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| 1 | MECHANICAL PROPERTIES OF FINE PITCH DEVICES SOLDERED JOINTS BASED ON CREEP MODEL显示文摘Nonlinear analyses of quad flat package (QFP) on printed circuit board (PCB) assemblies subjected to thermal cycling conditions are presented.Two different solders are considered,namely, Sn37Pb and Sn3.5Ag.The stress and strain response of fine pitch devices soldered joints was investigated by using finite element method based on Garofalo-Arrheninus model.The simulated results indicate creep distribution of soldered joints is not uniform,the heel and toe of soldered joints, the area between soldered joints and leads are the creep concentrated sites.The similar phenomena of stress curves simulated based on Garofalo-Arrhenlnus model and Anand equations is confirmed,and the creep strain value of Sn3.5Ag soldered joints is lower than that of Sn37Pb soldered joints. Thermal cycling results show that Sn3.5Ag strongly outperforms Sn37Pb for QFP devices under the studied test condition.This is well matched with the experimental outcome analyzed.In addition,the soldered devices were tested by micro-joints tester,the tensile strength of Sn3.5Ag soldered joints is found to be higher than that of Sn37Pb soldered joints.By analyzing the fracture microstructure of soldered joints,it is found that fracture mechanism of Sn3.5Ag soldered joints is toughness fracture, while fracture mechanism of Sn37Pb soldered joints includes brittle fracture and toughness fracture. The results of this study provide an important basis of understanding the mechanical properties of fine pitch devices with traditional Sn37Pb and Sn3.5Ag lead-free soldered joints. | ZHANG Liang XUE Songbai HAN Zongjie WANG Jianxin GAO Lili SHENG Zhong | 2008 | Chinese Journal of Mechanical Engineering2008，21，6： | 12 |
| 2 | Investigation on microstructure and mechanical properties of Al-Zn-Mg-Cu alloys with various Zn/Mg ratios显示文摘The effects of Zn/Mg ratios on microstructure and mechanical properties of Al-Zn-Mg-Cu alloys aged at 150℃have been investigated by using tensile tests,optical metallography,scanning electron microscopy,transmission electron microscopy and atom probe tomography analyses.With increasing Zn/Mg ratios,the ageing process is significantly accelerated and the time to peak ageing is reduced.T’phase predominates in alloys of lower Zn/Mg ratios whileη’phase predominates in alloys with a Zn/Mg ratio over 2.86.Co-existence of T’phase andη’phase with a large number density is beneficial to the high strength of alloys.Such precipitates together with narrow precipitate free zones cause a brittle intergranular fracture.A strength model has been established to predict the co-strengthening effect of T’phase andη’phase in Al-Zn-Mg-Cu alloys,including the factors of the grain boundary,solid solution and precipitation. | Yan Zou Xiaodong Wu Songbai Tang Qianqian Zhu Hui Song Mingxing Guo Lingfei Cao | 2021 | Journal of Materials Science & Technology2021，，26： | 12 |
| 3 | Identification and Characterization of Sulfur Compounds in Straight-Run Diesel Using Comprehensive Two-Dimensional GC Coupled with TOF MS显示文摘The solid-phase extraction using Pd-Al2O3 as the stationary phase was employed to pre-separate the sulfur compounds in straight-run diesel. The isolating effect was evaluated quantitatively by gas chromatography with a sulfur chemiluminescence detector to harvest a satisfactory result. The identification of the structure of sulfur compounds by comprehensive two-dimensional gas chromatography coupled with the time-of-flight mass spectrometry indicated that cyclo-sulfides, benzothiophenes, dibenzothiophenes, dihydro-benzothiophenes and tetrahydro-dibenzothiophenes were included in straightrun diesel obtained from the Arab medium crude(AM). A total of 259 individual compounds were detected and their molecular structures were identified. The analytical method was approved as an effective way to characterize the composition of sulfur compounds, which reduced the interference of other compounds, facilitated the data presentation and provided more detailed information about molecular composition of sulfur compounds. | Niu Luna Liu Zelong Tian Songbai | 2014 | China Petroleum Processing & Petrochemical Technology2014，16，3： | 10 |
