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| 1 | Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response显示文摘有积极表面费用的 Nanocarriers 以他们限制了他们的临床的应用的毒性著名。位于他们的毒性下面的机制例如煽动性的反应的正式就职,仍然保持大部分未知。在我们发现了 cationic nanocarriers 的那注射的现在的学习,包括 cationic liposomes, PEI,和 chitosan,导致了坏死的房间的快速的外观。cationic nanocarriers 导致的房间坏死依赖于他们的积极表面费用,但是不要求 RIP1 和 Mlkl。相反,细胞内部的 Na + 超载被发现伴随房间死亡。在文化媒介或有 Na +/K+-ATPase 阳离子绑定地点禁止者 ouabain 的房间的预告的处理的 Na + 的弄空,从房间坏死的保护的房间。而且,有 cationic nanocarriers 的处理在 vitro 并且在 vivo 禁止了 Na +/K+-ATPase 活动。计算模拟证明 cationic 搬运人能与 Na +/K+-ATPase 的阳离子绑定地点交往。有 ouabain 的小剂量的老鼠 pretreated 在 cationic nanocarriers 的致命的剂量的注射以后显示出改进幸存。进一步的分析建议 cationic nanocarriers 和 mitochondrial DNA 的产生的漏导致的那房间坏死能在 vivo 触发严重发炎,它被包含 TLR9 并且 MyD88 发信号的一条小径调停。一起拿,我们的结果揭示由此的新奇机制 cationic nanocarriers 通过和 mitochondrial 的随后的暴露的和 Na +/K+-ATPase, 的相互作用导致尖锐房间坏死是的联系损坏的分子的模式调停的一个关键事件煽动性的回答。我们的学习为评估 nanocarriers 的 biocompatibility 并且为药交货设计更好、更安全的有重要含意。 | Xiawei Wei Bin Shao Zhiyao He Tinghong Ye Min Luo Yaxiong Sang Xiao Liang Wei Wang Shuntao Luo Shengyong Yang Shuang Zhang Changyang Gong Maling Gou Hongxing Deng Yinglan Zhao Hanshuo Yang Senyi Deng Chengjian Zhao Li Yang Zhiyong Qian Jiong Li Xun Sun Jiahuai Han Chengyu Jiang Min Wu Zhirong Zhang | 2015 | Cell Research2015，25，2： | 21 |
| 2 | Early Intratracheal Administration of Corticosteroid and Pulmonary Surfactant for Preventing Bronchopulmonary Dysplasia in Preterm Infants with Neonatal Respiratory Distress Syndrome: A Meta-analysis显示文摘There is uncertain result with regard to the use of inhalation or instillation steroids to prevent bronchopulmonary dysplasia in preterm infants. This meta-analysis was designed to evaluate the efficacy and safety of early airway administration (within 2 days after birth) of corticosteroids and pulmonary surfactant (PS) for preventing bronchopulmonary dysplasia (BPD) in premature infants with neonatal respiratory distress syndrome (NRDS). The related studies were retrieved in PubMed, EMBASE, the Cochrane Library, Clinical Trial, CNKI, Wanfang and VIP Database from inception to August 2018. Two reviewers independently screened the studies to ensure that all patients with diagnosis of NRDS were enrolled to studies within 1 day after birth, assessed the quality of included studies by GRADEpro system and extracted the data for review. The meta-analysis was performed by RevMan 5.2 software. A subgroup analysis about inhaled corticosteroid (ICS) delivery method was made between ICS inhalation subgroup [inhalation of ICS by nebulizer or metered dose inhaler (MDI)] and ICS intratracheal instillation subgroup (PS used as a vehicle). Eight randomized controlled trials were enrolled in the meta-analysis, 5 trials of which stated the randomized method, grouping and blinded method, and the follow-up procedures were reported. GRADEpro system showed high quality of 4 trials (5 articles), and the rest 4 trials had moderate quality. Meta-analysis showed that the incidence of BPD was decreased in ICS group, the relative risk (RR) was 0.56 (95% CI: 0.42-0.76), and similar trends were found in ICS inhalation subgroup and ICS intratracheal instillation subgroup, with the corresponding RR being 0.58 (95% CI: 0.41-0.82) and 0.47 (95% CI: 0.24-0.95) respectively. ICS could also significantly reduce the mortality risk as compared with placebo control group (RR: 0.67;95% CI: 0.45-0.99), with RR of ICS inhalation subgroup and ICS intratracheal instillation subgroup being 0.81 (95% CI: 0.34-1.94) and 0.64 (95% CI: 0.41-0.99) respectively. Moreover, the percentage of infants using PS more than one time was lower in ICS group than in the placebo control group, with the RR and 95% CI being 0.55 (95% CI: 0.45-0.67), and that in ICS intratracheal instillation subgroup lower than in ICS inhalation subgroup (RR: 0.56;95% CI: 0.45-0.69, and RR: 0.35;95% CI:0.08-1.52 respectively). There was no significant difference in the incidence of infection