|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Polymorphisms of MTHFR and susceptibility to oesophageal adenocarcinoma in a Caucasian United Kingdom population显示文摘AIM:To identify if methylene tetra-hydrofolatereductase(MTHFR)C677T polymorphisms are associated with oesophageal adenocarcnomas in a Caucasian population and to test whether folic acid and homocysteine levels are linked with cancer risk.METHODS:A case control study comprising of 58 non cancer and 48 cancer patients,MTHFR C667T genotyping was made and serum folate,homocysteine and vitamin B12 levels were made.Tumour stage,differentiation and survival was recorded.A P value of less than0.05 was taken to be significant.Theχ2 used to compare discrete variables and the Mantel-Cox was used to compare survival.A P value less than 0.05 was deemed to be significant.RESULTS:MTHFR polymorphisms is associated with an increased risk of several cancers.A link between MTHFR C677T polymorphisms and oesophageal squamous cell carcinoma and gastric cardia adenocarcinoma has been demonstrated in at risk Chinese populations.In a Western European population the role of the MTHFR gene has not previously been investigated in the setting of oesophageal adenocarcinoma.No association between folic acid levels and cancer patients was found.The unstable MTHFR 667 TT genotype occurred in 11%cancers and 7%controls,but statistical significance was not reached,homocysteine levels and folic acid levels were not affected,cancer patients with TT genotype displayed a trend for a shorter survival 7 mo vs 20 mo.Serum vitamin B12 levels were higher in the cancer group.The MTHFR 667 TT genotype is much lower than previous population studies.CONCLUSION:We conclude that serum folic acid and MTHFR polymorphisms are not associated with an increased risk of oesophageal adenocarcinoma,although cancers with unstable TT genotype may indicate a more aggressive disease course. | Richard Keld Manyi Thian Chia Hau Jamil Sajid Narveen Kumar Yeng Ang | 2014 | World Journal of Gastroenterology2014，20，34： | 8 |
| 2 | Characterization of bbtTICAM from amphioxus suggests the emergence of a MyD88-independent pathway in basal chordates显示文摘MyD88 独立的小径,发信号的二关键 TLR 之一发送,被认为是脊椎动物革新。然而,一个新奇 Toll/interleukin-1 受体(TIR ) 适配器,指明的 bbtTICAM,在基础脊索动物文昌鱼被识别,连接这条小径到无脊椎动物。bbtTICAM 的蛋白质建筑学类似于脊椎动物 TICAM1 的(包含 TIR 适配器 molecule-1,也作为 TRIF 知道) 当种系发生的分析基于 TIR 领域显示了那时, bbtTICAM 是脊椎动物 TICAM1 和 TICAM2 的最旧的 ortholog (包含 TIR 适配器 molecule-2,是也知道电车) 。类似于人的 TICAM1, bbtTICAM 激活 NF-κ以由与受体交往蛋白质交往的一种 MyD88 独立的方式的 B (裂开) 经由它的 RHIM 主题。如此的激活要求 bbtTICAM 形成 homodimers 在里面内涵体,和它可以被文昌鱼 SARM 否定地调整(无菌的 α并且犰狳包含主题的蛋白质) 并且 TRAF2。然而, bbtTICAM 没导致类型的生产我干扰素。因此,我们的学习不仅介绍脊椎动物 TICAM1 和 TICAM2 的祖先的特征,而且从基础脊索动物揭示 MyD88 独立的小径的进化起源,它将帮助理解脊椎动物 TLR 网络的开发。 | Manyi Yang Shaochun Yuan Shengfeng Huang Jun Li Liqun Xu Huiqing Huang Xin Tao Jian Peng Anlong Xu | 2011 | Cell Research2011，21，10： | 5 |
| 3 | Selective dopamine D3 receptor antagonist YQA14 inhibits morphine-induced behavioral sensitization in wild type,but not in dopamine D3 receptor knockout mice显示文摘Increasing preclinical evidence demonstrates that dopamine D3 receptor (D3R) antagonists are a potential option for the treatment of drug addiction. The reinstatement of the addiction can be triggered by environmental stimuli that acquire motivational salience through repeated associations with the drug’s effects. YQA14 is a novel D3R antagonist that has exhibited pharmacotherapeutic efficacy in reducing cocaine and amphetamine reward and relapse to drug seeking in mice. In this study we investigated the effects of YQA14 on morphine-induced context-specific locomotor sensitization in mice. We showed that repeated injection of YQA14 (6.25–25mg/kg every day ip) prior to morphine (10mg/kg every day sc) not only inhibited the acquisition, but also significantly attenuated the expression of morphine-induced locomotor sensitization. Furthermore, in the expression phase, one single injection of YQA14 (6.25-25mg/kg, ip) dose-dependently inhibited the expression of morphine-induced