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| 1 | Past,present,and future of biochar显示文摘After entering the twenty-first century,biochar has become a focal point of multidisciplinary research because of its special characteristics,broad application,and promising development prospects.Basic and applied research on the application of biochar in the areas of agriculture,environment,and energy have increased dramatically in the face of food security,environmental pollution,and energy shortage.Although there are some disputes about biochar research,many studies have demonstrated the importance of biochar research from the perspective of scientific advancement and practical application.This paper briefly recalls the history of biochar application;introduces research progress on the basic characteristics of biochar and its associated production technologies;summarizes the research status and existing problems of biochar application in the areas of agriculture,environment,and energy;and analyzes the potential problems and development trends of biochar research in the future. | Wenfu Chen Jun Meng Xiaori Han Yu Lan Weiming Zhang | 2019 | Biochar2019，1，1： | 66 |
| 2 | Peripheral T-lymphocyte subpopulations in different clinical stages of chronic HBV infection correlate with HBV load显示文摘AIM: To characterize the peripheral T-cell subpopulation profiles and their correlation with hepatitis B virus (HBV) replication in different clinical stages of chronic HBV infection.METHODS: A total of 422 patients with chronic HBV infection were enrolled in this study. The patients were divided into three stages: immune-tolerant stage, immune active stage, and immune-inactive carrier stage. Composition of peripheral T-cell subpopulations was determined by flow cytometry. HBV markers were detected by enzyme-linked immunosorbent assay. SerumHBV DNA load was assessed by quantitative real-time polymerase chain reaction.RESULTS: CD8+ T-cells were significantly higher in patients at the immune-tolerant stage than in patients at the immune-active and -inactive carrier stages (36.87 ± 7.58 vs 34.37 ± 9.07, 36.87 ± 7.58 vs 28.09 ± 5.64, P < 0.001). The peripheral blood in patients at the immune-tolerant and immune active stages contained more CD8+ T-cells than CD4+ T-cells (36.87 ± 7.58 vs 30.23 ± 6.35, 34.37 ± 9.07 vs 30.92 ± 7.40, P < 0.01), whereas the peripheral blood in patients at the immune-inactive carrier stage and in normal controls contained less CD8+ T-cells than CD4+ T-cells (28.09 ± 5.64 vs 36.85 ± 6.06, 24.02 ± 4.35 vs 38.94 ± 3.39, P < 0.01). ANOVA linear trend test showed that CD8+ T-cells were signif icantly increased in patients with a high viral load (39.41 ± 7.36, 33.83 ± 7.50, 31.81 ± 5.95 and 26.89 ± 5.71, P < 0.001), while CD4+ T-cells were signif icantly increased in patients with a low HBV DNA load (37.45 ± 6.14, 33.33 ± 5.61, 31.58 ± 6.99 and 27.56 ± 5.49, P < 0.001). Multiple regression analysis displayed that log copies of HBV DNA still maintained its highly signif icant coefficients for T-cell subpopulations, and was the strongest predictors for variations in CD3+, CD4+ and CD8+ cells and CD4+/CD8+ ratio after adjustment for age at HBV-infection, maternal HBV-infection status, presence of hepatitis B e antigen and HBV mutation.CONCLUSION: Differences in peripheral T-cell subpopulation profi les can be found in different clinical stages of chronic HBV infection. T-cell impairment is signifi cantly associated with HBV load. | Jing You Lin Zhuang Yi-Feng Zhang Hong-Ying Chen Hutcha Sriplung Alan Geater Virasakdi Chongsuvivatwong Teerha Piratvisuth Edward McNeil Lan Yu Bao-Zhang Tang .lun-Hua Huang | 2009 | World Journal of Gastroenterology2009，15，27： | 39 |