| 4 | Petrogenesis and Geotectonic Significance of Early-Neoproterzoic Olivine-Gabbro within the Yangtze Craton: Constrains from the Mineral Composition, U-Pb Age and Hf Isotopes of Zircons显示文摘The olivine-gabbroic rocks located at the Huangling anticline within the Yangtze Craton are dated at circa 857–854 Ma by LA-ICP-MS method. The rocks belong to the sub-alkaline series and consist of pyroxene(35%–40%), plagioclase(40%–45%), olivine(8%–10%) and spinel(3%–5%). Olivine has Fo values of 73–83 that is classified as chrysolite. Pyroxene has relative low contents of Fe O(6.60 wt.%–8.23 wt.%) but high Ca O(20.23 wt.%–21.25 wt.%) contents, however, plagioclase has high Al_2O_3(31.78 wt.%–32.37 wt.%), Ca O(16.08 wt.%–16.25 wt.%) and An(79–80) values, but low Na2 O contents(1.95 wt.%–2.11 wt.%). Spinel are magnesioferrite with characteristics of high contents of Mg O(13.65 wt.%– 13.68 wt.%), Fe O(23.27 wt.%–23.40 wt.%) and Al_2O_3(62.43 wt.%–62.74 wt.%). Chemical compositions of these minerals are similar to those of gabbro rocks that were formed in the post-orogeny environment. The olivine-gabbro samples have negative zircon εHf values(-16.57±0.47) that resemble the mafic rocks in the same region, indicating that they are derived from the extremely enriched mantle source. On the compilation of documented Neoproterozoic mafic rocks in the Yangtze Craton, it is proposed that the mantle in the northern Yangtze Craton has experienced different degrees enrichment during the Neoproterozoic. | Xingfu Jiang Songbai Peng Timothy M.Kusky Lu Wang Hao Deng | 2018 | Journal of Earth Science2018，29，1： | 10 |
| 5 | Characterization of Basic Nitrogen Aromatic Species Obtained during Fluid Catalytic Cracking by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry显示文摘The basic-nitrogen aromatic compounds in feedstocks and liquid products from the micro-reactor and soluble components of coke obtained during fluid catalytic cracking (FCC) process were analyzed by the micro-electrospray ionization (ESI) 9.4T Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) with an average mass resolving power of 300 000 at a mass range of 100-1 200. The analytical results revealed that the coker gas oil (CGO) contained a higher abundance of basic-nitrogen aromatic compounds with the type of -5N to -9N compared with those in deasphalted oil (DAO) and mixed FCC feedstock. After catalytic cracking, the abundance of lowly condensed basic-nitrogen aromatic compounds was much less than those of highly condensed aromatics in the liquid products, with the carbon number mainly ranging from 6 to 25 and the average carbon number of the side-chains equating to 1-5. On the contrary, with respect to the soluble components of coke, the abundance of lowly condensed basic-nitrogen aromatic compounds was more than those of highly condensed aromatics, and the carbon number ranged from 12 to 30, which was much smaller than that of the mixed FCC feedstock but slightly larger than that of the cracked liquid products. These results have provided some fundamental information on FCC process. | Liu Yingrong Wang Wei Hu Qiuling Zhu Yuxia Deng Jinghui Tian Songbai | 2012 | China Petroleum Processing & Petrochemical Technology2012，14，2： | 8 |
| 6 | Changes of Petroleum Acid Distribution Characterized by FT-ICR MS in Heavy Acidic Crude Oil after True Boiling Point Distillation显示文摘The molecular transformations of carboxylic acids in heavy acidic SL crude before and after true boiling point distillation were examined by ultra-high resolution negative-ion electrospray ionization(ESI) Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR MS). The acid class(heteroatom number), type(z numbers) and carbon number distributions were positively characterized. It was found out that the total acid number(TAN) of SL crude decreased after true boiling point distillation, and the abundance of O2 class in mass spectra was also found to be reduced from 67.6% to 34.5% in SL TBP mixed crude as measured by MS spectra, indicating to a potential carboxylic acid decomposition. However, it was interesting that the carboxylic acids type distribution in both oils was almost the same although their relative abundance in SL TBP