behavioral sensitization. Moreover, YQA14 inhibited the expression of morphine-induced behavioral sensitization in wild mice (WT), but not in D3R knockout (D3R^-/-) mice in the expression phase. In addition, D3R^-/- mice also displayed the reduction in the expression phase compared with WT mice. In summary, this study demonstrates that blockade or knockout of the D3R inhibits morphine-induced behavior sensitization, suggesting that D3R plays an important role in the pathogenesis and etiology of morphine addiction, and it might be a potential target for clinical management of opioid addiction. | Yang Lv Rong-rong Hu Manyi Jing Tai-yun Zhao Ning Wu Rui Song Jin Li Gang Hu | 2019 | Acta Pharmacologica Sinica2019，40，5： | 4 |
| 4 | Swarming Responsive Photonic Nanorobots for Motile-Targeting Microenvironmental Mapping and Mapping-Guided Photothermal Treatment显示文摘Micro/nanorobots can propel and navigate in many hard-to-reach biological environments,and thus may bring revolutionary changes to biomedical research and applications.However,current MNRs lack the capability to collectively perceive and report physicochemical changes in unknown microenvironments.Here we propose to develop swarming responsive photonic nanorobots that can map local physicochemical conditions on the fly and further guide localized photothermal treatment.The RPNRs consist of a photonic nanochain of periodically-assembled magnetic Fe_(3)O_(4)nanoparticles encapsulated in a responsive hydrogel shell,and show multiple integrated functions,including energetic magnetically-driven swarming motions,bright stimuli-responsive structural colors,and photothermal conversion.Thus,they can actively navigate in complex environments utilizing their controllable swarming motions,then visualize unknown targets(e.g.,tumor lesion)by collectively mapping out local abnormal physicochemical conditions(e.g.,pH,temperature,or glucose concentra-tion)via their responsive structural colors,and further guide external light irradiation to initiate localized photothermal treatment.This work facilitates the development of intelligent motile nanosensors and versatile multifunctional nanotheranostics for cancer and inflam-matory diseases. | Luolin Li Zheng Yu Jianfeng Liu Manyi Yang Gongpu Shi Ziqi Feng Wei Luo Huiru Ma Jianguo Guan Fangzhi Mou | 2023 | Nano-Micro Letters2023，15，9： | 3 |
| 5 | A fundamental study on the fluorescence-quenching effect of nitro groups in tetraphenylethene AIE dyes with electron-withdrawing groups显示文摘A nitro group is a common fluorescence quencher,but its quenching efficiency can be easily affected by the surrounding environment.To date,there has been no systematic study on the effects of electronwithdrawing groups on the quenching efficiency of nitro groups.Herein,by virtue of experimental validation and theoretical calculations,we found that strong electron-withdrawing groups,such as pyridinium and dicyanovinyl groups,are detrimental to the quenching effect of nitro groups.Decreasing the electron-withdrawing ability could restore the nitro group’s quenching effect. | Cheng-Xiao Zhao Tian Liu Manyi Xu Hao Lin Chong-Jing Zhang | 2021 | Chinese Chemical Letters2021，32，6： | 2 |
| 6 | Improved Plasmonic Hot‑Electron Capture in Au Nanoparticle/Polymeric Carbon Nitride by Pt Single Atoms for Broad‑Spectrum Photocatalytic H_(2)Evolution显示文摘ABSTRACT Rationally designing broad-spectrum photocatalysts to harvest whole visible-light region photons and enhance solar energy conversion is a“holy grail”for researchers,but is still a challenging issue.Herein,based on the common polymeric carbon nitride(PCN),a hybrid co-catalysts system comprising plasmonic Au nanoparticles(NPs)and atomically dispersed Pt single atoms(PtSAs)with different functions was constructed to address this challenge.For the dual co-catalysts decorated PCN(PtSAs–Au_(2.5)/PCN),the PCN is photoexcited to generate electrons under UV and short-wavelength visible light,and the synergetic Au NPs and PtSAs not only accelerate charge separation and transfer