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| 1 | Biostratigraphy of Triassic Marine Reptiles in Southwest Guizhou and Its Adjacent Area显示文摘This paper briefly reviews the Triassic marine reptile fossils inGuizhou Province, especially the fossils that have been recently found in the Guanling area. Based on three sections at Guanling and Xingyi, Guizhou Province and Luoping, Yunnan Province, four horizons with vertebrate fossils are recognized in the Middle and Upper Triassic of this area; They are from bottom to top: Member I and Member Ⅱ of the Guanling Formation, and the Zhuganpo Member and the Wayao Member of the Falang Formation. | WANG Liting, LI Jinling, WANG Xinjin, LI Chun,WU Tianzhuang and LIU Jun Bureau of Geology and Mineral Exploration and Development of Guizhou ProvinceGuiyang 550004 Institute of Vertebrate Palaeontology and Palaeoanthropology,Chinese Academy of Sciences, Beijing 100044 Guizhou Museum, Guiyang 550004 | 2001 | Acta Geologica Sinica(English Edition)2001，75，4： | 17 |
| 2 | NLRP3-dependent pyroptosis is required for HIV-1 gp120- induced neuropathology显示文摘The human immunodeficiency virus-1(HIV-1)envelope protein gp120 is the major contributor to the pathogenesis of HIVassociated neurocognitive disorder(HAND).Neuroinflammation plays a pivotal role in gp120-induced neuropathology,but how gp120 triggers neuroinflammatory processes and subsequent neuronal death remains unknown.Here,we provide evidence that NLRP3 is required for gp120-induced neuroinflammation and neuropathy.Our results showed that gp120-induced NLRP3-dependent pyroptosis and IL-1βproduction in microglia.Inhibition of microglial NLRP3 inflammasome activation alleviated gp120-mediated neuroinflammatory factor release and neuronal injury.Importantly,we showed that chronic administration of MCC950,a novel selective NLRP3 inhibitor,to gp120 transgenic mice not only attenuated neuroinflammation and neuronal death but also promoted neuronal regeneration and restored the impaired neurocognitive function.In conclusion,our data revealed that the NLRP3 inflammasome is important for gp120-induced neuroinflammation and neuropathology and suggest that NLRP3 is a potential novel target for the treatment of HAND. | Xiaolong He Weijun Yang Zhijie Zeng Yi Wei Jie Gao Bao Zhang Li Li Liqun Liu Yu Wan Qing Zeng Zelong Gong Liting Liu Hanyun Zhang Yubin Li Shaojie Yang Tongtong Hu Lixian Wu Eliezer Masliah Shenghe Huang Hong Cao | 2020 | Cellular & Molecular Immunology2020，17，3： | 11 |
| 3 | Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice显示文摘Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse Col1 a1-Cre transgene minimally impacts bone mass in mice, but deleting Kindlin-2 using the 10-kb mouse Dmp1-Cre transgene, which targets osteocytes and mature osteoblasts, results in striking osteopenia in mice. Kindlin-2 loss reduces the osteoblastic population but increases the osteoclastic and adipocytic populations in the bone microenvironment. Kindlin-2 loss upregulates sclerostin in osteocytes,downregulates β-catenin in osteoblasts, and inhibits osteoblast formation and differentiation in vitro and in vivo. Upregulation ofβ-catenin in the mutant cells reverses the osteopenia induced by Kindlin-2 deficiency. Kindlin-2 loss additionally increases the expression of RANKL in osteocytes and increases osteoclast formation and bone resorption. Kindlin-2 deletion in osteocytes promotes osteoclast formation in osteocyte/bone marrow monocyte cocultures, which is significantly blocked by an anti-RANKLneutralizing antibody. Finally, Kindlin-2 loss increases osteocyte apoptosis and impairs osteocyte spreading and dendrite formation.Thus, we demonstrate an important role of Kindlin-2 in the regulation of bone homeostasis and provide a potential target for the treatment of metabolic bone diseases. | Huiling Cao Qinnan Yan Dong Wang Yumei Lai Bo Zhou Qi Zhang Wenfei Jin Simin Lin Yiming Lei Liting Ma Yuxi Guo Yishu Wang Yilin Wang Xiaochun Bai Chuanju Liu Jian QFeng Chuanyue Wu Di Chen Xu Cao Guozhi Xiao | 2020 | Bone Research2020，8，1： | 8 |
