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| 1 | Oral bacteria colonize and compete with gut microbiota in gnotobiotic mice显示文摘The oral microbiota is associated with oral diseases and digestive systemic diseases.Nevertheless,the causal relationship between them has not been completely elucidated,and colonisation of the gut by oral bacteria is not clear due to the limitations of existing research models.The aim of this study was to develop a human oral microbiota-associated (HOMA) mouse model and to investigate the ecological invasion into the gut.By transplanting human saliva into germ-free (GF) mice,a HOMA mouse model was first constructed.16S rRNA gene sequencing was used to reveal the biogeography of oral bacteria along the cephalocaudal axis of the digestive tract.In the HOMA mice,84.78% of the detected genus-level taxa were specific to the donor.Principal component analysis (PCA) revealed that the donor oral microbiota clustered with those of the HOMA mice and were distinct from those of specific pathogen-free (SPF) mice.In HOMA mice,OTU counts decreased from the stomach and small intestine to the distal gut.The distal gut was dominated by Streptococcus,Veillonella,Haemophilus,Fusobacterium,Trichococcus and Actinomyces.HOMA mice and human microbiota-associated (HMA) mice along with the GF mice were then cohoused.Microbial communities of cohoused mice clustered together and were significantly separated from those of HOMA mice and HMA mice.The Source Tracker analysis and network analysis revealed more significant ecological invasion from oral bacteria in the small intestines,compared to the distal gut,of cohoused mice.In conclusion,a HOMA mouse model was successfully established.By overcoming the physical and microbial barrier,oral bacteria colonised the gut and profiled the gut microbiota,especially in the small intestine. | Bolei Li Yang Ge Lei Cheng Benhua Zeng Jinzhao Yu Xian Peng Jianhua Zhao Wenxia Li Biao Ren Mingyun Li Hong Wei Xuedong Zhou | 2019 | International Journal of Oral Science2019，11，3： | 7 |
| 2 | ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer显示文摘The Serine-Glycien-One-Carbon(SGOC)pathway is pivotal in multiple anabolic processes.Expression levels of SGOC genes are deregulated under tumoeigenic condltions,suggesting panicipation of oncogenes in deregulating the SGOC biosynthetic pathway.However,the underlying mechanism remains elusive.Here,we identifed that Interleukin enfiarccer-binding factor 3(ILF3)is overexpressed in primary CRC patient specimens and correlates with poor progroosis.ILF3 is critical in regulating the SGOC pathway by directly regulating the mRNA stability of SGOC genes,thereby increasing SGOC genes expression and facilitating tumor growth.Mehhanktic studies showed that the EGF-MIEK-ERK pathway nnediates ILF3 phosphorylation,which hin ders E3 ligase speckle-type POZ protein(SPOP)-mediated poly-ubiquitination and degradation of ILF3.Sign iftca ntly,combination of SGOC inhibitor and the anti-EGFR monoclonal antibody cetuximab can hinder the growth of patient-derived xenografts that sustain high ERK-ILF3 levels.Taken together,deregutation of ILF3 via the EGF-ERK signaling plays an important role in systemic serine metabolic reprogramming and confers a predilection toward CRC development.Our findings indicate that clinical evaluation of SCOC inhibitor is warranted for CRC patients with ILF3 overexpression. | Kai Li Jian-lin Wu Baifu Qin Zongmin Fan Qin Tang Weisi Lu Haipeng Zhang Fan Xing Manqi Meng Shaomin Zou Wenxia Wei Honglei Chen Jian Cai Huaiming Wang Hui Zhang Jiayue Cai Ling Fang Xiqing Bian Chuangqi Chen Ping Lan Bart Ghesquiere Lekun Fang Mong-Hong Lee | 2020 | Cell Research2020，30，2： | 6 |
