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| 1 | RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening显示文摘AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard tests.METHODS One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance. | Max J Friedrich Matthias D Wimmer Jan Schmolders Andreas C Strauss Milena M Ploeger Hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau | 2017 | World Journal of Orthopedics2017，8，4： | 4 |
| 2 | Cytokine levels(IL-6 and IFN-γ) acute phase response and nutritional status as prognostic actors in lung cancer显示文摘 | Antonio Milena Emilio González-Reimers María J Brito | 1999 | Cytokine1999，11，1： | 1 |
| 3 | DNA damage and apoptosis in the mussel Mytilus galloprovincialis显示文摘 | Milena M Nevenka B Zeljko J | 2002 | Marine Environmental Research2002，53，： | 1 |
| 4 | Potential therapeutic applications of multifunctional host-defense peptides from frog skin as anti-cancer,anti-viral,immunomodulatory,and anti-diabetic agents显示文摘 | Michael Conlon J Milena Mechkarska Miodrag L Lukic | 2014 | Peptides2014，57，7： | 1 |
| 5 | Supplementation with vitamins c and e inhibits the release of interleukin-6 from contracting human skeletal muscle显示文摘 | CHRISTIAN P FISCHER NATALIE J HISCOCK MILENA PENKOWA | 2004 | J Physiol2004，558，2： | 1 |
| 6 | Using instruction block signatures to counter code injection attacks 显示文摘 | MILENA M ALEKSANDAR M EMIL J | | ACM Sigarch Computer Architecture News0，3，1： | 1 |
| 7 | Sorption of dyes from aqueous solutions onto fly ash 显示文摘 | Pavel J Hana B Milena R | 2003 | Water Res2003，37，2： | 1 |
| 8 | Sorption of dyes from aqueous solutions onto fly ash显示文摘 | Pavel Janol J Hana Buchtovd Milena Ryznarova | 2003 | Water Research2003，37，： | 1 |
| 9 | DNA damage and apoptosis in the mussel mytilus galloprovincialis显示文摘 | MILENA M NEVENKA B ZELJKO J | 2002 | Marine Environmental Research2002，53，： | 1 |
| 10 | Effect on osmotic fragility of red blood cells of whole blood submitted to vibrations in an oscillating platform显示文摘 | Milena O B Monteiro Nelson de Souza Pinto Pedro J | 2011 | African Journal of Biotechnology2011，64，14： | 1 |
| 11 | Measuring area vibration mode shapes with a continuous-scan LDV 显示文摘 | Anthony B Stanbridge Milena Martarelli David J Ewins | 2004 | Measurement(S0263-2241)2004，35，2： | 1 |
| 12 | Stress protocols and tracers显示文摘 | Milena J Henzlova MD Manuel D | 2006 | J Nucl Med2006，13，6： | 1 |
| 13 | Renal pro-inflammatory cytokine gene expression in diabetic nephropathy:effect of angiotensin-converting enzyme inhibition and pentoxifylline administration显示文摘 | Navarro J F Milena F J Mora C | 2006 | Am J Nephrol2006，26，6： | 1 |
| 14 | Epilepsia partialis contin- ua in children with fulminant subacute sclerosing panencephalitis 显示文摘 | Ruzica K Nebojsa J Milena D | 2010 | Neurol Sei2010，299，12： | 1 |
| 15 | Renal pro inflammatory cytokine gene expression in diabetic nephropathy:effect of angiotensin converting enzyme inhibition and pentoxifylline administration显示文摘 | Navarro J F Milena F J Mora C | 2006 | Am J Nephrol2006，26，6： | 1 |
| 16 | Renal pro-inflammatory cytokine gene expression in diabetic nephropathy : effect of angiotensin-convetting enzyme inhibition and pentoxifylline administration 显示文摘 | Navarro J F Milena F J Mora C | 2006 | Am J Nephrol2006，26，6： | 1 |
| 17 | Determination of pefloxacin in serum and pharmaceutical forms by derivative spectrophotometry 显示文摘 | Predrag D Milena J S Zoran M | 1997 | Mikrochim Acta1997，126，34： | 1 |
| 18 | Chemical and radiological vulnerability assessment in urban areas显示文摘 | Bo(z)idar S Milena J S | 2006 | Spatium2006，1314，： | 1 |
| 19 | Sorption of dyes from aqueous solutions onto fly ash 显示文摘 | PAVEL J HANA B MILENA R | 2003 | Water Research2003，37，2： | 1 |
| 20 | Construction and virulence testing of a collagenase mutant of Clostridium perfringens显示文摘 | Milena M Awad Darren M Ellemor Amy E Bryant Osamu Matsushita Richard L Boyd Dennis L Stevens John J Emmins Julian I Rood | 2000 | Microbial Pathogenesis2000，，2： | 1 |
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