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| 1 | Activins and activin antagonists in hepatocellular carcinoma显示文摘In many parts of the world hepatocellular carcinoma (HCC)is among the leading causes of cancer-related mortality but the underlying molecular pathology is still insufficiently understood.There is increasing evidence that activins,which are members of the transforming growth factorβ(TGFβ)superfamily of growth and differentiation factors,could play important roles in liver carcinogenesis.Activins are disulphide-linked homo- or heterodimers formed from four differentβsubunits termedβA,βB,βC,andβE,respectively.Activin A, the dimer of twoβA subunits,is critically involved in the regulation of cell growth,apoptosis,and tissue architecture in the liver,while the hepatic function of other activins is largely unexplored so far.Negative regulators of activin signals include antagonists in the extracellular space like the binding proteins follistatin and FLRG,and at the cell membrane antagonistic coreceptors like Cripto or BAMBI.Additionally,in the intracellular space inhibitory Smads can modulate and control activin activity.Accumulating data suggest that deregulation of activin signals contributes to pathologic conditions such as chronic inflammation,fibrosis and development of cancer.The current article reviews the alterations in components of the activin signaling pathway that have been observed in HCC and discusses their potential significance for liver tumorigenesis. | Alev Deli Emanuel Kreidl Stefan Santifaller Barbara Trotter Katja Seir Walter Berger Rolf Schulte-Hermann Chantal Rodgarkia-Dara Michael Grusch | 2008 | World Journal of Gastroenterology2008，14，11： | 8 |
| 2 | Effect of dyspnea and clinical variables on the quality of life and functional capacity in patients with chronic obstructive pulmonary disease and congestive heart failure显示文摘背景:长期的妨碍的肺的疾病(COPD ) 和充血心力衰竭(CHF ) 是否定地影响病人的生命的功能的条件和质量的二慢性病。我们在在 COPD 和 CHF 病人的生命的功能的能力和质量上估计了症状和临床的变量的效果。方法:学习包括了 42 COPD 和 39 个 CHF 病人。在两个耐心的组,呼吸困难用 Borg 规模被估计;由梭散步和心肺的锻练测试和由短 form-36 (SF36 ) 的生命的质量的功能的能力。结果:不,统计上,有效差量关于呼吸困难分数,梭散步测试和 SF36 的亚群分数的多数在两二个疾病组被发现(P >
0.05 ) 。一统计上,有效差量在山峰 VO (2 ) 被观察赞成 COPD 组(P <
0.05 ) 。没有重要关系在呼吸困难 20 之间被建立并且在 CHF 病人在 COPD 病人,和左室的喷射部分(LVEF ) 在一秒(FEV (1 )) 强迫了吐气的体积(P >
0.05 ) 。重要否定关联在在两个疾病组的呼吸困难分数和功能的能力测试之间被观察(P <
0.05 ) 。在另一方面,没有关系在 LVEF 和 FEV 和生命和功能的能力的质量(1 ) 之间被发现(P >
0.05 ) 。结论:然而,症状影响在两个疾病组的生命的功能的能力和质量,这被揭示疾病严厉的客观指示物不显示出一种类似的关系。除了与疾病有关的客观数据,因此,我们建议症状应该也被考虑估计心肺的康复节目并且在后面起来期间。 | Hale Karapolat Sibel Eyigor Alev Atasever Mehdi Zoghi Sanem Nalbantgil Berrin Durmaz | 2008 | Chinese Medical Journal2008，，7： | 4 |
| 3 | Correlation of neutrophil/lymphocyte and platelet/lymphocyte ratio with visual acuity and macular thickness in age-related macular degeneration显示文摘AIM:To investigate the place of neutrophil-to-lymphocyte ratio(NLR) and platelet-to-lymphocyte ratio(PLR) in the diagnosis of and prognosis for neovascular age-related macular degeneration(AMD). METHODS:One hundred AMD patients and 100 healthy controls were included in the study. Blood samples were obtained from the venous blood, which is used for routine analysis, and these samples were subjected to complete blood count. NLR was defined as the neutrophil count divided by the number of lymphocytes, and PLR was defined as the platelet count divided by the number of lymphocytes. RESULTS:No statistically significant difference was observed between the two groups under consideration in terms of demographic features(P>0.05). The average NLR in the patient group was found to be significantly higher than that in the healthy control group(P<0.05). The average PLR was significantly higher in the patient group as compared to the control group(P<0.05). As best corrected visual acuity(BCVA) increased, both NLR and PLR decreased(significant negative correlations