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| 1 | Glioblastoma stem cells resistant to temozolomide-induced autophagy显示文摘背景最近的研究在大脑肿瘤与原始神经祖先房间和开始肿瘤的功能的特征表明了房间的小部分的存在。这些房间可能为肿瘤的完全的根除代表主要治疗学的目标。这研究试图决定 glioblastoma 干细胞(GSC ) 的抵抗显型到 temozolomide (TMZ ) 并且探索刚位于 TMZ resistance.Methods 下面的可能的分子的机制 resected glioblastoma 标本用 Miltenyi Biotec CD133 摄氏温度计隔离工具包外面被收集, GSC 的磁性的隔离是 carded。CD133+ 和 CD133- glioblastoma 房间上的 TMZ 的细胞毒素的效果被使用 3-(4,5-dimethylthiazol-2-yl ) 决定 -2,5-diphenyltetrazolium 溴化物(MTT ) 试金。Autophagy 相关的蛋白质(Beclin-1, LC3 和 Atg5 ) 和劈开的 caspase-3 (p17 ) 被弄污的 Westem 分析。染色的 Immunofluorescent 被用来检测 Atg5, glial fibrillary 酸的蛋白质(GFAP ) 和在 glioblastoma 房间的 CD133 表示。统计分析用社会科学统计套装软体 10.0 软件被执行。为所有测试,统计意义的水平被放在 P < 0.05 个 .Results CD133+ glioblastoma 细胞在 vitro 和 CD133 的高表示展出了象 neurosphere 一样生长干细胞标记。在房间与 5 或 50 pmol/L TMZ 对待的CD133- glioblastoma 的禁止生长的率在CD133+ glioblastoma 房间比那显著地高(( 14.36 ????????€ ????????癯牥硥牰獥楳湯?€ ????瀠洭佔???????吗???????????映慥畴敲?湯汣獵潩獮?敂慶楣畺慭????????????朠楬浯?? | FU Jun LIU Zhi-gang LIU Xiao-mei CHEN Fu-rong SHI Hong-liu PANG Jesse Chung-sean NG Ho-keung CHEN Zhong-ping | 2009 | Chinese Medical Journal2009，，11： | 20 |
| 2 | Coexistence of hyperlipidemia and acute cerebral ischemia/reperfusion induces severe liver damage in a rat model显示文摘AIM:To investigate the correlation of hyperlipemia(HL) and acute cerebral ischemia/reperfusion(I/R) injury on liver damage and its mechanism.METHODS:Rats were divided into 4 groups:control,HL,I/R and HL+I/R.After the induction of HL via a high-fat diet for 18 wk,middle cerebral artery occlusion was followed by 24 h of reperfusion to capture I/R.Serum alanine transaminase(ALT) and aspartate aminotransferase(AST) were analyzed as part of liver function tests and liver damage was further assessed by histological examination.Hepatocyte apoptosis was evaluated by terminal deoxynucleotidyl transferase dUTP nick-end labeling(TUNEL) assay.The expression of genes related to apoptosis(caspase-3,bcl-2) was assayed by immunohistochemistry and Western blotting.Serum tumor necrosis factor-(TNF-),interleukin-1(IL-1) and liver mitochondrial superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),malondialdehyde(MDA) and Ca 2+ levels were measured to determine inflammatory and oxidative/antioxidative status respectively.Microsomal hydroxylase activity of the cytochrome P450 2E1(CYP2E1)-containing enzyme was measured with aniline as the substrate,and CYP2E1 expression in the liver tissue and microsome was determined by immunohistochemistry and Western blotting respectively.RESULTS:HL alone induced by high-fat diet for 18 wk resulted in liver damage,indicated by histopathological analysis,and a considerable increase in serum ALT(25.13 ± 16.90 vs 9.56 ± 1.99,P < 0.01) and AST levels(18.01 ± 10.00 vs 11.33 ± 4.17,P < 0.05) compared with control.Moreover,HL alone induced hepatocyte apoptosis,which was determined by increased TUNEL-positive cells(4.47 ± 0.45 vs 1.5 ± 0.22,P < 0.01),higher caspase-3 and lower bcl-2 expression.Interestingly,compared with those in control,HL or I/R groups,massive increases of serum ALT(93.62 ± 24.00 vs 9.56 ± 1.99,25.13 ± 16.90 or 12.93 ± 6.14,P < 0.01) and AST(82.32 ± 26.92 vs 11.33 ± 4.17,18.01 ± 10.00 or 14.00 ± 6.19,P < 0.01) levels in HL+I/R group were observed suggesting severe liver damage,which was confirmed by liver histology.In addition,HL combined with I/R also caused significantly increased hepatocyte apoptosis,as evidenced by increased TUNEL-positive cells(6.20 ± 0.29 vs 1.5 ± 0.22,4.47 ± 0.45 or 1.97 ± 0.47,P < 0.01),elevated expression of caspase-3 and lower expression of bcl-2.Furthermore,when compared to HL or I/R alone,HL plus I/R enhanced serum TNF-,IL-1,liver mitochondrial MDA and Ca 2+ levels,suppressed SOD and GSH-Px in liver mitochondria,and markedly up-regulated the activity(11.76 ± 2.36 vs 4.77 ± 2.31 or 3.11 ± 1.35,P < 0.01) and expression(3.24 ± 0.38 vs 1.98 ± 0.88 or 1.72 ± 0.58,P < 0.01) of CYP2E1 in liver.CONCLUSION:The coexistence of HL and acute cerebral I/R induces severe liver damage,suggesting that cerebral ischemic stroke would exaggerate the damage of liver caused by HL.This effect is possibly due to en-hanced CYP2E1 induction which further promotes oxidative damage,inflammation and hepatocyte apoptosis. | Wei-Hong Gong Wen-Xia Zheng Jun Wang Shi-Hui Chen Bo Pang Xia-Min Hu Xiao-Lu Cao | 2012 | World Journal of Gastroenterology2012，18，35： | 17 |