| 3 | The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types显示文摘The Genome Sequence Archive(GSA)is a data repository for archiving raw sequence data,which provides data storage and sharing services for worldwide scientific communities.Considering explosive data growth with diverse data types,here we present the GSA family by expanding into a set of resources for raw data archive with different purposes,namely,GSA(http://gffzz77e3413bc06540eds5o0uk69kwq666wko.ffgz.tsg.suse.edu.cn/gsa/),GSA for Human(GSA-Human,http://gffzz77e3413bc06540eds5o0uk69kwq666wko.ffgz.tsg.suse.edu.cn/gsa-human/),and Open Archive for Miscellaneous Data(OMIX,http://gffzz77e3413bc06540eds5o0uk69kwq666wko.ffgz.tsg.suse.edu.cn/omix/).Compared with the 2017 version,GSA has been significantly updated in data model,online functionalities,and web interfaces.GSA-Human,as a new partner of GSA,is a data repository specialized in human genetics-related data with controlled access and security.OMIX,as a critical complement to the two resources mentioned above,is an open archive for miscellaneous data.Together,all these resources form a family of resources dedicated to archiving explosive data with diverse types,accepting data submissions from all over the world,and providing free open access to all publicly available data in support of worldwide research activities. | Tingting Chen Xu Chen Sisi Zhang Junwei Zhu Bixia Tang Anke Wang Lili Dong Zhewen Zhang Caixia Yu Yanling Sun Lianjiang Chi Huanxin Chen Shuang Zhai Yubin Sun Li Lan Xin Zhang Jingfa Xiao Yiming Bao Yanqing Wang Zhang Zhang Wenming Zhao | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 38 |
| 4 | Differentiation profile of brain tumor stem cells:a comparative study with neural stem cells显示文摘大脑肿瘤干细胞(BTSC ) 的区别侧面的理解,在肿瘤房间人口之中的关键的,将通过有神经干细胞(NSC ) 的比较借卓见进 glioma 的起源并且最终产出新途径与这难处理的疾病作斗争。这里,我们从外科的 glioma 标本的有教养、净化的 BTSC 和 NSCsfrom 人的胎儿的大脑织物,并且进一步分析了他们的细胞的生物行为,他们的特别区别性质。是期望,区分进成熟神经显型的 NSC。然而, BTSC 展出了的 Inthe 一样的区别状况区分了差别。词法上,房间变得变平并且属于第一个星期,但是逐渐地此后聚集了并且改过漂浮的肿瘤范围。在相应时期期间,无差别的房间标记 CD133 和巢在的表示率在 BTSC 不停地减少,但是 1 个星期以后,他们重获上升趋势。有趣地,区分的房间标记 GFAP 和 beta-tubulinIIIshowed 表示变化逆到无差别的房间标记的。总起来说, BTSCswere 揭示了拥有一个能力抵抗区别,它实际上代表 glioma 的恶意的行为。 | Quan Bin Zhang Xiao Yan Ji Qiang Huang Jun Dong Yu De Zhu Qing Lan | 2006 | Cell Research2006，16，12： | 34 |
| 5 | Effect of viral load on T-lymphocyte failure in patients with chronic hepatitis B显示文摘AIM: To investigate peripheral T-lymphocyte sub-population profile and its correlation with hepatitis B virus (HBV) replication in patients with chronic hepatitis B (CHB).METHODS: Distribution of T-lymphocyte subpopulations in peripheral blood was measured by flow cytometry in 206 CHB patients. HBV markers were detected with ELISA. Serum HBV DNA load was assessed with quantitative real-time polymerase chain reaction (PCR). The relationship between HBV replication and variation in peripheral T-cell subsets was analyzed.RESULTS: CHB patients had significantly decreased CD3+ and CD4+ cells and CD4+/CD8+ ratio, and increased CD8+ cells compared with uninfected controls (55.44 ± 12.39 vs 71.07 ± 4.76, 30.92 ± 7.48 vs 38.94 ± 3.39, 1.01 ± 0.49 vs 1.67 ± 0.33, and 34.39 ± 9.22 vs 24.02 ± 4.35; P < 0.001, respectively). Univariate analysis showed a similar pattern of these parameters was significantly associated with high viral load, presence of serum hepatitis B e antigen (HBeAg) expression, liver disease severity, history of maternal HBV infection, and young age at HBV infection, all with P < 0.01. There was a significant linear relationship between viral load and