| 4 | Restudy of the storage and migration model of the Quaternary groundwater in Beijing Plain area显示文摘Through a wide-spread groundwater sampling mainly at nested monitoring wells in the Beijing Plain area,combined with data collection,the study analyzes water level,hydrochemistry,temperature,tritium,deuterium,18O,14C and other aspects,and indicates that there exits an obvious stratification phenomenon of the groundwater in the alluvial plain area down in the middle part of alluvial-pluvial fans,and the hydraulic connection between layers is very weak.The analysis of the tritium concentration suggests that the average influence depth of the modern precipitation is approximately 120m.Based on the analysis of the 22 paleowater samples through the D18O method and 14C isotopic dating,the deep groundwater circulation in the fine sediments area of Beijing Plain down in the fringe part of alluvial-pluvial fans is relatively slow.On average the paleowater point occurs approximately below the 180m at these points.The main reasons for the formation of stratification and paleowater points are the water-blocking effect of the clay type strata and the compaction effect during the sedimentary process,especially the differential compaction,which could form closed or relatively closed stagnant aquifers.Groundwater in this kind of stagnant aquifers to some degree belongs to non-renewable resource,and should be reconsidered and re-arranged in the water resources management strategy. | LIU YuanZhang WU Qiang LIN Pei LIU JiuRong XING LiTing GAO ZhiHui | 2012 | Science China Earth Sciences2012，55，7： | 7 |
| 5 | Famitinib in combination with concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 1, open-label, dose-escalation Study显示文摘Background:Famitinib is a tyrosine kinase inhibitor against multiple targets,including vascular endothelial growth factor receptor 2/3,platelet-derived growth factor receptor,and stem cell factor receptor(c-kit).Previous studies have demonstrated anti-tumour activities of famitinib against a wide variety of advanced-stage solid cancers.We aimed to determine the safety and efficacy of famitinib with concurrent chemoradiotherapy(CCRT)in patients with locoregionally advanced nasopharyngeal carcinoma(NPC).We also evaluated the feasibility of contrast-enhanced ultrasound(D-CEUS)as a predictor of early tumour response to famitinib and to correlate functional parameters with clinical efficacy.Methods:The trial was conducted in subjects with stage III or IVa-b NPC using a 3+3 design of escalating fami-tinib doses.Briefly,subjects received 2 weeks of famitinib monotherapy followed by 7 weeks of famitinib plus CCRT.D-CEUS of the neck lymph nodes was performed at day 0,8 and 15 after famitinib was administered before starting concurrent chemoradiotherapy.End points included safety,tolerability and anti-tumour activity.Results:Twenty patients were enrolled(six each for 12.5,16.5 and 20 mg and two for 25 mg).Two patients in the 25 mg cohort developed dose-limiting toxicities,including grade 4 thrombocytopenia and grade 3 hypertension.The most common grade 3/4 adverse events were leukopenia,neutropenia and radiation mucositis.D-CEUS tests showed that more than 60%of patients achieved a perfusion parameter response after 2 weeks taking famitinib alone,and the parameter response was associated with disease improvement.In the famitinib monotherapy stage,three patients(15%)showed partial responses.The complete response rate was 65%at the completion of treatment and 95%3 months after the treatment ended.After a median follow-up of 44 months,the 3-year progression-free survival(PFS)and distant metastasis-free survival were 70%and 75%,respectively.Subjects with a decrease of perfusion parameter response,such as peak intensity decreased at least 30%after 1 week of famitinib treatment,had higher 3-year PFS(90.9%vs.44.4%,95%CI 73.7%-100%vs.11.9%-76.9%,P<0.001)than those with an increase or a reduction of less than 30%.Conclusions:The recommended famitinib dose for phase II trial is 20 mg with CCRT for patients with local advanced NPC.D-CEUS is a reliable and early measure of efficacy for famitinib therapies.Further investigation is required to confirm the effects of famitinib plus chemoradiotherapy. | Qiuyan Chen Linquan Tang Na Liu Feng Han Ling Guo Shanshan Guo Jianwei Wang Huai Liu Yanfang Ye Lu Zhang Liting Liu Pan Wang Yingqin Li Qingmei He Xiaoqun Yang Qingnan Tang Yang Li YuJing Liang XueSong Sun Chuanmiao Xie Yunxian Mo Ying Guo Rui Sun Haoyuan Mo Kajia Cao Xiang Guo Musheng Zeng Haiqiang Mai Jun Ma | 2018 | Cancer Communications2018，38，1： | 6 |