or retinopathy of prematurity and neuro-motor system impairment between ICS group and placebo control group, with the corresponding RR being 0.95 (95% CI:0.59-1.52), 0.92 (95% CI: 0.62-1.38) and 1.13 (95% CI: 0.92-1.39), respectively. It was concluded that early administration of ICS and PS is an effective and safe option for preterm infants with NRDS in preventing BPD and reducing mortality, decreasing the additional PS usage, especially for the ICS intratracheal instillation subgroup. Furthermore, the appropriate dose and duration of ICS, combined use of inhalation or instillation of ICS with PS and the long-term safety of airway administration of corticosteroids need to be assessed in large trials. | Yan-yan ZHONG Jin-chun LI Ya-ling LIU Xiao-bo ZHAO Musa MALE Dong-kui SONG Yan BAI | 2019 | Current Medical Science2019，39，3： | 19 |
| 3 | 载人潜水器潜浮运动的模拟(英文)显示文摘In order to predict the dive motion of a deep manned submersible currently developed in China,a three-degree-of-freedom dynamic model is developed to simulate its dive motion restricted in the vertical plane. Being the nonlinear function of attack angle, the hydrodynamic forces acting upon the submersible are determined by a towing tank test.Based on these experimental values,the hydrodynamic forces are identified by a general regression neural network (GRNN) over a wide range of attack angles.Results of numerical examples are presented in this paper to explain practical applications of the method. | MALing CUIWei-cheng | 2004 | 船舶力学2004，8，3： | 9 |
| 4 | A Study of the Characteristics of Consumers' Behavior under the Web Environmen显示文摘The development of Internet has made shopping online possible. But while we are focusing ourselves on the environment design, plan for the information structures and items or business scales, another important factor has been ignored, that is, the changes of the characteristics of consumers behavior under the web environment. Because we are not able to make the exact online marketing strategy according to the changes of consumers behavior, and although many online shops have been opened, we are not able to get big sales. This article emphasises the analysis of the environment for on line transactions, attampts to investigate the basic modes for information movement and on line shopping of those consumers under the web environment, study the influence on consumers brought by Internet, the shopping styles and their characteristics. | LIU Li (Department of Management Engineering, Nanjing University of Posts and Telecommunications, Nanjing 210003, P.R.China)Biography:\ LIU Li (1958-), male, from Hunan Province, received MS degree in management from Northeast University in 1990, associ | 2001 | The Journal of China Universities of Posts and Telecommunications2001，8，1： | 3 |
| 5 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 6 | 铁道车辆轴承模糊可靠性寿命分析显示文摘根据客车运行的具体情况,对几种影响轴承寿命的模糊因素进行了分析,并建立了滚动轴承模糊当量动载荷的相关模糊数学计算模型,采用模糊综合评判法,定量地处理评判过程中的模糊因素,从而使结果更加合理、科学。 | Sun Yunqiang(male,born in 1955,lecturer,master,Mechanical Department of Shanghai Railway University,200331,Shanghai) | 1998 | 铁道车辆1998，36，10： | 2 |
| 7 | The Intelligent Door Monitoring System on Internet显示文摘The hardware structure and software function of intelligence door monitoring control systems on Internet is expounded. The remote managing function, database function, and the realization of dialing users are introduced. The reset card is installed to improve reliability. The design of the system is reasonable and reliable. Results showed that 10 percent of the line investment have been cut off. | LI Shu qiu,\ JIA Cheng yu,\ WANG Shi gang Biography:\ LI Shu qiu (1966-), male, from Jilin Province, M.S in optics and machinery, Jilin University, interested in the research of the study of communication and computer networks.(Department of Computer | 2001 | The Journal of China Universities of Posts and Telecommunications2001，8，1： | 2 |
