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| 1 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 2 | Expenditure of hospital care on cancer in China, from 2011 to 2015显示文摘Objective: A solid understanding of levels and trends of spending on cancer is important to evaluate whether our healthcare resources were wisely spent and to prioritize future resources for cancer treatment and prevention.However, studies on economic burden of cancers in China are scant and the results are inconsistent.Methods: The Chinese hospital information database and nearly 350 million inpatient medical record data were used. As the ratios of cancer inpatient payments to total inpatient payments were mainly influenced by the grades and sites of hospitals, the estimates of payments of cancer inpatients in this study were stratified by hospital grades and provinces. Only the payments of cancer inpatients happened in grade 2, grade 3 and specialized cancer hospitals were included in the analyses. The total medical payments of cancers in China were estimated based on the ratios of outpatient payments to inpatient payments in specialized cancer hospitals.Results: From 2011 to 2015, the payments of cancer inpatients in China have increased by 84.1% and the total inpatient payments reached 177.1 billion RMB in 2015, accounting for 4.3% of the total health expenditure in China. Based on the ratio of outpatient payments to inpatient payments, the total payments on cancer treatments in China were estimated to be 221.4 billion RMB in 2015. Among different cancer types, the highest payments were the treatment of trachea, bronchus and lung cancer. The major cancer inpatient payments(67.1% in 2015) spent in grade 3 general hospitals and this ratio increased continually from 2011 to 2015. The expenditure of cancer treatments also varies by region with the major expenditure in the eastern region of China.Conclusions: This study estimated the total payments of cancer treatments in China and analyzed how the money was spent on cancer treatments in the recent 5 years, which would provide information for decision makings on the allocation of resources to service provisioning, prevention strategies, research funding, and assessing whether the economic burden of cancer is affordable to the governments. | Yue Cai Ming Xue Wanqing Chen Maogui Hu Zhiwen Miao Lan Lan Rongshou Zheng Qun Meng | 2017 | Chinese Journal of Cancer Research2017，29，3： | 81 |
| 3 | Past,present,and future of biochar显示文摘After entering the twenty-first century,biochar has become a focal point of multidisciplinary research because of its special characteristics,broad application,and promising development prospects.Basic and applied research on the application of biochar in the areas of agriculture,environment,and energy have increased dramatically in the face of food security,environmental pollution,and energy shortage.Although there are some disputes about biochar research,many studies have demonstrated the importance of biochar research from the perspective of scientific advancement and practical application.This paper briefly recalls the history of biochar application;introduces research progress on the basic characteristics of biochar and its associated production technologies;summarizes the research status and existing problems of biochar application in the areas of agriculture,environment,and energy;and analyzes the potential problems and development trends of biochar research in the future. | Wenfu Chen Jun Meng Xiaori Han Yu Lan Weiming Zhang | 2019 | Biochar2019，1，1： | 66 |
