic hot-electrons for H_(2) evolution via direct electron transfer effect.Consequently,the PtSAs–Au_(2.5)/PCN exhibits excellent broad-spectrum photocatalytic H_(2) evolution activity with the H_(2) evolution rate of 8.8 mmol g^(−1) h^(−1) at 420 nm and 264μmol g^(−1) h^(−1) at 550 nm,much higher than that of Au_(2.5)/PCN and PtSAs–PCN,respectively.This work provides a new strategy to design broad-spectrum photocatalysts for energy conversion reaction. | Manyi Gao Fenyang Tian Xin Zhang Zhaoyu Chen Weiwei Yang Yongsheng Yu | 2023 | Nano-Micro Letters2023，15，8： | 2 |
| 5 | Protective effects of sodium butyrate on rotavirus inducing endoplasmic reticulum stress-mediated apoptosis via PERK-eIF2αsignaling pathway in IPEC-J2 cells显示文摘Background:Rotavirus(RV)is a major pathogen that causes severe gastroenteritis in infants and young animals.Endoplasmic reticulum(ER)stress and subsequent apoptosis play pivotal role in virus infection.However,the protective mechanisms of intestinal damage caused by RV are poorly defined,especially the molecular pathways related to enterocytes apoptosis.Thus,the aim of this study was to investigate the protective effect and mechanism of sodium butyrate(SB)on RV-induced apoptosis of IPEC-J2 cells.Results:The RV infection led to significant cell apoptosis,increased the expression levels of ER stress(ERS)markers,phosphorylated protein kinase-like ER kinase(PERK),eukaryotic initiation factor 2 alpha(eIF2α),caspase9,and caspase3.Blocking PERK pathway using specific inhibitor GSK subsequently reversed RV-induced cell apoptosis.The SB treatment significantly inhibited RV-induced ERS by decreasing the expression of glucose regulated protein 78(GRP78),PERK,and eIF2α.In addition,SB treatment restrained the ERS-mediated apoptotic pathway,as indicated by downregulation of C/EBP homologous protein(CHOP)mRNA level,as well as decreased cleaved caspase9 and caspase3 protein levels.Furthermore,siRNA-induced GPR109a knockdown significantly suppressed the protective effect of SB on RV-induced cell apoptosis.Conclusions:These results indicate that SB exerts protective effects against RV-induced cell apoptosis through inhibiting ERS mediated apoptosis by regulating PERK-eIF2αsignaling pathway via GPR109a,which provide new ideas for the prevention and control of RV. | Ye Zhao Ningming Hu Qin Jiang Li Zhu Ming Zhang Jun Jiang Manyi Xiong Mingxian Yang Jiandong Yang Linyuan Shen Shunhua Zhang Lili Niu Lei Chen Daiwen Chen | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 2 |
| 6 | Enhanced electrochemical performance of La_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3−δ)cathode via Ba-doping for intermediate-temperature solid oxide fuel cells显示文摘La_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3-δ)(LSCF)is recognized as one of the most promising cathode materials for the highly-desired intermediatetemperature solid oxide fuel cell(IT-SOFC)technology.However,it is still challenged by polarization losses due to reduced operation temperatures.In this work,a series of Ba^(2+)-doped La0.6-xBaxSr0.4Co0.2Fe0.8O3-δ(LBSCFx,x=0.05,0.10,0.15,and 0.20)materials are successfully synthesized and their electrochemical performances are evaluated as a cathode for IT-SOFC technology.The study shows that,compared to the un-doped LSCF,the Ba^(2+)-doped LBSCF possess higher electrical conductivities at 500-800℃ and display lower polarization resistances to oxygen adsorption/dissociation.As a result,the Ni-SDC|SDC|LBSCF0.20 cell(SDC=samarium-doped cerium,Sm_(0.2)Ce_(0.8)O_(1.9))delivers a high maximum power density of 0.704 W/cm^(2)at 750℃,which is>30%higher than the Ni-SDC|SDC|LSCF cell.This work reveals that Ba^(2+)-doping is effective in enhancing oxygen catalytic activity of LSCF-based cathode materials,demonstrating a new and commercial-feasible strategy in developing high performance cathode materials for the IT-SOFC technology. | Changkun Cai Manyi Xie Ke Xue Yu Shi Shuting Li Yuanyuan Liu Shengli An Hong Yang | 2022 | Nano Research2022，15，4： | 1 |