| 8 | Aneurysmal Fibrous Histiocytoma:Clinicopathology Analysis of 30 Cases of a Rare Variant of Cutaneous Fibrohistiocytoma显示文摘Aneurysmal fibrous histiocytoma is often clinically misdiagnosed.In this study,we put forward an insight on how to help diagnose this disease clinically.A retrospective chart review was performed on all patients diagnosed with aneuiysmal fibrous histiocytoma from 2007 to 2017 in the Department of Dermatology,Union Hospital,China,and all clinical data were collected from the hospital archives.From a total of 418 patients diagnosed with cutaneous fibrous histiocytoma,only 30 patients were confirmed to have aneurysmal fibrous histiocytoma out of which only 2 patients were clinically diagnosed with aneurysmal fibrous histiocytoma.The remaining 28 patients were diagnosed with various types of vascular tumors although pathology classified them as having aneurysmal fibrous histiocytoma.Among the 30 patients,9 were male and 21 were female.There were following age groups:13-19(mean 16,n=4),20-29(mean 26.25,n=8),30-39(mean 33,n=7),40-49(mean 44,n=4),50-59(mean 56.75,n=4)5 60 and above(mean 61,n=3).Tumors were present on the head,neck,back,waist,hips and upper and lower extremities.After complete excision,there was no recurrence and no complications.Histologically,lesions showed the typical pseudoangiomatoid spaces without endothelial lining and infiltration of fibrohistiocytes in hemosiderotic pigmentation.It was suggested that although the prognosis of aneurysmal fibrous histiocytoma is good,accurate diagnosis is paramount to avoid clinical misdiagnosis and subsequent complications. | Amelia Nabatanzi Musa Male Xiao-ying QU Yan-qiu LI Xie MENG Wu-shi DI Chang-zheng HUANG | 2019 | Current Medical Science2019，39，1： | 2 |
| 9 | Soil evaluation for grape rootstock selection in the field of Kastela 显示文摘 | Males P | 1998 | Agronomski-Glasnik1998，60，4： | 1 |
| 10 | Developmental hemostasis:pro-and anticoagulant systems during childhood显示文摘 | KUHLE S MALE C MITCHELL L | 2003 | Semin Thromb Hemest2003，29，： | 1 |
| 11 | Electrochemical biosensing platforms using platinum nanoparticles and carbon nanotubes显示文摘 | Hrapovic S Liu Y Male K B | 2004 | Anal Chem2004，76，4： | 1 |
| 12 | Workshop on noise policy developments-Q & A ( Noise-Con 2005) 显示文摘 | MALING G | 2006 | Noise/News International2006，14，2： | 1 |
| 13 | Recent advances in hydrotreating of pyrolysis bio-oil and its oxygen- containing model compounds 显示文摘 | Wang Huamin Male J Wang Yong | 2013 | Acs Catalysis2013，3，5： | 1 |
| 14 | White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury显示文摘 | Fernando Malee S Simpson Jolie E Matthews Fiona | 2006 | Stroke2006，37，6： | 1 |
| 15 | Magnesium:physiology and phar- macology显示文摘 | Fawcett W Haxby E Male D | 1999 | Br J Anaesth1999，83，2： | 1 |
| 16 | Electrochemical biosensing platforms using platinum nanoparticles and carbon nanotubes显示文摘 | Hrapovic S Liu Y Male K B | 2004 | Analytical Chemistry2004，76，4： | 1 |
| 17 | Synthesis and characterization of PEG-PCL-PEG thermosensitive hydrogel显示文摘 | ChangYang Gong Shuai Shi PengWei Dong Bing Kan MaLing Gou XianHuo Wang XingYi Li Feng Luo Xia Zhao YuQuan Wei ZhiYong Qian | 2008 | International Journal of Pharmaceutics2008，，1： | 1 |
| 18 | Heat and Mass Transfer in a Square Microchannel with Asymmetric Heating显示文摘 | MALE P V CROON M H | 2004 | International Journal of Heat and Mass Transfer2004，47，： | 1 |
| 19 | Allocating funds for rapair of leaky water distribution systems显示文摘 | Male J W Franz S L | 1986 | TIMS Studies in the ManagementSciences1986，22，3： | 1 |
| 20 | Self-assembled honokiol-loaded micelles based on poly(?-caprolactone)-poly(ethylene glycol)-poly(?-caprolactone) copolymer显示文摘 | XiaWei Wei ChangYang Gong Shuai Shi ShaoZhi Fu Ke Men Shi Zeng XiuLing Zheng MaLing Gou LiJuan Chen LiYan Qiu ZhiYong Qian | 2008 | International Journal of Pharmaceutics2008，，1： | 1 |
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