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| 1 | Diffuse intestinal ganglioneuromatosis an uncommon manifestation of Cowden syndrome显示文摘Diffuse intestinal ganglioneuromatosis is a hamartomatous polyposis characterized by a disseminated, intramural or transmural proliferation of neural elements involving the enteric plexuses. It has been associated with MEN Ⅱ, neurofibromatosis type 1 and hamartomatous polyposis associated with phosphatase and tensin homolog mutation. We report the case of a female patient with a history of a breast and endometrial tumor who presented in a colonoscopy performed for rectal bleeding diffuse ganglioneuromatosis, which oriented the search for other characteristic findings of Cowden syndrome given the personal history of the patient. The presence of an esophagogastric polyposis was also noted. Cowden syndrome is characterized by skin lesions, but it is rarely diagnosed by these lesions, because they are usually overlooked. Intestinal polyposis is not a major diagnostic criterion but it is very useful for early diagnosis. The combination of colonic polyposis and glucogenic acanthosis should orient the diagnosis to Cowden syndrome. | Maria Teresa Herranz Bachiller Jesus Barrio Andrés Fernando Pons Noelia Alcaide Suárez Rafael Ruiz-Zorrilla Lorena Sancho del Val Sara Lorenzo Pelayo Carlos De La Serna Higuera Ramon Atienza Sánchez Manuel Perez Miranda | 2013 | World Journal of Gastrointestinal Oncology2013，5，2： | 5 |
| 2 | Clinical and prognostic implications of delirium in elderly patients with non–ST-segment elevation acute coronary syndromes显示文摘Background Elderly patients with non-ST-segment elevation acute coronary syndromes(NSTE-ACS)may present delirium but its clinical relevance is unknown.This study aimed at detennining the clinical associated factors,and prognostic implications of delirium in old-aged patients admitted for NSTE-ACS.Methods LONGEVO-SCA is a prospective multicenter registry including unselected patients with NSTE-ACS aged>80 years.Clinical variables and a complete geriatric evaluation were assessed during hospitalization.The association between delirium and 6-month mortality was assessed by a Cox regression model weighted for a propensity score including the potential confounding variables.We also analysed its association with 6-month bleeding and cognitive or functional decline.Results Among 527 patients included,thirty-seven(7%)patients presented delirium during the hospitalization.Delirium was more frequent in patients with dementia or depression and in those from nursing homes(27.0%vs.3.1%,24.3%vs.11.6%,and 11.1%V5.2.2%,respectively;all P<0.05).Delirium was significantly associated with in-hospital infections(27.0%vs.5.3%,P<0.001)and usage of diuretics(70.3%vs.49.8%,P=0.02).Patients with delirium had longer hospitalizations[median 8.5(5.5-14)vs.6.0(4.0-10)days,P=0.02]and higher incidence of 6-month bleeding and mortality(32.3%vs.10.0%and 24.3%vs.10.8%,respectively;both P<0.05)but similar cognitive or functional decline.Delirium was independently associated with 6-month mortality(HR=1.47,95%CI:1.02-2.13,P=0.04)and 6-month bleeding events(OR=2.87;95%CI:1.98-4」6,P<0.01).Conclusions In-hospital delirium in elderly patients with NSTE-ACS is associated with some preventable risk factors and it is an independent predictor of 6-month mortality. | Miquel Vives-Borras Manuel Martinez-Selles Albert Ariza-Sole Maria T.Vidan Francesc Formiga Hector Bueno Juan Sanchis Oriol Alegre Albert Duran-Cambra Ramon Lopez-Palop Emad Abu-Assi Alessandro Sionis LONGEVO-SCA Investigators | 2019 | Journal of Geriatric Cardiology2019，16，2： | 3 |