though Schottky junctions and metal-support bond but also act as the co-catalysts for H_(2) evolution.Furthermore,the Au NPs absorb long-wavelength visible light owing to its localized surface plasmon resonance,and the adjacent PtSAs trap the plasmonic hot-electrons for H_(2) evolution via direct electron transfer effect.Consequently,the PtSAs–Au_(2.5)/PCN exhibits excellent broad-spectrum photocatalytic H_(2) evolution activity with the H_(2) evolution rate of 8.8 mmol g^(−1) h^(−1) at 420 nm and 264μmol g^(−1) h^(−1) at 550 nm,much higher than that of Au_(2.5)/PCN and PtSAs–PCN,respectively.This work provides a new strategy to design broad-spectrum photocatalysts for energy conversion reaction. | Manyi Gao Fenyang Tian Xin Zhang Zhaoyu Chen Weiwei Yang Yongsheng Yu | 2023 | Nano-Micro Letters2023，15，8： | 2 |
| 7 | Metal Free Mono- and 2,3-Bis-sulfenylation of Indoles in Water with Sodium Sulfinates as a Sulfur Source显示文摘 | Changqing Liu Jian Fan Manyi Wu Jiahui Chen Yiming Zhao Meihua Xie | 2018 | Chinese Journal of Chemistry2018，36，9： | 2 |
| 8 | Protective effects of sodium butyrate on rotavirus inducing endoplasmic reticulum stress-mediated apoptosis via PERK-eIF2αsignaling pathway in IPEC-J2 cells显示文摘Background:Rotavirus(RV)is a major pathogen that causes severe gastroenteritis in infants and young animals.Endoplasmic reticulum(ER)stress and subsequent apoptosis play pivotal role in virus infection.However,the protective mechanisms of intestinal damage caused by RV are poorly defined,especially the molecular pathways related to enterocytes apoptosis.Thus,the aim of this study was to investigate the protective effect and mechanism of sodium butyrate(SB)on RV-induced apoptosis of IPEC-J2 cells.Results:The RV infection led to significant cell apoptosis,increased the expression levels of ER stress(ERS)markers,phosphorylated protein kinase-like ER kinase(PERK),eukaryotic initiation factor 2 alpha(eIF2α),caspase9,and caspase3.Blocking PERK pathway using specific inhibitor GSK subsequently reversed RV-induced cell apoptosis.The SB treatment significantly inhibited RV-induced ERS by decreasing the expression of glucose regulated protein 78(GRP78),PERK,and eIF2α.In addition,SB treatment restrained the ERS-mediated apoptotic pathway,as indicated by downregulation of C/EBP homologous protein(CHOP)mRNA level,as well as decreased cleaved caspase9 and caspase3 protein levels.Furthermore,siRNA-induced GPR109a knockdown significantly suppressed the protective effect of SB on RV-induced cell apoptosis.Conclusions:These results indicate that SB exerts protective effects against RV-induced cell apoptosis through inhibiting ERS mediated apoptosis by regulating PERK-eIF2αsignaling pathway via GPR109a,which provide new ideas for the prevention and control of RV. | Ye Zhao Ningming Hu Qin Jiang Li Zhu Ming Zhang Jun Jiang Manyi Xiong Mingxian Yang Jiandong Yang Linyuan Shen Shunhua Zhang Lili Niu Lei Chen Daiwen Chen | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 2 |
| 9 | Proximally Based Conjoined Tendon Transfer for Coracoclavieular Reconstruction in the Treatment of Acromioclavicular Dislocation 显示文摘 | CHUNYAN JIANG MANYI WANG GUOWEI RONG | 2007 | J Bone Joint Surg(Am)2007，89，： | 1 |
| 10 | 显示文摘 | MANYI(满毅) ZONGRUILONG(宗瑞隆) ZHUYONG-FA(朱永法) | 2007 | 物理化学学报2007，23，： | 1 |
| 11 | Comparison study of two surgical options for distal tibia fracture-minimally invasive plate osteosynthesis vs open reduction and internal fixa- tion显示文摘 | CHENG W LI Y MANYI W | 2011 | Int Orthop2011，35，5： | 1 |
| 12 | Treatment of proximal humeral fracture with a proximal humeral nail显示文摘 | Yiming Zhu Yi Lu Manyi Wang Chunyan Jiang | 2010 | Journal of Shoulder and Elbow Surgery2010，，2： | 1 |