| 3 | Multimorbidity patterns and association with mortality in 0.5 million Chinese adults显示文摘Background:Few studies have assessed the relationship between multimorbidity patterns and mortality risk in the Chinese population.We aimed to identify multimorbidity patterns and examined the associations of multimorbidity patterns and the number of chronic diseases with the risk of mortality among Chinese middle-aged and older adults.Methods:We used data from the China Kadoorie Biobank and included 512,723 participants aged 30 to 79 years.Multimorbidity was defined as the presence of two or more of the 15 chronic diseases collected by self-report or physical examination at baseline.Multimorbidity patterns were identified using hierarchical cluster analysis.Cox regression was used to estimate the associations of multimorbidity patterns and the number of chronic diseases with all-cause and cause-specific mortality.Results:Overall,15.8%of participants had multimorbidity.The prevalence of multimorbidity increased with age and was higher in urban than rural participants.Four multimorbidity patterns were identified,including cardiometabolic multimorbidity(diabetes,coronary heart disease,stroke,and hypertension),respiratory multimorbidity(tuberculosis,asthma,and chronic obstructive pulmonary disease),gastrointestinal and hepatorenal multimorbidity(gallstone disease,chronic kidney disease,cirrhosis,peptic ulcer,and cancer),and mental and arthritis multimorbidity(neurasthenia,psychiatric disorder,and rheumatoid arthritis).During a median of 10.8 years of follow-up,49,371 deaths occurred.Compared with participants without multimorbidity,cardiometabolic multimorbidity(hazard ratios[HR]=2.20,95%confidence intervals[CI]:2.14-2.26)and respiratory multimorbidity(HR=2.13,95%CI:1.97-2.31)demonstrated relatively higher risks of mortality,followed by gastrointestinal and hepatorenal multimorbidity(HR=1.33,95%CI:1.22-1.46).The mortality risk increased by 36%(HR=1.36,95%CI:1.35-1.37)with every additional disease.Conclusion:Cardiometabolic multimorbidity and respiratory multimorbidity posed the highest threat on mortality risk and deserved particular attention in Chinese adults. | Junning Fan Zhijia Sun Canqing Yu Yu Guo Pei Pei Ling Yang Yiping Chen Huaidong Du Dianjianyi Sun Yuanjie Pang Jun Zhang Simon Gilbert Daniel Avery Junshi Chen Zhengming Chen Jun Lyu Liming Li On Behalf of the China Kadoorie Biobank Collaborative Group | 2022 | Chinese Medical Journal2022，，6： | 17 |
| 4 | The TH Express high performance interconnect networks显示文摘 | Zhengbin PANG Min XIE Jun ZHANG Yi ZHENG Guibin WANG Dezun DONG Guang SUO | 2014 | Frontiers of Computer Science2014，8，3： | 15 |
| 5 | A dynamic N^6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors显示文摘 | Fei Yan Aref AI-Kali Zijie Zhang Jun Liu Jiuxia Pang Na Zhao Chuan He Mark R. Litzow Shujun Liu | 2018 | Cell Research2018，28，11： | 15 |
| 6 | Multicenter Evaluation of the Molecular Line Probe Assay for Multidrug Resistant Mycobacterium Tuberculosis Detection in China显示文摘In order to evaluate the performance of a molecular Hain line probe assay(Hain LPA)for rapid detection of rifampicin and isoniazid resistance of Mycobacterium tuberculosis in China。 | LI Qiang DONG Hai Yan PANG Yu XIA Hui OU Xi Chao ZHANG Zhi Ying LI Jun Chen ZHANG Jian Kang HUAN Shi Tong CHIN Daniel P KAM Kai Man ZHAO Yan Lin | 2015 | Biomedical and Environmental Sciences2015，28，6： | 13 |