mixed crude turned to be much lower, suggesting that various petroleum carboxylic acid types have the similar thermal decomposition reaction behavior. Furthermore, for each O2 type of acids in SL TBP mixed crude, the abundance of carboxylic acids with carbon number higher than 35 was reduced greatly, especially for those with carbon number higher than 60, the mass peaks of which were nearly totally removed, indicating that the large carboxylic acid molecules in heavy fractions decomposed more significantly because of longer heating time during the true boiling point distillation process. As a result, the reduction of TAN may be caused by the thermal decomposition of carboxylic acids especially those with high carbon number, suggesting that quick distillation or much lower pressure is required to avoid the thermal decomposition. | Liu Yingrong Zhang Qundan Wang Wei Liu Zelong Zhu Xinyi Tian Songbai | 2014 | China Petroleum Processing & Petrochemical Technology2014，16，1： | 8 |
| 7 | EFFECTS OF LEAD WIDTHS AND PITCHES ON RELIABILITY OF QUAD FLAT PACKAGE(QFP)SOLDERED JOINTS显示文摘有限元素方法(女性) 被用来在焊接关节的可靠性上分析铅宽度和程度的效果。为 QFP 设备的最佳模拟也被研究。结果显示当铅程度是一样时,焊接关节的最大的相等的压力与增加铅宽度增加,当焊接关节的可靠性减少时。当铅宽度是一样时,焊接关节的最大的相等的压力不与增加铅程度完全减少,最大的相等的压力价值的最小的价值在所有曲线存在。在这个条件下面,焊接关节的最大的相等的压力是相对最不,焊接关节的可靠性高,集会是优秀的。模仿的结果显示最好的参数:铅宽度是 0.2 公里,铅沥青是 0.3 公里(在二领先之间的距离是 0.1 公里) ,它现在为 QFP 设备的 micromation 被有益于。当铅宽度是 0.25 公里,铅沥青是 0.35 公里时,焊接关节的最大的相等的压力的最小的值存在(在二领先之间的距离是 0.1 公里) ,设备能很长时间服务,可靠性最高,汇编是优秀的。模仿的结果也显示铅宽度是 0.15 公里和铅沥青的事实也许是 0.2 公里 QFP 的限制,它为高级的铅计数和汇编的 micromation 是重要的。 | XUE Songbai WU Yuxiu HAN Zongjie WANG Jianxin | 2007 | Chinese Journal of Mechanical Engineering2007，20，4： | 7 |
| 8 | Snaill is involved in de novo cardiac fibrosis after myocardial infarction in mice显示文摘Epithelialmesenchymal 转变(EMT ) 是在心肌的梗塞(MI ) 以后的心脏的纤维变性的重要机制。然而,它仍然保持不清楚是否 Snail1, EMT 的一个重要管理者,涉及心脏的纤维变性。在这研究,我们在老鼠探索了 Snail1 和心脏的纤维变性 markerperiostinafter MI 的表示模式然后在老鼠在 MI 以后调查了在 Snail1 和 periostin 之间的合作表示。我们的结果证明 Snail1 和 periostin 的 mRNA 和蛋白质层次显著地在梗塞区域被增加。Snail1 表示模式看起来在在 MI 以后的 14 天以内寓言。另外在 MI 以后,所有 Snail1 积极的房间能表示 periostin。这些结果显示 Snail1 主要在梗塞区域被激活并且涉及 de novo 在在老鼠的 MI 以后的心脏的纤维变性。因此,它是在为在 MI 以后的室的改变的药干预的发展的一个潜在的分子的目标。 | Yajie Liu Jianlin Du Jin Zhang Minjie Weng Xiaoqun Li Di Pu Lingzhi Gao Songbai Deng Shuang Xia Qiang She | 2012 | Acta Biochimica et Biophysica Sinica2012，44，11： | 7 |
| 9 | Pituitary tumor transforming gene: a novel therapeutic target for glioma treatment显示文摘有强壮的增长和 angiogenesis 能力的 Glioma 是在中央神经系统的最普通、恶意的主要肿瘤。垂体肿瘤转变基因(PTTG ) 在垂体肿瘤被发现,并且在房间增长,房间周期,房间 apoptosis,和 angiogenesis 起重要作用。然而,在 glioma 的 PTTG 的角色仍然不完全地被调查。这里,我们探索了在 PTTG 和 glioma 等级,以及微容器的密度(MVD ) 之间的关联。另外, siRNA 包括 U87MG, U251,和 SHG44 在 glioma 房间线习惯于沉默 PTTG 表示。房间增长, apoptosis,侵略,和 angiogenesis 在 vitro 并且在 vivo 被学习。我们的结果证明那 PTTG 表情在 glioma 是显著地起来调整的,并且与 glioma 等级和 MVD 有积极关联。PTTG 的 Silencing 禁止了 glioma 房间增长,迁居 / 侵略,和 angiogenesis,导致了房间 apoptosis,压制了房间侵略,并且逮捕了在 G0/G1 舞台的房间周期。PTTG 的 Silencing 能也在 vivo 禁止肿瘤生长,侵略,和 angiogenesis。我们的数据显示 PTTG 可能是为 glioma 处理的一个潜在的目标。 | Lishan Cui Songbai Xu Zhengmao Song Gang Zhao Xiaoqian Liu Yuwen Song | 2015 | Acta Biochimica et Biophysica Sinica2015，47，6： | 6 |
| 10 | Characteristics of subsurface density variations before the 4.20 Lushan M_s7.0 earthquake in the Longmenshan area: inversion results显示文摘The 4.20 Lushan MS7.0 earthquake occurred on the southwest segment of the Longmenshan fault on 20 April 2013. Some meaningful information on the preparation and occurrence of this earthquake was found based on the dynamic variation of gravity(DVG). To examine the great progress of the Lushan earthquake, we obtained the density variation(DENV) derived from the DVG using the compact gravity inversion method in this article. The inversion results reveal three main findings:(1) the DENV in the crust in the Jinshajiang fault area changed from positive in 2010–2011 to negative in 2011–2012.(2) The DENV in the Xianshuihe fault area decreased continuously from 2010 to 2012.(3) The DENV of the uppermost mantle of South China decreased in 2010–2011 and increased in 2011–2012. We propose that the flow/expansion of the middle-lower crust beneath the Bayan Har block and Moho subsidence on the southwest margin of the Chuan-Dian block may have been the major causes of the Lushan earthquake. | Songbai Xuan Chongyang Shen Hui Li Hongtao Hao | 2015 | Earthquake Science2015，28，1： | 5 |