| 7 | Facile fabrication of free-standing colloidal-crystal films by interfacial self-assembly显示文摘 | Jianan Zhang Mozhen Wang Xuewu Ge Mingyuan Wu Qingyun Wu Jianjun Yang Manyi Wang Zhilai Jin Nannan Liu | 2010 | Journal of Colloid And Interface Science2010，，1： | 1 |
| 8 | Curcumin is a biologically active copper chelator with antitumor activity显示文摘 | Wei Zhang Changmai Chen Hengfei Shi Manyi Yang Yu Liu Ping Ji Huijun Chen Ren Xiang Tan Erguang Li | 2015 | Phytomedicine2015，，： | 1 |
| 9 | A Novel Fluorescent Probe for ATP Detection Based on Synergetic Effect of Aggregation-induced Emission and Counterion Displacement显示文摘In this work,a fluorescent probe(TPEBe-I)was developed for adenosine triphosphate(ATP)detection based on the synergetic effect of aggregation-induced emission and counterion displacement.TPEBe-I gave weak emission in aqueous solution due to the heavy-atom effect of counter iodide ion.However,upon the addition of ATP,the new aggregate complex(TPEBe-ATP)was formed between the cationic unit of TPEBe-I and ATP through electrostatic interactions,which not only restricted the intramolecular motion of luminogen but also eliminated the quenching effect of iodide ion.As a result,the fluorescent light-up detection for ATP was successfully achieved.Moreover,TPEBe-I exhibited high selectivity towards ATP and showed a wide linear detection region towards the logarithm of ATP concentration(5—600µmol/L)with a detection limit of 1.0µmol/L,enabling TPEBe-I as a promising probe for ATP quantitative analysis. | PAN Quan MA Feiyan PU Xinqing ZHAO Manyi WU Qiling ZHAO Na YANG Jun TANG Ben Zhong | 2021 | Chemical Research in Chinese Universities2021，37，1： | 1 |
| 10 | Telomere-to-telomere pear (Pyrus pyrifolia) reference genome reveals segmental and whole genome duplication driving genome evolution显示文摘Previously released pear genomes contain a plethora of gaps and unanchored genetic regions.Here,we report a telomere-to-telomere(T2T)gap-free genome for the red-skinned pear,‘Yunhong No.1’(YH1;Pyrus pyrifolia),which is mainly cultivated in Yunnan Province(southwest China),the pear’s primary region of origin.The YH1 genome is 501.20 Mb long with a contig N50 length of 29.26 Mb.All 17 chromosomes were assembled to the T2T level with 34 characterized telomeres.The 17 centromeres were predicted and mainly consist of centromeric-specific monomers(CEN198)and long terminal repeat(LTR)Gypsy elements(≥74.73%).By filling all unclosed gaps,the integrity of YH1 is markedly improved over previous P.pyrifolia genomes(‘Cuiguan’and‘Nijisseiki’).A total of 1531 segmental duplication(SD)driven duplicated genes were identified and enriched in stress response pathways.Intrachromosomal SDs drove the expansion of disease resistance genes,suggesting the potential of SDs in adaptive pear evolution.A large proportion of duplicated gene pairs exhibit dosage effects or sub-/neo-functionalization,whichmay affect agronomic traits like stone cell content,sugar content,and fruit skin russet.Furthermore,as core regulators of anthocyanin biosynthesis,we found that MYB10 and MYB114 underwent various gene duplication events.Multiple copies of MYB10 and MYB114 displayed obvious dosage effects,indicating role differentiation in the formation of red-skinned pear fruit.In summary,the T2T gap-free pear genome provides invaluable resources for genome evolution and functional genomics. | Manyi Sun Chenjie Yao Qun Shu Yingyun He Guosong Chen Guangyan Yang Shaozhuo Xu Yueyuan Liu Zhaolong Xue Jun Wu | 2023 | Horticulture Research2023，10，11： | 0 |