| 7 | Clinical evaluation of surgery-induced astigmatism in cataract surgery using 2.2 mm or 1.8 mm clear corneal micro-incisions显示文摘● AIM: To evaluate corneal astigmatism after phacoemulsification using 2.2 mm or 1.8 mm clear corneal micro-incisions and its effects on visual function.● METHODS: Sixty cases(60 eyes) with cataract were randomly divided into groups A(n=30) and B(n=30) respectively underwent 2.2 mm and 1.8 mm clear corneal tunnel incision phacoemulsification combined with folding intraocular lens implantation from the time direction of 11:00. On day 1 and at 1, 4, and 6wk after operation, patients' vision was measured and both the corneal curvature and corneal thickness(CT) were recorded using Pentacam. ● RESULTS: The measured surgery-induced astigmatism(SIA) in both groups A and B peaked on day 1 after operation, and then gradually decreased and eventually stabilized in week 4. No statistically significant difference was found in corneal astigmatism between two groups(P>0.05). The measured corneal astigmatism at 4wk and 6wk postoperatively were 0.28±0.09 D and 0.27±0.10 D for groups A and 0.27±0.09 D and 0.25±0.10 D for groups B without statistically significant difference(P>0.05). In addition, no significant differences in visual acuity and CT were found between groups A and B before or after operation.● CONCLUSION: Both 2.2 mm and 1.8 mm micro-incision cataract surgeries result in relatively small SIA with no difference in visual function and corneal astigmatism between two surgery approaches. Thus, the two types of surgical systems are safe and efficient for cataract treatment, by which satisfactory uncorrected visual acuity can be regained early postoperatively. | Jun Yang Xiu Wang Hong Zhang Yi Pang Rui-Hua Wei | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 8 | Risk factors for cardiovascular disease in the Chinese population:recent progress and implications显示文摘Cardiovascular disease(CVD)is the leading cause of death in both urban and rural areas of China.The current evidence regarding CVD risk factors was primarily established in Western countries,with limited generalizability to the Chinese population.In China,a growing number of population-based prospective cohort studies have emerged that have yielded substantial research data on CVD risk factors in the past five years.The research studies have covered biological risk factors(e.g.,blood lipids,blood pressure,blood glucose,adiposity),lifestyle risk factors(e.g.,smoking,alcohol,diet,physical activity),environmental risk factors(e.g.,ambient and indoor air pollution),and risk prediction.This study aimed to systematically review the research progress on CVD risk factors in the Chinese population in the past five years.Prospective studies in China have identified biological,lifestyle,and environmental risk factors for CVD and its main subtypes,along with some protective factors unique to the Chinese(e.g.,spicy food and green tea).This review aimed to provide high-quality evidence for achieving the Outline of Healthy China 2030,developing disease prevention guidelines and measures,and deepening efforts for popularization of health knowledge. | Yuanjie Pang Jun Lyu Canqing Yu Yu Guo Liming Lee | 2020 | Global Health Journal2020，4，3： | 12 |
| 9 | Pregnancy outcomes and risk factors for low birth weight and preterm delivery among HIV-infected pregnant women in Guangxi, China显示文摘在中国的背景六省在 2009 和五个省在这个国家说明了所有报导 HIV/AIDS 案例的 70-80 说明了属于的 HIV cases.Because Guangxi 的 78 所有报导 mother-to-child 传播( MTCT )两个组,加节目的 Mother-to-Child 传播( PMTCT )的预防在那里被建立理解更好低的出生重量( LBW )和 preterm 交货( PD )出生结果和他们的联系风险因素 better.Methods 怀孕结果被检验在之中95 CI 1.11-25.55 ) 并且 CD4 房间计数 100-199 cells/l (AOR 3.40;95 Cl 1.03-11.25,与 CD4 房间计数 350 cells/l 相比) , gestational 年龄 37 星期(AOR 4.38;95 CI 1.29-14.82,与 37 个星期相比) ,母亲的重量 45 kg (AOR 5.64;95 Cl 1.09-29.07 ) 并且母亲的重量 45-54 kg (AOR 3.55;95 Cl 1.31-9.60,与 55 kg 相比) 在注册,和 HIV RNA 100 在注册的 000 copies/ml (AOR 4.22;95 Cl 1.24-14.32 ) 并且 20 000-99 999 (AOR 2.77;95 CI 1.01-7.77,与 20 000 copies/ml 相比) 与 LBW.For PD 的更高的风险被联系,仅仅母亲的注射药使用作为 HIV 传播的线路(AOR 5.30; 95 CI 1.33-21.14 ,与通过性传播感染 HIV 的那些相比)显著地与 PD.Conclusions 更低的 CD4 房间计数的更高的风险被联系,在注册的更高的 HIV RNA 病毒的负担与 LBW.Optimal 胎儿的照顾被联系包括更早胎儿的屏蔽和 HIV 诊断,对更早的 PMTCT 预防或 HIV treatent 批评阻止 HIV 的传播到婴儿并且也阻止 LBW 怀孕结果。 | Yu Lan Li Wen-ying Chen, Ray Y. Tang Zhi-rong Pang Jun Gui Xiu-zhi Meng Xiu-ning Zhang Fu-jie | 2012 | Chinese Medical Journal2012，，3： | 10 |
