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| 1 | 耕作对东北黑土团聚体粒级分布及其稳定性的短期影响显示文摘 | 梁爱珍 张晓平 杨学明 Neil McLaughlin 申艳 李文凤 | 2009 | 土壤学报2009，46，1： | 41 |
| 2 | 东北黑土区保护性耕作的发展现状与成效研究显示文摘东北黑土区承担着国家粮食安全“稳压器”的重要责任。然而,由于长期超负荷开发利用导致黑土日益退化,黑土资源的永续利用受到严重制约。理论与实践证明,保护性耕作是保护黑土地、推动黑土耕地质量和耕作效益绿色增长的发展模式。综述了保护性耕作的基本内涵及其在东北黑土区的发展现状与技术概况,从保护性耕作在土壤保持、保墒效益、结构改善、固碳培肥和土壤生物多样性增加、节本增效等方面系统评估了东北黑土区实施保护性耕作后的生态与经济效益,提出黑土区实施保护性耕作存在的问题与未来发展方向,以促进黑土地保护与利用协调发展、推动保护性耕作高质量跨越式发展。 | 梁爱珍 张延 陈学文 张士秀 黄丹丹 杨学明 张晓平 李秀军 田春杰 McLaughlin Neil B 相洋 | 2022 | 地理科学2022，42，8： | 26 |
| 3 | Vanishing bile duct syndrome in human immunodeficiency virus infected adults:A report of two cases显示文摘Vanishing bile duct syndrome(VBDS) is a group of rare disorders characterized by ductopenia,the progressive destruction and disappearance of intrahepatic bile ducts leading to cholestasis.Described in association with medications,autoimmune disorders,cancer,transplantation,and infections,the specific mechanisms of disease are not known.To date,only 4 cases of VBDS have been reported in human immunodeficiency virus(HIV) infected patients.We report 2 additional cases of HIV-associated VBDS and review the features common to the HIV-associated cases.Presentation includes hyperbilirubinemia,normal liver imaging,and negative viral and autoimmune hepatitis studies.In HIV-infected subjects,VBDS occurred at a range of CD4+ T-cell counts,in some cases following initiation or change in antiretroviral therapy.Lymphoma was associated with two cases;nevirapine,antibiotics,and viral co-infection were suggested as etiologies in the other cases.In HIV-positive patients with progressive cholestasis,early identification of VBDS and referral for transplantation may improve outcomes. | Ana Paula Oppenheimer Christopher Koh Mary McLaughlin John C Williamson Thomas D Norton Jennifer Laudadio Theo Heller David E Kleiner Kevin P High Caryn G Morse | 2013 | World Journal of Gastroenterology2013，19，1： | 8 |
| 4 | The role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognition显示文摘在人的不孕病人的精子在场的最普通的损害之一是精子鸡蛋识别的自发的失败。尽管这个唯一的细胞的相互作用现在能被象 intracytoplasmic 精子注射(ICSI ) 那样的帮助繁殖策略乐意地绕过,最近的大规模流行病学的研究鼓励了这种技术的小心的使用并且为对为有缺点的精子鸡蛋识别负责的机制的进一步的研究加亮需要。这个领域里的以前的工作证实了为卵母细胞相互作用负责的精子领域在动态地在女繁殖的道在 epididymal 成熟和 capacitation 期间被修改以前在精子发生期间被形成。当为这些顺序的 maturational 事件的规定负责的因素无疑是复杂的时,新兴的研究识别了分子的女伴,加热吃惊蛋白质 A2 (HSPA2 ) ,,在人的精子的这些事件的一个关键管理者。HSPA2 是支持合拢,运输,和集会蛋白质建筑群的 70 kDa 热吃惊蛋白质家庭的一个充实睾丸的成员并且断然被相关与在 vitro 授精(IVF ) 成功。而且,从人的精子 proteome 减少了 HSPA2 的表示为跟随 IVF 和 ICSI 的积云矩阵疏开,精子鸡蛋识别和授精导致一个损害能力。在这评论,我们考虑在精子功能支持 HSPA2 的角色的证据并且探索它被在不肥沃的病人的精子弄空的潜在的机制。进管理精子的分子的机制的如此的信息提议小说卓见工作。 | Brett Nixon Elizabeth G Bromfield Matthew D Dun Kate A Redgrove Eileen A McLaughlin R John Aitken | 2015 | Asian Journal of Andrology2015，17，4： | 8 |
| 5 | Do probiotics have a therapeutic role in gastroenterology?显示文摘Several hundred species of bacteria inhabit the gut, and affect its cell biology, morphology and homeostasis. Many bacteria are however potential pathogens, especially if the integrity of the epithelial barrier is physically or functionally breached. Conversely, the interaction between host and commensal microbes can confer important health benefits. This has led to commercial and public interest in ’probiotics’, live microbes principally taken as food supplements. Might probiotics also be used in disease therapy? Experimental evidence that probiotics modulate gut physiology, particularly barrier integrity and immunological function, underpins exciting new gastroenterological research. We discuss below the scienti?c basis for probiotic effects and present a critical perspective for their use in relation to gastrointestinal disease. | Jimmy K Limdi Catherine O’Neill John McLaughlin | 2006 | World Journal of Gastroenterology2006，12，34： | 6 |
