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| 1 | Developing the Science Product Algorithm Testbed for Chinese Next-Generation Geostationary Meteorological Satellites:Fengyun-4 Series显示文摘Fengyun-4A(FY-4A), the first of the Chinese next-generation geostationary meteorological satellites, launched in2016, offers several advances over the FY-2: more spectral bands, faster imaging, and infrared hyperspectral measurements. To support the major objective of developing the prototypes of FY-4 science algorithms, two science product algorithm testbeds for imagers and sounders have been developed by the scientists in the FY-4 Algorithm Working Group(AWG). Both testbeds, written in FORTRAN and C programming languages for Linux or UNIX systems, have been tested successfully by using Intel/g compilers. Some important FY-4 science products, including cloud mask, cloud properties, and temperature profiles, have been retrieved successfully through using a proxy imager, Himawari-8/Advanced Himawari Imager(AHI), and sounder data, obtained from the Atmospheric Infra Red Sounder, thus demonstrating their robustness. In addition, in early 2016, the FY-4 AWG was developed based on the imager testbed—a near real-time processing system for Himawari-8/AHI data for use by Chinese weather forecasters.Consequently, robust and flexible science product algorithm testbeds have provided essential and productive tools for popularizing FY-4 data and developing substantial improvements in FY-4 products. | Min MIN Chunqiang WU Chuan LI Hui LIU Na XU Xiao WU Lin CHEN Fu WANG Fenglin SUN Danyu QIN Xi WANG Bo LI Zhaojun ZHENG Guangzhen CAO Lixin DONG | 2017 | Journal of Meteorological Research2017，31，4： | 35 |
| 2 | Characterization of personal exposure concentration of fine particles for adults and children exposed to high ambient concentrations in Beijing, China显示文摘In China, the health risk from overexposure to particles is becoming an important public health concern. To investigate daily exposure characteristics to PM 2.5 with high ambient concentration in urban area, a personal exposure study was conducted for school children, and office workers in Beijing, China. For all participants (N = 114), the mean personal 24-hr exposure concentration was 102.5, 14.7, 0.093, 0.528, 0.934, 0.174 and 0.703 μg/m 3 for PM 2.5 , black carbon, Mn, Al, Ca, Pb, and Fe. Children's exposure concentrations of PM 2.5 were 4-5 times higher than those in related studies. The ambient concentration of PM 2.5 (128.5 μg/m 3 ) was significantly higher than the personal exposure concentration (P < 0.05), and exceed the reference concentration (25 μg/m 3 ) of WHO air quality guideline. Good correlation relationships and significant differences were identified between ambient concentration and personal exposure concentration. The relationships indicate that the ambient concentration is the main factor influencing personal exposure concentration, but is not a good indicator of personal exposure concentration. Outdoor activities (commute mode, exposure to heating, workday or weekend travel) influenced personal exposure concentrations significantly, but the magnitude of the influence from indoor activities (exposure to cooking) was masked by the high ambient concentrations. | Xuan Du Qian Kong Weihua Ge Shaojun Zhang Lixin Fu | 2010 | Journal of Environmental Sciences2010，22，11： | 24 |
| 3 | CO2 hydrogenation to methanol over Cu/CeO2 and Cu/ZrO2 catalysts:Tuning methanol selectivity via metal-support interaction显示文摘Copper-based catalysts for CO2 hydrogenation to methanol are supported on ZrO2 and CeO2,respectively.Reaction results at 3.0 MPa and temperatures between 200 and 300°C reveal that Cu catalysts supported on ZrO2 and CeO2 exhibit better activity and selectivity than pure Cu catalyst due to Cu-support(ZrO2 and CeO2)interaction.Combining the structural characterizations with in-situ diffuse reflectance infrared Fourier transform spectroscopy(in-situ DRIFTS),Cu/CeO2 shows the higher methanol selectivity due to the formation of main carbonates intermediates,which are closely related with the oxygen vacancies over Cu/CeO2.In contrast,bicarbonate and carboxyl species are observed on Cu/ZrO2,which originates from the hydroxyl groups presented on catalyst surfaces.Difference in CO2 adsorption intermediates results in the distinct methanol selectivity over the two catalysts. | Weiwei Wang Zhenping Qu Lixin Song Qiang Fu | 2020 | Journal of Energy Chemistry2020，29，1： | 11 |