| 10 | Main progress and problems in research on Ordovician hydrocarbon accumulation in the Tarim Basin显示文摘The Tarim Basin is the largest petroliferous basin in the northwest of China, and is composed of a Paleozoic marine craton basin and a Meso-Cenozoic continental foreland basin. It is of great significance in exploration of Ordovician. In over 50 years of exploration, oil and gas totaling over 1.6 billion tonnes oil-equivalent has been discovered in the Ordovician carbonate formation. The accumulation mechanisms and distribution rules are quite complicated because of the burial depth more than 3,500 m, multi-source, and multi-stage accumulation, adjustment, reconstruction and re-enrichment in Ordovician. In this paper, we summarized four major advances in the hydrocarbon accumulation mechanisms of Ordovician carbonate reservoirs. First, oil came from Cambrian and Ordovician source rocks separately and as a mixture, while natural gas was mainly cracked gas generated from the Cambrian-Lower Ordovician crude oil. Second, most hydrocarbon migrated along unconformities and faults, with different directions in different regions. Third, hydrocarbon migration and accumulation had four periods: Caledonian, early Hercynian, late Hercynian and Himalayan, and the latter two were the most important for oil and gas exploration. Fourth, hydrocarbon accumulation and evolution can be generally divided into four stages: Caledonian (the period of hydrocarbon accumulation), early Hercynian (the period of destruction), late Hercynian (the period of hydrocarbon reconstruction and re-accumulation), and Himalayan (the period of hydrocarbon adjustment and re-accumulation). Source rocks (S), combinations of reservoir-seal (C), paleo-uplifts (M), structure balance belt (B) matched in the same time (T) control the hydrocarbon accumulation and distribution in the Ordovician formations. Reservoir adjustment and reconstruction can be classified into two modes of physical adjustment and variation of chemical compositions and five mechanisms. These mechanisms are occurrence displacement, biodegradation, multi-source mixing, high-temperature cracking and late gas invasion. Late hydrocarbon accumulation effects controlled the distribution of current hydrocarbon. The T-BCMS model is a basic geological model to help understanding the control of reservoirs. At present, the main problems of hydrocarbon accumulation focus on two aspects, dynamic mechanisms of hydrocarbon accumulation and the quantitative models of oil-bearing in traps, which need further systemic research. | Pang Xiongqi Tian Jun Pang Hong Xiang Caifu Jiang Zhenxue Li Sumei | 2010 | Petroleum Science2010，7，2： | 10 |
| 11 | A bHLH transcription activator regulates defense signaling by nucleo-cytosolic trafficking in rice显示文摘Crosstalk between plant hormone signaling pathways is vital for controlling the immune response during pathogen invasion.Salicylic acid(SA)and jas-monic acid(JA)often play important but antagonistic roles in the immune responses of higher plants.Here,we identify a basic helix-loop-helix transcription acti-vator,OsbHLH6,which confers disease resistance in rice by regulating SA and JA signaling via nucleo-cytosolic trafficking in rice(Oryza sativa).OsbHLH6 expression was upregulated during Magnaporthe oryzae infection.Transgenic rice plants overexpressing OsbHLH6 display increased JA responsive gene expression and enhanced disease susceptibility to the pathogen.Nucleus-localized OsbHLH6 activates JA signaling and suppresses SA signaling;however,the SA regulator OsNPR1(Nonexpressor of PR genes 1)sequesters OsbHLH6 in the cytosol to alleviate its effect.Our data suggest that OsbHLH6 controls disease re-sistance by dynamically regulating SA and JA signaling. | Fanwei Meng Chao Yang Jidong Cao Huan Chen Jinhuan Pang Qiqi Zhao Zongyi Wang Zheng Qing Fu Jun Liu | 2020 | Journal of Integrative Plant Biology2020，62，10： | 10 |
