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| 1 | Biostratigraphy of Triassic Marine Reptiles in Southwest Guizhou and Its Adjacent Area显示文摘This paper briefly reviews the Triassic marine reptile fossils inGuizhou Province, especially the fossils that have been recently found in the Guanling area. Based on three sections at Guanling and Xingyi, Guizhou Province and Luoping, Yunnan Province, four horizons with vertebrate fossils are recognized in the Middle and Upper Triassic of this area; They are from bottom to top: Member I and Member Ⅱ of the Guanling Formation, and the Zhuganpo Member and the Wayao Member of the Falang Formation. | WANG Liting, LI Jinling, WANG Xinjin, LI Chun,WU Tianzhuang and LIU Jun Bureau of Geology and Mineral Exploration and Development of Guizhou ProvinceGuiyang 550004 Institute of Vertebrate Palaeontology and Palaeoanthropology,Chinese Academy of Sciences, Beijing 100044 Guizhou Museum, Guiyang 550004 | 2001 | Acta Geologica Sinica(English Edition)2001，75，4： | 17 |
| 2 | NLRP3-dependent pyroptosis is required for HIV-1 gp120- induced neuropathology显示文摘The human immunodeficiency virus-1(HIV-1)envelope protein gp120 is the major contributor to the pathogenesis of HIVassociated neurocognitive disorder(HAND).Neuroinflammation plays a pivotal role in gp120-induced neuropathology,but how gp120 triggers neuroinflammatory processes and subsequent neuronal death remains unknown.Here,we provide evidence that NLRP3 is required for gp120-induced neuroinflammation and neuropathy.Our results showed that gp120-induced NLRP3-dependent pyroptosis and IL-1βproduction in microglia.Inhibition of microglial NLRP3 inflammasome activation alleviated gp120-mediated neuroinflammatory factor release and neuronal injury.Importantly,we showed that chronic administration of MCC950,a novel selective NLRP3 inhibitor,to gp120 transgenic mice not only attenuated neuroinflammation and neuronal death but also promoted neuronal regeneration and restored the impaired neurocognitive function.In conclusion,our data revealed that the NLRP3 inflammasome is important for gp120-induced neuroinflammation and neuropathology and suggest that NLRP3 is a potential novel target for the treatment of HAND. | Xiaolong He Weijun Yang Zhijie Zeng Yi Wei Jie Gao Bao Zhang Li Li Liqun Liu Yu Wan Qing Zeng Zelong Gong Liting Liu Hanyun Zhang Yubin Li Shaojie Yang Tongtong Hu Lixian Wu Eliezer Masliah Shenghe Huang Hong Cao | 2020 | Cellular & Molecular Immunology2020，17，3： | 11 |
| 3 | Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice显示文摘Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse Col1 a1-Cre transgene minimally impacts bone mass in mice, but deleting Kindlin-2 using the 10-kb mouse Dmp1-Cre transgene, which targets osteocytes and mature osteoblasts, results in striking osteopenia in mice. Kindlin-2 loss reduces the osteoblastic population but increases the osteoclastic and adipocytic populations in the bone microenvironment. Kindlin-2 loss upregulates sclerostin in osteocytes,downregulates β-catenin in osteoblasts, and inhibits osteoblast formation and differentiation in vitro and in vivo. Upregulation ofβ-catenin in the mutant cells reverses the osteopenia induced by Kindlin-2 deficiency. Kindlin-2 loss additionally increases the expression of RANKL in osteocytes and increases osteoclast formation and bone resorption. Kindlin-2 deletion in osteocytes promotes osteoclast formation in osteocyte/bone marrow monocyte cocultures, which is significantly blocked by an anti-RANKLneutralizing antibody. Finally, Kindlin-2 loss increases osteocyte apoptosis and impairs osteocyte spreading and dendrite formation.Thus, we demonstrate an important role of Kindlin-2 in the regulation of bone homeostasis and provide a potential target for the treatment of metabolic bone diseases. | Huiling Cao Qinnan Yan Dong Wang Yumei Lai Bo Zhou Qi Zhang Wenfei Jin Simin Lin Yiming Lei Liting Ma Yuxi Guo Yishu Wang Yilin Wang Xiaochun Bai Chuanju Liu Jian QFeng Chuanyue Wu Di Chen Xu Cao Guozhi Xiao | 2020 | Bone Research2020，8，1： | 8 |