| 3 | MEF2C mediates the activation induced cell death(AICD)of macrophages显示文摘有免疫力的房间的导致激活的房间死亡(AICD ) 广泛地被相信为有免疫力的回答的规定关键。尽管巨噬细胞 apoptosis 在许多病理学的条件下面被观察了,是否并且怎么有巨噬细胞的 AICD 的问题巨噬细胞寿命被调整很好没被探讨。在巨噬细胞的 AICD 要求二个信号。一个人是 LPS 或另外的细菌的部件触发的房间激活。其它是存在在的一个事件 AICD 易受影响(告知) 然而并非 unsusceptible (休息) 巨噬细胞。这里,我们证明当它与沙门氏菌 typhimurium,类型 5 侵入人体气管粘膜的病菌(Ad5 ) 或 IFN-gamma 被告知时,那个 RAW264.7 房间产生 LPS 刺激。我们发现抄写因素 MEF2C 的稳定性在告知的 RAW264.7 房间被增加。MEF2C 的一种主导的否定形式的 Transfection 保护告知的巨噬细胞免受 LPS 触发的房间死亡的伤害。我们的数据证明 MEF2C 蛋白质稳定性的增加是在巨噬细胞的 AICD 的一个关键因素。 | Wenxia Fu Jinxue Wei Jun Gu | 2006 | Cell Research2006，16，6： | 5 |
| 4 | Expert consensus on regenerative endodontic procedures显示文摘Regenerative endodontic procedures(REPs)is a biologic-based treatment modality for immature permanent teeth diagnosed with pulp necrosis.The ultimate objective of REPs is to regenerate the pulp-dentin complex,extend the tooth longevity and restore the normal function.Scientific evidence has demonstrated the efficacy of REPs in promotion of root development through case reports,case series,cohort studies,and randomized controlled studies.However,variations in clinical protocols for REPs exist due to the empirical nature of the original protocols and rapid advancements in the research field of regenerative endodontics.The heterogeneity in protocols may cause confusion among dental practitioners,thus guidelines and considerations of REPs should be explicated.This expert consensus mainly discusses the biological foundation,the available clinical protocols and current status of REPs in treating immature teeth with pulp necrosis,as well as the main complications of this treatment,aiming at refining the clinical management of REPs in accordance with the progress of basic researches and clinical studies,suggesting REPs may become a more consistently evidence-based option in dental treatment. | Xi Wei Maobin Yang Lin Yue Dingming Huang Xuedong Zhou Xiaoyan Wang Qi Zhang Lihong Qiu Zhengwei Huang Hanguo Wang Liuyan Meng Hong Li Wenxia Chen Xiaoying Zou Junqi Ling | 2022 | International Journal of Oral Science2022，14，4： | 5 |
| 5 | Investigation of laminar plasma remehing/cladding processing显示文摘 | Ma Wei Fei Qunxing Pan Wenxia | 2006 | Applied Surface Science2006，252，10： | 1 |
| 6 | Interface-engineered MoS_(2)/CoS/NF bifunctional catalysts for highly-efficient water electrolysis显示文摘The utilization of non-noble metal catalysts with robust and highly efficient electrocatalytic activity for hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)are extremely important for the large-scale implementation of renewable energy devices.Integration of bifunctional electrocatalysts on both anode and cathode electrodes remains a significant challenge.Herein,we report on a novel and facile strategy to construct the ordered and aligned MoS_(2)nanosheet-encapsulated metal–organic frameworks(MOFs)derived hollow CoS polyhedron,in-situ grown on a nickel foam(NF).The starfish-like MoS_(2)/CoS/NF heterojunctions were formed due to the ordered growth of the material caused by NF substrate.The optimized 2-MoS_(2)/CoS/NF heterojunction exhibits robust bifunctional electrocatalytic activity with a low overpotential of 67 and 207 m V toward the HER and OER at 10 mA cm^(-2),and the long-term stability,which exceeds most of the reported bifunctional electrocatalysts.Such high electrocatalytic performance arises due to the synergistic effect between the MoS_(2)and CoS phases across the interface,the abundant active sites,as well as the hierarchical pore framework,which collectively enhance the mass and electron transfer during the reactions.The work provides a promising approach to fabricating bifunctional catalysts with custom-designed heterojunctions and remarkable performance for applications in electrochemical energy devices and related areas. | Wenxia Chen Xingwang Zhu Rui Wang Wei Wei Meng Liu Shuai Dong Kostya Ken Ostrikov Shuang-Quan Zang | 2022 | Journal of Energy Chemistry2022，，12： | 1 |