| 12 | Assessment of liver fibrosis by Fibroscan as compared to liver biopsy in biliary atresia显示文摘AIM: To evaluate liver stiffness measurement(LSM)using non-invasive transient elastography(Fibroscan)in comparison with liver biopsy for assessment of liver fibrosis in children with biliary atresia(BA).METHODS: Thirty-one children with BA admitted to the Department of Pediatric Surgery of Beijing Children's Hospital from March 2012 to February 2013 were included in this study. Their preoperative LSM, liver biopsy findings, and laboratory results were studied retrospectively.RESULTS: The grade of liver fibrosis in all 31 patients was evaluated according to the METAVIR scoring system, which showed that 4 cases were in group F2, 20 in group F3 and 7 in group F4. There were 24non-cirrhosis cases(F2-F3) and 7 cirrhosis cases(F4).In groups F2, F3 and F4, the mean LSM was 9.10 ±3.30 kPa, 11.02 ± 3.31 kPa and 22.86 ± 12.43 kPa,respectively. LSM was statistically different between groups F2 and F4(P = 0.002), and between groups F3 and F4(P = 0.000), however, there was no statistical difference between groups F2 and F3(P = 0.593). The area under the receiver operating characteristic curve of LSM for ≥ F4 was 0.866. The cut-off value of LSM was 15.15 kPa for ≥ F4, with a sensitivity, specificity,positive predictive value and negative predictive value of 0.857, 0.917, 0.750 and 0.957, respectively.CONCLUSION: Fibroscan can be used as a noninvasive technique to assess liver fibrosis in children with BA. The cut-off value of LSM(15.15 kPa) can distinguish cirrhotic patients from non-cirrhotic patients. | Qiu-Long Shen Ya-Jun Chen Zeng-Meng Wang Ting-Chong Zhang Wen-Bo Pang Jun Shu Chun-Hui Peng | 2015 | World Journal of Gastroenterology2015，21，22： | 9 |
| 13 | Physclon, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma显示文摘Physcion 是在繁体中文药根值 et 根茎 Rhei 的主要 bioactive 成分,它有 anthraquinone 化学药品结构并且展出包括的许多药理学活动缓泻, hepatoprotective,反煽动性,抗菌剂和 anti-proliferative 效果。在这研究,我们在 vitro 并且在位于反肿瘤 action.Methods 下面的 vivo,以及机制在人的鼻咽的癌上调查了 physcion 的效果:鼻咽的癌房间线 CNE2 与 physcion 被对待,并且房间生存能力用 MTT 和殖民地形成试金被检测。流动 cytometry 被用来估计房间周期拘捕, mitochondrial 膜潜力损失, apoptosis, autophagy 和细胞内部的 ROS 产生。Apoptotic 房间死亡被 TUNEL 试金也证实。目标或标记分子的表示用西方的弄污被决定。caspase-3 的活动, 8,和 9 与一个 ELISA 工具包被检测。异种皮移植鼠科的模型被用来评估在里面 physcion 的 vivo 反肿瘤行动,老鼠被管理 physcion (10, 20 mg 畬楳湯?? | Ming-jie PANG Zhun YANG Xing-lin ZHANG Zhao-fang LIU Jun FAN Hong-ying ZHANG | 2016 | Acta Pharmacologica Sinica2016，37，12： | 9 |
| 14 | Human umbilical cord mesenchymal stem cells to treat spinal cord injury in the early chronic phase: study protocol for a prospective, multicenter, randomized, placebo-controlled, single-blinded clinical trial显示文摘Human umbilical cord mesenchymal stem cells(hUC-MSCs)support revascularization,inhibition of inflammation,regulation of apoptosis,and promotion of the release of beneficial factors.Thus,they are regarded as a promising candidate for the treatment of intractable spinal cord injury(SCI).Clinical studies on patients with early chronic SCI(from 2 months to 1 year post-injury),which is clinically common,are rare;therefore,we will conduct a prospective,multicenter,randomized,placebo-controlled,single-blinded clinical trial at the Third Affiliated Hospital of Sun Yat-sen University,West China Hospital of Sichuan University,and Shanghai East