these parameters of T-lymphocyte subpopulations (linear trend test P < 0.001). There was a negative correlation between the levels of CD3+ and CD4+ cells and CD4+/CD8+ ratio and serum level of viral load in CHB patients (r = -0.68, -0.65 and -0.75, all P < 0.0001), and a positive correlation between CD8+ cells and viral load (r = 0.70, P < 0.0001). There was a significant decreasing trend in CD3+ and CD4+ cells and CD4+/CD8+ ratio with increasing severity of hepatocyte damage and decreasing age at HBV infection (linear trend test P < 0.01). In multiple regression (after adjustment for age at HBV infection, maternal HBV infection status and hepatocyte damage severity) log copies of HBV DNA maintained a highly significant predictive coefficient on T-lymphocyte subpopulations, and was the strongest predictor of variation in CD3+, CD4+, CD8+ cells and CD4+/CD8+ ratio. However, the effect of HBeAg was not significant.CONCLUSION: T-lymphocyte failure was signifi-cantly associated with viral replication level. The substantial linear dose-response relationship and strong independent predictive effect of viral load on T-lymphocyte subpopulations suggests the possibility of a causal relationship between them, and indicates the importance of viral load in the pathogenesis of T cell hyporesponsiveness in these patients. | Jing You Hutcha Sriplung Alan Geater Virasakdi Chongsuvivatwong Lin Zhuang Hong-Ying Chen Lan Yu Bao-Zhang Tang Jun-Hua Huang | 2008 | World Journal of Gastroenterology2008，14，7： | 30 |
| 6 | Roles of Fas signaling pathway in vitamin E succinateinduced apoptosis in human gastric cancer SGC-7901 cells显示文摘AIM: To investigate the roles of Fas signaling pathway in vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells.METHODS: Human gastric cancer SGC-7901 cells were treated with VES at 5, 10, 20 mg@L-1, succinic acid and vitamin E as vehicle control and condition media only as untreated (UT) control. Apoptotic morphology was observed by DAPI staining. Western blot analysis was applied to measure the expression of Fas, FADD and caspase-8 proteins. After the cells were transiently transfected with Fas and FADD antisense oligonucleotides, respectively, caspase-8 activity was determined by flurometric method.RESULTS: The morphologically apoptotic changes were observed after VES treatment by DAPI staining. 23.7 % and 89.6 % apoptosis occurred after 24 h and 48 h of 20 mg@L-1 VES treatment, respectively. The protein levels of Fas, FADD and caspase-8 were evidently increased in a dose-dependent manner after 24 h of VES treatment. The blockage of Fas by transfection with Fas antisense oligonucleotides obviously inhibited the expression of FADD protein. After SGC-7901 cells were transfected with Fas and FADD antisense oligonucleotides, caspase-8 activity was obviously decreased (P<0.01), whereas Fas blocked more than FADD.CONCLUSION: VES-induced apoptosis in human gastric cancer SGC-7901 cells involves Fas signaling pathway including the interaction of Fas, FADD and caspase-8. | Kun Wu Yao Li Yan Zhao Yu-Juan Shah Wei Xia Lan Zhao,Department of Nutrition and Food Hygiene,Public Health School,Harbin Medical University,Harbin 150001,Heilongjiang Province,China Wei-Ping Yu,Genetics Institute,Texas University of USA,Austin,USA | 2002 | World Journal of Gastroenterology2002，8，6： | 30 |