| 3 | Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial显示文摘 | Rafael Rosell Enric Carcereny Radj Gervais Alain Vergnenegre Bartomeu Massuti Enriqueta Felip Ramon Palmero Ramon Garcia-Gomez Cinta Pallares Jose Miguel Sanchez Rut Porta Manuel Cobo Pilar Garrido Flavia Longo Teresa Moran Amelia Insa Filippo De Marinis | 2012 | Lancet Oncology2012，，3： | 1 |
| 4 | Rapid determination of chemical oxygen demand显示文摘 | Ramon Ramon Francisco Valero Manuel del valle | 2003 | Analytica Chimica Acta2003，491，： | 1 |
| 5 | Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial显示文摘 | Rafael Rosell Enric Carcereny Radj Gervais Alain Vergnenegre Bartomeu Massuti Enriqueta Felip Ramon Palmero Ramon Garcia-Gomez Cinta Pallares Jose Miguel Sanchez Rut Porta Manuel Cobo Pilar Garrido Flavia Longo Teresa Moran Amelia Insa Filippo De Marinis | 2012 | Lancet Oncology2012，，3： | 1 |
| 6 | Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial显示文摘 | Rafael Rosell Enric Carcereny Radj Gervais Alain Vergnenegre Bartomeu Massuti Enriqueta Felip Ramon Palmero Ramon Garcia-Gomez Cinta Pallares Jose Miguel Sanchez Rut Porta Manuel Cobo Pilar Garrido Flavia Longo Teresa Moran Amelia Insa Filippo De Marinis | 2012 | Lancet Oncology2012，，3： | 1 |
| 7 | Seasonal effect on chemical composition and biological activities of Sonoran propolis显示文摘 | Dora Valencia Efrain Alday Ramon Robles-Zepeda Adriana Garibay-Escobar Juan C. Galvez-Ruiz Magali Salas-Reyes Manuel Jiménez-Estrada Enrique Velazquez-Contreras Javier Hernandez Carlos Velazquez | 2011 | Food Chemistry2011，，2： | 1 |
| 8 | Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial显示文摘 | Rafael Rosell Enric Carcereny Radj Gervais Alain Vergnenegre Bartomeu Massuti Enriqueta Felip Ramon Palmero Ramon Garcia-Gomez Cinta Pallares Jose Miguel Sanchez Rut Porta Manuel Cobo Pilar Garrido Flavia Longo Teresa Moran Amelia Insa Filippo De Marinis | 2012 | Lancet Oncology2012，，3： | 1 |
| 9 | Integrated Landslide Susceptibility Analysis and Hazard Assessment in the Principality of Andorra显示文摘 | Jordi Corominas Ramon Copons Joan Manuel Vilaplana Joan Altimir Jordi Amigó | 2003 | Natural Hazards2003，，3： | 1 |
| 10 | Current status and potential of morphometric sperm analysis显示文摘精子是知道的最多样的房间类型,这差异被认为在精子功能反映差别。在精子形态学的差异怎么并且什么角色在种形成期间产生了然而,不同专门化在精子功能玩仍然保持不完全地描绘了。这个工作考察建议向精子解释词法进化的假设,与精子 morphometric 评估的一些方面的一个焦点;morphometrics 的能力也被讨论预言精子 cryoresistance 和男富饶。为这,而不是在不同阶段的精子头的 morphometric 特征的学习,在整个一个过程的精子头 morphometry 的变化的模式的评估与不同精子 cryoconservation 能力允许男性的更好的鉴定。和雇用很多个人的更多的研究,这些新途径被需要在精子功能上有关精子 morphometry 的角色获得新奇结果。未来研究应该瞄准理解精子的原因设计产生他们的差异和机制,把增加的注意给除精子头以外的另外的精子结构。科学、工艺的进展的实现能有益于精子显型和精子功能的同时的考试,证明精子 morphometry 能是为精子评价的一个有用工具。 | Alejandro Maroto-Morales Olga Garcia-Alvarez Manuel Ramon Felipe Martinez-Pastor M Rocio Fernandez-Santos A Josefa Soler Jose Julian Garde | 2016 | Asian Journal of Andrology2016，18，6： | 1 |
| 11 | Sodium inhibition in the anaerobic digestion process: antagonism and adaptation phenomena 显示文摘 | Gumersindo F Manuel S Ramon M | 1995 | Enzyme and Microbial Technology1995，17，2： | 1 |
| 12 | Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial显示文摘 | Rafael Rosell Enric Carcereny Radj Gervais Alain Vergnenegre Bartomeu Massuti Enriqueta Felip Ramon Palmero Ramon Garcia-Gomez Cinta Pallares Jose Miguel Sanchez Rut Porta Manuel Cobo Pilar Garrido Flavia Longo Teresa Moran Amelia Insa Filippo De Marinis | 2012 | Lancet Oncology2012，，3： | 1 |