| 6 | 湖泊沉积物中氨氧化微生物的amoA基因数量显示文摘采用定量PCR方法测定了4个湖泊沉积物中氨氧化微生物的amoA基因数量,并分析了其与环境因子之间的关系. 结果表明:小南湖AOA(氨氧化古菌)和AOB(氨氧化细菌)的amoA基因数量最多,分别达2.1×104和2.8×103copiesg(以干质量计,下同);梁子湖仅检测到了AOA amoA基因的存在,平均值为4.9×103copiesg. 东湖和汤逊湖的AOA amoA基因数量比较接近,约为3.0×103copiesg,然而AOB的amoA基因数量在这2个湖泊中仅分别为37和86copiesg;在这些采样点中,AOA的amoA基因数量是AOB的3-278倍. 统计分析发现,随着湖泊营养水平和间隙水中ρ(NH4+)的上升,AOA和AOB的amoA基因数量均呈增加趋势,但ρ(NH4+)增加对AOB的促进作用要大于AOA,导致AOA和AOB的amoA基因数量比值与间隙水中ρ(NH4+)呈显著负相关. pH上升对2类氨氧化微生物的抑制作用则与ρ(NH4+)增加对它们的促进作用相反. 沉积物中amoA基因数量与间隙水中ρ(NO2-)无显著相关性,但与ρ(NO3-)呈显著正相关. 由于ρ(NH4+)与ρ(DO)之间呈显著负相关,因此认为ρ(DO)与氨氧化微生物amoA基因数量之间的显著负相关可能更多的是对ρ(NH4+)与氨氧化微生物amoA基因数量之间紧密关系的一种间接反应. | 王松波 RICHARD William Mclaughlin 程国军 邓克俭 | 2013 | 环境科学研究2013，26，10： | 6 |
| 7 | RNA binding proteins in spermatogenesis: an in depth focus on the Musashi family显示文摘控制基因规定为维持繁殖潜力在配偶子开发期间是重要的。在哺乳动物的精子发生的复杂过程期间,尽管有重翻译要求,男细菌房间为继续的生长和区别经历不活跃的抄写的扩大时期。因此,精子发生高度依赖基因表示的 posttranscriptional 规定的机制,由 RNA 有约束力的蛋白质(RBP ) 便于,它仍然保持富有地在整个这进程表示了。一如此的组蛋白质是 Musashi 家庭,以前在果蝇识别了睾丸细菌房间开发和成熟分裂的同样批评的管理者,并且也出现对在老鼠的精子开发和繁殖潜力重要。这评论在男细菌房间开发的范围以内描述 RBP 的角色和函数,集中于我们在精子发生的 Musashi 蛋白质的最近的知识。RBP 在房间以内利用的功能的机制在与模式的关系深入地亚 cellular 本地化和阶段特定的表示的,和意义被构画出, posttranscriptional 规定的影响也被加亮。当原来在果蝇和 Xenopus 描绘了,我们在干细胞功能和房间命运决心强调 RBP 的 Musashi 家庭的历史的角色,并且与我们微分角色的当前的理解和哺乳动物的 Musashi 蛋白质, Musashi-1 和 Musashi-2 的功能得出结论,与我们在精子发生的调查结果的一个主要焦点。这评论两个都作为男配偶子开发的主人管理者加亮 RBP 的必要贡献到 posttranscriptional 规定和 Musashi 家庭的重要性。 | Jessie M Sutherland Nicole A Siddall Gary R Hime Eileen A McLaughlin | 2015 | Asian Journal of Andrology2015，17，4： | 4 |
| 8 | Opioid growth factor and the treatment of human pancreatic cancer:A review显示文摘Opioid growth factor(OGF),chemically termed[Met5]-enkephalin,and its receptor,OGF receptor(OGFr),form a biological axis that tonically regulates cell proliferation by delaying the G1/S interface of the cell cycle under homeostatic conditions or in neoplasia.Modulation of the OGF-OGFr pathway mediates the course of pancreatic cancer,with exogenous OGF or upregulation of OGFr repressing growth of human pancreatic cancer cells in culture and in nude mice.OGF therapy alone or in combination with standard chemotherapies such as gemcitabine and 5-fluorouracil results in enhanced inhibition of DNA synthesis and tumor growth.Molecular manipulation of OGFr confirms that the receptor is specific for OGF’s inhibitory action.Preclinical studies have warranted PhaseⅠand PhaseⅡclinical trials using OGF infusions as a treatment for patients with advanced,unresectable pancreatic cancers.OGF,an endogenous neuropeptide,is a safe,non-toxic,and effective biotherapy that utilizes the OGF-OGFr axis to mediate pancreatic tumor progression. | Ian S Zagon Patricia J McLaughlin | 2014 | World Journal of Gastroenterology2014，20，9： | 4 |
| 9 | Brine Shrimp: A Convenient General Bioassay for Active Plant Constituents显示文摘 | B. Meyer N. Ferrigni J. Putnam L. Jacobsen D. Nichols J. McLaughlin | 1982 | Planta Med1982，，05： | 3 |
| 10 | The chemistry and biology of febrifugine and halofuginone显示文摘 | Noel P. McLaughlin Paul Evans Mark Pines | 2014 | Bioorganic & Medicinal Chemistry2014，，： | 3 |
| 11 | ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension显示文摘 | Vallerie V. McLaughlin Stephen L. Archer David B. Badesch Robyn J. Barst Harrison W. Farber Jonathan R. Lindner Michael A. Mathier Michael D. McGoon Myung H. Park Robert S. Rosenson Lewis J. Rubin Victor F. Tapson John Varga | 2009 | Journal of the American College of Cardiology2009，，17： | 2 |