| 7 | Object-oriented Information Extraction and Application in High-resolution Remote Sensing Image显示文摘 | Wenxia WEI Xiuwan Chen Ainai Ma | | 0，，11： | 1 |
| 8 | B-cell-derived IL-10 promotes allergic sensitization in asthma regulated by Bcl-3显示文摘Aeroallergen sensitization,mainly mediated by lung epithelium and dendritic cells(DCs),is integral to allergic asthma pathogenesis and progression.IL-10 has a dual role in immune responses,as it inhibits myeloid cell activation but promotes B-cell responses and epithelial cell proliferation.Here,we report a proinflammatory function of B-cell-derived IL-10 modulated by Bcl-3 in allergic asthma.Specifically,Bcl-3^(−/−)mice showed elevated IL-10 levels and were found to be highly vulnerable to allergic asthma induced by house dust mites(HDMs).IL-10 had a positive correlation with the levels of the DC chemoattractant CCL-20 in HDM-sensitized mice and in patients with asthma and induced a selective increase in CCL-20 production by mouse lung epithelial cells.Blockade of IL-10 or IL-10 receptors during sensitization dampened both HDM-induced sensitization and asthma development.IL-10 levels peaked 4 h post sensitization with HDM and IL-10 was primarily produced by B cells under Bcl-3–Blimp-1–Bcl-6 regulation.Mice lacking B-cell-derived IL-10 displayed decreased lung epithelial CCL-20 production and diminished DC recruitment to the lungs upon HDM sensitization,thereby demonstrating resistance to HDM-induced asthma.Moreover,responses to HDM stimulation in Bcl-3^(−/−)mice lacking B-cell-derived IL-10 were comparable to those in Bcl-3^(+/+)mice.The results revealed an unexpected role of B-cell-derived IL-10 in promoting allergic sensitization and demonstrated that Bcl-3 prevents HDM-induced asthma by inhibiting B-cell-derived IL-10 production.Thus,targeting the Bcl-3/IL-10 axis to inhibit allergic sensitization is a promising approach for treating allergic asthma. | Guojun Qian Wenxia Jiang Donglin Sun Zhun Sun Anning Chen Hongwei Fang Jingyao Wang Yongzhong Liu Zhinan Yin Haiming Wei Hao Fang Xiaoren Zhan | 2023 | Cellular & Molecular Immunology2023，20，11： | 1 |
| 9 | Investigation of laminar plasma cladding processing显示文摘 | Ma Wei Fei Qunxing Pan Wenxia and Wu Chengkang | 2006 | Applied Surface Science2006，252，： | 1 |
| 10 | Characteristics of argon laminar dc plasma jet at atmospheric pressure 显示文摘 | Pan Wenxia Zhang Wenhong Ma Wei | 2002 | Plasma Chemistry and Plasma Processing2002，22，2： | 1 |
| 11 | Characteristics of Argon Laminar DC Plasma Jet at Atmospheric Pressure显示文摘 | Pan Wenxia Zhang Wenhong Ma Wei | 2002 | Plasma Chemistry and Plasma Processing2002，22，2： | 1 |
| 12 | The Effect of Attendance Patterns on the Lek Mating System in the Omei Treefrog(Rhacophorus omeimontis)显示文摘Attendance patterns are a key factor affecting sexual selection and mating systems in lekbreeding species.However,there are few systematic studies on attendance patterns in lek-breeding anurans.In this study,we monitored a population of Omei treefrogs(Rhacophorus omeimontis) for four consecutive years to reveal in detail the effects of attendance patterns on mating systems.We found that(1) female nightly attendance was affected by male nightly attendance,and operational sex ratios(determined by male and female nightly attendance) ultimately determined the extent of female polyandry;(2) males surviving more than one breeding season maintained high chorus attendance and mating success,suggesting that male chorus attendance is a good predictor of male genetic quality;(3) the distributions of male mating success were not significantly different from a Poisson distribution,indicating a random mating pattern;and male mating success was not