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| 1 | Antioxidant dietary approach in treatment of fatty liver: New insights and updates显示文摘Non-alcoholic fatty liver disease(NAFLD) is a common clinicopathological condition, encompassing a range of conditions caused by lipid deposition within liver cells. To date, no approved drugs are available for the treatment of NAFLD, despite the fact that it represents a serious and growing clinical problem in the Western world. Identification of the molecular mechanisms leading to NAFLD-related fat accumulation, mitochondrial dysfunction and oxidative balance impairment facilitates the development of specific interventions aimed at preventing the progression of hepatic steatosis. In this review, we focus our attention on the role of dysfunctions in mitochondrial bioenergetics in the pathogenesis of fatty liver. Major data from the literature about the mitochondrial targeting of some antioxidant molecules as a potential treatment for hepatic steatosis are described and critically analysed. There is ample evidence of the positive effects of several classes of antioxidants, such as polyphenols(i.e., resveratrol, quercetin, coumestrol, anthocyanins, epigallocatechin gallate and curcumin), carotenoids(i.e., lycopene, astaxanthin and fucoxanthin) and glucosinolates(i.e., glucoraphanin, sulforaphane, sinigrin and allyl-isothiocyanate), on the reversion of fatty liver. Although the mechanism of action is not yet fully elucidated, in some cases an indirect interaction with mitochondrial metabolism is expected. We believe that such knowledge will eventually translate into the development of novel therapeutic approaches for fatty liver. | Alessandra Ferramosca Mariangela Di Giacomo Vincenzo Zara | 2017 | World Journal of Gastroenterology2017，23，23： | 15 |
| 2 | Modulation of hepatic steatosis by dietary fatty acids显示文摘Non-alcoholic fatty liver disease(NAFLD)describes a range of conditions caused by fat deposition within liver cells.Liver fat content reflects the equilibrium between several metabolic pathways involved in triglyceride synthesis and disposal,such as lipolysis in adipose tissue and de novo lipogenesis,triglyceride esterification,fatty acid oxidation and very-low-density lipoprotein synthesis/secretion in hepatic tissue.In particular,it has been demonstrated that hepatic de novo lipogenesis plays a significant role in NAFLD pathogenesis.It is widely known that the fatty acid composition of the diet influences hepatic lipogenesis along with other metabolic pathways.Therefore,dietary fat may not only be involved in the pathogenesis of hepatic steatosis,but may also prevent and/or reverse hepatic fat accumulation.In this review,major data from the literature about the role of some dietary fats as a potential cause of hepatic fat accumulation or as a potential treatment for NAFLD are described.Moreover,biochemical mechanisms responsible for an increase or decrease in hepatic lipid content are critically analyzed.It is noteworthy that both quantitative and qualitative aspects of dietary fat influence triglyceride deposition in the liver.A high-fat diet or the dietary administration of conjugated linoleic acids induced hepatic steatosis.In contrast,supplementation of the diet with krill oil or pine nut oil helped in the prevention and/or in the treatment of steatotic liver.Quite interesting is the'case'of olive oil,since several studies have often provided different and or conflicting results in animal models. | Alessandra Ferramosca Vincenzo Zara | 2014 | World Journal of Gastroenterology2014，20，7： | 6 |
| 3 | Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development显示文摘cytosine 的 Methylation 是与基因压抑联系的 DNA 修正。最近,新奇 cytosine 修正, 5-hydroxymethylcytosine (5-hmC ) 被发现了。这里,我们在哺乳动物的开发期间并且在细胞的系统检验 5-hmC 分发,并且证明 5-hmC 的发展动力学与 5-methylcytosine (5-mC ) 的那些不同;特别地 5-hmC 与成年纸巾相比在胚胎的上下文被充实。一个可检测的 5-hmC 信号在在父亲的染色体受到 5-mC 的染色体宽的 hydroxylation 的地方,在接合子阶段开始的培植前开发出现,它精确在父亲的前核与 5-mC 信号的损失与一致。5-hmC 的层次与在老鼠的表示 nestin 房间人口在在胚囊,和修正 colocalises 的内部房间团的房间高培植以后的胚胎。比作另外的成年哺乳动物的机关, 5-hmC 强烈在骨头髓和大脑被充实, 5-hmC 内容在那里高是 neuronal 祖先和 mitotic 以后神经原的一个特征。我们证明 5-hmC 的那高水平是在老鼠和人的胚胎的干细胞(转换字符) 的不仅现在并且,在区别期间输以前被报导了,而且在导致的 pluripotent 干细胞的产生期间重现;因此, 5-hmC 丰富与一个 pluripotent 房间状态相关。我们的调查结果建议除了 neuronal 系的房间, genomic 5-hmC 的高水平是胚胎的房间人口和细胞的 pluri 系和多系力量的一个 epigenetic 特征。到我们的知识, 5-hmC 那么代表其丰富是的发现的 DNA 的第一 epigenetic 修正房间类型特定。 | Alexey Ruzov Yanina Tsenkina Andrea Serio Tatiana Dudnakova Judy Fletcher Yu Bai Tatiana Chebotareva Steve Pells Zara Hannoun Gareth Sullivan Siddharthan Chandran David C Hay Mark Bradley Ian Wilmut Paul De Sousa | 2011 | Cell Research2011，21，9： | 4 |