| 4 | Interrogation of Streptomyces avermitilis for efficient production of avermectins显示文摘The 2015 Nobel Prize in Physiology or Medicine has been awarded to avermectins and artemisinin,respectively.Avermectins produced by Streptomyces avermitilis are excellent anthelmintic and potential antibiotic agents.Because wild-type strains only produce low levels of avermectins,much research effort has focused on improvements in avermectin production to meet the ever increasing demand for such compounds.This review describes the strategies that have been widely employed and the future prospects of synthetic biology applications in avermectin yield improvement.With the help of genome sequencing of S.avermitilis and an understanding of the avermectin biosynthetic/regulatory pathways,synthetic and systems biotechnology approaches have been applied for precision engineering.We focus on the design and synthesis of biological chassis,parts,devices,and modules from diverse microbes to reconstruct and optimize their dynamic processes,as well as predict favorable effective overproduction of avermectins by a 4Ms strategy(Mine,Model,Manipulation,and Measurement). | Jinsong Chen Mei Liu Xueting Liu Jin Miao Chengzhang Fu Heyong Gao Rolf Muller Qing Zhang Lixin Zhang | 2016 | Synthetic and Systems Biotechnology2016，1，1： | 10 |
| 5 | Inactivation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea显示文摘Erythromycin A is a widely used antibiotic produced by Saccharopolyspora erythraea;however,its biosynthetic cluster lacks a regulatory gene,limiting the yield enhancement via regulation engineering of S.erythraea.Herein,six TetR family transcriptional regulators(TFRs)belonging to three genomic context types were individually inactivated in S.erythraea A226,and one of them,SACE_3446,was proved to play a negative role in regulating erythromycin biosynthesis.EMSA and qRT-PCR analysis revealed that SACE_3446 covering intact N-terminal DNA binding domain specifically bound to the promoter regions of erythromycin biosynthetic gene eryAI,the resistant gene ermE and the adjacent gene SACE_3447(encoding a longchain fatty-acid CoA ligase),and repressed their transcription.Furthermore,we explored the interaction relationships of SACE_3446 and previously identified TFRs(SACE_3986 and SACE_7301)associated with erythromycin production.Given demonstrated relatively independent regulation mode of SACE_3446 and SACE_3986 in erythromycin biosynthesis,we individually and concomitantly inactivated them in an industrial S.erythraea WB.Compared with WB,the WBΔ3446 and WBΔ3446Δ3986 mutants respectively displayed 36%and 65%yield enhancement of erythromycin A,following significantly elevated transcription of eryAI and ermE.When cultured in a 5 L fermentor,erythromycin A ofWBΔ3446 and WBΔ3446Δ3986 successively reached 4095 mg/L and 4670 mg/L with 23%and 41%production improvement relative to WB.The strategy reported here will be useful to improve antibiotics production in other industrial actinomycete. | Hang Wu Yansheng Wang Li Yuan Yongrong Mao Weiwei Wang Lin Zhu Panpan Wu Chengzhang Fu Rolf Muller David T.Weaver Lixin Zhang Buchang Zhang | 2016 | Synthetic and Systems Biotechnology2016，1，1： | 7 |