at 49.8% and 63.0%, respectively), whereas as central macular thickness(CMT) increased, both NLR and PLR increased(significant positive correlations at 59.3% and 70.0%, respectively).CONCLUSION:NLR and PLR levels are higher among neovascular AMD patients as compared to healthy control group. NLR and PLR levels were found to be inversely proportional to BCVA and directly proportional to CMT. | Elvan Alper Sengul Ozgur Artunay Alev Kockar Ceyda Afacan Rifat Rasier Palmet Gun Nazli Gul Yalcin Erdal Yuzbasioglu | 2017 | International Journal of Ophthalmology(English edition)2017，10，5： | 4 |
| 4 | Characterization of tertiary amine and epoxy functional all-acrylic coating system显示文摘 | Alev P R Bicen I A A | 2013 | Progress in Organic Coatings2013，76，6： | 1 |
| 5 | Muscle protein turnover in endurance training: a review显示文摘 | Seene T Kaasik P Alev K | 2011 | International journal of sports medicine2011，32，12： | 1 |
| 6 | Local transplantation of ex vivo expanded bone marrow- derived CD34- positive cells accel- erates fracture healing显示文摘 | Kawakami Y Ii M Alev C | 2012 | Cell Transplantation2012，21，12： | 1 |
| 7 | Lnk deletion reinforces the function of bone marrow progenitors in promoting neovascularization and astrogliosis following spinal cord injury显示文摘 | Kamei N Kwon SM Alev C | 2010 | Stem Cells2010，28，2： | 1 |
| 8 | Leader-member Exchange,Organizational Identification and the Mediating Role of Job Involvement for Nurses 显示文摘 | Alev Katrinli Gulem Atabay Gonca Gunay | 2008 | Journal of Advance Nursing2008，64，4： | 1 |
| 9 | The reflections of student teachers on project based learning and investigating self evaluation versus teacher evaluation显示文摘 | Makbule Ba(s)bay Alev Ate(s) | 2009 | Procedia-Social and Behavioral Sciences2009，1，1： | 1 |
| 10 | Derivations et automorphismes de quelques algebres quantiques 显示文摘 | ALEV J CHAMARIE M | 1992 | Commun Alge- bra1992，20，6： | 1 |
| 11 | Antioxidant activity and proline content of leaf extracts from dorystoechas hastate 显示文摘 | Arife Alev Karag?zler | 2008 | Food Chemistry2008，111，： | 1 |
| 12 | Effects of silicon content on the mechanical and tribological properties of monotectoid- based zinc-aluminium-silicon alloys 显示文摘 | TEMEL S ALEV A | 2004 | Wear2004，257，1： | 1 |
| 13 | The role of notch signaling in endothelial progenitor cell biology 显示文摘 | Kwon SM Alev C Asahara T | 2009 | Trends Cardiovasc Med2009，19，5： | 1 |
| 14 | Relationship between anaemia and cognitive functions in elderly people显示文摘 | Hakan M. Terekeci Yasar Kucukardali Yalcin Onem Alev Akyol Erikci Betul Kucukardali Burak Sahan Ozkan Sayan Serkan Celik Mahir Gulec Yavuz S. Sanisoglu Selim Nalbant Cihan Top Cagatay Oktenli | 2009 | European Journal of Internal Medicine2009，，2： | 1 |
| 15 | The role of notch signaling in endothelial progenitor cell biology 显示文摘 | Kwon SM Alev C Asahara T | 2009 | Trends Cardiovasc Med2009，19，5： | 1 |
| 16 | Derivations et automorphismes de quetques algebras quantiques 显示文摘 | ALEV J CHAMARIE M | 1992 | Commun Algebra1992，20，6： | 1 |
| 17 | Effects of silicon content on the mechanical and tribological properties of monotectoid-based zinc aluminium silicon alloys显示文摘 | Temel Savaskan Alev Aydiner | | 0，，： | 1 |
| 18 | Asymmetric dimethylarginine and coronary collateral vessel development显示文摘 | Sinan Altan Kocaman Asife Sahinarslan Gursel Biberoglu Alev Hasanoglu Ahmet Akyel Timur Timurkaynak Atiye Cengel | 2008 | Coronary Artery Disease2008，，7： | 1 |
| 19 | Endothelial progenitor cells : a novel tool for the therapy of isehemie diseases 显示文摘 | Alev C Ii M Asahara T | 2011 | Antioxid Redox Signal2011，15，4： | 1 |
| 20 | Evaluation of hazardous waste transportation firms by using a two step fuzzy-AHP and TOPSIS methodology显示文摘 | Alev Taskin Gumus | 2009 | Expert Systems with Applications2009，36，2： | 1 |
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