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| 1 | Hemostasis in liver transplantation:Pathophysiology,monitoring,and treatment显示文摘Recent findings in the pathophysiology and monitoring of hemostasis in patients with end stage liver disease have major impact on coagulation management during liver transplantation. There is increasing evidence, that the changes in both coagulation factors and platelet count regularly observed in patients with liver cirrhosis cannot be interpreted as a reliable indicator of diffuse bleeding risk. Instead, a differentiated view on hemostasis has led to the concept of a rebalanced coagulation system: While it is important to recognize that procoagulant factors are reduced in liver cirrhosis, it is also evident that synthesis of anticoagulant factors and fibrinolytic proteins produced in the liver is also diminished. Similarly, the decreased platelet count may be counterbalanced by increased platelet aggregability caused by highly active von Willebrand multimeres. The coagulation system is therefor stated to be rebalanced. While under normal 'unstressed' conditions diffuse bleeding is rarely observed, however both diffuse bleeding or thrombus formation may occur when compensation mechanisms are exhausted. While most patients presenting for liver transplantation have severe cirrhosis, liver function and thus production of pro- and anticoagulant factors can be preserved especially in cholestatic liver disease. During liver transplantation, profound changes in the hemostasis system can occur. Surgical bleeding can lead to diffuse bleeding as coagulation factors and platelets are already reduced. Ischemia and tissue trauma can lead to alterations of hemostasis comparable to trauma induced coagulopathy. A further common disturbance often starting with the reperfusion of the transplanted organ is hyperfibrinolysis which can eventually precipitate complete consumption of fibrinogen and an endogenous heparinization by glycocalyx shedding. Moreover, thrombotic events inliver transplantations are not uncommon and contribute to increased mortality. Besides conventional laboratory methods, bed-side monitoring of hemostasis(e.g., thrombelastography, thrombelastometry) is often used during liver transplantation to rapidly diagnose decreases in fibrinogen and platelet count as well as hyperfibrinolysis and to guide treatment with blood products, factor concentrates, and antifibrinolytics. There is also evidence which suggests when algorithms based on bed-side hemostasis monitoring are used a reduction of blood loss, blood product use, and eventual mortality are possible. Notably, the bed-side monitoring of anticoagulant pathways and the thrombotic risk is not possible at time and thus a cautious and restrictive use of blood products is recommended. | Matthias Hartmann Cynthia Szalai Fuat H Saner | 2016 | World Journal of Gastroenterology2016，22，4： | 11 |