related to body size(size-assortative mating was not evident) but was significantly correlated with chorus attendance.Since the chorus attendance is a predictor of male genetic quality,females performing random mating were more likely to mate with more frequently present males and could therefore gain indirect benefits from mating with higher-than-average quality males,thereby producing good offspring without incurring the significant costs involved in prolonged searching for,and assessing males.Our systematic survey on the relationship between attendance patterns and the lek mating system in R.omeimontis could help us better understand in-depth anuran lek mating systems. | Yue GUO Wenxia WANG Wei ZANG Hui WANG Chenliang LI Mian ZHAO Hua WU | 2020 | Asian Herpetological Research2020，11，4： | 0 |
| 13 | Solid Solution Sm_(1+x)Ba_(2-x)Cu_3O_y and Effect of Quench Temperature on SmBa_2Cu_3O_y显示文摘By X-ray powder diffraction technique and oxygen content analysis, a solid solution Sm1+xBa2-xCu3Oy has been determined in the range 0≤x≤0.4. When x<0.25. the Sm1+xBa2-xCu3Oy presents orthorhombic symmetry, and the orthorhombic-tetragonaJ transition ocCurs at x = 0.25. With the increase of x, TC decreases and finally breaks. The correlation between ox ygen content and phase structure at different quench temperatures related to Sm Ba2Cu3Oy has been investigated as | Xianran XING Zhiyu QIAO Wenxia YUAN and Shoukun WEI (University of Science and Technology Beijing, Beijing, 100083, China)(To whom correspondence should be addressed)Xiaolong CHEN, Guanghui RAO and Jingkui LIANG (Institute of Physics, Chinese Academy o | 1994 | Journal of Materials Science & Technology1994，10，4： | 0 |
| 14 | The Super-large Ensemble Experiments of CAS FGOALS-g3显示文摘A super-large ensemble simulation dataset with 110 members has been produced by the fully coupled model FGOALS-g3 developed by researchers at the Institute of Atmospheric Physics,Chinese Academy of Sciences.This is the first dataset of large ensemble simulations with a climate system model developed by a Chinese modeling center.The simulation has the largest realizations up to now worldwide in terms of single-model initial-condition large ensembles.Each member includes a historical experiment(1850-2014)and an experiment(2015-99)under the very high greenhouse gas emissions Shared Socioeconomic Pathway scenario(SSP5-8.5).The dataset includes monthly and daily temperature,precipitation,and other variables,requiring storage of 275 TB.Additionally,the surface air temperature(SAT)and land precipitation simulated by the FGOALS-g3 super-large ensemble have been validated and projected.The ensemble can capture the response of SAT and land precipitation to external forcings well,and the internal variabilities can be quantified.The availability of more than 100 realizations will help researchers to study rare events and improve the understanding of the impact of internal variability on forced climate changes. | Pengfei LIN Bowen ZHAO Jilin WEI Hailong LIU Wenxia ZHANG Xiaolong CHEN Jie JIANG Mengrong DING Wenmin MAN Jinrong JIANG Xu ZHANG Yuewen DING Wenrong BAI Chenyang JIN Zipeng YU Yiwen LI Weipeng ZHENG Tianjun ZHOU | 2022 | Advances in Atmospheric Sciences2022，39，10： | 0 |