| 13 | Laparoscopic radiofrequency ablation for hepatocellularcarcinoma显示文摘Aim:The optimal treatment for hepatocellular carcinoma(HCC)is either surgical resection or liver transplantation,but only one-third of the patients are suitable candidates for surgery.Laparoscopic radiofrequency ablation(RFA)in selected patients is a safe,feasible technique,which has proved to be superior to the percutaneous approach in patients with severe liver disease or in lesions in which the percutaneous approach is impossible.The aim of this study is to present our experience with laparoscopic RFA and demonstrate its safety as an alternative therapeutic procedure in selected patients with HCC.Methods:This is a retrospective study of patients with HCC who underwent laparoscopic RFA between March 2009 and December 2014.Results:Thirty-two patients with 37 tumors underwent laparoscopic RFA.Median tumor size was 2.24 cm(0.7-4.45 cm).Major complications occurred in 8 patients.Initial complete ablation was achieved in 94.6%(35/37)lesions and sustained complete ablation rate was 62.85%(22/35).Overall survival rates at 1-,2-,and 3-year were 89%,67.5%,and 40%,respectively.Conclusion:Laparoscopic RFA of HCC is safe and the long-term outcomes are similar to those achieved with liver resection.Further trials combining chemoembolization and RFA are needed to improve long-term outcomes and to limit local tumor progression. | Anna Sánchez-López Anna Pallisera-Lloveras Ramon Saiz-Mendiguren Manuel Ferrer-Marsal JoséCarlos Vicens-Arbona JoséAndrés Cifuentes-Ródenas Jose Manuel Ramia | 2015 | Hepatoma Research2015，1，1： | 1 |
| 14 | Selection of non- Saccharomyces yeast strains for reducing alcohol levels in wine by sugar respiration显示文摘 | Manuel Quirós Virginia Rojas Ramon Gonzalez Pilar Morales | 2014 | International Journal of Food Microbiology2014，，： | 1 |
| 15 | Factors involved in the production of liposomes with a high - pressure homogenizer显示文摘 | Ramon Barnadas - Rodriguez Manuel Sabes | 2001 | International Journal of Pharmaceutics2001，213，： | 1 |
| 16 | Metabolic Modulation of Acute Myocardial Infarction: The ECLA Glucose-Insulin-Potassium Pilot Trial显示文摘 | Rafael Diaz Ernesto A. Paolasso Leopoldo S. Piegas Carlos D. Tajer Manuel Gil Moreno Ramon Corvalan Jesus E. Isea Graciela Romero | 1998 | Circulation1998，，21： | 1 |
| 17 | Increased risk of tumor seeding after percutaneous radiofrequency ablation for single hepatocellular carcinoma显示文摘 | Josep M. Llovet Ramon Vilana Concepció Brú Llu??s Bianchi Joan Manuel Salmeron Loreto Boix Sergi Ganau Margarita Sala Mario Pagès Carmen Ayuso Manel Solé Joan Rodés Jordi Bruix | 2001 | Hepatology2001，，5： | 1 |
| 18 | Integrated landslide susceptibility analysis and hazard assessment in the principality of Andorra显示文摘 | JORD CORMINAS RAMON COPONS JOAN MANUEL VILAPLANA | 2003 | Natural Hazards2003，30，3： | 1 |
| 19 | Selection of non -Saccharomyces yeast strains for reducing alcohol levels in wine by sugar respiration 显示文摘 | Manuel Q C Virginia R B Ramon G | 2014 | International Journal of Food Microbiology2014，，7： | 1 |
| 20 | Threedimensional space vector modulation in abc coordinates for four-leg voltage source converters 显示文摘 | Manuel M M P Perales A Ramon Portillo | 2003 | IEEE Power ElectronicsLetters2003，，4： | 1 |
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