| 7 | A study of the efficacy of bacterial biofilm cleanout for gastrointestinal endoscopes显示文摘AIM:To compare the influence and clearance effect of enzymatic and non-enzymatic detergents against Escherichia coli (E. coli) biofilm on the inner surface of gastroscopes.METHODS:Teflon tubes were incubated in a mixture of different detergents and E. coli culture (106 CFU/mL) for 72 h at 15℃,and biofilms on the inner surface of the teflon tubes were analyzed by bacterial count and scanning electron microscopy. To evaluate the clear-ance effect of detergents,after biofilms were formed on the inner surface of Teflon tubes by 72 h lavage with E. coli culture,tubes were lavaged by enzymatic and non-enzymatic detergents at a speed of 250 mL/min,then biofilms on the inner surface were analyzed by bacterial count and scanning electron microscopy.RESULTS:Non-enzymatic detergent had a better inhi-bition function on biofilm formation than enzymatic de-tergent as it reduced bacterial burden by 2.4 log compared with the control samples (P = 0.00). Inhibition function of enzymatic detergent was not significantly different to that of control samples and reduced bac-terial burden by 0.2 log on average (P > 0.05). After lavaging at 250 mL/min for 3 min,no living bacteria were left in the tubes. Scanning electron microscopy observation showed biofi lms became very loose by the high shear force effect. CONCLUSION:Non-enzymatic detergent has a better inhibition effect on biofilm formation at room temperature. High speed pre-lavage and detergents are very important in temporal formed biofilm elimination. | Fang, Ying Shen, Zhe Li, Lan Cao, Yong Gu, Li-Ying Gu, Qing Zhong, Xiao-Qi Yu, Chao-Hui Li, You-Ming | 2010 | World Journal of Gastroenterology2010，16，8： | 28 |
| 8 | Transumbilical single-port laparoscopic cholecystectomy: a case report显示文摘 | GUO Wei ZHANG Zhong-tao HAN Wei LI Jian-she JIN Lan LIU Jun ZHAO Xiao-mu WANG Yu | 2008 | Chinese Medical Journal2008，，23： | 26 |
| 9 | Mechanical Properties Prediction of the Mechanical Clinching Joints Based on Genetic Algorithm and BP Neural Network显示文摘For optimal design of mechanical clinching steel-aluminum joints, the back propagation(BP) neural network is used to research the mapping relationship between joining technique parameters including sheet thickness, sheet hardness, joint bottom diameter etc., and mechanical properties of shearing and peeling in order to investigate joining technology between various material plates in the steel-aluminum hybrid structure car body.Genetic algorithm(GA) is adopted to optimize the back-propagation neural network connection weights.The training and validating samples are made by the BTM? Tog-L-Loc system with different technologic parameters.The training samples' parameters and the corresponding joints' mechanical properties are supplied to the artificial neural network(ANN) for training.The validating samples' experimental data is used for checking up the prediction outputs.The calculation results show that GA can improve the model's prediction precision and generalization ability of BP neural network.The comparative analysis between the experimental data and the prediction outputs shows that ANN prediction models after training can effectively predict the mechanical properties of mechanical clinching joints and prove the feasibility and reliability of the intelligent neural networks system when used in the mechanical properties prediction of mechanical clinching joints.The prediction results can be used for a reference in the design of mechanical clinching steel-aluminum joints. | LONG Jiangqi LAN Fengchong CHEN Jiqing YU Ping | 2009 | Chinese Journal of Mechanical Engineering2009，22，1： | 22 |