| 4 | Sequencing of Cultivated Peanut, Arachis hypogaea, Yields Insights into Genome Evolution and Oil Improvement显示文摘Cultivated peanut (Arachis hypogaea) is an allotetraploid crop planted in Asia, Africa, and America for edible oil and protein. To explore the origins and consequences of tetraploidy, we sequenced the allotetraploid A. hypogaea genome and compared it with the related diploid Arachis duranensis and Arachis ipaensis genomes. We annotated 39 888 A-subgenome genes and 41 526 B-subgenome genes in allotetraploid peanut. The A. hypogaea subgenomes have evolved asymmetrically, with the B subgenome resembling the ancestral state and the A subgenome undergoing more gene disruption, loss, conversion, and transposable element proliferation, and having reduced gene expression during seed development despite lacking genome-wide expression dominance. Genomic and transcriptomic analyses identified more than 2 500 oil metabolism-related genes and revealed that most of them show altered expression early in seed development while their expression ceases during desiccation, presenting a comprehensive map of peanut lipid biosynthesis. The availability of these genomic resources will facilitate a better understanding of the complex genome architecture, agronomically and economically important genes, and genetic improvement of peanut. | Xiaoping Chen Qing Lu Hao Liu Jianan Zhang Yanbin Hong Haofa Lan Haifen Li Jinpeng Wang Haiyan Liu Shaoxiong Li Manish K.Pandey Zhikang Zhang Guiyuan Zhou Jigao Yu Guoqiang Zhang Jiaqing Yuan Xingyu Li Shijie Wen Fanbo Meng Shanlin Yu Xiyin Wang Kadambot H.M.Siddique Zhong-Jian Liu Andrew H.Paterson Rajeev K.Varshney Xuanqiang Liang | 2019 | Molecular Plant2019，12，7： | 23 |
| 5 | Clinical Characteristics, Radiological Features and Gene Mutation in 10 Chinese Families with Spinocerebellar Ataxias显示文摘 | Jian-Wen Chen Li Zhao Feng Zhang Lan Li Yu-Hang Gu Jing-Yuan Zhou Hui Zhang Ming Meng Kai-Hua Zhang Wei-Dong Le Chun-Bo Dong | 2015 | Chinese Medical Journal2015，，13： | 14 |
| 6 | Effect of aerial spray adjuvant applying on the efficiency of small unmanned aerial vehicle for wheat aphids control显示文摘Small unmanned aerial vehicles(UAVs)have been widely used in different aspects of modern farming management,including pest and disease control in China in recent years.In this study,the spray performance of a small plant protection UAV at low volume spray was evaluated by adjusting the pesticide dosage and adding aerial spraying adjuvants.Droplet deposition,droplet density,coverage,control effect and pesticide residue from field trials were assessed.In addition,the residue and control effect of UAV spray were compared to manual knapsack at high volume spray.The results showed that,the adjuvant applying improved the efficiency of UAV spray.Also,the adjuvant applying reduced the dosage of imidacloprid by 20%.However,there was no significant difference on initial residue between UAV spray and knapsack spray.Thus,plant protection UAV spraying pesticide by adding appropriate adjuvant showed the ability of improving the pesticide effectiveness by improving the control efficiency,reducing the pesticide dosage and residue. | Yanhua Meng Yubin Lan Guiying Mei Yongwang Guo Jianli Song Zhiguo Wang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，5： | 13 |
| 7 | WEAR FAILURE MECHANISM AND MULTI-IMPACT PROPERTY OF AUTOMOTIVE ENGINE CHAIN显示文摘The multi-impact characteristics and failure mechanism of two kinds of automotive enginechain made in China are studied through engine assembly and road-drive tests. The worn surfacemorphologies of rubbing area between pin, bush and roller are also analyzed based on scanning elec-tron microscope. The results show that the main wear mechanism of automotive engine chain is fa-tigue wear, and its failure mechanism is the forming, extending and flaking of cracks on top layer ofpin and bush. In addition, the material, hot-treatment method and shaping technique for roller have agreat influence upon the resistance to multi-impact. Ensuring sufficient strength and plasticity ofroller, as well as adopting suitable shaping technique are the effective method to increase its resistanceto multi-impact. | Meng Fanzhong Wang Shukun Lan Hong Xu Rongjin Xu Hanxue | 2005 | Chinese Journal of Mechanical Engineering2005，18，3： | 12 |