| 11 | Design of a memory polynomial predistorter for wideband envelope tracking amplifiers显示文摘Efficiency and linearity of the microwave power amplifier are critical elements for mobile communication systems. A memory polynomial baseband predistorter based on an indirect learning architecture is presented for improving the linearity of an envelope tracing (ET) amplifier with application to a wireless transmitter. To deal with large peak-to-average ratio (PAR) problem, a clipping procedure for the input signal is employed. Then the system performance is verified by simulation results. For a single carrier wideband code division multiple access (WCDMA) signal of 16-quadrature amplitude modulation (16-QAM), about 2% improvement of the error vector magnitude (EVM) is achieved at an average output power of 45.5 dBm and gain of 10.6 dB, with adjacent channel leakage ratio (ACLR) of -64.55 dBc at offset frequency of 5 MHz. Moreover, a three-carrier WCDMA signal and a third-generation (3G) long term evolution (LTE) signal are used as test signals to demonstrate the performance of the proposed linearization scheme under different bandwidth signals. | Jing Zhang Songbai He Lu Gan | 2011 | Journal of Systems Engineering and Electronics2011，22，2： | 5 |
| 12 | Diode Laser Soldering Technology of Fine Pitch QFP Devices显示文摘The laser provides a controllable means of supplying localized energy for solder joint formation and is a valuable tool in electronics manufacture.Diode laser soldering for fine pitch QFP devices were carried out with Sn-Ag-Cu lead-free solder and Sn-Pb solder respectively,and the mechanical properties of micro-joints of the QFP devices were tested and studied by STR-1000 micro-joints tester.The results indicate that sound QFP micro-joints without bridging or solder ball are gained by means of diode laser soldering method with appropriate laser processing parameters,and the pitch of the QFP devices is as fine as to 0.4mm.Tensile strength of QFP micro-joints increases gradually with the increase of laser output power,the maximum tensile strength presents when the laser output power increase to a certain value.The results also indicate that the mechanical properties of QFP micro-joints soldered by diode laser soldering system are better than those of QFP micro-joints soldered by IR reflow soldering method.The experimental results may provide a theory guide for investigation of diode laser soldering. | XUE Songbai ZHANG Liang HAN Zongjie WANG Jianxin YU Shenglin | 2011 | Chinese Journal of Mechanical Engineering2011，24，5： | 5 |
| 13 | Application of the modern ophiolite concept with special reference to Precambrian ophiolites显示文摘Much has been learned in the past 40 years about the great diversity of the internal structure and geochemical compositions of Phanerozoic ophiolites, indicating that these on-land fragments of ancient oceanic lithosphere formed in distinctly different tectonic settings during their igneous evolution. Recent studies in Archean and Proterozoic greenstone belts have shown that the Precambrian rock record may also include exposures of a diverse suite of ophiolite complexes as part of craton development in the early history of the Earth. We review the salient features of the Precambrian ophiolite record to highlight what has been learned about Precambrian oceanic spreading systems since the original Penrose definition of ophiolites in 1972. Some of the diagnostic, characteristic, typical, and rare aspects of ophiolites of all ages are presented in a table in order to help determine if tectonically deformed and metamophosed sequences in Precambrian shield areas may be considered as ophiolites. The results of this comparative study are important in that they enable researchers to more realistically characterize allochthonous mafic/ultramafic rock sequences as ophiolitic or non-ophiolitic. This approach is more deterministic in contrast to some other arbitrary classification schemes requiring three or four of the Penrose-style ophiolitic units to be present in the Precambrian record for a specific rock sequence to be considered ophiolitic. Once these tectonic fragments are recognized as remnants of ancient oceanic lithosphere, great progress shall be made in understanding early Earth history. We discuss the significance and implications of the Precambrian ophiolite record to constrain the mode and nature of the plate tectonics that operated in deep time. | Timothy M. KUSKY WANG Lu Yildirim DILEK Paul ROBINSON PENG SongBai HUANG XuYa | 2011 | Science China Earth Sciences2011，54，3： | 4 |