Hospital,Tongji University School of Medicine,China.The trial plans to recruit 66 early chronic SCI patients.Eligible patients will undergo randomization at a 2:1 ratio to two arms:the observation group and the control group.Subjects in the observation group will receive four intrathecal transplantations of stem cells,with a dosage of 1×106/kg,at one calendar month intervals.Subjects in the control group will receive intrathecal administrations of 10 mL sterile normal saline in place of the stem cell transplantations.Clinical safety will be assessed by the analysis of adverse events and laboratory tests.The American Spinal Injury Association(ASIA)total score will be the primary efficacy endpoint,and the secondary efficacy outcomes will be the following:ASIA impairment scale,International Association of Neural Restoration-Spinal Cord Injury Functional Rating Scale,muscle tension,electromyogram,cortical motor and cortical sensory evoked potentials,residual urine volume,magnetic resonance imaging–diffusion tensor imaging,T cell subtypes in serum,neurotrophic factors and inflammatory factors in both serum and cerebrospinal fluid.All evaluations will be performed at 1,3,6,and 12 months following the final intrathecal administration.During the entire study procedure,all adverse events will be reported as soon as they are noted.This trial is designed to evaluate the clinical safety and efficacy of subarachnoid transplantation of hUC-MSCs to treat early chronic SCI.Moreover,it will establish whether cytotherapy can ameliorate local hostile microenvironments,promote tracking fiber regeneration,and strengthen spinal conduction ability,thus improving overall motor,sensory,and micturition/defecation function in patients with early chronic SCI.This study was approved by the Stem Cell Research Ethics Committee of the Third Affiliated Hospital of Sun Yat-sen University,China(approval No.[2018]-02)on March 30,2018,and was registered with ClinicalTrials.gov(registration No.NCT03521323)on April 12,2018.The revised trial protocol(protocol version 4.0)was approved by the Stem Cell Research Ethics Committee of the Third Affiliated Hospital of Sun Yat-sen University,China(approval No.[2019]-10)on February 25,2019,and released on ClinicalTrials.gov on April 29,2019. | Yang Yang Mao Pang Yu-Yong Chen Liang-Ming Zhang Hao Liu Jun Tan Bin Liu Li-Min Rong | 2020 | Neural Regeneration Research2020，15，8： | 9 |
| 15 | Preliminary analysis of spatiotemporal pattern of global land surface water显示文摘Land surface water(LSW) is one of the most important resources for human survival and development, and it is also a main component of global water recycling. A full understanding of the spatial distribution of land surface water and a continuous measuring of its dynamics can support to diagnose the global ecosystem and environment. Based on the Global Land 30-water 2000 and Global Land 30-water 2010 products, this research analyzed the spatial distribution pattern and temporal fluctuation of land surface water under scale-levels of global, latitude and longitude, continents, and climate zones. The Global Land 30-water products were corrected the temporal inconsistency of original remotely sensed data using MODIS time-series data, and then calculated the indices such as water area, water ration and coefficient of spatial variation for further analysis. Results show that total water area of land surface is about 3.68 million km2(2010), and occupies 2.73% of land area. The spatial distribution of land surface water is extremely uneven and is gathered mainly in mid- to high-latitude area of the Northern Hemisphere and tropic area. The comparison of water ratio between 2000 and 2010 indicates the overall fluctuation is small but spatially differentiated. The Global Land 30-water products and the statistics provided the fundamental information for analyzing the spatial distribution pattern and temporal fluctuation of land surface water and diagnosing the global ecosystem and environment. | CAO Xin CHEN Jun CHEN LiJun LIAO AnPing SUN FangDi LI Yang LI Lei LIN ZhongHui PANG ZhiGuo CHEN Jin HE ChaoYing PENG Shu | 2014 | Science China Earth Sciences2014，57，10： | 8 |