| 8 | Functional organization of complex brain networks modulated by acupuncture at different acupoints belonging to the same anatomic segment显示文摘 | CHEN Shang-jie MENG Lan YAN Hao BAI Li-jun WANG Fang HUANG Yong LI Jian-ping PENG Xu-ming SHI Xue-min | 2012 | Chinese Medical Journal2012，，15： | 12 |
| 9 | Brown adipose tissue transplantation improves whole-body energy metabolism显示文摘 | Qingsheng Chi Dehua Wang Zhaoyun Zhang Chenzhong Li Yiming Li Yaoming Xue John R Speakma Wanzhu Jin Xiaomeng Liu Zongji Zhen Xiaoming Zhu Minghui Meng Lan Li Yanyan Shen | 2013 | Cell Research2013，23，6： | 11 |
| 10 | Ag nanoparticles sensitize IR-induced killing of cancer cells显示文摘 | Ruizhi Xu Jun Ma Xinchen Sun ZhongpingChen Xiaoli Jiang Zhirui auo Lan Huang YangLi Meng Wang Changling Wang Jiwei Liu XuFan Jiayu Gu Xi Chen Yu Zhang Ning Gu | 2009 | Cell Research2009，19，8： | 11 |
| 11 | Pregnancy outcomes and risk factors for low birth weight and preterm delivery among HIV-infected pregnant women in Guangxi, China显示文摘在中国的背景六省在 2009 和五个省在这个国家说明了所有报导 HIV/AIDS 案例的 70-80 说明了属于的 HIV cases.Because Guangxi 的 78 所有报导 mother-to-child 传播( MTCT )两个组,加节目的 Mother-to-Child 传播( PMTCT )的预防在那里被建立理解更好低的出生重量( LBW )和 preterm 交货( PD )出生结果和他们的联系风险因素 better.Methods 怀孕结果被检验在之中95 CI 1.11-25.55 ) 并且 CD4 房间计数 100-199 cells/l (AOR 3.40;95 Cl 1.03-11.25,与 CD4 房间计数 350 cells/l 相比) , gestational 年龄 37 星期(AOR 4.38;95 CI 1.29-14.82,与 37 个星期相比) ,母亲的重量 45 kg (AOR 5.64;95 Cl 1.09-29.07 ) 并且母亲的重量 45-54 kg (AOR 3.55;95 Cl 1.31-9.60,与 55 kg 相比) 在注册,和 HIV RNA 100 在注册的 000 copies/ml (AOR 4.22;95 Cl 1.24-14.32 ) 并且 20 000-99 999 (AOR 2.77;95 CI 1.01-7.77,与 20 000 copies/ml 相比) 与 LBW.For PD 的更高的风险被联系,仅仅母亲的注射药使用作为 HIV 传播的线路(AOR 5.30; 95 CI 1.33-21.14 ,与通过性传播感染 HIV 的那些相比)显著地与 PD.Conclusions 更低的 CD4 房间计数的更高的风险被联系,在注册的更高的 HIV RNA 病毒的负担与 LBW.Optimal 胎儿的照顾被联系包括更早胎儿的屏蔽和 HIV 诊断,对更早的 PMTCT 预防或 HIV treatent 批评阻止 HIV 的传播到婴儿并且也阻止 LBW 怀孕结果。 | Yu Lan Li Wen-ying Chen, Ray Y. Tang Zhi-rong Pang Jun Gui Xiu-zhi Meng Xiu-ning Zhang Fu-jie | 2012 | Chinese Medical Journal2012，，3： | 10 |
| 12 | Development of the straw biochar returning concept in China显示文摘Biochar produced from straw has been shown to improve soil physicochemical properties.This review introduces the fundamental concepts,the broad applications,and underlying theory of straw biochar returning.Current developments in biochar industry and the production practices prevalent among enterprises in China are critiques.This review analyzes current knowledge gaps,challenges,and opportunities in the industrial application of straw biochar returning.Biochar standards,the quantitative and qualitative analysis methods for biochar,and high-value-added products that are based on biochar are critically examined with goal of providing recommendations for future studies.We propose production and modification of biochar that is application oriented to enhance its fitness for purpose as well as long-term and large-space-scale field study to better understand its impact on soil properties and ecotoxicology.Finally,we make prospects for the future development of SBR,including constructing a standard system about straw biochar returning and promoting self-discipline of biochar industry and the establishment of a biochar-based agricultural production model. | Jun Meng Tianyi He Edmond Sanganyado Yu Lan Weiming Zhang Xiaori Han Wenfu Chen | 2019 | Biochar2019，1，2： | 9 |