| 10 | Sequencing of Cultivated Peanut, Arachis hypogaea, Yields Insights into Genome Evolution and Oil Improvement显示文摘Cultivated peanut (Arachis hypogaea) is an allotetraploid crop planted in Asia, Africa, and America for edible oil and protein. To explore the origins and consequences of tetraploidy, we sequenced the allotetraploid A. hypogaea genome and compared it with the related diploid Arachis duranensis and Arachis ipaensis genomes. We annotated 39 888 A-subgenome genes and 41 526 B-subgenome genes in allotetraploid peanut. The A. hypogaea subgenomes have evolved asymmetrically, with the B subgenome resembling the ancestral state and the A subgenome undergoing more gene disruption, loss, conversion, and transposable element proliferation, and having reduced gene expression during seed development despite lacking genome-wide expression dominance. Genomic and transcriptomic analyses identified more than 2 500 oil metabolism-related genes and revealed that most of them show altered expression early in seed development while their expression ceases during desiccation, presenting a comprehensive map of peanut lipid biosynthesis. The availability of these genomic resources will facilitate a better understanding of the complex genome architecture, agronomically and economically important genes, and genetic improvement of peanut. | Xiaoping Chen Qing Lu Hao Liu Jianan Zhang Yanbin Hong Haofa Lan Haifen Li Jinpeng Wang Haiyan Liu Shaoxiong Li Manish K.Pandey Zhikang Zhang Guiyuan Zhou Jigao Yu Guoqiang Zhang Jiaqing Yuan Xingyu Li Shijie Wen Fanbo Meng Shanlin Yu Xiyin Wang Kadambot H.M.Siddique Zhong-Jian Liu Andrew H.Paterson Rajeev K.Varshney Xuanqiang Liang | 2019 | Molecular Plant2019，12，7： | 23 |
| 11 | Preliminary molecular epidemiology of the Staphylococcus aureus in lower respiratory tract infections: a multicenter study in China显示文摘 | LI De-zhi CHEN Yu-sheng YANG Jing-ping ZHANG Wei HU Cheng-ping LI Jia-shu MU Lan HU Ying-hui GENG Rong HU Ke CAI Shao-xi WAN Huan-ying WANG Qiu-yue WEI Li-ping DU Juan YU Qin ZHONG Xiao-ning WANG Rui-qin MA Jian-jun TIAN Gui-zhen WANG Si-qin GAO Zhan-cheng | 2011 | Chinese Medical Journal2011，，5： | 21 |
| 12 | 老年患者下呼吸道医院感染与控制对策显示文摘目的探讨老年患者下呼吸道医院感染的现状,并制定控制对策。方法对158例老年下呼吸道感染患者的临床资料进行调查,分析其感染现状及危险因素。结果我院老年患者医院感染发病率为9.7%,感染部位以下呼吸道为主;158例下呼吸道医院感染老年患者均患有各种慢性消耗性原发基础疾病,痰培养病原菌以革兰阴性杆菌和真菌为主,分别占48.1%和38.9%。结论抵抗力降低、住院时间长、严重的原发基础疾病及不合理使用抗生素是老年患者医院感染的危险因素,应重视老年患者医院感染的监控管理。 | 余兰 朱艳萍 YU Lan ZHU Yan-ping | 2005 | 中华医院感染学杂志2005，15，10： | 20 |
| 13 | Combined monitoring of evoked potentials during microsurgery for lesions adjacent to the brainstem and intracranial aneurysms显示文摘在外科期间监视的背景 Neurophysiologic 是阻止永久神经病学的损害源于外科的操作。改进 intraoperative neuromonitoring 的精确性和敏感, transcranial 监视电的刺激马达联合唤起了潜力( TES-MEPs ), somatosensory 唤起了潜力( SSEP )和 brainstem 听觉的唤起的潜力( BAEP )为邻近与 SSEP 联合 TES-MEPs 监视的 brainstem 和 intracranial aneurysms.Methods 的损害在 microsurgery 被尝试象 intracranial 一样与邻近 brainstem 的损害在 68 个连续病人被尝试一在他们之中, 31 个病人(31 个手术, 28 个以后的头部的窝肿瘤, 3 个以后的发行量动脉瘤) 也受到 BAEP 监视。监视结果和临床的结果的关联是 68 个病人的唤起的潜力(EP ) 监视联合在 64 被做的学习 prospectively.Results (94.1%) 。监视的 MEP 为 4 个病人(5.9%) 是不可能的。没有复杂并发症在在所有病人监视联合期间被观察。(66.2%) 在 45, 68 个病人,, EP 是稳定的,并且他们是神经病学地未经触动的。马达机能障碍被 MEP 在 4 在 8 个病人,在 5 的 SSEP ,和 BAEP 检测, respectively.Conclusions A 结束关系在手术后的马达功能之间存在, TES-MEPs monitoring.TES-MEPs 的结果在检测马达机能障碍,而是联合 EP 比 SSEP 和 BAEP 优异用作一只保险箱,为马达神经系统的功能监视的 intraoperative 的有效、侵略的方法。为邻近 brainstem 和 intracranial 动脉瘤的损害在 microsurgery 期间联合 EP 监视可以检测潜在地危险的演习并且改进随后的过程的安全。 | KANG De-zhi WU Zan-yi LAN Qing YU Liang-hong LIN Zhang-ya WANG Chen-yang LIN Yuan-xiang | 2007 | Chinese Medical Journal2007，，18： | 20 |
| 14 | Aneuploidy in Early Miscarriage and its Related Factors显示文摘 | Chan-Wei Jia Li Wang Yong-Lian Lan Rui Song Li-Yin Zhou Lan Yu Yang Yang Yu Liang Ying Li Yan-Min Ma Shu-Yu Wang | 2015 | Chinese Medical Journal2015，，20： | 20 |
