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| 1 | In vitro effect of pantoprazole on lower esophageal sphincter tone in rats显示文摘AIM:To investigate the in vitro effects of pantoprazole on rat lower esophageal sphincter(LES)tone.METHODS:Rats weighing 250-300 g,provided by the Yeditepe University Experimental Research Center(Yü-DETAM),were used throughout the study.They were anesthetized before decapitation.LES tissues whose mucosal lining were removed were placed in a stan-dard 30-mL organ bath with a modif ied Krebs solution and continuously aerated with 95% oxygen-5% carbon dioxide gas mixture and kept at room temperature.The tissues were allowed to stabilize for 60 min.Sub-sequently,the contractile response to 10-6 mol/L carba-chol was obtained.Different concentrations of freshly prepared pantoprazole were added directly to the tis-sue bath to generate cumulative concentrations of 5×10-6 mol/L,5×10-5 mol/L,and 1.5×10-4 mol/L.Activi-ties were recorded on an online computer via a 4-channeltransducer data acquisition system using the software BSL PRO v 3.7,which also analyzed the data.RESULTS:Pantoprazole at 5×10-6 mol/L caused a small,but statistically insignif icant,relaxation in the car-bachol-contracted LES(2.23% vs 3.95%).The 5×10-5 mol/L concentration,however,caused a signif icant relax-ation of 10.47% compared with the control.1.5×10-4 mol/L concentration of pantoprazol caused a 19.89% relaxation in the carbachol contracted LES(P<0.001).CONCLUSION:This is the fi rst study to demonstrate that pantoprazole has a relaxing effect in isolated LESs.These results might have signif icant clinical implications for the subset of patients using proton pump inhibitors who do not receive full symptomatic alleviation from gastroesophageal reflux disease. | Mustafa Duman Mahmut zer Enver Rean Yeliz Demirci Ali E Atιcι Tahsin Dalgι Erdal B Bostancι Ece Gen | 2011 | World Journal of Gastroenterology2011，17，46： | 3 |
| 2 | On the ruled surface in Minkowski 3-space显示文摘 | ALPER OSMAN HANDAN B MAHMUT E | 2006 | Journal of Zhejiang University Science A2006，7，3： | 1 |
| 3 | Postoperative Irradia tion with or without concomitant chemotherapy for locally ad vanced head and neck cancer显示文摘 | Jacques B Christian D Mahmut O | 2004 | N Engl J Med2004，350，19： | 1 |
| 4 | Tetra-2-[2-(dimethylamino)ethoxy]ethoxy substituted zinc phthalocyanines and their quaternized analoques: Synthesis, characterization, photophysical and photochemical properties显示文摘 | Zekeriya B?y?kl?o?lu Mahmut Durmu? Halit Kantekin | 2011 | Journal of Photochemistry & Photobiology A: Chemistry2011，，1： | 1 |
| 5 | Surgical treatment of hydatid disease of the hver (review of 304cases)显示文摘 | Abmet AB Mahmut B Fehmi C | 1999 | Arch Surg1999，16，2： | 1 |
| 6 | Effects of different carbon sources on a particle size of LiFePOJC nanocomposite cathode ac- tive material for lithium-ion batteries 显示文摘 | AHMET 0 EMRAH B MAHMUT O | 2011 | Advanced Science2011，，3： | 1 |
| 7 | A new approach to estimate anthropometric measurements by adaptive neuron fuzzy inference system 显示文摘 | KAYA M D HASILOGLU A S MAHMUT B | 2003 | International Journal of Industrial Ergonomics2003，，32： | 1 |
| 8 | Isolated torsion of fallopian tube in a post-menopausal patient: a case report显示文摘 | Mahmut TO Cem B Cagdas T | 2007 | Maturitas2007，57，3： | 1 |
| 9 | Isolated torsion of fallopian tube in a postmenopausal patient a case report显示文摘 | Mahmut TO Cem B Cagdas T | 2007 | Maturitas2007，57，3： | 1 |
| 10 | Treatment of textile wastewaters by electrocoagulation using iron and aluminum electrodes显示文摘 | MEHMET K ORHAN T C MAHMUT B | 2003 | Journal of Hazardous Materials2003，100，123： | 1 |
| 11 | Isolated torsion of fallopian tube in a post- menopausal patient a case report显示文摘 | Mahmut TO Cem B Cagdas T | 2007 | Maturi- tas2007，57，3： | 1 |
| 12 | Periampullary Diverticula Causing Pancreaticobiliary Disease显示文摘 | M. ?lhan Yildirgan Mahmut Ba?o?lu ?smayil Yilmaz S. Sel?uk Atamanalp Ahmet A. Balik Bülent Aydinli Gürkan ?ztürk | 2004 | Digestive Diseases and Sciences (-)2004，，11： | 1 |
| 13 | The “Lasso” technique: Snare-assisted endoscopic-radiological rendezvous technique for the management of complete transection of the main bile duct显示文摘 | Bülent ?demi? Ali Shorbagi Ayd?n ?eref K?ksal Ensar ?zdemir Serkan Torun Mahmut Yüksel Ertu?rul Kaya?etin | 2013 | Gastrointestinal Endoscopy2013，，： | 1 |
| 14 | Surgical treatment of hydatid disease of the liver (review of 304 cases) 显示文摘 | 1,Ahmet AB Mahmut B Fehmi C | 1999 | Arch Surg1999，134，2： | 1 |
| 15 | Tetra-2-[2-(dimethylamino)ethoxy]ethoxy substituted zinc phthalocyanines and their quaternized analoques: Synthesis, characterization, photophysical and photochemical properties显示文摘 | Zekeriya B?y?kl?o?lu Mahmut Durmu? Halit Kantekin | 2011 | Journal of Photochemistry & Photobiology A: Chemistry2011，，1： | 1 |
| 16 | Surgical treatment of hydatid dis- ease of the fiver显示文摘 | Abmet AB Mahmut B Fehmi C | 1999 | Arch1999，16，2： | 1 |
| 17 | Surgical treatment of hydatid disease of the liver(review of 304 casas)显示文摘 | Ahmet AB Mahmut B Fehmi C | 1999 | Arch Sarg1999，134，2： | 1 |
| 18 | The'Reading Man'Procedure A New Technique for the Closure of Circular SkinDefects显示文摘 | Mehmet M Mahmut S Omer B | 2008 | Ann Plast Surg2008，60，： | 1 |
| 19 | CD8+CD28? cells and CD4+CD25+ regulatory T cells in the peripheral blood of advanced stage lung cancer patients显示文摘 | Bülent Karag?z O?uz Bilgi Mahmut Gümüs Alev Akyol Erik?i ?zkan Sayan Orhan Türken Emin G?khan Kandemir Ahmet ?ztürk Mustafa Yaylac? | 2010 | Medical Oncology2010，，1： | 1 |
| 20 | Novel alpha-7-oxy-4-(4- methoxyphenyl)-8-methylcoumarin substitutedmetal-free, Co( Ⅱ ) and Zn ( Ⅱ ) phthalocyanines: photochemistry, photophysics, conductance and electrochemistry 显示文摘 | Zafer O Efe B O Mahmut D | 2012 | Dyes Pigments2012，95，： | 1 |
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