| 13 | Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield显示文摘Artemisia annua is the major natural source of artemisinin,an anti-malarial medicine commonly used worldwide.Here,we present chromosome-level haploid maps for two A.annua strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin production.High-fidelity sequencing,optical mapping,and chromatin conformation capture sequencing were used to assemble the heterogeneous and repetitive genome and resolve the haplotypes of A.annua.Approximately 5o,ooo genes were annotated for each haplotype genome,and a triplication event that occurred approximately 58.12million years ago was examined for the first time in this species.A total of 3,903,467-5,193,414 variants(SNPs,indels,and structural variants)were identified in the 1.5-Gb genome during pairwise comparison between haplotypes,consistent with the high heterozygosity of this species.Genomic analyses revealed a correlation between artemisinin concents and the copy number of amorpha-4,11-dienes ynthasegenes.This correlation was further confirmed by resequencing of 36A.annua samples with varied artemisinin contents.Circular consensus sequencing of transcripts facilitated the detection of paralog expression.Collectively,our study provides chromosome-level allele-aware genome assemblies for two A.annua strains and new insights into the biosynthesis of artemisinin and its regulation,which will contribute to conquering malaria worldwide. | Baosheng Liao Xiaofeng Shen Li Xiang Shuai Guo Shiyu Chen Ying Meng Yu Liang Dandan Ding Junqi Bai Dong Zhang Tomasz Czechowski Yi Li Hui Yao Tingyu Mai Caroline Howard Chao Sun Haitao Liu Jiushi Liu Jin Pei Jihai Gao Jigang Wang Xiaohui Qiu Zhihai Huang Hongyi Li Ling Yuan Jianhe Wei lan Graham Jiang Xu Boli Zhang Shilin Chen | 2022 | Molecular Plant2022，15，8： | 9 |
| 14 | Effect of Pulsed Radiofrequency on Rat Sciatic Nerve Chronic Constriction Injury: A Preliminary Study显示文摘 | Duo-Yi Li Lan Meng Nan Ji Fang Luo | 2015 | Chinese Medical Journal2015，，4： | 9 |
| 15 | Analysis of inpatient payments of breast cancer patients with different medical insurance coverages in China(mainland) in 2011–2015显示文摘Objective: An understanding of the levels and trends of medical cost is made for breast cancer patients with different medical insurance coverages in China(mainland), in an attempt to offer a clue to further control the costs.Methods: The inpatient payments of 9,716,180 breast cancer patients spent in medical institutions of different types and grades during 2011–2015 were collected from the inpatient medical record home page(IMRHP) dataset.The data were then processed with SAS(Version 9.3; SAS Institute, Cary, NC, USA). Indicators like means,increase(decrease) percentages were used to descriptively analyze the average hospitalization expense of each time(AHEET) and its trends of breast cancer patients with different medical insurance coverages treated in medical institutions of different types and grades.Results:In 2011–2015,the AHEET borne by breast cancer patients in China had been constantly increasing.Specifically,the self-pay inpatients had the largest increase,inpatients covered by Urban Employee Basic Medical Insurance(UEBMI)and Urban Resident Basic Medical Insurance(URBMI)were the next,and those covered by New Rural Cooperative Medical System(NRCMS)had the least increase.Breast cancer inpatient treated in public hospitals had quite greater increase and higher expenditure level than those in private hospitals.The AHEET borne by the inpatients in Grade 3 hospitals had greater increase and higher cost than those in Grade 2 hospitals.Conclusions:The inpatient payments of breast cancer patients will be wisely controlled by reducing the number of self-pay inpatients,taking advantage of restriction mechanism of the medical insurances,and promoting healthy competition between private hospitals and public hospitals.The economic burden imposed on the society by breast cancer can be relieved through further control of inpatient payments of UEBMI-and URBMI-covered breast cancer patients and of Grade 3 hospitals. | Rui Li Liang Zhang Jinxia Yang Yue Cai Wanqing Chen Lan Lan Ming Xue Qun Meng | 2017 | Chinese Journal of Cancer Research2017，29，5： | 9 |
