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| 1 | RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening显示文摘AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard tests.METHODS One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance. | Max J Friedrich Matthias D Wimmer Jan Schmolders Andreas C Strauss Milena M Ploeger Hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau | 2017 | World Journal of Orthopedics2017，8，4： | 4 |
| 2 | Mapping QTL for grain yield and plant traits in a tropical maize popula- tion显示文摘 | Milena L Souza C Bento D | 2006 | Mol Breed2006，17，： | 1 |
| 3 | Neurological complications of celiac disease and autoimmune mechanisms: A prospective study显示文摘 | Chiara Briani Gabriella Zara Armin Alaedini Francesca Grassivaro Susanna Ruggero Elisabetta Toffanin Maria Paola Albergoni Milena Luca Bruno Giometto Mario Ermani Franca De Lazzari Anna D’Odorico Leontino Battistin | 2008 | Journal of Neuroimmunology2008，，1： | 1 |
| 4 | Reliability of an instrument to assess the readiness of preterm infants for oral feeding显示文摘 | Cristina lF Nelma EZ Milena D | 2007 | Pro Fono2007，19，2： | 1 |
| 5 | Heat-unstable protein re- moval by different bentonite labels in white wines 显示文摘 | MILENA L ROBERTA D MARZIA G | 2012 | Food Sd Teeh- nol2012，46，： | 1 |
| 6 | Using wavelet analysis for text categorization in digital libraries : a first experiment with Strathprints 显示文摘 | Srndor D Peter W Milena D | 2012 | International Journal on Digital Libraries2012，12，1： | 1 |
| 7 | Dietary fish oil does not influence acute rejection rate and graft survival after renal transplantation:a randomized placebo-controlled study显示文摘 | HERNANDEZ D GUERRA R MILENA A | 2002 | Nephrol Dial Transplant2002，17，5： | 1 |
| 8 | Shelf-life modeling of ready-toeat coconut显示文摘 | Milena S Maria R C Daniela D A | 2003 | International Journal of Food Science and Technology2003，38，5： | 1 |
| 9 | Determinants of Reduction of Coronary Flow Reserve in Patients With Type 2 Diabetes Mellitus or Arterial Hypertension Without Angiographically Determined Epicardial Coronary Stenosis显示文摘 | Maurizio Galderisi Brunella Capaldo Milena Sidiropulos Arcangelo D’Errico Luigi Ferrara Annamelia Turco Pasquale Guarini Gabriele Riccardi Oreste de Divitiis | 2007 | American Journal of Hypertension2007，，： | 1 |
| 10 | The ever changing face of digital curation: introduction to the special issue on digital curation 显示文摘 | Milena D Wendy M D | 2015 | Archival Science2015，，3： | 1 |
| 11 | Mapping QTL for grain yield and plant traits in a tropical maize population 显示文摘 | MILENA L SOUZA C BENTO D | 2006 | Mol Breed2006，17，： | 1 |
| 12 | Pro-inflammatory effects of metals in persons and animals exposed to tobacco smoke显示文摘 | Halina M Milena S Magdalena D | 2015 | Journal of Trace Elements in Medicine and Biology2015，，29： | 1 |
| 13 | On-line adaptive clustering for process monitoring and fault detection显示文摘 | Milena P Rapaic M R Jelicic Z D | 2012 | Expert System with Applications2012，39，10： | 1 |
| 14 | Two-photon 'Ghost' Imaging with Thermal Light 显示文摘 | ALEJANDRA VALENCIA GIULIANO SCARCELLI MILENA D′ANGELO | 2005 | Phys Rev Lett2005，94，06： | 1 |
| 15 | Mapping QTL for grain yield and plant traits in a tropical maize population显示文摘 | MILENA L SOUZA C BENTO D | 2006 | Mol Breed2006，17，： | 1 |
| 16 | Influence of postharvest chitosan treatment on enzymatic browning and antioxidant enzyme activity in sweet cherry fruit显示文摘 | Maria S P Donatella D Francesco M Luigi Z Marco S Milena P | 2015 | Postharvest Biology and Technology2015，109，11： | 1 |
| 17 | Shelf-life modeling of ready-to-eat coconut显示文摘 | Milena S Maria R C Daniela D A | 2003 | International Journal of Food Science and Technology2003，38，： | 1 |
| 18 | Stress protocols and tracers显示文摘 | Milena J Henzlova MD Manuel D | 2006 | J Nucl Med2006，13，6： | 1 |
| 19 | Dietary fish oil does not influence acute rejection rate and graft survival after renal transplantation: a randomized placebo-controlled study 显示文摘 | Hernandez D Guerra R Milena A | 2002 | Nephrol Dial Transplant2002，17，5： | 1 |
| 20 | Genotype-related changes of ganglioside composition in brain regions of transgenic mouse models of Alzheimer's disease 显示文摘 | LAURENCE B SABRINA I MILENA D | 2007 | Neur of Aging2007，28，： | 1 |
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