| 6 | Earth Observation Brain(EOB):an intelligent earth observation system显示文摘Since the twenty-first century,with the rapid development of high-resolution earth observation satellites,the earth observation satellite system has developed from the initial single satellite observation model to the current satellite constellation formed by light and small satellites observation model.All-weather and all-directional fine earth observation can now be realized.In the future,the satellite constellation,communication satellites,navigation satellites,and aircrafts are linked through dynamic linking network to form an air-space information network to realize real-time services of intelligent air-space information.To further enhance the perception,cognition,and quick response ability of the network,we propose the concept and model of the Earth Observation Brain(EOB)−the intelligent earth system based on events perception in this paper.Then,some key technologies needed to be solved in the EOB are also described.An application example is illustrated to show the process of perception and cognition in the primary stage of the EOB.In the future,EOB can observe what change of what object,the when and where to push these right information to mobile terminal of right people at the right time and right place.Global users can obtain any data,information,and knowledge in real-time through the EOB. | Deren Li Mi Wang Zhipeng Dong Xin Shen Lite Shi | 2017 | Geo-Spatial Information Science2017，20，2： | 6 |
| 7 | AFAP1-AS1: a rising star among oncogenic long non-coding RNAs显示文摘Long non-coding RNAs(lncRNAs)have become a hotspot in biomedical research.This interest reflects their extensive involvement in the regulation of the expression of other genes,and their influence on the occurrence and development of a variety of human diseases.Actin filament associated protein 1-Antisense RNA 1(AFAP1-AS1)is a recently discovered oncogenic lncRNA.It is highly expressed in a variety of solid tumors,and regulates the expression of downstream genes and signaling pathways through adsorption and competing microRNAs,or by the direct binding to other proteins.Ultimately,AFAP1-AS1 promotes proliferation,chemotherapy resistance,and resistance to apoptosis,maintains stemness,and enhances invasion and migration of tumor cells.This paper summarizes the research concerning AFAP1-AS1 in malignant tumors,including the clinical application prospects of AFAP1-AS1 as a potential molecular marker and therapeutic target of malignant tumors.We also discuss the limitations in the knowledge of AFAP1-AS1 and directions of further research.AFAP1-AS1 is expected to provide an example for studies of other lncRNA molecules. | Fang Xiong Kunjie Zhu Su Deng Hongbin Huang Liting Yang Zhaojian Gong Lei Shi Yi He Yanyan Tang Qianjin Liao Jianjun Yu Xiaoling Li Yong Li Guiyuan Li Zhaoyang Zeng Wei Xiong Shanshan Zhang Can Guo | 2021 | Science China(Life Sciences)2021，64，10： | 4 |
| 8 | Self‑Assembly MXene‑rGO/CoNi Film with Massive Continuous Heterointerfaces and Enhanced Magnetic Coupling for Superior Microwave Absorber显示文摘MXene, as a rising star of two-dimensional(2 D) materials, has been widely applied in fields of microwave absorption and electromagnetic shielding to cope with the arrival of the 5 G era. However, challenges arise due to the excessively high permittivity and the difficulty of surface modification of few-layered MXenes severely, which infect the microwave absorption performance. Herein, for the first time, a carefully designed and optimized electrostatic selfassembly strategy to fabricate magnetized MXene-r GO/Co Ni film was reported. Inside the synthesized composite film, r GO nanosheets decorated with highly dispersed Co Ni nanoparticles are interclacted into MXene layers, which effectively suppresses the originally self-restacked of MXene nanosheets, resulting in a reduction of high permittivity. In addition, owing to the strong magnetic coupling between the magnetic Fe Co alloy nanoparticles on the r GO substrate, the entire MXener GO/Co Ni film exhibits a strong magnetic loss capability. Moreover, the local dielectric polarized fields exist at the continuous heterointerfaces between 2 D MXene and r GO further improve the capacity of microwave loss. Hence, the synthesized composite film exhibits excellent microwave absorption property with a maximum reflection loss value of-54.1 d B at 13.28 GHz. The electromagnetic synergy strategy is expected to guide future exploration of high-efficiency MXene-based microwave absorption materials. | Xiao Li Zhengchen Wu Wenbin You Liting Yang Renchao Che | 2022 | Nano-Micro Letters2022，14，5： | 4 |