| 16 | Pulsed radiofrequency inhibits expression of P2X3 receptors and alleviates neuropathic pain induced by chronic constriction injury in rats显示文摘Background:Pulsed radiofrequency (PRF) is a minimally invasive interventional technique that provides a novel and effective treatment strategy for neuropathic pain (NP).PRF is advantageous because it does not damage nerves and avoids sensory loss after treatment.At present,animal studies have demonstrated that PRF is safe and effective for relieving the NP associated with sciatic nerve damage in rats with chronic constriction injury (CCI).However,the mechanism through which this effect occurs is unknown.An increasing body of evidence shows that the expression of the P2X ligand-gated ion channel 3 (P2X3) receptor is closely related to NP;this study was to investigate whether the expression of this receptor is involved in NP relief due to PRF.Methods:A total of 36 healthy adult male Sprague-Dawley (SD) rats were randomly divided into three groups:Sham group,CCI group,and PRF group.The right sciatic nerve was ligated in CCI group and PRF group to establish a CCI model;the right sciatic nerve was separated but not ligated in Sham group.On day 14 after the operation,PRF was administered to the ligated sciatic nerve in PRF group (42℃,45 V,2 min).A non-live electrode was placed at the exposed sciatic nerve for the rats in Sham and CCI groups.The hindpaw withdrawal threshold (HWT) and thermal withdrawal latency (TWL) were measured at the right hindpaw at different time points before and after PRF or sham therapy.On day 28 after treatment,the dorsal root ganglion (DRG) and spinal dorsal horn of the right L4-6 were harvested from each group to determine the mRNA and protein levels of the P2X3 receptor.Results:On day 28 after PRF treatment,the HWT (8.33 ± 0.67 g vs.3.62 ± 0.48 g) and TWL (25.42 ± 1.90 s vs.15.10 ± 1.71 s) were significantly higher in PRF group as compared to CCI group (P < 0.05).The mRNA expression of the P2X3 receptor in the DRG in PRF group was 23.7% lower than that in CCI group (P < 0.05),in the spinal dorsal horns in PRF group was 22.7% lower than that in CCI group (P < 0.05).The protein expression of the P2X3 receptor in the DRG in PRF group was 27.8 % lower than that in CCI group (P < 0.05),in the spinal dorsal horns in PRF group was 35.6% lower than that in CCI group (P < 0.05).Conclusion:PRF possibly reduces NP in CCI rats by inhibiting the expression of the P2X3 receptor in the L4-6 DRG and spinal dorsal horns. | Miao Fu Lan Meng Hao Ren Fang Luo | 2019 | Chinese Medical Journal2019，，14： | 8 |
| 17 | Corn cob biochar increases soil culturable bacterial abundance without enhancing their capacities in utilizing carbon sources in Biolog Eco-plates显示文摘Biochar has been shown to influence soil microbial communities in terms of their abundance and diversity.However,the relationship among microbial abundance,structure and C metabolic traits is not well studied under biochar application.Here it was hypothesized that the addition of biochar with intrinsic properties(i.e.,porous structure)could affect the proliferation of culturable microbes and the genetic structure of soil bacterial communities.In the meantime,the presence of available organic carbon in biochar may influence the C utilization capacities of microbial community in Biolog Eco-plates.A pot experiment was conducted with differenct biochar application(BC)rates:control(0 t ha^(–1)),BC1(20 t ha^(–1))and BC2(40 t ha^(–1)).Culturable microorganisms were enumerated via the plate counting method.Bacterial diversity was examined using denaturing gradient gel electrophoresis(DGGE).Microbial capacity in using C sources was assessed using Biolog Eco-plates.The addition of biochar stimulated