| 6 | Integrating full-length transcriptomics and metabolomics reveals the regulatory mechanisms underlying yellow pigmentation in tree peony(Paeonia suffruticosa Andr.)flowers显示文摘Tree peony(Paeonia suffruticosa Andr.)is a popular ornamental plant in China due to its showy and colorful flowers.However,yellow-colored flowers are rare in both wild species and domesticated cultivars.The molecular mechanisms underlying yellow pigmentation remain poorly understood.Here,petal tissues of two tree peony cultivars,“High Noon”(yellow flowers)and“Roufurong”(purple–red flowers),were sampled at five developmental stages(S1–S5)from early flower buds to full blooms.Five petal color indices(brightness,redness,yellowness,chroma,and hue angle)and the contents of ten different flavonoids were determined.Compared to“Roufurong,”which accumulated abundant anthocyanins at S3–S5,the yellow-colored“High Noon”displayed relatively higher contents of tetrahydroxychalcone(THC),flavones,and flavonols but no anthocyanin production.The contents of THC,flavones,and flavonols in“High Noon”peaked at S3 and dropped gradually as the flower bloomed,consistent with the color index patterns.Furthermore,RNA-seq analyses at S3 showed that structural genes such as PsC4Hs,PsDFRs,and PsUFGTs in the flavonoid biosynthesis pathway were downregulated in“High Noon,”whereas most PsFLSs,PsF3Hs,and PsF3’Hs were upregulated.Five transcription factor(TF)genes related to flavonoid biosynthesis were also upregulated in“High Noon.”One of these TFs,PsMYB111,was overexpressed in tobacco,which led to increased flavonols but decreased anthocyanins.Dual-luciferase assays further confirmed that PsMYB111 upregulated PsFLS.These results improve our understanding of yellow pigmentation in tree peony and provide a guide for future molecular-assisted breeding experiments in tree peony with novel flower colors. | Xiaoning Luo Daoyang Sun Shu Wang Sha Luo Yaqi Fu Lixin Niu Qianqian Shi Yanlong Zhang | 2021 | Horticulture Research2021，8，1： | 5 |
| 7 | Clinical and pathological features of miR-10b and RHOC gene expression in hepatocellular carcinoma显示文摘Aberrant expression of microRNAs(miRNAs)was reported frequently in different human cancers.The major role of miRNA is targeting 30-UTR of coding gene and causing translational repression or mRNA degradation.miR-10b overexpression was reported to promote breast cancer metastasis by up-regulating RHOC expression.But its expression in hepatocellular carcinoma(HCC)remains unclear.Our study indicated that the expression of miR-10b was different in HCC and adjacent tissue samples,and reduced expression of miR-10b in HCC was related tovein invasion.High-level expression of RHOC was also related to vein invasion in HCC.But no correlation was found between miR-10b and RHOC expression.These results suggest that miR-10b and RHOC are independent predictors of HCC invasion and metastasis. | Jingli Du Yulan Wang Hanjiang Fu Xiaofei Zheng Minggui Lin Mingzhou Guo Lixin Wei | 2014 | Chinese Science Bulletin2014，59，19： | 4 |
| 8 | Evaluating the emission status of light-duty gasoline vehicles and motorcycles in Macao with real-world remote sensing measurement显示文摘Roadside remote sensing measurement was used to explore the real-world emission status of light duty gasoline vehicles(LDGVs) and motorcycles in Macao. Both fuel-based and distance-based emission factors were derived using the mass balance method. The emission concentration profile of LDGVs illustrated the benefits of tightening emission standards at the source country or region of import. The distance-based emission factors for CO, HC and NOx of LDGVs registered before 2000 were 8.00, 1.04 and 1.36 g/km,respectively. The distance-based emission factors for CO, HC and NOx of LDGVs registered in or after 2000 were 1.16, 0.15 and 0.18 g/km, respectively. The fuel-based CO emission factors of light duty motorcycles(LDMCs) and heavy duty motorcycles(HDMCs) registered before 2000 were about 10 times higher than those of LDGVs of the same age group. As the emissions of LDGVs decreased more quickly after 2000, the gap widens for newer vehicles.The distance-based HC emission factors of LDMCs and HDMCs registered before 2000 were4.81 and 2.91 g/km, respectively. The distance-based HC emission factors of LDMCs and HDMCs registered in or after 2000 were 3.52 and 0.93 g/km, respectively. The poor emission performance of motorcycles and their larger share in the traffic flow will cause them to be the major contributor to traffic CO and HC emissions. LDMCs, especially two-stroke models,should be the priority for vehicle emission control efforts in Macao. | Yu Zhou Ye Wu Shaojun Zhang Lixin Fu Jiming Hao | 2014 | Journal of Environmental Sciences2014，26，11： | 3 |