| 14 | Corresponding Factors Influencing Crude Oils Assay Using Low-field Nuclear Magnetic Resonance显示文摘In this study, the main factors influencing the measurements by means of the off-line low-field 1H NMR in the lab were discussed base on a robust calibration model established by the PLS algorithm using 255 crude oil samples. The preheating temperature had a great influence on the viscosity of oil samples and the resolution of spectral analysis. The repeatability of spectral measurements was impacted by the metal and wax content of the oil samples. For the case of high wax content oils, the wax species began to crystallize in the course of determination that could affect the repeatability of spectral measurements. These factors have evidenced why the preheating devices and filter unit are necessary when low field NMR system is used in the online analysis process. The investigation is very important for the on-line application of the low field NMR. | Feng Yunxia Chu Xiaoli Xu Yupeng Tian Songbai | 2014 | China Petroleum Processing & Petrochemical Technology2014，16，2： | 4 |
| 15 | Estimating Moho basement and faults using gravity inversion in Yushu-earthquake area,China显示文摘A gravity survey was conducted one month after the 2010 Yushu earthquake in the epicenter area.The cross-fault survey line was 500 km long,from Langqian county to Qingshuihe county,in a transition zone between Bayan Har block and Qiangtang block,in an area of high elevation,large undulating terrain,and complex geological features.An interpretation of the data was carried out together with other kinds of data,such as seismic exploration and magnetic exploration.The result shows that gravity is sensitive to fault boundary;the geologic structure of the region is complex at middle and upper depths,and the density profile reveals an eastward-pushing fault movement. | Yang Guangliang | 2012 | Geodesy and Geodynamics2012，3，2： | 4 |
| 16 | Effect of Thermal Cycling on Properties and Microstructure of SnAgCuCe Soldered Joints in QFP Devices显示文摘Increasing global concern about the environment is bringing regulatory (European directives) and consumer ('green products') pressure on the electronics industry in Europe and Japan to reduce or completely eliminate the use of lead (Pb) in products. Among all lead-free solder alloys, SnAgCu solder system, which has better thermo-mechanical properties compared with those of SnPb solder, is proven to be one of the promising candidates for electronic assembly. Previous work also revealed that adding a small amount of rare earth Ce into SnAgCu solder can visibly improve the properties and inhibit the excessive growth of the intermetallic compound layer. Thermal fatigue properties of SnAgCuCe soldered joints in QFP devices under thermal conditions have been investigated by finite element method and experiments. Based on creep model of low stress and high stress, corresponding creep subroutine was established for simulating the stress and strain response of SnAgCuCe soldered joint from -55 ℃ to 125 ℃, and fatigue life was calculated using creep fatigue life prediction equation. Moreover, thermal cycling experiments were conducted, the experimental results were found to be close to the simulated results. In addition, the tensile force of SnAgCuCe soldered joints decreased with increasing number of thermal cycles, and the fracture mechanism transformed from toughness fracture to brittle intergranular fracture. Moreover the tensile force changes and fracture microstructure evolution could benefit the quantitative evaluations of the mechanical performances of lead-free soldered joints under thermal cycling loadings. | ZHANG Liang XUE Songbai GAO Lili ZENG Guang YU Shenglin SHENG Zhong | 2011 | Chinese Journal of Mechanical Engineering2011，24，4： | 4 |