the growth of actinomyces and bacteria,especially the ammonifying bacteria and azotobacteria,but had no significant effect on fungi proliferation.The phylogenetic distribution of the operational taxonomic units could be divided into the following groups with the biochar addition:Firmicutes,Acidobacteria,Gemmatimonadetes,Actinobacteria,Cyanobacteria andα-,β-,γ-andδ-Proteobacteria(average similarity>95%).Biochar application had a higher capacity utilization for L-asparagine,Tween 80,D-mannitol,L-serine,γ-hydroxybutyric acid,N-acetyl-D-glucosamine,glycogen,itaconic acid,glycyl-L-glutamic acid,α-ketobutyricacid and putrescine,whereas it had received decreased capacities in using the other 20 carbon sources in Biolog Eco-plates.Redundancy analysis(RDA)revealed that the physico-chemical properties,indices of bacterial diversity,and C metabolic traits were positively correlated with the appearance of novel sequences under BC2 treatment.Our study indicates that the addition of biochar can increase culturable microbial abundance and shift bacterial genetic structure without enhancing their capacities in utilizing C sources in Biolog Eco-plates,which could be associated with the porous structure and nutrients from biochar. | JIANG Lin-lin HAN Guang-ming LAN Yu LIU Sai-nan GAO Ji-ping YANG Xu MENG Jun CHEN Wen-fu | 2017 | Journal of Integrative Agriculture2017，16，3： | 7 |
| 18 | A Resource for Inactivation of MicroRNAs Using Short Tandem Target Mimic Technology in Model and Crop Plants显示文摘microRNAs (miRNAs)are endogenous small non-coding RNAs that bind to mRNAs and target them for cleavage and/or translational repression,leading to gene silencing.We previously developed short tandem target mimic (STTM)technology to deactivate endogenous miRNAs in Arabidopsis.Here,we created hundreds of STTMs that target both conserved and species-specific miRNAs in Arabidopsis,tomato,rice,and maize,providing a resource for the functional interrogation of miRNAs.We not only revealed the functions of several miRNAs in plant development,but also demonstrated that tissue-specific inactivation of a few miRNAs in rice leads to an increase in grain size without adversely affecting overall plant growth and development.RNA-seq and small RNAseq analyses of STTM156/157 and STTM165/166 transgenic plants revealed the roles of these miRNAs in plant hormone biosynthesis and activation,secondary metabolism,and ion-channel activity-associated electrophysiology,demonstrating that STTM technology is an effective approach for studying miRNA functions.To facilitate the study and application of STTM transgenic plants and to provide a useful platform for storing and sharing of information about miRNA-regulated gene networks,we have established an online Genome Browser (http://gffzzc750bc0108fa4044s6qnu09ok0pfb6qnk.ffgz.tsg.suse.edu.cn/designindex2.php) to display the transcriptomic and miRNAomic changes in STTMinduced miRNA knockdown plants. | Ting Peng Mengmeng Qiao Haiping Liu Sachin Teotia Zhanhui Zhang Yafan Zhao Bobo Wang Dongjie Zhao Lina Shi Cui Zhang Brandon Le Kestrel Rogers Chathura Gunasekara Haitang Duan Yiyou Gu Lei Tian Jinfu Nie Jian Qi Fanrong Meng Lan Huang Qinghui Chen Zhenlin Wang Jinshan Tang Xiaoqing Tang Ting Lan Xuemei Chen Hairong Wei Quanzhi Zhao Guiliang Tang | 2018 | Molecular Plant2018，11，11： | 7 |