| 13 | Tire Dynamics Modeling Method Based on Rapid Test Method显示文摘Combined with the tire dynamics theoretical model,a rapid test method to obtain tire lateral and longitudinal both steady-state and transient characteristics only based on the tire quasi-steady-state test results is proposed.For steady state data extraction,the test time of the rapid test method is half that of the conventional test method.For transient tire characteristics the rapid test method omits the traditional tire test totally.At the mean time the accuracy of the two method is much closed.The rapid test method is explained theoretically and the test process is designed.The key parameters of tire are extracted and the comparison is made between rapid test and traditional test method.The result show that the identification accuracy based on the rapid test method is almost equal to the accuracy of the conventional one.Then,the heat generated during the rapid test method and that generated during the conventional test are calculated separately.The comparison shows that the heat generated during the rapid test is much smaller than the heat generated during the conventional test process.This benefits to the reduction of tire wear and the consistency of test results.Finally,it can be concluded that the fast test method can efficiently,accurately and energy-efficiently measure the steady-state and transient characteristics of the tire. | Dang Lu Lei Lu Haidong Wu Wei Wang Manyi Lv | 2020 | Chinese Journal of Mechanical Engineering2020，33，6： | 1 |
| 14 | Comparison study of two surgical options for disal tibia fractures-minimally invasive plate osteosyuthesis vs 显示文摘 | Cheng W Li Y Manyi W | 2011 | Open Reduct Inter Fixat Orth2011，35，5： | 1 |
| 15 | Enhanced electrochemical performance of La_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3−δ)cathode via Ba-doping for intermediate-temperature solid oxide fuel cells显示文摘La_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3-δ)(LSCF)is recognized as one of the most promising cathode materials for the highly-desired intermediatetemperature solid oxide fuel cell(IT-SOFC)technology.However,it is still challenged by polarization losses due to reduced operation temperatures.In this work,a series of Ba^(2+)-doped La0.6-xBaxSr0.4Co0.2Fe0.8O3-δ(LBSCFx,x=0.05,0.10,0.15,and 0.20)materials are successfully synthesized and their electrochemical performances are evaluated as a cathode for IT-SOFC technology.The study shows that,compared to the un-doped LSCF,the Ba^(2+)-doped LBSCF possess higher electrical conductivities at 500-800℃ and display lower polarization resistances to oxygen adsorption/dissociation.As a result,the Ni-SDC|SDC|LBSCF0.20 cell(SDC=samarium-doped cerium,Sm_(0.2)Ce_(0.8)O_(1.9))delivers a high maximum power density of 0.704 W/cm^(2)at 750℃,which is>30%higher than the Ni-SDC|SDC|LSCF cell.This work reveals that Ba^(2+)-doping is effective in enhancing oxygen catalytic activity of LSCF-based cathode materials,demonstrating a new and commercial-feasible strategy in developing high performance cathode materials for the IT-SOFC technology. | Changkun Cai Manyi Xie Ke Xue Yu Shi Shuting Li Yuanyuan Liu Shengli An Hong Yang | 2022 | Nano Research2022，15，4： | 1 |
| 16 | Postoperative malro- tation of humeral shaft fracture after plating compared with intramedullary nailing显示文摘 | Ying L Cheng W Manyi W | 2011 | J Shoulder Elbow Surg2011，20，6： | 1 |
| 17 | Comparison of the Icare Tonometer and the Hand-held Goldmann Applanation Tonometer in Pediatric Aphakia显示文摘 | Yunping Li Luosheng Tang Manyi Xiao Songbai Jia Ping Liu Yi Zhou Huihui Chen Jiexi Zeng | 2013 | Journal of Glaucoma2013，，7： | 1 |
| 18 | Comparison study of twosur gicaloptions for distaltibia fracture -minimall yinvasive plateoste osynthesisvs, open reduction andintennal fixation 显示文摘 | cheng W Li Y Manyi W | 2011 | Intorthop2011，35，5： | 1 |
| 19 | Comparison study of two surgical options for distal tibia fracture-minimally invasive plate osteosynthesis open reduction and internal fixation显示文摘 | Cheng W Li Y Manyi W | 2011 | Int Orthop2011，35，5： | 1 |
| 20 | Comparison of two -staged ORIF and limited internal fixation with external fixator for closed tibial plafond fractures 显示文摘 | Cheng W Ying L Lei H Manyi W | 2010 | Areh Orthop trauma surg2010，130，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员