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| 1 | Serum Mac-2 binding protein is a novel biomarker for chronic pancreatitis显示文摘AIM: To determine the efficacy of Mac-2 binding protein(Mac-2bp) for diagnosis of chronic pancreatitis.METHODS: Fifty-nine healthy volunteers(HV), 162 patients with chronic pancreatitis(CP), and 94 patients with pancreatic ductal adenocarcinoma(PDAC) were enrolled in this study. We measured serum Mac-2bp using our developed enzyme-linked immunosorbent assay kit. Additional biochemical variables were measured using an automated analyzer(including aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline phosphatase, triglyceride, C-reactive protein, and amylase levels) or chemiluminescent enzyme immunoassay(carbohydrate antigen 19-9 and carcinoembryonic antigen). The ability of Mac-2bp to predict CP diagnosis accurately was assessed using receiver operating characteristic(ROC) analyses.RESULTS: Serum Mac-2bp levels were significantly increased in CP patients compared to HV(P < 0.0001) and PDAC patients(P < 0.0001). Area under the ROC curve values of Mac-2bp for the discrimination of CP from HV and PDAC were 0.727 and 0.784, respectively. Multivariate analyses demonstrated that serum Mac-2bp levels were independent determinants for CP diagnosis from HV and PDAC patients. Immunohistological staining showed that Mac-2bp was expressed faintly in the pancreas tissues of both CP and PDAC patients. Serum aspartate aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline phosphatase, and triglyceride levels were significantly higher in patients with CP or PDAC. Serum Mac-2bp levels were highly correlated with protein levels of alanine aminotransferase, γ-glutamyltransferase, and C-reactive protein, but not amylase, suggesting that the damaged liver produces Mac-2bp. CONCLUSION: Measurement of serum Mac-2bp may be a novel and useful biomarker for CP diagnosis as well as liver fibrosis in the general population. | Tomohiro Maekawa Yoshihiro Kamada Yusuke Ebisutani Makiko Ueda Tomoki Hata Koichi Kawamoto Shinji Takamatsu Kayo Mizutani Mayuka Shimomura Tomoaki Sobajima Hironobu Fujii Kotarosumitomo Nakayama Kimihiro Nishino Makoto Yamada Takashi Kumada Toshifumi Ito Hidetoshi Eguchi Hiroaki Nagano Eiji Miyoshi | 2016 | World Journal of Gastroenterology2016，22，17： | 3 |
| 2 | Expression of LYVE-1 in sinusoidal endothelium is reduced in chronically inflamed human livers显示文摘 | Junko Arimoto Yoshihiro Ikura Takehisa Suekane Masashi Nakagawa Chizuko Kitabayashi Yoko Iwasa Kenichi Sugioka Takahiko Naruko Tetsuo Arakawa Makiko Ueda | 2010 | Journal of Gastroenterology2010，，3： | 1 |
| 3 | Neutrophil Infiltration of Culprit Lesions in Acute Coronary Syndromes显示文摘 | Takahiko Naruko Makiko Ueda Kazuo Haze Allard C. van der Wal Chris M. van der Loos Akira Itoh Ryushi Komatsu Yoshihiro Ikura Masayuki Ogami Yoshihisa Shimada Shoichi Ehara Minoru Yoshiyama Kazuhide Takeuchi Junichi Yoshikawa Anton E. Becker | 2002 | Circulation: Journal of the American Heart Association2002，，23： | 1 |
| 4 | Expression of angiotensin II type 1 receptor in human cirrhotic livers: Its relation to fibrosis and portal hypertension显示文摘 | Yoshihiro Ikura Masahiko Ohsawa Nobuyuki Shirai Yoshimi Sugama Hiroko Fukushima Takehisa Suekane Michihiko Hirayama Shoichi Ehara Takahiko Naruko Makiko Ueda | 2005 | Hepatology Research2005，，2： | 1 |
