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| 1 | Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model显示文摘AIM: To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model.METHODS: To increase hepatoma cell chemosensitivity for the prodrug 5-fluorocytosine (5-FC), we generated a chimeric bifunctional SuperCD suicide gene, a fusion of the yeast cytosine deaminase (YCD) and the yeast uracil phosphoribosyltransferase (YUPRT) gene.RESULTS: In vitro stably transduced Morris rat hepatoma cells (MH) expressing the bifunctional SuperCD suicide gene (MH SuperCD) showed a clearly marked enhancement in cell killing when incubated with 5-FC as compared with MH ceils stably expressing YCD solely (MH YCD) or the cytosine deaminase gene of bacterial origin(MH BCD), respectively. In vivo, MH SuperCD tumors implanted both subcutaneously as well as orthotopically into the livers of syngeneic ACI rats demonstrated significant tumor regressions (P<0.01) under both high dose as well as low dose systemic 5-FC application,whereas MH tumors without transgene expression (MH naive) showed rapid progression. For the first time, an order of in vivo suicide gene effectiveness (SuperCD>>YCD > > BCD > > > negative control) was defi ned as a result of a directin vivo comparison of all three suicide genes.CONCLUSION: Bifunctional SuperCD suicide gene expression is highly effective in a rat hepatoma model,thereby significantly improving both the therapeutic index and the efficacy of hepatocellular carcinoma killing by fluorocytosine. | Florian Graepler Marie-Luise Lemken Wolfgang A Wybranietz Ulrike Schmidt Irina Smirnow Christine D GroB Martin Spiegel Andrea Schenk Schenk Hansj(o|¨)rg Graf Ulrike A Lauer Reinhard Vonthein Michael Gregor Sorin Armeanu Michael Bitzer Ulrich M.Lauer | 2005 | World Journal of Gastroenterology2005，11，44： | 2 |
| 2 | 热浸镀锌超高强钢板钒微合金化技术研究显示文摘对超高强度钢板进行热处理,模拟热浸镀锌和合金化镀锌工艺的热循环,并考察获得的力学性能和微观组织。研究用钢含有适量的碳(~0.2%)、锰(1.2%)和铬(0.4%),保证钢板在奥氏体化后在镀锌前的连续退火线上进行快速冷却时能够完全转变成马氏体。采用不同的钒含量(0~0.1%)和氮含量(0.002%~0.012%),研究这些微合金化元素对回火马氏体强度的影响。尤其与高氮相配合情况下,钒有助于抵抗回火效应,因此在镀锌后大部分原始强化贡献被保留下来,使得钢的抗拉强度超过1 000 MPa。使用铝或硅进行不同脱氧试验,发现在同一碳含量下两者具有相同的强度水平,但是Si镇静钢的弯曲性能明显优异。对退火钢板进行微观组织观察,但是钒产生有益作用的原因还未完全掌握。通过研究得出这样结论:钒微合金化对耐腐蚀超高强度钢板的开发而言是一种极具前景的途径。 | Hutchinson B Martin D Karlsson O Lindberg F Thoors H Marceau R K W Taylor A S | 2016 | 钢铁钒钛2016，37，6： | 2 |
| 3 | EEG analysis using wavelet-based information tools 显示文摘 | ROSSO O A MARTIN M T FIGLIOLA A | 2006 | J Neurosci Methods2006，153，2： | 1 |
| 4 | Agro- industrial residues as low-price feedstock for diesel- like fuel production by thermal cracking显示文摘 | Santos A L F Martins D U Iha O K | 2010 | Bioresource Technology2010，101，： | 1 |
| 5 | Behaviour of a multi-storey steel framed building subjected to fire attaek显示文摘 | O'Connor M A Martin D M | 1998 | Journal of Constructional Steel Research1998，46，13： | 1 |
| 6 | Immunogenic death of colon cancer cells treated with oxaliplatin显示文摘 | Tesniere A Schlemmer F Boige V Kepp O Martins I Ghiringhelli F | 2010 | Oncogene2010，29，： | 1 |
| 7 | Photoreactor analysis and design: fundamentals and applications 显示文摘 | Cassano A E Martin C A Brand R J Alfamo O M | 1995 | Ind Eng Chem Res1995，34，： | 1 |
| 8 | Synthesis of mesoporous Al2O3 macrospheres using the biopolymer chitosan as a template:a novel active catalyst system for CO2 reforming of methane显示文摘 | FAIARDO H V MARTINS A O DE ALMEID R M | 2005 | Materials Letters2005，59，： | 1 |
| 9 | Influence of the structure on the electrochemical performance of lithium transition metal phosphates as cathode materials in rechargeable lithium batteries : A new high - pressure form of LiMPO4(M =Fe and Ni)显示文摘 | Garci'A - Martin O Alvarez - Vega M Garcia - Alvarado F | 2001 | Chem Mater2001，13，： | 1 |
| 10 | Effect of grazing on community structure and productivity of a Uruguayan grassland显示文摘 | ALICE A MARTIN O ELSA L | 2005 | Plant Ecology2005，179，： | 1 |
| 11 | The Multifaceted effects of granulocyte colony-stimulating factor in immunomodula- tion and potential roles in intestinal immune homeostasis 显示文摘 | MARTINS A HAN J KIM S O | 2010 | IUBMBLife2010，62，8： | 1 |
| 12 | E2F3amplifcation and overexpression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer显示文摘 | Martin O San J A T Peter S | 2004 | Oncogene2004，23，33： | 1 |
| 13 | Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria显示文摘 | Cereghetti GM Stangherlin A Martins de Brito O | 2008 | Proc Natl Acad Sci USA2008，105，15： | 1 |
| 14 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 15 | Identification of phases in zinc alloy powders using electron backscatter diffraction显示文摘 | Martin G Perez Edward A Kenik Matthew J O'Keefe F Scott Miller Benedict Johnson | 2006 | Mater Sci Eng A2006，424，： | 1 |
| 16 | Pharmaceutical care for patients with persistent asthma: assessment of treatment compliance and use of inhaled medications 显示文摘 | Santos Dde O Martins MC Cipfiano SL Pinto RM Cukier A Stelmaeh R | 2010 | J Brag Pneumo12010，36，1： | 1 |
| 17 | Ambulatory surgery in orthopedics: experience of over 10,000 patients显示文摘 | Martin Ferrero M A Faour Martin O Simon Perez C | 2014 | J Orthop Sci2014，19，2： | 1 |
| 18 | Triazine formation in cyanate-based resin systems at room temperature conditions 显示文摘 | OWUSU A O MARTIN G C J T GOTRO | 1996 | Polymer1996，37，21： | 1 |
| 19 | Plasticity of the prolactin (PRL) axis: mechanisms underlying regulation of output in female mice显示文摘 | Le Tissier P R Hodson D J Martin A O | 2015 | Adv Exp Med Biol2015，84，： | 1 |
| 20 | EEG analysis us- ing wavelet-based information tools显示文摘 | Rosso O A Martin M T Figliola A | 2006 | Journal of Neuroscience Methods2006，153，2： | 1 |
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