| 12 | Development of EMD-based denoising methods inspired by wavelet thresholding显示文摘 | Kopsinis Y McLaughlin S | | 0，，04： | 2 |
| 13 | Ambrisentan for the Treatment of Pulmonary Arterial Hypertension: Results of the Ambrisentan in Pulmonary Arterial Hypertension, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy (ARIES) Study 1 and 2显示文摘 | Nazzareno Galiè Horst Olschewski Ronald J. Oudiz Fernando Torres Adaani Frost Hossein A. Ghofrani David B. Badesch Michael D. McGoon Vallerie V. McLaughlin Ellen B. Roecker Michael J. Gerber Christopher Dufton Brian L. Wiens Lewis J. Rubin | 2008 | Circulation2008，，23： | 2 |
| 14 | Use of polymerase chain reaction for rapid detection of gene insertions in whole yeast cells显示文摘 | Sathe G M OBrien S Mclaughlin M M | 1991 | Nucleic Acids Res1991，19，： | 2 |
| 15 | 一项3h葡萄糖耐量试验值升高的妇女其不良围生期结局风险是否升高显示文摘Objective: The purpose of this study was to examine whetherw omen with one elevated value of the 3- hour glucose tolerance test are at increased risk for adverse perinatal outcomes.Study design: This was a retrospective cohort study of singleton pregnancies that were screened for gestational diabetes mellitus with the use of the glucose loading test and with a glucose tolerance test for follow up, if screened values were positive. Perinatal outcomes in women with one elevated glucose tolerance test value were compared with the outcomes in women who screened negative by glucose loading test. The chi-square test was used to compare categorical outcomes, and multivariate logistic regression analysis was used to control for potential confounding factors; a P value of < .05 indicated statistical significance. Results:Of 14,036 women who met the study criteria, women with one elevated glucose tolerance test value exhibited higher rates of cesarean delivery (in nulliparous women only)- , preeclampsia, chorioamnionitis, birth weight > 4000 g and > 4500 g, and neonatal admission to the intensive care nursery as compared with women who screened negative (P < .05 for all). Conclusion: Although women with one elevated glucose tolerance test value are not diagnosed with gestational diabetes mellitus, they are still at risk for adverse perinatal outcomes. | McLaughlin G.B. Caughey A.B. 张新艳 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，2，9： | 2 |
| 16 | A prospective study of obesity and cancer risk (Sweden)显示文摘 | Alicja Wolk Gloria Gridley Malin Svensson Olof Nyrén Joseph K. McLaughlin Joseph F. Fraumeni Hans-Olov Adami | 2001 | Cancer Causes and Control2001，，1： | 2 |
| 17 | Colestyramine slows gastric emptying of liquids and reduces appetite in healthy subjects显示文摘 | A. Psichas T. Little S. Lal J. McLaughlin | 2012 | Neurogastroenterology & Motility2012，，12： | 2 |
| 18 | Cancer risk in patients with diabetes mellitus显示文摘 | Hans-Olov Adami Joseph McLaughlin Anders Ekbom Christian Berne Debra Silverman David Hacker Ingemar Persson | 1991 | Cancer Causes and Control1991，，5： | 2 |
| 19 | The impact of agricultural practices on biodiversity显示文摘 | Alison McLaughlin Pierre Mineau | 1995 | Agriculture, Ecosystems and Environment1995，，3： | 2 |
| 20 | Inflammatory bowel disease and pregnancy: Lack of knowledge is associated with negative views显示文摘 | Christian P. Selinger Jayne Eaden Warwick Selby D. Brian Jones Peter Katelaris Grace Chapman Charles McDondald John McLaughlin Rupert W.L. Leong Simon Lal | 2012 | Journal of Crohn’s and Colitis2012，，： | 2 |
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