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| 1 | In vitro effect of pantoprazole on lower esophageal sphincter tone in rats显示文摘AIM:To investigate the in vitro effects of pantoprazole on rat lower esophageal sphincter(LES)tone.METHODS:Rats weighing 250-300 g,provided by the Yeditepe University Experimental Research Center(Yü-DETAM),were used throughout the study.They were anesthetized before decapitation.LES tissues whose mucosal lining were removed were placed in a stan-dard 30-mL organ bath with a modif ied Krebs solution and continuously aerated with 95% oxygen-5% carbon dioxide gas mixture and kept at room temperature.The tissues were allowed to stabilize for 60 min.Sub-sequently,the contractile response to 10-6 mol/L carba-chol was obtained.Different concentrations of freshly prepared pantoprazole were added directly to the tis-sue bath to generate cumulative concentrations of 5×10-6 mol/L,5×10-5 mol/L,and 1.5×10-4 mol/L.Activi-ties were recorded on an online computer via a 4-channeltransducer data acquisition system using the software BSL PRO v 3.7,which also analyzed the data.RESULTS:Pantoprazole at 5×10-6 mol/L caused a small,but statistically insignif icant,relaxation in the car-bachol-contracted LES(2.23% vs 3.95%).The 5×10-5 mol/L concentration,however,caused a signif icant relax-ation of 10.47% compared with the control.1.5×10-4 mol/L concentration of pantoprazol caused a 19.89% relaxation in the carbachol contracted LES(P<0.001).CONCLUSION:This is the fi rst study to demonstrate that pantoprazole has a relaxing effect in isolated LESs.These results might have signif icant clinical implications for the subset of patients using proton pump inhibitors who do not receive full symptomatic alleviation from gastroesophageal reflux disease. | Mustafa Duman Mahmut zer Enver Rean Yeliz Demirci Ali E Atιcι Tahsin Dalgι Erdal B Bostancι Ece Gen | 2011 | World Journal of Gastroenterology2011，17，46： | 3 |
| 2 | On the ruled surface in Minkowski 3-space显示文摘 | ALPER OSMAN HANDAN B MAHMUT E | 2006 | Journal of Zhejiang University Science A2006，7，3： | 1 |
| 3 | A preliminary study on the genetic diversity of Xin jiang Tarim red deer(Cervus elaphus yarkandensis) using microsatellite DNA method显示文摘 | Mahmut H Ganzorig S Onuma M E | 2001 | Japanese Journal of Veterinary Research2001，49，3： | 1 |
| 4 | Novel Links between the Long Pentraxin 3,Endothelial Dysfunction,and Albuminuria in Early and Advanced Chronic Kidney Disease显示文摘 | Mohamed E Suliman Mahmut I Yilmaz Juan J Carrero | 2008 | Clin J Am Soc Nephrol2008，3，4： | 1 |
| 5 | Effects of chlorpyrifos on reproduc- tive performances of guppy ( Poecilia reticulata ) 显示文摘 | Mahmut S Rabia S Figen E | 2005 | Chemo- sphere2005，58，9： | 1 |
| 6 | Effcts of Chlorpyrifos on Re- productive Performances of Guppy ( Poecilia retieulata) 显示文摘 | MAHMUT S RABIA S FIGEN E | 2005 | Chem- osphe2005，58，9： | 1 |
| 7 | The use of alfalfa, Medicago sativaas a natural carotenoid source in diets of goldfish, Carassius auratus 显示文摘 | Mahmut Y Zeynep E Arzu H | 2008 | Aquaculture2008，284，： | 1 |
| 8 | Computational fluid dynamics modeling of momentum transport in rotating wall perfused bioreactor for cartilage tissue engineering显示文摘 | Mahmut N. Cinbiz R. Seda T??l? I??l Ger?ek Be?karde? Menem?e Gümü?derelio?lu üner ?olak | 2010 | Journal of Biotechnology2010，，3： | 1 |
| 9 | The synthesis, spectroscopic and thermal properties of phenoxycyclotriphosphazenyl-substituted phthalocyanines显示文摘 | Ferda Hac?velio?lu Mahmut Durmu? Serkan Ye?ilot Ay?e Gül Gürek Adem K?l?? Vefa Ahsen | 2008 | Dyes and Pigments2008，，1： | 1 |
| 10 | Very late antigen 5 and leukocyte function associated antigen 1 are critical for early stage hematopoietic progenitor cell homing显示文摘 | Asaumi N Omoto E Mahmut N | 2001 | Ann Hematol2001，80，4： | 1 |
| 11 | Very late antigen-5 and leukocyte function-associated antigen-1 are critical for early stage hematopoietic progenitor cell homing显示文摘 | Asaumi N Omoto E Mahmut N | 2001 | Ann Hematol2001，80，7： | 1 |
| 12 | Steering-wheel grip force characteristics of drivers as a function of gender, speed, and road condition显示文摘 | Mahmut E Kemal K | 2008 | International Journal of Industrial Ergonomics2008，38，4： | 1 |
| 13 | Elevated plasma adva- nced oxidation protein products in children with Henoch-Scht~n- lein purpura显示文摘 | Nurcan K Mahmut C Murat E | 2011 | Pediatric Nephrol2011，26，： | 1 |