| 4 | Restudy of the storage and migration model of the Quaternary groundwater in Beijing Plain area显示文摘Through a wide-spread groundwater sampling mainly at nested monitoring wells in the Beijing Plain area,combined with data collection,the study analyzes water level,hydrochemistry,temperature,tritium,deuterium,18O,14C and other aspects,and indicates that there exits an obvious stratification phenomenon of the groundwater in the alluvial plain area down in the middle part of alluvial-pluvial fans,and the hydraulic connection between layers is very weak.The analysis of the tritium concentration suggests that the average influence depth of the modern precipitation is approximately 120m.Based on the analysis of the 22 paleowater samples through the D18O method and 14C isotopic dating,the deep groundwater circulation in the fine sediments area of Beijing Plain down in the fringe part of alluvial-pluvial fans is relatively slow.On average the paleowater point occurs approximately below the 180m at these points.The main reasons for the formation of stratification and paleowater points are the water-blocking effect of the clay type strata and the compaction effect during the sedimentary process,especially the differential compaction,which could form closed or relatively closed stagnant aquifers.Groundwater in this kind of stagnant aquifers to some degree belongs to non-renewable resource,and should be reconsidered and re-arranged in the water resources management strategy. | LIU YuanZhang WU Qiang LIN Pei LIU JiuRong XING LiTing GAO ZhiHui | 2012 | Science China Earth Sciences2012，55，7： | 7 |
| 5 | Self‑Assembly MXene‑rGO/CoNi Film with Massive Continuous Heterointerfaces and Enhanced Magnetic Coupling for Superior Microwave Absorber显示文摘MXene, as a rising star of two-dimensional(2 D) materials, has been widely applied in fields of microwave absorption and electromagnetic shielding to cope with the arrival of the 5 G era. However, challenges arise due to the excessively high permittivity and the difficulty of surface modification of few-layered MXenes severely, which infect the microwave absorption performance. Herein, for the first time, a carefully designed and optimized electrostatic selfassembly strategy to fabricate magnetized MXene-r GO/Co Ni film was reported. Inside the synthesized composite film, r GO nanosheets decorated with highly dispersed Co Ni nanoparticles are interclacted into MXene layers, which effectively suppresses the originally self-restacked of MXene nanosheets, resulting in a reduction of high permittivity. In addition, owing to the strong magnetic coupling between the magnetic Fe Co alloy nanoparticles on the r GO substrate, the entire MXener GO/Co Ni film exhibits a strong magnetic loss capability. Moreover, the local dielectric polarized fields exist at the continuous heterointerfaces between 2 D MXene and r GO further improve the capacity of microwave loss. Hence, the synthesized composite film exhibits excellent microwave absorption property with a maximum reflection loss value of-54.1 d B at 13.28 GHz. The electromagnetic synergy strategy is expected to guide future exploration of high-efficiency MXene-based microwave absorption materials. | Xiao Li Zhengchen Wu Wenbin You Liting Yang Renchao Che | 2022 | Nano-Micro Letters2022，14，5： | 4 |