| 16 | Control of Formation of Lithological Reservoirs by Surrounding Mudstone显示文摘Taking the Jiyang depression as an example, this paper discusses the control of the formation of lithological reservoir by surrounding rocks by integrated application of geological analysis, physical simulation, and the analysis of oil & gas accumulation mechanism. Geological statistical shows that the major burial depth and interval of lithological reservoirs in the Jiyang depression are related to the hydrocarbon generation in and expulsion from the Lower Tertiary source rocks and the time of the formation of most lithological reservoirs coincides with the peak of hydrocarbon generation and expulsion. The lithological traps located in the center of effective source rocks are propitious to high oil saturation than those located on the margin of effective source rocks. The hydrocarbon charge degree of the lithological reservoir has a positive correlation with the intensity of hydrocarbon expulsion from surrounding source rocks. Geological analyses and NMR experiments also show that the oil saturation of surrounding source rocks control the hydrocarbon potential of lithological traps, and a critical value for oil saturation of surrounding mudstone is required, that is, when the oil saturation of surrounding mudstone is lower than this critical value, no oil and gas accumulate in the lithological trap. The control of surrounding mudstone on the oil-bearing properties of lithological reservoirs is also analyzed by the mechanisms of hydrocarbon generation and expulsion as well as accumulation. | Jiang Zhenxue Chen Dongxia Pang Xiongqi Zhang Jun Tian Fenghua | 2006 | Petroleum Science2006，3，2： | 7 |
| 17 | Control of Facies and Potential on Jurassic Hydrocarbon Accumulation and Prediction of Favorable Targets in the Hinterland Region of the Junggar Basin显示文摘Exploration practices show that the Jurassic System in the hinterland region of the Junggar Basin has a low degree of exploration but huge potential,however the oil/gas accumulation rule is very complicated,and it is difficult to predict hydrocarbon-bearing properties.The research indicates that the oil and gas is controlled by structure facies belt and sedimentary system distribution macroscopically,and hydrocarbon-bearing properties of sand bodies are controlled by lithofacies and petrophysical facies microscopically.Controlled by ancient and current tectonic frameworks,most of the discovered oil and gas are distributed in the delta front sedimentary system of a palaeo-tectonic belt and an ancient slope belt.Subaqueous branch channels and estuary dams mainly with medium and fine sandstone are the main reservoirs and oil production layers,and sand bodies of high porosity and high permeability have good hydrocarbon-bearing properties;the facies controlling effect shows a reservoir controlling geologic model of relatively high porosity and permeability.The hydrocarbon distribution is also controlled by relatively low potential energy at the high points of local structure macroscopically, while most of the successful wells are distributed at the high points of local structure,and the hydrocarbon-bearing property is good at the place of relatively low potential energy;the hydrocarbon distribution is in close connection with faults,and the reservoirs near the fault in the region of relatively low pressure have good oil and gas shows;the distribution of lithologic reservoirs at the depression slope is controlled by the distribution of sand bodies at positions of relatively high porosity and permeability.The formation of the reservoir of the Jurassic in