| 15 | Acupuncture improves dendritic structure and spatial learning and memory ability of Alzheimer's disease mice显示文摘Acupuncture can improve the cognitive state of Alzheimer's disease, but its mechanism is not clear. Dendritic atrophy and synaptic loss in Alzheimer's disease brain are positively correlated with cognitive damage. Therefore, we speculated that the effect of acupuncture on improving cognitive function may be associated with reduced dendritic damage in the brain. Acupuncture at Qihai(CV6), Zhongwan(CV12), Danzhong(CV17), bilateral Zusanli(ST36), and bilateral Xuehai(SP10) acupoints was performed once a day(1-day rest after 6-day treatment) for 14 consecutive days. Senescence-accelerated mouse prone 8(SAMP8) mice without acupuncture and senescence-accelerated mouse resistant 1(SAMR1) mice were used as normal controls. After 14 days of treatment, spatial learning and memory ability of mice was assessed in each group using the Morris water maze. Dendritic changes of pyramidal cells in the hippocampal CA1 region were analyzed by quantitative Golgi staining. Our results showed that acupuncture shortened escape latency and lengthened retention time of the former platform quadrant in SAMP8 mice. Further, SAMP8 mice exhibited a significant increase in the number of apical and basal dendritic branches and total length of apical and basal dendrites after acupuncture. These results suggest that acupuncture improves spatial learning and memory ability of middle-aged SAMP8 mice by ameliorating dendritic structure. | Bo-Hong Kan Jian-Chun Yu Lan Zhao Jie Zhao Zhen Li Yan-Rong Suo Jing-Xian Han | 2018 | Neural Regeneration Research2018，13，8： | 18 |
| 16 | Fluorescence in situ hybridization in uncultured amniocytes for detection of aneuploidy in 4210 prenatal cases显示文摘在为出生前的诊断的工具包使用的 situ 杂交(鱼) 的几乎所有报导荧光探查从的背景外国(非中国) 国家。这研究的目的是分析可靠性国内(汉语)鱼探查设定检测染色体的 aneuploidies 13 , 18 , 21 ,与在细胞发生的 karyotyping 是的 4210 cases.Methods 的出生前的诊断有关的 X ,和 Y carded 外面作为标准出生前的诊断测试,并且羊膜的液体房间分裂期间鱼分析用探针的二个集合被执行(为染色体的 centromeric 探针 18 , X ,和 Y ,和为染色体的地点特定的探针 13 和 21 )由 GP 医药技术提供了,然后,我们比较了二结果并且在 4210 种情况中由国内工具包 probes.Results 为 aneuploidies 的增进知识的鱼结果发现表演特征, 4126 个案例产生了 karyotype 结果和 133 反常 karyotypes (包括 97 aneuploidies ) 被发现。98 个案例的鱼结果(在他们之中, 31 个案例给了正常细胞发生的结果) 是 uninformative。反常案例的率是 3.2%(133/4126 ) 。为反常 karyotypes, aneuploidy 的率是 72.9%(97/133 ) 。在 97 aneuploidies 之中,有三染色体性 21 的 58 个盒子(58/97, 59.8%) ,三染色体性 13 的四个盒子,性 chromosomal aneuploidies 的三染色体性 18,和 12 盒子的 23 个盒子。二个方法的全部的词语索引是 97.9%(95/97;二个盒子是有反常房间的一个低百分比的马赛克) ,并且由二个方法的三染色体性 21, 13,和 18 的词语索引是二国内鱼工具包探针设置的 100%.Conclusions 为出生前的诊断是可靠的。结果表明那条鱼是为染色体 aneuploidies 的出生前的鉴定的一个快速、精确的临床的方法。 | JIA Chan-wei WANG Shu-yu MA Yan-min LAN Yong-lian SI Yan-mei YU Lan ZHOU Li-ying | 2011 | Chinese Medical Journal2011，，8： | 17 |
| 17 | Coinfection with influenza A virus enhances SARS-CoV-2 infectivity显示文摘The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health.Through experimental coinfection with influenza A virus(IAV)and either pseudotyped or live SARS-CoV-2 virus,we found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types.Remarkably,in vivo,increased SARS-CoV-2 viral load and more severe lung damage were observed in mice coinfected with IAV.Moreover,such enhancement of SARS-CoV-2 infectivity was not observed with several other respiratory viruses,likely due to a unique feature of IAV to elevate ACE2 expression.This study illustrates that IAV has a unique ability to aggravate SARS-CoV-2 infection,and thus,prevention of IAV infection is of great significance during the COVID-19 pandemic. | Lei Bai Yongliang Zhao Jiazhen Dong Simeng Liang Ming Guo Xinjin Liu Xin Wang Zhixiang Huang Xiaoyi Sun Zhen Zhang Lianghui Dong Qianyun Liu Yucheng Zheng Danping Niu Min Xiang Kun Song Jiajie Ye Wenchao Zheng Zhidong Tang Mingliang Tang Yu Zhou Chao Shen Li Zhou Yu Chen Huan Yan Ke Lan Ke Xu | 2021 | Cell Research2021，31，4： | 16 |