| 6 | Cell Membrane-camouflaged Multi-functional Dendritic Large Pore Mesoporous Silica Nanoparticles for Combined Photothermal Therapy and Radiotherapy of Cancer显示文摘Combining photothermal therapy and radiotherapy(PTT-RT) with reducing tumor hypoxia acts as an important antitumor modality. However, it is a great challenge to realize photothermal therapy, radiotherapy and exogenous oxygen supply in one nanosystem. To realize a combination of the three functions, we fabricated a red blood cell membrane(RBCm)-camouflaged, red blood cell content(RBCc) and the copper sulfide(CuS) co-loaded dendritic large pore mesoporous silica nanoparticle(DLMSN/CuS/RBCc/ RBCm). The cell membrane coating endowed the nanoparticles with good stability in the physiological environment, and CuS allowed the nanoparticle exhibiting good photothermal and radiosensitization properties. RBCc loaded nanoparticle DLMSN/CuS/RBCc enhanced superior anti-tumor effect than DLMSN/CuS during combined PTT-RT therapy because the introduction of RBCc increased the exogenous oxygen supply. The in vitro study further demonstrated that the combination of photothermal therapy and radiotherapy induced superior antitumor efficacy than single therapy. Our work thus presents a unique multifunctional nanoscale platform favorable for combined PTT and RT. | WU Liting XIN Yujia GUO Zhaoyang GAO Wei ZHU Yanpeng WANG Yinsong RAN Ruixue YANG Xiaoying | 2022 | Chemical Research in Chinese Universities2022，38，2： | 1 |
| 7 | Building the Chordata Olfactory Receptor Database using more than 400,000 receptors annotated by Genome2OR显示文摘Olfactory receptors are poorly annotated for most genome-sequenced chordates.To address this deficiency,we developed a nhmmer-based olfactory receptor annotation tool Genome2OR(http://gffzz188fe103f8f1460as9bbqb9nwwuun6u9b.ffgz.tsg.suse.edu.cn/To Hanwei/Genome2OR.git),and used it to process 1,695 sequenced chordate genomes in the NCBI Assembly database as of January,2021.In total,765,248 olfactory receptor genes were annotated,with 404,426 functional genes and 360,822 pseudogenes,which represents a four-fold increase in the number of annotated olfactory receptors.Based on the annotation data,we built a database called Chordata Olfactory Receptor Database(CORD,http://gffzz608a37c433994787s9bbqb9nwwuun6u9b.ffgz.tsg.suse.edu.cn)for archiving,analysing and disseminating the data.Beyond the primary data,we offer derivative information,including pictures of species,cross references to public databases,structural models,sequence similarity networks and sequence profiles in the CORD.Furthermore,we did brief analyses on these receptors,including building a huge protein sequence similarity network covering all receptors in the database,and clustering them into 20 communities,classifying the 20 communities into three categories based on their presences/absences in ray-finned fish and/or lobe-finned fish.We infer that olfactory receptors should have unique activation and desensitization mechanisms by analysing their sequences and structural models.We believe the CORD can benefit the researchers and the general public who are interested in olfaction. | Wei Han Yiran Wu Liting Zeng Suwen Zhao | 2022 | Science China(Life Sciences)2022，65，12： | 1 |
| 8 | Thermal and mechanical properties of epoxy resin toughened with epoxidized soybean oil显示文摘 | Chen Yan Yang Liting Wu Jiahui | 2013 | Journal of Thermal Analysis and Calorimetor2013，113，2： | 1 |
| 9 | Facile synthesis of CoFe_2O_4 nanoparticles anchored on graphene sheets for enhanced performance of lithium ion battery显示文摘Recently, metal oxides as high capacity anode materials had been investigated for lithium ion batteries.However, the fast capacity fading upon cycling leaded poor durability, which hindered their application as higher energy density of lithium ion battery. In this paper, a nanostructured nanocomposite with graphene supported CoFe_2O_4 nanoparticles(NPs) was prepared via simple hydrothermal reaction. The uniform CoFe_2O_4 NPs were anchored on graphene sheets, which brought a good performance on cyclability. Combined with the optimization of graphene content, the anode delivered a better capacity retention of 944 m A h g^(-1)over 50 cycles at current density of 100 m A g^(-1)and the good reversible capacity as 990 m A h g^(-1)when the rate returned from 5 A g^(-1)to 0.1 A g^(-1)after 60 cycles. The present work provided a desired structure for conversion anode materials or other electrode materials of large volume change. | Wen Qi Pei Li Ying Wu Hong Zeng Liting Hou Chunjiang Kuang Pei Yao Shaoxiong Zhou | 2016 | Progress in Natural Science:Materials International2016，26，5： | 1 |
