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| 1 | AFAP1-AS1: a rising star among oncogenic long non-coding RNAs显示文摘Long non-coding RNAs(lncRNAs)have become a hotspot in biomedical research.This interest reflects their extensive involvement in the regulation of the expression of other genes,and their influence on the occurrence and development of a variety of human diseases.Actin filament associated protein 1-Antisense RNA 1(AFAP1-AS1)is a recently discovered oncogenic lncRNA.It is highly expressed in a variety of solid tumors,and regulates the expression of downstream genes and signaling pathways through adsorption and competing microRNAs,or by the direct binding to other proteins.Ultimately,AFAP1-AS1 promotes proliferation,chemotherapy resistance,and resistance to apoptosis,maintains stemness,and enhances invasion and migration of tumor cells.This paper summarizes the research concerning AFAP1-AS1 in malignant tumors,including the clinical application prospects of AFAP1-AS1 as a potential molecular marker and therapeutic target of malignant tumors.We also discuss the limitations in the knowledge of AFAP1-AS1 and directions of further research.AFAP1-AS1 is expected to provide an example for studies of other lncRNA molecules. | Fang Xiong Kunjie Zhu Su Deng Hongbin Huang Liting Yang Zhaojian Gong Lei Shi Yi He Yanyan Tang Qianjin Liao Jianjun Yu Xiaoling Li Yong Li Guiyuan Li Zhaoyang Zeng Wei Xiong Shanshan Zhang Can Guo | 2021 | Science China(Life Sciences)2021，64，10： | 4 |
| 2 | Complement pathway in Alzheimer’s pathology and retinal neurodegenerative disorders–the road ahead显示文摘Chronic inflammation has increasingly been acknowledged as a hallmark feature of several progressive neurodegenerative disorders. Accruing evidence indicates that sustained inflammation compromises the core neuroprotective mechanisms underlying neural injury in Alzheimer's disease (AD) and retinal neurodegenerative disorders. | Mehdi Mirzaei Liting Deng Veer Bala Gupta Stuart Graham Vivek Gupta | 2020 | Neural Regeneration Research2020，15，2： | 2 |
| 3 | Immobilization of Streptomyces olivaceoviridis E-86 xylanase on Eudragit S-100 for xylo-oligosaccharide production显示文摘 | Zhilu Ai Zhengqiang Jiang Lite Li Wei Deng Isao Kusakabe Huishang Li | 2005 | Process Biochemistry2005，，8： | 1 |
| 4 | Amyloid-beta peptide neurotoxicity in human neuronal cells is associated with modulation of insulin-like growth factor transport, lysosomal machinery and extracellular matrix receptor interactions显示文摘Extracellular deposits of the amyloid-beta peptide(Aβ) are known as the main pathological hallmark of Alzheimer's disease. In Alzheimer's disease, neurons are injured and die throughout the brain, a process in which Aβ neurotoxicity is considered to play an important role. However, the molecular mechanisms underlying Aβ toxicity that lead to neurodegeneration are not clearly established. Here we have elucidated the molecular pathways and networks which are impacted by Aβ in neurons using SH-SY5Y human neuroblastoma cells as a model. These cells were treated with Aβ_(1–42) peptides to study changes in biochemical networks using tandem mass tag labeled quantitative proteomic technique followed by computational analysis of the data. The molecular impacts of Aβ on cells were evident in a time-and dose-dependent manner, albeit the duration of treatment induced greater differential changes in cellular proteome compared to the effects of concentration. Aβ induced early changes in proteins associated with lysosomes, collagen chain trimerization and extracellular matrix receptor interaction, complement and coagulation cascade, oxidative stress induced senescence, ribosome biogenesis, regulation of insulin-like growth factor transport and uptake by insulin-like growth factor-binding protein. These novel findings provide molecular insights on the effects of Aβ on neurons, with implications for better understanding the impacts of Aβ on early neurodegeneration in Alzheimer's disease pathology. | Liting Deng Paul AHaynes Yunqi Wu Ardeshir Amirkhani Karthik Shantharam Kamath Jemma XWu Kanishka Pushpitha Veer Gupta Stuart Graham Vivek KGupta Mehdi Mirzaei | 2020 | Neural Regeneration Research2020，15，11： | 1 |
| 5 | Molecular characterization and phylogenetic analysis of the reticuloendotheliosis virus isolated from wild birds in Northeast China显示文摘 | Lili Jiang Xiaole Qi Yulong Gao Yuping Hua Kai Li Xiaoyun Deng Qi Wang Lizhou Zhang Hongliang Chai Yuming Chen Chunhong Yin Honglei Gao Liting Qin Yongqiang Wang Yue Qu Qiang Chen Zhaobin Fan Xiaomei Wang | 2013 | Veterinary Microbiology (-)2013，，1： | 1 |