| 9 | 3D Seed-Germination-Like MXene with In Situ Growing CNTs/Ni Heterojunction for Enhanced Microwave Absorption via Polarization and Magnetization显示文摘Ti_(3)C_(2)Tx MXene is widely regarded as a potential micro-wave absorber due to its dielectric multi-layered structure.However,missing magnetic loss capability of pure MXene leads to the unmatched electromagnetic parameters and unsatisfied impedance matching condi-tion.Herein,with the inspiration from dielectric-magnetic synergy,this obstruction is solved by fabricating magnetic CNTs/Ni hetero-structure decorated MXene substrate via a facile in situ induced growth method.Ni2+ions are successfully attached on the surface and interlamination of each MXene unit by intensive electrostatic adsorption.Benefiting from the possible“seed-germination”effect,the“seeds”Ni^(2+)grow into“buds”Ni nanoparticles and“stem”carbon nanotubes(CNTs)from the enlarged“soil”of MXene skeleton.Due to the improved impedance matching con-dition,the MXene-CNTs/Ni hybrid holds a superior microwave absorp-tion performance of−56.4 dB at only 2.4 mm thickness.Such a distinctive 3D architecture endows the hybrids:(i)a large-scale 3D magnetic coupling network in each dielectric unit that leading to the enhanced magnetic loss capability,(ii)a massive multi-heterojunction interface structure that resulting in the reinforced polarization loss capability,confirmed by the off-axis electron holography.These outstanding results provide novel ideas for developing magnetic MXene-based absorbers. | Xiao Li Wenbin You Chunyang Xu Lei Wang Liting Yang Yuesheng Li Renchao Che | 2021 | Nano-Micro Letters2021，13，10： | 4 |
| 10 | Liquid metal as reconnection agent for peripheral nerve injury显示文摘This study demonstrated an unconventional way to cure peripheral nerve injury(PNI) with liquid metal gallium employed as the reconnection agent. In vivo experiments were performed, in which transected sciatic nerve of mouse was reconnected by liquid metal gallium.The nerve signals detected was found to be almost the same as those from the complete nerve, where the negative bursting firing caused by PNI was absent on the neural discharge curve after nerve-reconnection surgery. Meanwhile the atrophy tendency of gastrocnemius muscle was distinctly procrastinated according to the results of pathological examinations, which showed fibrillation potentials emerged immediately for mice with PNI but did not emerge until the third month for those received nerve-reconnection surgery. Furthermore, physical properties of gallium were studied, showing that its impedance was slightly influenced by the frequency of transmitted signal and the temperature, which confirmed the stability of gallium in future clinical usage. This technology is expected to perform well in clinical surgery for PNI and even central nervous system injury in the coming time. | Fujun Liu Yongze Yu Liting Yi Jing Liu | 2016 | Science Bulletin2016，61，12： | 4 |
| 11 | Effects of electroacupuncture at Zusanli (ST 36) on neurons in the colonic myenteric plexus in rats with irritable bowel syndrome with constipation显示文摘We studied the effects of electroacupuncture at Zusanli (ST 36) on neurons in the colonic myenteric plexus and on defecation in rats with irritable bowel syndrome with constipation (IBS-C). We also used intragastric administration of pinaverium bromide as a positive control treatment to reveal the pathway mediating the onset of IBS-C. Both electroacupuncture and pinaverium bromide greatly improved defecation in rats with IBS-C. Immunohistochemical staining of the enteric nervous system neuronal marker protein gene product 9.5 in the colonic myenteric plexus showed that electroacupuncture by itself, or in combination with pinaverium bromide, increased the number of neurons and the staining intensity of protein gene product 9.5 in the colonic myenteric plexus. We conclude that visceral hypersensitivity is likely to be a primary cause of constipation in IBS-C rats. | Liting Zhu Zhonghan Li Bin Xu Chen Xia Jie Cheng Xiaoren Xiang Yi Zhu | 2011 | Neural Regeneration Research2011，6，33： | 3 |
| 12 | Effects of Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum on chemotactic migration of alveolar macrophages and inters regions macrophages in rats显示文摘OBJECTIVE: To observe the effects of serum containing Mahuang(Herba Ephedra Sinica) or Wuweizi(Fructus Schisandrae Chinensis) on the migration of alveolar macrophages(AM) and interstitial macrophages(IM) from normal rats, and to analyze and compare the mechanisms leading to cell migration differences.METHODS: Rats were randomly divided into three groups: Mahuang(Herba Ephedra Sinica), Wuweizi(Fructus Schisandrae Chinensis), and blank serum. After treatment with the herbs, serum was extracted from the rats. AM and IM were isolated from normal rats and cultured. The effects of Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum on normal rat AM and IM chemotactic migration were determined by transwell assays. The CC chemokine receptor(CCR) 2, CCR5, voltage-gated Kvl. 3 K^+channel(Kv1. 3), and voltage-gated Kvl. 5 K^+channel(Kv1. 