| 14 | Comparative Analysis of Fuzzy Inference Systems for Water Con- sumption Prediction 显示文摘 | Mahmut F Mustafa E T Mehmet A Y | 2009 | Journal of Hydrology2009，37，34： | 1 |
| 15 | Nomophobia,Anxiety,and Burnout of Medical Students in Syria显示文摘Purpose: Nomophobia is a term that refers to an extreme fear of leaving the smartphone. Individuals with nomophobia have great anxiety about being separated from the smartphone. Intensive lectures in medical faculty can cause students to feel anxious. Compelling medical education curriculum and medical students living in harsh conditions in Syria since 2011 may experience nomophobia, anxiety and burnout. In this study, we aimed to determine the nomophobia, anxiety, and burnout levels of Syrian medical students. Methods: Preparation and first year medical students studying at the University of Health Sciences Cobanbey School of Medicine participated in three online surveys to measure nomophobia (n = 111), anxiety (n = 102), and burnout (n = 111). Results: Majority of medical students (82.9% (n = 92)) felt uncomfortable when they were constantly unable to access information from their smartphones. The majority of the students (79.4% (n = 81)) stated that they were anxious. Most of the medical students thought that their paying attention in lessons has decreased while they started school;88.3% of the medical students (n = 98) felt emotionally exhausted from their lessons. Conclusions: Nomophobia, anxiety, and burnout situations are expected in Syrian medical students due to the living-conditions. Developments in the education curriculum for the protection of the mental health of future physicians is crucial. | Betul Rana Celik Tasnim Hokan Mahmut Barkut Hasan Hayani Sidra Altaha Ayşe Altaha Dilek Bal Habiba Eyvazova Cemal Elrahmun Kursad Nuri Baydili Mehmet Okumus Enes Akyuz | 2023 | Journal of US-China Medical Science2023，20，1： | 0 |
| 16 | Development of a multicellular 3D-bioprinted microtissue model of human periodontal ligament-alveolar bone biointerface:Towards a pre-clinical model of periodontal diseases and personalized periodontal tissue engineering显示文摘While periodontal (PD) disease is among principal causes of tooth loss worldwide, regulation of concomitant soft and mineralized PD tissues, and PD pathogenesis have not been completely clarified yet. Besides, relevant pre-clinical models and in vitro platforms have limitations in simulating human physiology. Here, we have harnessed three-dimensional bioprinting (3DBP) technology for developing a multi-cellular microtissue model resembling PD ligament-alveolar bone (PDL-AB) biointerface for the first time. 3DBP parameters were optimized;the physical, chemical, rheological, mechanical, and thermal properties of the constructs were assessed. Constructs containing gelatin methacryloyl (Gel-MA) and hydroxyapatite-magnetic iron oxide nanoparticles showed higher level of compressive strength when compared with that of Gel-MA constructs. Bioprinted self-supporting microtissue was cultured under flow in a microfluidic platform for >10 days without significant loss of shape fidelity. Confocal microscopy analysis indicated that encapsulated cells were homogenously distributed inside the matrix and preserved their viability for >7 days under microfluidic conditions. Immunofluorescence analysis showed the cohesion of stromal cell surface marker-1+ human PDL fibroblasts containing PDL layer with the osteocalcin+ human osteoblasts containing mineralized layer in time, demonstrating some permeability of the printed constructs to cell migration. Preliminary tetracycline interaction study indicated the uptake of model drug by the cells inside the 3D-microtissue. Also, the non-toxic levels of tetracycline were determined for the encapsulated cells. Thus, the effects of tetracyclines on PDL-AB have clinical significance for treating PD diseases. This 3D-bioprinted multi-cellular periodontal/osteoblastic microtissue model has potential as an in vitro platform for studying processes of the human PDL. | Murat Taner Vurat ŞükranŞeker Özge Lalegül-Ülker Mahmut Parmaksiz Ayşe Eser Elçin Yaşar Murat Elçin | 2022 | Genes & Diseases2022，9，4： | 0 |
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