the Junggar Basin shows characteristics of favorable facies and low-potential coupling control,and among the currently discovered reservoirs and industrial hydrocarbon production wells,more than 90%are developed within the scope of faciespotential index FPI>0.5,while the FPI and oil saturation of the discovered reservoir and unascertained traps have relatively good linear correlation.By establishing the relation model between hydrocarbonbearing properties of traps and FPI,totally 43 favorable targets are predicted in four main target series of strata and mainly distributed in the Badaowan Formation and the Sangonghe Formation,and the most favorable targets include the north and east of the Shinan Sag,the middle and south of the Mobei Uplift,Cai-35 well area of the Cainan Oilfield,and North-74 well area of the Zhangbei fault-fold zone. | CHEN Dongxia PANG Xiongqi KUANG Jun KANG Dejiang LEI Lei DENG Yougen | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 7 |
| 18 | Comparison of the Surface and Underground Natural Gas Occurrences in the Tazhong Uplift of the Tarim Basin显示文摘体积由探索的井的生产率揭示了的油,气体和水不反映实际地下的状况。在地质的条件下面,溶解天然气的某个数量在油或水被存储。在 Tazhong 基于探索的井的生产测试数据 Tarim 盆高举,这篇论文详细在在表面和地下的天然气之间的出现和分发 featrues 讨论差别;在不同温度,压力和中等条件下面根据天然气的可溶性介绍表面气体出现的恢复给实际地下的地质的条件;并且分类天然气进三个状态,即 oversaturated,浸透并且 undersaturated,根据它的相对内容地下。通过在表面和天然气的地下的出现的差别的比较分析,它讨论烃水库形成机制和分发规则,从而在学习区域为潜在的天然气水库分发的预言作为新方法和技术提供指导。 | TIAN Jun CHEN Junqing JIAO Jiao PANG Xiongqi | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 6 |
| 19 | Molecular Cytogenetic Characterization of a Wheat-Leymus mollis 3D(3Ns) Substitution Line with Resistance to Leaf Rust显示文摘Leymus mollis(Trin.)Pilger(NsNsXmXm,2n?28),a wild relative of common wheat,possesses many potentially valuable traits that could be transferred to common wheat during breeding programs.In this study,the karyotypic constitution of a wheat e L.mollis 3D(3Ns#1)disomic substitution line isolated from the F5progeny of octoploid Tritileymus M842-16 Triticum durum cv.D4286,which was designated as 10DM57,was determined using genomic in situ hybridization(GISH),fluorescent in situ hybridization(FISH),SSR markers,and ESTSTS markers.Screening of mitosis and meiosis showed that 10DM57 had a chromosome karyotype of 2n?42?21II.GISH indicated that10DM57 was a line with 40 chromosomes from wheat and two of the Ns chromosomes from L.mollis,which formed a ring bivalent in pollen mother cells at metaphase I.FISH analysis showed that the chromosome 3D may be replaced by 3Ns#1 in 10DM57.DNA markers,including SSR and EST-STS primers,showed that the pair of wheat chromosome 3D in 10DM57 was substituted by the pair of chromosome 3Ns#1from L.mollis.Evaluation of the agronomic traits showed that,compared with its common wheat relative 7182,10DM57 was resistant to leaf rust while the spike length and number of spikes per plant were improved significantly,which correlated with a higher wheat yield.The new germplasm,10DM57,could be exploited as an intermediate material in wheat genetic and breeding programs. | Yuhui Pang Xinhong Chen Jixin Zhao Wanli Du Xueni Cheng Jun Wu Yanli Li Liangming Wang Jing Wang Qunhui Yang | 2014 | Journal of Genetics and Genomics2014，41，4： | 6 |
| 20 | Oxidative stress and peripheral skeletal muscle dysfunction in rats with emphysema显示文摘在有长期的妨碍的肺的疾病(COPD ) 的病人的背景外部骨胳的肌肉机能障碍可能由于疾病本身或由于使因素惊讶的伴随物。尽管功能的缺陷是的机械学的基础 forthis 不明确的、氧化应力可以起一个作用。这研究的目的到过 investigatewhether 本地氧化应力在 situ 在老鼠 withemphysema.Methods 与减少的外部骨胳的肌肉表演被联系 gastrocnemius 的机械性质在 Sprague-Dawley 老鼠被测量任何一个 elastase 的 5 月 afterintratracheal 灌输(EMP, n=10 )或正常盐(反对, n=10 )。Lipofuscin 包括, myocyteapoptosis 和抗氧化剂酶活动在 gastrocnemius muscle.Results Lipofuscin 包括被检验与反对相比在 EMP 的 gastrocnemius 肌肉是显著地更高的(3.2 ???????? 坎 ??????????????\ | ZHANG Xiao-lei PANG Bao-sen HOU Xiao-li WANG Jun WANG Chen | 2010 | Chinese Medical Journal2010，，1： | 6 |
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