| 2 | Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension显示文摘AIM:To explore the role of heat shock protein-90 (HSP-90) for nitrergic vasorelaxation in the splanchnic circulation in rats with and without portal hypertension. METHODS: Neuronal nitric oxide synthase (nNOS) and HSP-90 were analyzed by immunofluorescence, western blotting and co-immunoprecipitation in the mesenteric vasculature and isolated nerves of portal-vein-ligated (PVL) rats and sham operated rats. In vitro perfused de-endothelialized mesenteric arterial vasculature was preconstricted with norepinephrine (EC80) and tested for nNOS-mediated vasorelaxation by periarterial nerve stimulation (PNS, 2-12 Hz, 45V) before and after incubation with geldanamycin (specific inhibitor of HSP-90 signalling, 3 μg/mL) or L-NAME (non-specific NOSblocker, 10-4 mol/L). RESULTS: nNOS and HSP-90 expression was significantly increased in mesenteric nerves from PVL as compared to sham rats. Moreover, nNOS and HSP-90 were visualized in mesenteric nerves by immunofluorescence and immunoprecipitation of nNOS co-immunoprecitated HSP-90 in sham and PVL rats. PNS induced a frequencydependent vasorelaxation which was more pronounced in PVL as compared to sham rats. L-NAME and geldanamycin markedly reduced nNOS-mediated vasorelaxation abrogating differences between the study groups. The effect of L-NAME and geldanamycin on nNOS-mediated vasorelaxation was significantly greater in PVL than in sham animals. However, no difference in magnitude of effect between L-NAME and geldanamycin was noted. CONCLUSION: HSP-90 acts as a signalling mediator of nNOS-dependent nerve mediated vascular responses in mesenteric arteries, and the increased nitrergic vasorelaxation observed in portal hypertension is mediated largely by HSP-90. | Lukas Moleda Lars Jurzik Matthias Froh Erwin Gbele Claus Hellerbrand Rainer H Straub Jürgen Schlmerich Reiner Wiest | 2010 | World Journal of Gastroenterology2010，16，15： | 4 |
| 3 | 以食物为基础的膳食模式与慢性疾病预防显示文摘Matthias B Schulze及其同事讨论了目前已知的膳食模式与癌症、冠心病、卒中及2型糖尿病的关联,重点在仍不确定的领域和未来的研究方向。 | Matthias B Schulze Miguel A Martínez-González Teresa T Fung Alice H Lichtenstein Nita G Forouhi 陈夏燕(译) 王燕芳(译) 武阳丰(校) | 2021 | 英国医学杂志中文版2021，24，3： | 3 |
| 4 | Leptospirosis: a zoonotic disease of global importance显示文摘 | Ajay R Bharti Jarlath E Nally Jessica N Ricaldi Michael A Matthias Monica M Diaz Michael A Lovett Paul N Levett Robert H Gilman Michael R Willig Eduardo Gotuzzo Joseph M Vinetz | 2003 | The Lancet Infectious Diseases2003，，12： | 2 |
| 5 | Epithelial-to-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma and Pancreatic Tumor Cell Lines: The Role of Neutrophils and Neutrophil-Derived Elastase显示文摘 | Thomas Gro?e-Steffen Thomas Giese Nathalia Giese Thomas Longerich Peter Schirmacher G. Maria H?nsch Matthias M. Gaida G. Opdenakker | 2012 | Clinical and Developmental Immunology2012，，： | 2 |
| 6 | 具有聚集诱导发光行为的环状多烯类分子(英文)显示文摘研究了4H-pyrans,fulvenes,siloles等环状多烯结构的小分子荧光染料在溶液,固态及薄层层析板上的荧光发射行为。与大多数传统的荧光染料小分子不同,这些多烯类荧光染料分子在稀溶液中基本没有荧光,而在聚集态下呈现非常明亮的荧光发射,同时伴随着荧光量子效率的大幅提高(聚集诱导发光)。它们在薄层层析板上也具有很强的荧光发射。但当薄层层析板暴露于有机溶剂气氛下,荧光消失,离开有机溶剂气氛,荧光恢复,这一可逆过程并可多次重复。在固体状态,它们的荧光发射与聚集态结构密切相关。通过从无定型态到结晶态以及从一种结晶态到另一种结晶态的变化,可以有效的调节它们的固体荧光发射。 | 童辉 董永强 Huβler Matthias 唐本忠 | 2006 | 发光学报2006，27，3： | 2 |
| 7 | The digital front-end of software radio terminals 显示文摘 | Tim H Matthias H Gerhard F | 1999 | IEEE Personal Communications1999，6，8： | 1 |