| 15 | Expert consensus on digital guided therapy for endodontic diseases显示文摘Digital guided therapy(DGT)has been advocated as a contemporary computer-aided technique for treating endodontic diseases in recent decades.The concept of DGT for endodontic diseases is categorized into static guided endodontics(SGE),necessitating a meticulously designed template,and dynamic guided endodontics(DGE),which utilizes an optical triangulation tracking system.Based on cone-beam computed tomography(CBCT)images superimposed with or without oral scan(OS)data,a virtual template is crafted through software and subsequently translated into a 3-dimensional(3D)printing for SGE,while the system guides the drilling path with a real-time navigation in DGE.DGT was reported to resolve a series of challenging endodontic cases,including teeth with pulp obliteration,teeth with anatomical abnormalities,teeth requiring retreatment,posterior teeth needing endodontic microsurgery,and tooth autotransplantation.Case reports and basic researches all demonstrate that DGT stand as a precise,time-saving,and minimally invasive approach in contrast to conventional freehand method.This expert consensus mainly introduces the case selection,general workflow,evaluation,and impact factor of DGT,which could provide an alternative working strategy in endodontic treatment. | Xi Wei Yu Du Xuedong Zhou Lin Yue Qing Yu Benxiang Hou Zhi Chen Jingping Liang Wenxia Chen Lihong Qiu Xiangya Huang Liuyan Meng Dingming Huang Xiaoyan Wang Yu Tian Zisheng Tang Qi Zhang Leiying Miao Jin Zhao Deqin Yang Jian Yang Junqi Ling | 2023 | International Journal of Oral Science2023，15，4： | 0 |
| 16 | FBXW7βloss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth显示文摘Continuous de novo fatty acid synthesis is required for the biosynthetic demands of tumor.FBXW7 is a highly mutated gene in CRC,but its biological functions in cancer are not fully characterized.Here,we report that FBXW7β,a FBXW7 isoform located in the cytoplasm and frequently mutated in CRC,is an E3 ligase of fatty acid synthase(FASN).Cancer-specific FBXW7βmutations that could not degrade FASN can lead to sustained lipogenesis in CRC.COP9 signalosome subunit 6(CSN6),an oncogenic marker of CRC,increases lipogenesis via interacting with and stabilizing FASN.Mechanistic studies show that CSN6 associates with both FBXW7βand FASN,and antagonizes FBXW7β’s activity by enhancing FBXW7βautoubiquitination and degradation,which in turn prevents FBXW7β-mediated FASN ubiquitination and degradation,thereby regulating lipogenesis positively.Both CSN6 and FASN are positively correlated in CRC,and CSN6-FASN axis,regulated by EGF,is responsible for poor prognosis of CRC.The EGF-CSN6-FASN axis promotes tumor growth and implies a treatment strategy of combination of orlistat and cetuximab.Patient-derived xenograft experiments prove the effectiveness of employing orlistat and cetuximab combination in suppressing tumor growth for CSN6/FASN-high CRC.Thus,CSN6-FASN axis reprograms lipogenesis to promote tumor growth and is a target for cancer intervening strategy in CRC. | Wenxia Wei Baifu Qin Weijie Wen Boyu Zhang Haidan Luo Yuzhi Wang Hui Xu Xiaoshan Xie Sicheng Liu Xin Jiang Mengan Wang Qin Tang Jiayu Zhang Runxiang Yang Zongmin Fan Haiwen Lyu Junzhong Lin Kai Li Mong-Hong Lee | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 17 | One-dimensional Ag2S/ZnS/ZnO nanorod array films for photocathodic protection for 304 stainless steel显示文摘Highly ordered Ag2 S/ZnS/ZnO nanorod array film photoanodes were prepared on a Ti substrate for photocathodic cathodic protection.The results indicated that the photoresponse range of the Ag2S/ZnS/ZnO composite film was extended compared to those of the ZnO and ZnS/ZnO films,indicating its higher light absorption capacity.When the Ag2S/ZnS/ZnO composite film served as a photoanode,the film can provide the best effective photocathodic protection for 304 stainless steel in a 3.5 wt%NaCl solution under white light illumination compared to the ZnO and ZnS/ZnO films.Additionally,in comparison to pure ZnO film,the photocurrent for the ZnS/ZnO film remained the same without noticeable fluctuation after illumination for 1 h,indicating that the ZnS functionalization improved the stability by overcoming the photocorrosion effect of the ZnO photoanode under light irradiation. | Na Wei Yuan Lin Zhenkui Li Wenxia Sun Guosong Zhang Mingliang Wang Hongzhi Cui | 2020 | Journal of Materials Science & Technology2020，42，7： | 0 |