| 11 | K_(2)S_(2)O_(8)-mediated acylarylation of unactivated alkenes via acyl radical addition/C–H annulation cascade of N-allyl-indoles with silver cocatalysis显示文摘A silver-catalyzed,K_(2)S_(2)O_(8)-mediated protocol to access regioselective acylarylation of unactivated alkenes was developed.The reaction between N-allyl-indoles andα-oxocarboxylic acids proceeded smoothly and involved an acyl radical addition/C–H cyclization cascade.The protocol showed a broad substrate scope and good tolerance of functional groups.The reaction proceeded with both internal and terminal alkenes to furnish many functional pyrrolo[1,2-a]indoles bearing the ketone carbonyl group,and this feature also provides the potential to construct structurally complex N-containing heterocycles. | Jitan Zhang Manyi Wu Hu Ju Haitao Yang Baiyang Qian Ke Ding Jiaping Wu Meihua Xie | 2022 | Organic Chemistry Frontiers2022，9，1： | 0 |
| 12 | Sulfur vacancies-induced“Electron Bridge”in Ni_(4)Mo/Sv-Zn_(x)Cd_(1-x)S regulates electron transfer for efficient H_(2)-releasing photocatalysis显示文摘Despite the existence of plentiful photocatalyst heterojunctions,their separation efficiency and charge flow precision remain low on account of lacking interfacial modulation.Herein,through a defect-induced heterojunction constructing strategy,Ni4Mo alloys were in-situ grown on the unsaturated coordinated sulfur atoms of sulfur vacancies-rich ZCS(Sv-ZCS)via interfacial Ni-S covalent bonds.The experimental and theoretical results reveal that these unsaturated sulfur atoms induced by sulfur vacancies vastly facilitate to anchor more Ni-Mo nanoparticles and form abundant Ni-S covalent bonds,meanwhile,these sulfur vacancies could form dual internal electric field(IEF)and work with Ni-S covalent bonds as“Electron Bridge”to further accelerate photoelectrons transfer,as well as promote the activation of water molecules and the desorption of hydrogen proton.Accordingly,the optimized Ni_(4)Mo/Sv-ZCS composite achieves an improved photocatalytic hydrogen evolution(PHE)rate of 94.69 mmol h^(-1)g^(-1)without an evident decrease after 6 cycles of photocatalytic tests,which is 21.2 and 1.94 times higher than those of Pt/ZCS and Ni_(4)Mo/ZCS,respectively.This tactic opens a new way for optimizing Zn_(x)Cd_(1-x)S-based heterojunctions by constructing sulfur vacancies and covalent bonds as“Electron Bridge”to enhance the activity of PHE. | Xin Zhang Manyi Gao Longyu Qiu Jie Sheng Weiwei Yang Yongsheng Yu | 2023 | Journal of Energy Chemistry2023，，4： | 0 |
| 13 | Swarming magnetic photonic-crystal microrobots withon-the-fly visual pH detection and self-regulated drug delivery显示文摘Swarming magnetic micro/nanorobots hold great promise for biomedical applications,but at present suffer from inferior capabilities to perceive and respond to chemical signals in local microenvironments.Here we demonstrate swarming magnetic photonic crystal microrobots(PC-bots)capable of sponta-neously performing on-the-fly visual pH detection and self regulated drug delivery by perceiving local pH changes.The magnetic PC-bots consist of pH-responsive hydrogel microspheres with encapsulated one-dimensional periodic assemblies of Fe3O4 nanoparticles.By programming extemnal rotating magnetic fields,they can self-organize into large swarms with much-enhanced collective velocity to actively find targets while shining bright“blinking”structural colors.When approaching the target with abnormal pH conditions(e.g.an ulcerated superficial tumor lesion),the PC-bots can visualize local pH changes on the fly via pH-responsive structural colors,and realize self-regulated release of the loaded drugs by recognizing local pH.This work facilita tes the develop-ment of intelligent micro/nanorobots for active“motile-targeting”tumor diag-nosis and treatment. | Zheng Yu Luolin Li Fangzhi Mou Shimin Yu Di Zhang Manyi Yang Qing Zhao Huiru Ma Wei Luo Tianlong Li Jianguo Guan | 2023 | InfoMat2023，5，10： | 0 |
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