| 4 | ELASTIC MEMBRANE EQUATION WITH MEMORY TERM AND NONLINEAR BOUNDARY DAMPING:GLOBAL EXISTENCE,DECAY AND BLOWUP OF THE SOLUTION显示文摘In this paper we consider the Elastic membrane equation with memory term and nonlinear boundary damping.Under some appropriate assumptions on the relaxation function h and with certain initial data,the global existence of solutions and a general decay for the energy are established using the multiplier technique.Also,we show that a nonlinear source of polynomial type is able to force solutions to blow up in finite time even in presence of a nonlinear damping. | Abderrahmane ZARA Nasser-eddine TATAR Salem ABDELMALEK | 2013 | Acta Mathematica Scientia2013，33，1： | 2 |
| 5 | Long-term acupuncture treatment has a multitargeting regulation on multiple brain regions in rats with Alzheimer's disease:a positron emission tomography study显示文摘The acute effect of acupuncture on Alzheimer’s disease,i.e.,on brain activation during treatment,has been reported.However,the effect of long-term acupuncture on brain activation in Alzheimer’s disease is unclear.Therefore,in this study,we performed long-term needling at Zusanli(ST36)or a sham point(1.5 mm lateral to ST36)in a rat Alzheimer’s disease model,for 30 minutes,once per day,for 30 days.The rats underwent 18F-fluorodeoxyglucose positron emission tomography scanning.Positron emission tomography images were processed with SPM2.The brain areas activated after needling at ST36 included the left hippocampus,the left orbital cortex,the left infralimbic cortex,the left olfactory cortex,the left cerebellum and the left pons.In the sham-point group,the activated regions were similar to those in the ST36 group.However,the ST36 group showed greater activation in the cerebellum and pons than the sham-point group.These findings suggest that long-term acupuncture treatment has targeted regulatory effects on multiple brain regions in rats with Alzheimer’s disease. | Yang-jia Lu Xiao-wen Cai Gui-feng Zhang Yong Huang Chun-zhi Tang Bao-ci Shan Shao-yang Cui Jun-qi Chen Shan-shan Qu Zheng Zhong Xin-sheng Lai Genevieve Zara Steiner | 2017 | Neural Regeneration Research2017，12，7： | 2 |
| 6 | Virtual Campeche: a Web Based Virtual Three-Dimensional Tour 显示文摘 | Zara J Benes B | 2004 | Computer Science2004，，19： | 1 |
| 7 | Rough approximation of a preference relation by a multi-attribute stochastic dominance for determinist and stochastic evaluation problems显示文摘 | Zaras K | 2001 | European J of Operational Research2001，130，： | 1 |
| 8 | Genetic testing inbenign familial epilepsies of the first year of life : clinical anddiagnostic significance 显示文摘 | ZARA F SPECCHIO N STRIANO P | 2013 | Epilepsia2013，54，3： | 1 |
| 9 | Positive and negative effects of thalidomide on refractory cutaneous lupus erythematosus显示文摘 | Briani C Zara G Rondinone R | 2005 | Autoimrnunity2005，38，7： | 1 |
| 10 | Service Quality Evaluation Models Determined by Online Consumer Perception and Satisfacion显示文摘 | Maria-Cristiana Munthiu Bogdan C fin Velicu Mihaela Tu Adina lulia Zara | 2014 | Procedia - Social and Behavioral Sciences2014，，12： | 1 |
| 11 | The impact of Thlfl'h2 re- sponse variations on risk of developing childhood leukaemia: a pilot study 显示文摘 | Zara MJ David GC David CJ | 2005 | Blood (ASH Annual Meeting Abstracts)2005，10，6： | 1 |
| 12 | Transfusion-transmitted virus infection in HIV-1-positive patients显示文摘 | Debiaggi M Zara F Sacchi P | 2000 | Clin Microbiol Infect2000，6，5： | 1 |
| 13 | Procedures for selecting items for computerized adaptive tests 显示文摘 | Kingsbury G G Zara A R | 1989 | Applied Measurement in Education1989，4，： | 1 |
| 14 | Covariance of tricarboxylate carrier activity and lipogenesis in liver of poly- unsaturated fatty acid (n-6) fed rats显示文摘 | ZARA V GIUDETTI AM SICULELLA L | 2001 | Eur J Biochem2001，268，22： | 1 |
| 15 | Pyridoxine-dependent epilepsy:an under-recognised cause of intractable seizures显示文摘 | Yeghiazaryan NS Zara F Capovilla G | | 0，，03： | 1 |
| 16 | Geometric skinning with approximate dual quaternion blending显示文摘 | Kavan L Collins S Zara J | 2008 | ACM Transaction on Graphics2008，27，4： | 1 |
| 17 | Rough approximation of a preference relationby a multi-attribute dominance for deterministic, stochastic and fuzzy decision problems 显示文摘 | AZIMIERZ Zaras | 2004 | European Journal of Operational Research2004，159，： | 1 |
| 18 | Practically Orien- ted Parallel Delaunay Triangulation in Ez for Com- puters with Shared Memory 显示文摘 | Kohout J Kolingerova I Zara J | 2004 | Computers Graphics2004，28，5： | 1 |
| 19 | Neurological complications of celiac disease and autoimmune mechanisms: A prospective study显示文摘 | Chiara Briani Gabriella Zara Armin Alaedini Francesca Grassivaro Susanna Ruggero Elisabetta Toffanin Maria Paola Albergoni Milena Luca Bruno Giometto Mario Ermani Franca De Lazzari Anna D’Odorico Leontino Battistin | 2008 | Journal of Neuroimmunology2008，，1： | 1 |
| 20 | Genetic analysis of vesicular stomatitis virus-New Jersey from the 1995 outbreak in the western United States显示文摘 | Zara N Llewellyn Xiu Ou Gwong-Jen Chang | 2000 | AMJVR2000，6，11： | 1 |
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