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| 1 | 美国临床肿瘤学会IV期非小细胞肺癌化疗的临床实践指南更新显示文摘本文旨在为IV期非小细胞肺癌患者的治疗提供更新版推荐。本文资料检索源自2002年以来公布的相关随机试验文献。此指南范围限于化疗与生物治疗。更新委员会对这些文献进行了总结并提供了推荐更新。162篇文献符合标准被纳入参考。本推荐基于可改善总生存期的治疗方法。仅改善无进展生存期的治疗方法推动了对毒性及生存质量的监测。对于体力状态评分为0分或1分患者的一线治疗,可推荐以铂类为基础的细胞毒性药物的两药联用。对铂类治疗有禁忌的患者,可采用非铂类细胞毒性两药联合。对于体力状态评分为2分的患者,单一细胞毒性药物即可。对于疾病进展或经过4个周期的治疗仍对治疗无反应的患者,应停止一线细胞毒性化疗。即使在6个周期后患者对治疗仍有反应,亦应停止两药细胞毒性化疗。对于伴有明确的表皮生长因子受体(epidermal growth factor receptor,EGFR)突变的患者,可推荐一线采用吉非替尼治疗;对于EGFR突变为阴性或不明确的患者,细胞毒性化疗更佳。除具有特定临床特征的患者外,可推荐贝伐单抗与卡铂-紫杉醇联用。对于通过免疫组化证实EGFR阳性的肿瘤患者,可推荐西妥昔单抗与顺铂-长春瑞滨联用。多西紫杉醇、厄洛替尼、吉非替尼或培美曲塞被推荐作为二线治疗。对于未曾接受过厄洛替尼或吉非替尼治疗的患者,可推荐厄洛替尼作为三线治疗。现有数据不足以推荐常规三线采用细胞毒性药物。已有的证据也不足以推荐常规应用分子标记物选择化疗。 | Christopher G. AZZOLI Sherman Baker JR Sarah TEMIN William PAO Timothy ALIFF Julie BRAHMER David H. JOHNSON Janessa L. LASKIN Gregory MASTERS Daniel MILTON Luke NORDQUIST David G. PFISTER Steven PIANTADOSI Joan H. SCHILLER Reily SMITH Thomas J. SMITH John R. STRAWN David TRENT Giuseppe GIACCONE 丁燕(翻译) 南娟(翻译) 刘谦(翻译) 周清华(校对) 陈军(校对) | 2010 | 中国肺癌杂志2010，13，3： | 43 |
| 2 | Computed tomography overestimation of esophageal tumor length: Implications for radiotherapy planning显示文摘AIM:To assess the relationship between preoperative computed tomography(CT)and postoperative pathological measurements of esophageal tumor length and the prognostic significance of CT tumor length data.METHODS:A retrospective study was carried out in 56 patients who underwent curative esophagogastrectomy.Tumor lengths were measured on the immediate preoperative CT and on the post-operative resection specimens.Inter-and intra-observer variations in CT measurements were assessed.Survival data were collected.RESULTS:There was a weak correlation between CT and pathological tumor length(r=0.30,P=0.025).CT lengths were longer than pathological lengths in 68%(38/56)of patients with a mean difference of 1.67 cm(95%CI:1.18-2.97).The mean difference in measurements by two radiologists was 0.39 cm(95% CI:-0.59-1.44).The mean difference between repeat CT measured tumor length(intra-observer variation) were 0.04 cm(95%CI:-0.59-0.66)and 0.47 cm (95%CI:-0.53-1.47).When stratified,patients not receiving neoadjuvant chemotherapy showed a strong correlation between CT and pathological tumor length(r =0.69,P=0.0014,n=37)than patients that did(r= 0.13,P=0.43,n=19).Median survival with CT tumor length>5.6 cm was poorer than with smaller tumors,but the difference was not statistically significant.CONCLUSION:Esophageal tumor length assessed using CT does not reflect pathological tumor extent and should not be the only modality used for management decisions,particularly for planning radiotherapy. | Karim Sillah Luke R Williams Hans-Ulrich Laasch Azeem Saleem Gillian Watkins Susan A Pritchard Patricia M Price Catharine M West Ian M Welch | 2010 | World Journal of Gastrointestinal Oncology2010，2，4： | 10 |
| 3 | FRP加强R/C梁防火性能调查研究(英文)显示文摘对纤维加强聚合物(FRP)材料加强钢筋混凝土梁在火灾中的防火性能进行了研究。试验结果显示,防火材料能够帮助构件达到标准防火性能,同时对不断增长的FRP应用也很重要。介绍了不同文献对FRP在高温下的性能所做的研究以及目前标准对建筑构件的耐火极限要求。对两个大型试验进行了介绍。试验材料为混凝土梁构件,外部用FRP板加强,并且三分之二用专利耐火隔热材料保护。给出了试验结果,并重点强调了曝火状态下所测得的构件温度。试验数据验证了热传导数值模型,该模型可用于预测加强并绝缘钢筋混凝土梁构件内的温度。试验结果和模型数据显示,正确设计和进行绝缘保护的FRP加强梁构件耐火极限能够达到4h或者以上。 | BREA WILLIAMS LUKE BISBY VENKATESH KODUR JOSEPH SU MARK GREEN | 2007 | 消防科学与技术2007，26，5： | 2 |
| 4 | Simulation of the performance of electrical capacitance tomography for muasurement of dense phase pneumatic conveying显示文摘 | K L Ostrowski S P Luke R A Williams | 1997 | Chemical Engineering Journal1997，，6： | 1 |
| 5 | The iPod and the Bathtub:managing perceptions through design language显示文摘 | Luke Williams | 2005 | Frogdesign2005，3，9： | 1 |