| 6 | A novel, ultra-large xylanolytic complex (xylanosome) secreted by Streptomyces olivaceoviridis显示文摘 | JIANG Zhengqiang DENG Wei LI Lite | 2004 | Biotechnology Letters2004，26，5： | 1 |
| 7 | Wear Characteristics of the Nuclear Control Rod Drive Mechanism(CRDM)Movable Latch Serviced in High Temperature Water显示文摘The current research of nuclear control rod drive mechanism(CRDM)movable latch only makes a simple measurement of wear mass.The wear volume and difference in various claw surfaces are ignored and the degradation mechanism of each claw surface is not clear.In this paper,a detailed degradation analysis was carried out on each claw surface of movable latch combined with wear result and worn morphology.Results indicate that the boundary of carbide is preferred for corrosion because carbide presents a nobler Volta potential compared to the metal matrix or boundary region.Due to the oscillation of drive shaft between the claw surfaces of movable latch,the dominant wear mechanism on the upper surface of claw(USC)and lower surface of claw(LSC)is plastic deformation caused by impact wear.Mechanical impact wear will cause the fragmentation of carbides because of the high hardness and low ductility of carbides.Corrosion promotes the broken carbides to fall off from the metal matrix.The generated fine carbides(abrasive particles)cause extra abrasive wear on USC when the movable brings the drive shaft upward or downward.As a result,USC has a higher wear volume than LSC.This research proposes a method to evaluate the wear on the whole movable latches using a 3D full-size scanner. | Tianda Yu Guozhong Fu Yanqing Yu Liting Zhu Maofu Liu Wei Li Qiang Deng Zhenbing Cai | 2022 | Chinese Journal of Mechanical Engineering2022，35，2： | 1 |
| 8 | Behaviours of Multi-Stakeholders under China’s Renewable Portfolio Standards:A Game Theory-Based Analysis显示文摘China has implemented both quantitative and policy incentives for renewable energy development since 2019 and is currently in the policy transition stage.The implementation of renewable portfolio standards(RPSs)is difficult due to the interests of multiple stakeholders,including power generation enterprises,power grid companies,power users,local governments,and the central government.Based on China’s RPS policy and power system reform documents,this research sorted out the core game decision problems of China’s renewable energy industry and established a conceptual game decision model of the renewable energy industry from the perspective of local governments,power generation enterprises and power grid companies.The results reveal that for local governments,the probability of meeting the earnings quota or punishments for not reaching quota completion are the major determinants for active participation in quota supervision.For power grid firms,the willingness to accept renewable electricity quotas depends on the additional cost of receiving renewable electricity and governmental incentives.It is reasonable,from the theoretical perspective,to implement the RPS policy on the power generation side.Electricity reform will help clarify the electricity price system and increase the transparency of the quota implementation process.Policy implications are suggested to achieve sustainable development of the renewable energy industry from price incentives and quantity delivery. | Bing Wang Kailei Deng Liting He Zhenming Sun | 2021 | Energy Engineering2021，118，5： | 0 |
| 9 | Incidence of Eczema in Early Infancy and the Prenatal Risk Factors—Guangzhou,Guangdong,China,2018–2019显示文摘What is already known on this topic?Eczema is a common allergic disease in children,which seriously affects the quality of life of children and their families.What is added by this report?The results showed that the incidence of very-earlyonset eczema was 12.4%.Primiparity was associated with a higher risk of eczema[risk ratio(95%confidence interval):1.23(1.06–1.42)].What are the implications for public health practice?Very-early-onset eczema is common.Given its adverse impact on children’s health and life quality,this previously neglected public health issue needs to be prioritized.In addition,maternal parity could serve as an indicator in risk assessment and prediction for infant eczema. | Liting Deng Huihui Liu Dongmei Wei Jinhua Lu Chengrui Wang Songying Shen Jianrong He Xiu Qiu | 2021 | China CDC weekly2021，3，33： | 0 |
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