| 10 | Development of an antigen-capture ELISA for the detection of avian leukosis virus p27 antigen显示文摘 | Bingling Yun Delong Li Haibo Zhu Wen Liu Liting Qin Zaisi Liu Guan Wu Yongqiang Wang Xiaole Qi Honglei Gao Xiaomei Wang Yulong Gao | 2013 | Journal of Virological Methods2013，，2： | 1 |
| 11 | Directed orthogonal self-assembly of homochiral coordination polymers for heterogeneous enantioselective hydrogenation显示文摘 | Yu Liting Wang Zheng Wu Jiang | 2010 | Angew Chem Int Ed2010，49，： | 1 |
| 12 | Chitosan disrupts Penicillium expansum and controls postharvest blue mold of jujube fruit显示文摘 | Liting Wang Hao Wu Guozheng Qin Xianghong Meng | 2014 | Food Control2014，，： | 1 |
| 13 | Effect of Roucongrong(Herba Cistanches Deserticolae) decoction on the substantia nigra through Wnt/β-catenin signaling pathway in rats with Parkinson's disease induced by 6-hydroxydopamine hydrochloride显示文摘OBJECTIVE:To investigate the effect of Roucongrong(Herba Cistanches Deserticolae)decoction on the substantia nigra in rats with Parkinson’s disease(PD)induced by 6-hydroxydopamine hydrochloride(6-OHDA).To further determine whether the Wnt/β-catenin signaling pathway is involved in the action.METHODS:A rat model of PD was established by intracranial injection of 6-OHDA.Subsequently,three concentrations of Roucongrong(Herba Cistanches Deserticolae)decoction were prepared and administered to rats by gavage therapy for 14 d.Behavioral changes were measured in PD rats.In vivo tyrosine hydroxylase(TH)levels in the substantia nigra were examined by immunohistochemistry.Additionally,gene and protein expression levels of members of the Wnt/β-catenin signaling pathway were examined by Western blotting and polymerase chain reaction.Lastly,a Wnt/β-catenin inhibitor was used to investigate the mechanism of action in 1-methyl-4-phenylpyridinium(MPP+)-treated MES23.5 cells in vitro.RESULTS:Roucongrong(Herba Cistanches Deserticolae)decoction improved performance in the stride and gait adjustment tests in PD rats.It also increased TH in the substantia nigra and altered the expression of genes and proteins in the Wnt/β-catenin signaling pathway.Wnt/β-catenin inhibitor reduced the effect of Roucongrong(Herba Cistanches Deserticolae)decoction in MPP+-treated MES23.5 cells.CONCLUSION:Roucongrong(Herba Cistanches Deserticolae)decoction may promote neuronal survival in PD in vivo and in vitro by increasing TH content in the substantia nigra and by activating the Wnt/β-catenin signaling pathway. | XU Qian QIN Wei WU Fangzhen LIN Yao HONG Liting CHEN Dan HU Xuefeng CAI Jing | 2021 | Journal of Traditional Chinese Medicine2021，41，5： | 1 |
| 14 | Smac is another pathway in the anti-tumour activity of Trichosanthin and reverses Trichosanthin resistance in Ca Ski cervical cancer cells Smac显示文摘 | Lei Cui Jian Song Liting Wu | 2015 | Biomedicine&Pharmacotherapy2015，69，： | 1 |
| 15 | HSCS:a hybrid shared cache scheduling scheme for multiprogrammed workloads显示文摘The traditional dynamic random-access memory (DRAM)storage medium can be integrated on chips via modem emerging 3D-stacking technology to architect a DRAM shared cache in multicore systems.Compared with static random-access memory (SRAM),DRAM is larger but slower.In the existing research,a lot of work has been devoted to improving the workload performance using SRAM and stacked DRAM together in shared cache systems,ranging from SRAM structure improvement to optimizing cache tags and data access.However,little attention has been paid to designing a shared cache scheduling scheme for multiprogrammed workloads with different