| 9 | Anthropogenic emissions of non-methane volatile organic compounds in China显示文摘 | Zbigniew Klimont David G. Streets Shalini Gupta Janusz Cofala Fu Lixin Yoichi Ichikawa | 2002 | Atmospheric Environment2002，，8： | 2 |
| 10 | The impact of transportation control measures on emission reductions during the 2008 Olympic Games in Beijing, China显示文摘 | Yu Zhou Ye Wu Liu Yang Lixin Fu Kebin He Shuxiao Wang Jiming Hao Jinchuan Chen Chunyan Li | 2009 | Atmospheric Environment2009，，3： | 2 |
| 11 | Photosynthesis of Populus euphratica and its response to elevated CO_2 concentration in an arid environment显示文摘The photosynthetic characterization of Populus euphratica and its response to the elevated carbon dioxide concentration ([CO2]) were analyzed based on its net photosynthetic rate (Pn), stomatal conductance (gs), intercellular CO2 concentration (Ci), transpiration rate (Tr), and water use effciency (WUE) at different groundwater depths measured by a portable gas exchange system (LI-6400) in the lower reaches of the Tarim River. The results showed that the elevation of [CO2] decreased the gs, and increased the Pn, Ci and WUE of P. euphratica. However, the effects of the elevated [CO2] on gs, Pn, Ci and WUE varied considerably with groundwater depth. The response of photosynthesis to rising [CO2] was stronger at the greater groundwater depth (more than 6 m) than that at the shallower groundwater depth (less than 6 m). The critical groundwater depth required to maintain the normal survival of P. euphratica was less than 6 m. When the groundwater depth increased to more than 6 m, P. euphratica encountered moderate water stress, and the plant suffered severe water stress when the groundwater depth increased to more than 7 m. | Honghua Zhou Yaning Chen Weihong Li Yapeng Chen Lixin Fu | 2009 | Progress in Natural Science:Materials International2009，19，4： | 2 |
| 12 | A LIL for independent non-identically distributed random variables in Banach space and its applications显示文摘In this paper,we prove a general law of the iterated logarithm (LIL) for independent non-identically distributed B-valued random variables.As an interesting application,we obtain the law of the iterated logarithm for the empirical covariance of Hilbertian autoregressive processes. | LIU WeiDong FU KeAng ZHANG LiXin | 2008 | Science China Mathematics2008，51，2： | 2 |
| 13 | An investigation of Zr/Ce ratio influencing the catalytic performance of CuO/Ce1-xZrxO2 catalyst for CO2 hydrogenation to CH3OH显示文摘A series of CuO/Ce1-xZrxO2 catalysts(x=0.2,0.4,0.6 and 0.8)are applied to elaborate the effect of the Zr/Ce ratio on the catalytic performance of CO2 hydrogenation to CH3OH.The best catalytic performance is achieved with CuO/Ce0.4Zr0.6O2,exhibiting XCO2=13.2%and YCH3OH=9.47%(T=280℃,P=3 MPa).The formation of dispersed surface CuO species and larger number of oxygen vacancies are detected over CuO/Ce0.4Zr0.6O2 due to stronger interaction between CuO and Ce0.4Zr0.6O2,resulting in the superior activation ability for H2 and CO2 respectively.Additionally,the evidence is provided by in situ DRIFTS under the activity test pressure(3 MPa)that bi/m-HCOO* species are preferable for accumulating over ceria-rich(CuO/Ce0.6Zr0.4O2 and CuO/Ce0.8Zr0.2O2)catalysts while zirconia-rich(CuO/Ce0.4Zr0.6O2 and CuO/Ce0.2Zr0.8O2)catalysts are benefit to encourage the transformation of bi/m-HCOO* species to CH3OH.The abundant population and high activity of intermediate species over CuO/Ce0.4Zr0.6O2 give a strong positive effect on the catalytic performance. | Weiwei Wang Zhenping Qu Lixin Song Qiang Fu | 2020 | Journal of Energy Chemistry2020，29，8： | 2 |