| 6 | Industrial applications of electrical tomography to solid conveying显示文摘 | LUKE S P WILLIAMS R A | 1997 | Measurement & Control1997，，30： | 1 |
| 7 | 动态预涂层在CE联用技术中的应用显示文摘毛细管电泳与传统分离方法相比,具有分析时间短、分辨率高、样品/缓冲液用量少、易于自动化、功能多样性等优点。尽管如此,毛细管电泳在分析领域仍未能展现出全部的潜力。这是由于在大多数要求比较苛刻的实际应用中,毛细管电泳难以获得较高的重现性。本文对该问题进行了阐述,并提出了一个很有前途的解决方法。 | William W.P. Chang Christine Hobson David C. Bomberger Luke V. Schneider | 2007 | 生命科学仪器2007，5，2： | 1 |
| 8 | 20S-Protopanaxadiol Inhibits P-Glycoprotein in Multidrug Resistant Cancer Cells显示文摘 | Yan Zhao Luke Bu Hang Yan William Jia | 2009 | Planta Med2009，，10： | 1 |
| 9 | Human rhinovirus C: Age, season, and lower respiratory illness over the past 3 decades显示文摘 | Jodell E. Linder David C. Kraft Yassir Mohamed Zengqi Lu Luke Heil Sharon Tollefson Benjamin R. Saville Peter F. Wright John V. Williams E. Kathryn Miller | 2013 | The Journal of Allergy and Clinical Immunology2013，，1： | 1 |
| 10 | Endoscopic Mucosal Resection Outcomes and Prediction of Submucosal Cancer From Advanced Colonic Mucosal Neoplasia显示文摘 | Alan Moss Michael J. Bourke Stephen J. Williams Luke F. Hourigan Gregor Brown William Tam Rajvinder Singh Simon Zanati Robert Y. Chen Karen Byth | 2011 | Gastroenterology2011，，7： | 1 |
| 11 | Real-time PCR detectionof salmonella in suspect foods from a gastroenteritis outbreak inken county,texas显示文摘 | Luke T D William J B Kentonll | 2002 | Jounral of Cilnical Microbiology2002，40，8： | 1 |
| 12 | Simulation of the performance of electrical capacitance tomography for measurement of dense phase pneumatic conveying显示文摘 | OSTROWSKI K L LUKE S P WILLIAMS R A | 1997 | Chemical Engineering Journal1997，68，23： | 1 |
| 13 | Application of conjugate harmonics to electrical process tomography 显示文摘 | Ostrowski K L Luke S P Williams R A | 1996 | Meas Sci Technol1996，7，： | 1 |
| 14 | Simulation of the performance of electrical capacitance tomography for measurement of dense phase pneumatic conveying 显示文摘 | OSTROWSKI K L LUKE S P WILLIAMS R A | 1997 | Chemical Engineering Journal1997，6，： | 1 |
| 15 | Simulation of the performance of electrical capacitance topography for measurement of dense phase pneumatic conveying显示文摘 | OSTROWSKI K L LUKE S P WILLIAMS R A | 1997 | Chemical Engineering Journal1997，68，23： | 1 |
| 16 | Elevation of Transgene Expression Level by Flanking Matrix Attachment Regions (MAR) is Promoter Dependent: A Study of the Interactions of Six Promoters with the RB7 3′ MAR显示文摘 | S. Luke Mankin George C. Allen Thomas Phelan Steven Spiker William F. Thompson | 2003 | Transgenic Research2003，，1： | 1 |
| 17 | The glial glutamate transporter, GLT‐1, is oxidatively modified by 4‐hydroxy‐2‐nonenal in the Alzheimer’s disease brain: the role of Aβ1–42显示文摘 | Christopher M.Lauderback Janna M.Hackett Feng F.Huang Jeffrey N.Keller Luke I.Szweda William R.Markesbery D. AllanButterfield | 2001 | Journal of Neurochemistry2001，，2： | 1 |
| 18 | Real-time PCR detection of salmonella in suspend food from a gastroenter- itis outbreak in kerr county,texas 显示文摘 | Luke T D William J B Kenton L L | 2002 | Journal of Clinical Microbiology2002，40，8： | 1 |
| 19 | Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3显示文摘 | Jason D. Fontenot Jeffrey P. Rasmussen Luke M. Williams James L. Dooley Andrew G. Farr Alexander Y. Rudensky | 2005 | Immunity2005，，3： | 1 |
| 20 | Fire Endurance of Fiber-Reinforced Polymer Strengthened Concrete T-Beams显示文摘 | Williams Brea Kodur Venkatesh Green Mark F Bisby Luke | 2008 | ACI Structural Journal2008，，1： | 1 |
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