| 18 | ppGpp is present in,and functions to regulate sleep of,Drosophila显示文摘Sleep is essential for animals,and receives inputs from circadian,homeostasis,and environment,yet the mechanisms of sleep regulation remain elusive.Discovery of molecules in living systems and demonstration of their functional roles are pivotal in furthering our understanding of the molecular basis of biology.Here,we report that guanosine-50-diphos-phate,30-diphosphate(ppGpp)is present in Drosophila,and plays an important role in regulation of sleep and starvation-induced sleep loss(SISL).ppGpp is detected in germ-free Drosophila and hydrolyzed by an enzyme encoded by the mesh1 gene in Drosophila.Nighttime sleep and SISL were defected in mesh1 mutant flies,and rescued by expression of wildtype Mesh1,but not the enzymatically defective mutant Mesh1E66A.Ectopic expression of RelA,the Escherichia coli synthetase for ppGpp,phenocopied mesh1 knockout mutants,whereas overexpression of Mesh1 resulted in the opposite phenotypes,supporting that ppGpp is both necessary and sufficient in sleep regulation.A chemo connectomic screen followed by genetic intersection experiments implicates the Dilp2 neurons in the pars intercerebralis(PI)brain region as the site of ppGpp function.Our results have thus validated the presence of ppGpp in Drosophila and revealed a physiological role of ppGpp in sleep regulation for the first time. | Xihuimin Dai Wei Yang Xiaohui Zhang Enxing Zhou Renbo Mao Ying Liu Tao Wang Wenxia Zhang Xinxiang Zhang Yi Rao | 2023 | hLife2023，1，2： | 0 |
| 19 | 肠上皮受体LRRC19促进招募免疫细胞及肠道炎症显示文摘哺乳动物胃肠道有大量和多样化的共生菌。近年来的研究逐渐表明,人类健康高度依赖于肠道其生菌对免疫的贡献。 | Shuisong Cao Xiaomin Su Benhua Zeng Hui Yan Yugang Huang Enlin Wang Huan Yun Yuan Zhang Feifei Liu Wenxia Li Hong Wei Yongzhe Che 杨荣存 | 2017 | 科学新闻2017，19，4： | 0 |
| 20 | Expert consensus on difficulty assessment of endodontic therapy显示文摘Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the removal of inflamed or necrotic pulp tissue and the replacement by gutta-percha. However, it is very essential for endodontic treatment to debride the root canal system and prevent the root canal system from bacterial reinfection after root canal therapy(RCT). Recent research, encompassing bacterial etiology and advanced imaging techniques, contributes to our understanding of the root canal system’s anatomy intricacies and the technique sensitivity of RCT. Success in RCT hinges on factors like patients, infection severity, root canal anatomy, and treatment techniques. Therefore, improving disease management is a key issue to combat endodontic diseases and cure periapical lesions. The clinical difficulty assessment system of RCT is established based on patient conditions, tooth conditions, root canal configuration, and root canal needing retreatment, and emphasizes pre-treatment risk assessment for optimal outcomes. The findings suggest that the presence of risk factors may correlate with the challenge of achieving the high standard required for RCT. These insights contribute not only to improve education but also aid practitioners in treatment planning and referral decision-making within the field of endodontics. | Dingming Huang Xiaoyan Wang Jingping Liang Junqi Ling Zhuan Bian Qing Yu Benxiang Hou Xinmei Chen Jiyao Li Ling Ye Lei Cheng Xin Xu Tao Hu Hongkun Wu Bin Guo Qin Su Zhi Chen Lihong Qiu Wenxia Chen Xi Wei Zhengwei Huang Jinhua Yu Zhengmei Lin Qi Zhang Deqin Yang Jin Zhao Shuang Pan Jian Yang Jiayuan Wu Yihuai Pan Xiaoli Xie Shuli Deng Xiaojing Huang Lan Zhang Lin Yue Xuedong Zhou | 2024 | International Journal of Oral Science2024，16，1： | 0 |
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