| 5 | Induction of smooth muscle cells in the fibrous capsule of human hepatocellular carcinoma but not in the septa of hepatic cirrhosis显示文摘 | Akiko Kojima K. Kaneda Makiko Ueda Atsuhiko Maki Arimichi Takabayashi Shoji Fukushima Masami Sakurai Ryozo Nagai Isao Matsui-Yuasa | 1999 | Virchows Archiv1999，，5： | 1 |
| 6 | Elevated Levels of Oxidized Low Density Lipoprotein Show a Positive Relationship With the Severity of Acute Coronary Syndromes显示文摘 | Shoichi Ehara Makiko Ueda Takahiko Naruko Kazuo Haze Akira Itoh Masato Otsuka Ryushi Komatsu Toshihiko Matsuo Hiroyuki Itabe Tatsuya Takano Yoshiaki Tsukamoto Minoru Yoshiyama Kazuhide Takeuchi Junichi Yoshikawa Anton E. Becker | 2001 | Circulation: Journal of the American Heart Association2001，，15： | 1 |
| 7 | Noninvasive laboratory tests proposed for predicting cirrhosis in patients with chronic hepatitis C are also useful in patients with non-alcoholic steatohepatitis显示文摘 | Hideki Fujii Masaru Enomoto Wakaba Fukushima Satoko Ohfuji Mami Mori Sawako Kobayashi Shuji Iwai Hiroyasu Morikawa Akihiro Tamori Hiroki Sakaguchi Yoshihiro Ikura Makiko Ueda Norifumi Kawada | 2009 | Journal of Gastroenterology2009，，6： | 1 |
| 8 | Ectopic expression of Smad7 inhibits transforming growth factor-β responses in vascular smooth muscle cells显示文摘 | Seiya Kato Seiji Ueda Kiyoshi Tamaki Makiko Fujii Kohei Miyazono Peter ten Dijke Minoru Morimatsu Seiya Okuda | 2001 | Life Sciences2001，，22： | 1 |
| 9 | Spotty Calcification Typifies the Culprit Plaque in Patients With Acute Myocardial Infarction: An Intravascular Ultrasound Study显示文摘 | Shoichi Ehara Yoshiki Kobayashi Minoru Yoshiyama Kenei Shimada Yoshihisa Shimada Daiju Fukuda Yasuhiro Nakamura Hajime Yamashita Hiroyuki Yamagishi Kazuhide Takeuchi Takahiko Naruko Kazuo Haze Anton E. Becker Junichi Yoshikawa Makiko Ueda | 2004 | Circulation2004，，22： | 1 |
| 10 | Human Smooth Muscle Myosin Heavy Chain Isoforms as Molecular Markers for Vascular Development and Atherosclerosis显示文摘 | Masanori Aikawa Palanisamy Nalla Sivam Makoto Kuro-o Kenjiro Kimura Ken-ichi Nakahara Shun-ichi Takewaki Makiko Ueda Hiroshi Yamaguchi Yoshio Yazaki Muthu Periasamy Ryozo Nagai | 1993 | Circulation Research1993，，： | 1 |
| 11 | Elevated Levels of Oxidized Low Density Lipoprotein Show a Positive Relationship With the Severity of Acute Coronary Syndromes显示文摘 | Shoichi Ehara Makiko Ueda Takahiko Naruko Kazuo Haze Akira Itoh Masato Otsuka Ryushi Komatsu Toshihiko Matsuo Hiroyuki Itabe Tatsuya Takano Yoshiaki Tsukamoto Minoru Yoshiyama Kazuhide Takeuchi Junichi Yoshikawa Anton E. Becker | 2001 | Circulation: Journal of the American Heart Association2001，，15： | 1 |
| 12 | Neointimal Tissue Response at Sites of Coronary Stenting in Humans: Macroscopic, Histological, and Immunohistochemical Analyses显示文摘 | Ryushi Komatsu Makiko Ueda Takahiko Naruko Akiko Kojima Anton E. Becker | 1998 | Circulation1998，，3： | 1 |
| 13 | Immunolocalization of platelet glycoprotein IIb/IIIa and P-selectin,and neutrophil - platelet interaction in human coronary unstable plaques显示文摘 | Takeshi Ikuta Takahiko Naruko Yoshihiro Ikura Masahiko Ohsawa Hiroko Fukushima Nobuyuki Shirai Akira Itoh Kazuo Haze Shoichi Ehara Yasuyuki Sasaki Toshihiko Shibata Shigefumi Suehiro Makiko Ueda | 2005 | International Journal of Molecular Medicine2005，，： | 1 |
| 14 | Radiofrequency Ablated Lesion in the Normal Porcine Lung: Long-Term Follow-Up with MRI and Pathology显示文摘 | Yoshimasa Oyama Kenji Nakamura Toshiyuki Matsuoka Masami Toyoshima Akira Yamamoto Tomohisa Okuma Yoshihiro Ikura Makiko Ueda Yuichi Inoue | 2005 | CardioVascular and Interventional Radiology2005，，3： | 1 |
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