| 19 | Characteristics of fault zones and their control on remaining oil distribution at the fault edge: a case study from the northern Xingshugang Anticline in the Daqing Oilfield, China显示文摘Most major oil zones in the Daqing Oilfield have reached a later,high water cut stage,but oil recovery is still only approximately 35%,and 50%of reserves remain to be recovered.The remaining oil is primarily distributed at the edge of faults,in poor sand bodies,and in insufficiently injected and produced areas.Therefore,the edge of faults is a major target for remaining oil enrichment and potential tapping.Based on the dynamic change of production from development wells determined by the injection-recovery relationship at the edge of faults,we analyzed the control of structural features of faults on remaining oil enrichment at the edge.Our results show that the macroscopic structural features and their geometric relationship with sand bodies controlled remaining oil enrichment zones like the edges of NNE-striking faults,the footwalls of antithetic faults,the hard linkage segments(two faults had linked together with each other to form a bigger through-going fault),the tips of faults,and the oblique anticlines of soft linkages.Fault edges formed two types of forward microamplitude structures:(1) the tilted uplift of footwalls controlled by inverse fault sections and(2) the hanging-wall horizontal anticlines controlled by synthetic fault points.The remaining oil distribution was controlled by microamplitude structures.Consequently,such zones as the tilted uplift of the footwall of the NNW-striking antithetic faults with a fault throw larger than 40 m,the hard linkage segments,the tips of faults,and the oblique anticlines of soft linkage were favorable for tapping the remaining oil potential.Multi-target directional drilling was used for remaining oil development at fault edges.Reasonable fault spacing was determined on the basis of fault combinations and width of the shattered zone.Well core and log data revealed that the width of the shattered zone on the side of the fault core was less than 15 m in general;therefore,the distance from a fault to the development target should be larger than 15 m.Vertically segmented growth faults should take the separation of the lateral overlap of faults into account.Therefore,the safe distance of remaining oil well deployment at the fault edge should be larger than the sum of the width of shattered zone in faults and the separation of growth faults by vertical segmentation. | Xiao-Fei Fu Xiao Lan Ling-Dong Meng Hai-Xue Wang Zong-Bao Liu Zhi-Qiang Guo Zai-He Chen | 2016 | Petroleum Science2016，13，3： | 7 |
| 20 | ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer显示文摘The Serine-Glycien-One-Carbon(SGOC)pathway is pivotal in multiple anabolic processes.Expression levels of SGOC genes are deregulated under tumoeigenic condltions,suggesting panicipation of oncogenes in deregulating the SGOC biosynthetic pathway.However,the underlying mechanism remains elusive.Here,we identifed that Interleukin enfiarccer-binding factor 3(ILF3)is overexpressed in primary CRC patient specimens and correlates with poor progroosis.ILF3 is critical in regulating the SGOC pathway by directly regulating the mRNA stability of SGOC genes,thereby increasing SGOC genes expression and facilitating tumor growth.Mehhanktic studies showed that the EGF-MIEK-ERK pathway nnediates ILF3 phosphorylation,which hin ders E3 ligase speckle-type POZ protein(SPOP)-mediated poly-ubiquitination and degradation of ILF3.Sign iftca ntly,combination of SGOC inhibitor and the anti-EGFR monoclonal antibody cetuximab can hinder the growth of patient-derived xenografts that sustain high ERK-ILF3 levels.Taken together,deregutation of ILF3 via the EGF-ERK signaling plays an important role in systemic serine metabolic reprogramming and confers a predilection toward CRC development.Our findings indicate that clinical evaluation of SCOC inhibitor is warranted for CRC patients with ILF3 overexpression. | Kai Li Jian-lin Wu Baifu Qin Zongmin Fan Qin Tang Weisi Lu Haipeng Zhang Fan Xing Manqi Meng Shaomin Zou Wenxia Wei Honglei Chen Jian Cai Huaiming Wang Hui Zhang Jiayue Cai Ling Fang Xiqing Bian Chuangqi Chen Ping Lan Bart Ghesquiere Lekun Fang Mong-Hong Lee | 2020 | Cell Research2020，30，2： | 6 |
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