memory footprints in multicore systems.Motivated by this,we propose a hybrid shared cache scheduling scheme that allows a multicore system to utilize SRAM and 3D-stacked DRAM efficiently, thus achieving better workload performance.This scheduling scheme employs (1)a cache monitor,which is used to collect cache statistics;(2)a cache evaluator,which is used to evaluate the cache information during the process of programs being executed;and (3)a cache switcher,which is used to self-adaptively choose SRAM or DRAM shared cache modules.A cache data migration policy is naturally developed to guarantee that the scheduling scheme works correctly.Extensive experiments are conducted to evaluate the workload performance of our proposed scheme.The experimental resuits showed that our method can improve the multiprogrammed workload performance by up to 25%compared with state-of-the-art methods (including conventional and DRAM cache systems). | Jingyu ZHANG Chentao WU Dingyu YANG Yuanyi CHEN Xiaodong MENG Liting XU Minyi GUO | 2018 | Frontiers of Computer Science2018，12，6： | 1 |
| 16 | Constipation in Taiwan elementary school students: A nationwide survey显示文摘 | Tzee-Chung Wu Liang-Kung Chen Wen-Han Pan Ren-Bin Tang Shinn-Jang Hwang Lite Wu Frank Eugene James Po-Hon Chen | 2011 | Journal of the Chinese Medical Association2011，，2： | 1 |
| 17 | A modified Min Sum decoding algorithm based on LMMSE for LDPC codes显示文摘 | WU Zijing SU Kaixiong GUO Liting | 2014 | AEUInternationalJournal of Electronics and Communications2014，68，10： | 1 |
| 18 | Chitosan disrupts Penicillium expansum and controls postharvest blue mold of jujube fruit显示文摘 | WANG Liting WU Hao QIN Guozhcng | 2014 | Food Control2014，41，： | 1 |
| 19 | Amyloid-beta peptide neurotoxicity in human neuronal cells is associated with modulation of insulin-like growth factor transport, lysosomal machinery and extracellular matrix receptor interactions显示文摘Extracellular deposits of the amyloid-beta peptide(Aβ) are known as the main pathological hallmark of Alzheimer's disease. In Alzheimer's disease, neurons are injured and die throughout the brain, a process in which Aβ neurotoxicity is considered to play an important role. However, the molecular mechanisms underlying Aβ toxicity that lead to neurodegeneration are not clearly established. Here we have elucidated the molecular pathways and networks which are impacted by Aβ in neurons using SH-SY5Y human neuroblastoma cells as a model. These cells were treated with Aβ_(1–42) peptides to study changes in biochemical networks using tandem mass tag labeled quantitative proteomic technique followed by computational analysis of the data. The molecular impacts of Aβ on cells were evident in a time-and dose-dependent manner, albeit the duration of treatment induced greater differential changes in cellular proteome compared to the effects of concentration. Aβ induced early changes in proteins associated with lysosomes, collagen chain trimerization and extracellular matrix receptor interaction, complement and coagulation cascade, oxidative stress induced senescence, ribosome biogenesis, regulation of insulin-like growth factor transport and uptake by insulin-like growth factor-binding protein. These novel findings provide molecular insights on the effects of Aβ on neurons, with implications for better understanding the impacts of Aβ on early neurodegeneration in Alzheimer's disease pathology. | Liting Deng Paul AHaynes Yunqi Wu Ardeshir Amirkhani Karthik Shantharam Kamath Jemma XWu Kanishka Pushpitha Veer Gupta Stuart Graham Vivek KGupta Mehdi Mirzaei | 2020 | Neural Regeneration Research2020，15，11： | 1 |
| 20 | Metastable Phase Equilibrium of the Quaternary System Na^+, Rb^+, Mg^+//Cl^--H2O at 298.2 K显示文摘 | WU Liting ZENG Ying YAN Dongming FENG Shan YU Xudong | 2018 | Chemical Research in Chinese Universities2018，34，5： | 1 |
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