| 8 | Epilepsy and Obstructive Sleep Apnea显示文摘 | Peter H Ramin K Matthias G | 2006 | Eur Neurol2006，55，： | 1 |
| 9 | Long-term biocompat-ibility of a corrodible peripheral iron stent in the porcinedescending aorta 显示文摘 | Matthias PXarola H Tirza S | 2006 | Biomaterials2006，27，28： | 1 |
| 10 | Combining Laser Chemical Processing and Aerosol Jet Printing:a Laboratory Scale Feasibility Study显示文摘 | DREW Kristine HOPMAN Sybille H(..O)RTEIS Matthias | | 0，，： | 1 |
| 11 | 肿瘤18F-FDG PET/MRI全身显像专家共识(德国)显示文摘PET/MRI一体机在2006年被首次提出可应用于临床;2010年,首台临床型PET/MRI一体机诞生。在20世纪早期,PET/CT和SPECT/CT一体机的广泛应用体现了融合显像的优势,为PET/MRI一体机的产生奠定了基础。目前,全球大约有150台全身PET/MRI一体机投入了临床应用,其中肿瘤显像是PET/MRI的主要应用领域之一。迄今为止,尽管PET/MRI临床应用在增加,但标准化的PET/MRI扫描方案还很少。因此,有必要制定患者检查和多中心研究都可遵循的标准化且一致性好的显像方案。该文总结了18F-脱氧葡萄糖(FDG)PET/MRI全身显像的患者就诊、检查准备、工作流程、显像方案以及报告书写等主要方面的专家共识,由长期使用PET、MRI和较早使用PET/MRI的相关资深专家制定。 | 王洋洋 杨光杰(译) 王振光(审校) Lale Umutlu Thomas Beyer Johannes Stefan Grueneisen Christoph Rischpler Harald H Quick Veit-Haibach Patrick Matthias Eiber Sandra Purz Gerald Antoch Sergios Gatidis Konstantin Nikolaou Jürgen FSchaefer IvoRausch Herrmann Ken K.Herrmann B.J.Krause S.O.Schoenberg L.Umutlu F.Anton G.Antoch M.Hacker M.Luster S.Neumann D.Vorwerk | 2020 | 中华核医学与分子影像杂志2020，40，9： | 1 |
| 12 | Biodiversity and nutrition in rice-based aquatic ecosystems显示文摘 | MATTHIAS H | 2006 | Journal of Food Composition and Analysis2006，19，67： | 1 |
| 13 | Thedeoxyxylulose phosphate pathway of terpenoid biosynthesisin plants and microorganisms显示文摘 | Wolfgang Eisenreicha Matthias Schwarzb Alain Cartayradeb Duilio Arigonib Meinhart H Zenkc Adelbert Bacher | 1998 | Chemistry&Biology1998，5，9： | 1 |
| 14 | Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma显示文摘 | Matthias L?hr Anne Hoffmeyer Jens-Christian Kr?ger Mathias Freund Johannes Hain Albrecht Holle Peter Karle Wolfram T Kn?fel Stefan Liebe Petra Müller Horst Nizze Matthias Renner Robert M Saller Thomas Wagner Karlheinz Hauenstein Walter H Günzburg Brian Sa | 2001 | The Lancet2001，，9268： | 1 |
| 15 | FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex显示文摘 | Marta Muzio Arul M Chinnaiyan Frank C Kischkel Karen O’Rourke Andrej Shevchenko Jian Ni Carsten Scaffidi James D Bretz Mei Zhang Reiner Gentz Matthias Mann Peter H Krammer Marcus E Peter Vishva M Dixit | 1996 | Cell1996，，： | 1 |
| 16 | Microstructure of sol-gel derived TiO2 thin films characterized by atmospheric ellipsometric porosimetry 显示文摘 | Matthias B Bettina H Pe L | 2009 | Thin Solid Films2009，517，： | 1 |
| 17 | Papillomavirus type 16 oncogenes downregulate expression of interferon-responsive genes and upregulate proliferation-associated and NF-kB-responsive genes in cervical keratinocytes显示文摘 | Matthias N Joel MG Tehila H | 2001 | J Virol2001，75，9： | 1 |
| 18 | Synthesis approaches towards 2-iminothiazolidines:an overview显示文摘 | Matthias D H Norbert D K | 2006 | Tetrahedron2006，62，4： | 1 |
| 19 | FIRMS:A Mapping System for Future Internet Routing显示文摘 | MICHAEL M MATTHIAS H MICHAEL H(o)fling | | 0，，08： | 1 |
| 20 | Uroguanylin: how the gut got another satiety hormone显示文摘 | Seeley Randy J Tsch?p Matthias H | 2011 | Journal of Clinical Investigation2011，，9： | 1 |
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