| 14 | CO_(2)hydrogenation to methanol promoted by Cu and metastable tetragonal Ce_(x)Zr_(y)O_(z) interface显示文摘Designing effective catalyst to improve the activity of CO_(2) hydrogenation to methanol is a potential avenue to realize the utilization of CO_(2) resources. Herein we construct three kinds of Cu/Ce_(x)Zr_(y)O_(z)(CCZ) catalysts with different crystal phases of Ce_(x)Zr_(y)O_(z)solid solutions, which demonstrate distinct activity and methanol selectivity in the order of metastable tetragonal-CCZ(CCZ-t’’, parts of oxygen in Ce_(x)Zr_(y)O_(z) were replaced by tetragonal phase from cubic fluorite phase) > tetragonal-CCZ(CCZ-t) > cubic-CCZ(CCZ-c) for CO_(2) hydrogenation to methanol. Structural analysis reveals that oxygen vacancies, surface hydroxyls and unsaturated Cu species of CCZ all follow the same sequence as that of activity and methanol selectivity,indicating that the above features are beneficial to improve the catalytic reaction performance.Temperature programmed experiments and mechanism studies show that the interface between Cu and tetragonal(t and t’’) Ce_(x)Zr_(y)O_(z) can promote CO_(2) adsorption, and the adsorbed CO_(2) is more reactive and can generate active bidentate carbonate species, which can be hydrogenated to form active monodentate and bidentate formate species under CO_(2) and H_(2) atmosphere. These intermediates should be crucial to the formation of methanol product. CCZ-t’’has stronger H_(2) activation ability than CCZ-t, which makes the former catalyst have more intermediates and higher methanol selectivity. In contrast, CO_(2) mainly adsorbs on cubic Ce_(x)Zr_(y)O_(z) support of CCZ-c, but its H_(2) spillover ability is low, which hinders the reaction process. In addition, the strong adsorption of surface intermediates on CCZ-c is also not conducive to methanol formation. Results here demonstrate that constructing active Cu-support interfaces may be an important approach to design effective catalyst for CO_(2)hydrogenation. | Na Li Weiwei Wang Lixin Song Hui Wang Qiang Fu Zhenping Qu | 2022 | Journal of Energy Chemistry2022，31，5： | 2 |
| 15 | Application of a LRT Model to Acid Rain Control in China显示文摘 | Jiming Hao Lei Duan Xuelong Zhou Lixin Fu | 2001 | Environmental Science&Technology2001，35，34： | 1 |
| 16 | CO2and pollutant emissions from passenger cars in China显示文摘 | Wang Haikun Fu Lixin Bi Jun | 2011 | Energy Policy2011，39，3： | 1 |
| 17 | Characterization of commercial Cu-SSZ-13 and Cu-SAPO-34 catalysts with hydrothermal treatment for NH 3 -SCR of NO x in diesel exhaust显示文摘 | Lei Ma Yisun Cheng Giovanni Cavataio Robert W. McCabe Lixin Fu Junhua Li | 2013 | Chemical Engineering Journal2013，，： | 1 |
| 18 | Trends in vehicular emissions in China's mega cities from 1995 to 2005 显示文摘 | WANG Haikun FU Lixin ZHOU Yu | 2010 | Environmental Pollution2010，158，2： | 1 |
| 19 | On-road vehicle emission inventory and its uncertainty analysis for Shanghai, China显示文摘 | Haikun Wang Changhong Chen Cheng Huang Lixin Fu | 2008 | Science of the Total Environment2008，，1： | 1 |
| 20 | Specific cross-dimerization of terminal alkynes via Pd/TMEDA catalysis显示文摘The cross-dimerization of terminal alkynes is the most straightforward and attractive approach to differently substituted 1,3-enynes,which are vital structural motifs in natural products,biologically active compounds,and organic functional materials,etc.However,due to the inherent issues of the stereo-,regio-,and chemoselectivity,the strategy is less explored and remains problematic in substrate scope,selectivity,and screening of catalytic system,etc.Herein,a specific cross-dimerization of terminal alkynes is developed under Pd/TMEDA catalysis,which produces a series of gem-1,3-enynes(58 examples)in totally moderate to high yields with outstanding functional group tolerance.A cyclopalladium compound might be the key imtermediate,which performs anti-addition-carbometallation,and leads to the exclusive cross-selectivity.The unprecedented features of the reaction,such as anti-addition-carbometallation,easy control of selectivity,wide range of the donor alkynes,and very simple catalytic conditions,allow it not only a facile and functionally diverse synthesis of 1,3-enynes,but also a substantial progress for the textbook reaction. | Lixin Liu Jianyu Dong Zuqi Fu Lebin Su Shaofeng Wu Qian Shang Shuang-Feng Yin Yongbo Zhou | 2022 | Science China Chemistry2022，65，12： | 1 |
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