| 17 | Molecular Characterization of Hydrotreated Atmospheric Residue Derived from Arabian Heavy Crude by GC FI/FD TOF MS and APPI FT-ICR MS显示文摘High resolution mass spectrometry in combination with distillation and SARA fractionation provides us an opportunity for in-depth understanding about the hydrotreating process at the molecular level. In this study, the atmospheric residue derived from Arabian heavy crude and its hydrotreated products were initially subjected to distillation and SARA fractionation. The saturates were characterized by GC FI/FD TOF MS. The aromatics and resins were characterized by APPI FT-ICR MS. Compositional changes of different compounds (paraffins, naphthenes, aromatic hydrocarbons, and heteroatomic compounds) contained in different distillates (vacuum gas oil, vacuum residue) were obtained. More detailed knowledge about the hydrotreating process was achieved. | Diao Rui Wang Wei Wang Naixin Liu Zelong Dai Lishun Tian Songbai | 2012 | China Petroleum Processing & Petrochemical Technology2012，14，4： | 4 |
| 18 | Weighted Estimates for Marcinkiewicz Integrals with Non-Doubling Measures显示文摘Let μ be a nonnegative Radon measure on R d which satisfies the growth condition μ(B(x,r)) ≤ C0rn for all x ∈Rd and r >0,where C0 is a fixed constant and 0 | Songbai WANG Yinsheng JIANG Baode LI | 2012 | Journal of Mathematical Research with Applications2012，32，2： | 4 |
| 19 | A Method for Crude Oil Selection and Blending Optimization Based on Improved Cuckoo Search Algorithm显示文摘Refineries often need to find similar crude oil to replace the scarce crude oil for stabilizing the feedstock property. We introduced the method for calculation of crude blended properties firstly, and then created a crude oil selection and blending optimization model based on the data of crude oil property. The model is a mixed-integer nonlinear programming(MINLP) with constraints, and the target is to maximize the similarity between the blended crude oil and the objective crude oil. Furthermore, the model takes into account the selection of crude oils and their blending ratios simultaneously, and transforms the problem of looking for similar crude oil into the crude oil selection and blending optimization problem. We applied the Improved Cuckoo Search(ICS) algorithm to solving the model. Through the simulations, ICS was compared with the genetic algorithm, the particle swarm optimization algorithm and the CPLEX solver. The results show that ICS has very good optimization efficiency. The blending solution can provide a reference for refineries to find the similar crude oil. And the method proposed can also give some references to selection and blending optimization of other materials. | Yang Huihua Ma Wei Zhang Xiaofeng Li Hu Tian Songbai | 2014 | China Petroleum Processing & Petrochemical Technology2014，16，4： | 4 |
| 20 | Role of EGFL7/EGFR-signaling pathway in migration and invasion of growth hormone-producing pituitary adenomas显示文摘Currently, the primary therapeutic strategy for most growth hormone-producing pituitary adenomas(GHPA) is surgery. Due to the invasiveness of GHPA, high recurrence has limited the benefit of complete adenoma removal surgery. Epidermal growth factor-like domain 7(EGFL7) is a secreted factor implicated in tumor angiogenesis, growth, invasiveness and metastasis in GHPA. Herein, we observed that the expression level of EGFL7 and p-EGFR in invasive GHPAwas much higher than that of non-invasive GHPA. The overexpression of EGFL7 was positively correlated with activation of EGFR(p-EGFR). Noticeably, EGFL7 knockdown significantly inhibited activation of EGFR signaling cascades, including p-ERGR, p-AKT and p-ERK. Further studies showed that EGFL7 knockdown or pharmacological inhibition of EGFR-pathway, using EGFR inhibitor Tyrphostin AG-1478, significantly suppressed migration and invasion of GH3 and GT1-1 cells. In summary, our findings suggest that EGFL7 is a key factor for regulation of EGFR signaling pathway and plays an important role in migration and invasion of invasive GHPA. | Qian Liu Junwen Zhang Hua Gao Taoyang Yuan Jie Kang Lu Jin Songbai Gui Yazhuo Zhang | 2018 | Science China(Life Sciences)2018，61，8： | 4 |
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