| 18 | Clinical Study on 136 Children with Sudden Sensorineural Hearing Loss显示文摘 | Feng-Jiao Li Da-Yong Wang Hong-Yang Wang Li Wang Feng-Bo Yang Lan Lan Jing Guan Zi-Fang Yin UII Rosenhall Lan Yu Sten Hellstrom Xi-Jun Xu Mao-Li Duan Qiu-Ju Wang | 2016 | Chinese Medical Journal2016，，8： | 15 |
| 19 | A systematic review and meta-analysis of the Chinese literature for the treatment of achalasia显示文摘AIM: To evaluate the effect of different approaches in the treatment of achalasia in China. METHODS: We performed a systematic review and meta-analysis of Chinese literature by searching the Chinese Biomedical Database and Chinese scientific Journals database (up to March 2008). All cohort studies (controlled or uncontrolled) in which the patients were observed for more than a year were reviewed in detail. Dichotomous outcomes were reported as relative risks (RR) with 95% confidence interval (CI) for controlled trials. The efficacy in uncontrolled trials was assessed by a pooled estimate of response rate with individual studies weighted in proportion to the sample size. RESULTS: Seven controlled trials compared the effect of botulinum toxin injection (BoTx) with pneumatic dilation (PD). PD was superior to BoTx [65.2% vs 45.3%; RR 1.47 (95% CI 1.23-1.77), P < 0.0001], and had a lower clinical relapse rate (BoTx 30.2% vs PD 10%, RR 0.32 (0.16-0.65), P = 0.001). Heller myotomy (HM) had superior remission rate compared to PD [HM 94.0% vs PD 64.1%, RR 1.48 (1.15-1.99), P = 0.002]. In uncontrolled trials, the effectiveness of PD was 86.6% (23.9%) vs 94.8% (10.6%) for HM. The main complications of PD were perforation and gastroesophageal reflux disease. CONCLUSION: HM is the most effective long-term treatment for patients with achalasia in China. In the future, controlled clinical trials on the treatment of achalasia should focus on comparing laparoscopic myotomy with or without antireflux procedure,including different partial and total fundoplication techniques. | Lan Wang You-Ming Li Lan Li Chao-Hui Yu | 2008 | World Journal of Gastroenterology2008，14，38： | 14 |
| 20 | Survivable Virtual Network Mapping Using Optimal Backup Topology in Virtualized SDN显示文摘Software-Defined Network architecture offers network virtualization through a hypervisor plane to share the same physical substrate among multiple virtual networks.However,for this hypervisor plane,how to map a virtual network to the physical substrate while guaranteeing the survivability in the event of failures,is extremely important.In this paper,we present an efficient virtual network mapping approach using optimal backup topology to survive a single link failure with less resource consumption.Firstly,according to whether the path splitting is supported by virtual networks,we propose the OBT-Ⅰ and OBT-Ⅱ algorithms respectively to generate an optimal backup topology which minimizes the total amount of bandwidth constraints.Secondly,we propose a Virtual Network Mapping algorithm with coordinated Primary and Backup Topology(VNM-PBT)to make the best of the substrate network resource.The simulation experiments show that our proposed approach can reduce the average resource consumption and execution time cost,while improving the request acceptance ratio of VNs. | WANG Zhiming WU Jiangxing WANG Yu QI Ning LAN Julong | 2014 | China Communications2014，11，2： | 14 |
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