5) protein levels were analyzed by western blotting.RESULTS: The migration quantities of AM and IM in the Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum groups were significantly higher than those in the blank serum group(P < 0.01). Compared with the Wuweizi(Fructus Schisandrae Chinensis) medicated serum group, the migration quantity of cultured rat AM in the Mahuang(Herba Ephedra Sinica) medicated serum group was significantly increased(P <0.01). Meanwhile, compared with the Mahuang(Herba Ephedra Sinica) medicated serum group, the migration quantity of cultured rat IM in the Wuweizi(Fructus Schisandrae Chinensis) medicated serum group was significantly increased(P < 0.01).CCR2, CCR5, Kv1. 3, and Kv1. 5 proteins were expressed on the AM cell surface, and showed significantly higher expression in the Mahuang(Herba Ephedra Sinica) medicated serum group compared with the Wuweizi(Fructus Schisandrae Chinensis)medicated serum group. In contrast, CCR5, Kv1.3,and Kv1.5 proteins were expressed on the IM cell surface, and showed significantly higher expression in the Wuweizi(Fructus Schisandrae Chinensis)medicated serum group compared with the Mahuang(Herba Ephedra Sinica) medicated serum group.CONCLUSION: Mahuang(Herba Ephedra Sinica)and Wuweizi(Fructus Schisandrae Chinensis) can promote AM and IM migration ability, with Mahuang(Herba Ephedra Sinica) targeting AM more apparently and Wuweizi(Fructus Schisandrae Chinensis) targeting IM more apparently. The mechanism may be that, by stimulating cells, Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) promote expression of CCR2 and CCR5 receptors on the AM and IM cell surface,which pass signals to Kvl.3 and Kvl.5 ion channels,leading to changes in the cytoskeleton, and ultimately promoting chemotactic cell migration. | Yuan Yiping Zhai Huaqiang Zhang Tian Guo Zhaojuan Kong Liting Jia Xiaoyu Wang Ningning Dai Ying Liu Guoxiu Wang Yanping | 2017 | Journal of Traditional Chinese Medicine2017，37，5： | 3 |
| 13 | Synthesis of Chitosan-Hydroxyapatite Composites and Its Effect on the Properties of Bioglass Bone Cement显示文摘Chitosan-hydroxyapatite(CS-HA) composite powders were synthesized via in situ co-precipitation method,through the reaction of Ca(NO3)2 and H3PO4 in the simulated body fluid(SBF) containing appropriate amount of chitosan.The thermal evolution,microstructure and morphology were studied by TG-DTA(thermogravimetry-differential thermal analysis),XRD(X-ray diffraction),FTIR(Fourier transform infrared spectroscopy) and TEM(transmission electron microscopy).The in vitro bioactivity test showed that the obtained CS-HA composites had higher capability of inducing calcium ions deposition.Effects of CS-HA composites on the bioactivity and compressive strength of bioglass bone cement were investigated.The results indicated that the bioactivity of bioglass bone cement could be improved further when CS-HA composite powders were added into the cement,and appropriate amount of CS-HA additive was favorable for compressive strength improvement of bioglass bone cement. | Jingxiao Liu Fei Shi Ling Yu Liting Niu Shanshan Gao | 2009 | Journal of Materials Science & Technology2009，25，4： | 3 |
| 14 | Single-cell transcriptomes of peripheral blood cells indicate and elucidate severity of COVID-19显示文摘The blood and immune system of coronavirus disease 2019(COVID-19)infected patients are dysfunctional,and numerous studies have been conducted to resolve their characteristics and pathogenic mechanisms.Nevertheless,the variations of immune responses along with disease severity have not been comprehensively documented.Here,we profiled the single-cell transcriptomes of 96,313 peripheral blood mononuclear cells(PBMCs)derived from 12 COVID-19 patients(including four moderate,four severe and four critical cases)and three healthy donors.We showed that proliferative CD8 effector T cells with declined immune functions and cytotoxicity accumulated in the critical stage.By contrast,the quantity of natural killer(NK)cells was significantly reduced,while they exhibited enhanced immune activities.Notably,a gradually attenuated responseto COVID-19 along with disease severity was observed in monocytes,in terms of cellular composition,transcriptional discrepancy and transcription factor regulatory network.Furthermore,we identified immune cell-type dependent cytokine signatures distinguishing the severity of COVID-19 patients.In addition,cell interactions between CD8 effector T/NK cells and monocytes mediated by inflammatory cytokines were enhanced in moderate and severe stages,but weakened in critical cases.Collectively,our work uncovers the cellular and molecular players underlying the disordered and heterogeneous immune responses associated with COVID-19 severity,which could provide valuable insights for the treatment of critical COVID-19 patients. | Xiaowei Xie Xuelian Cheng Gaoxiang Wang Biao Zhang Mengyao Liu Liting Chen Hui Cheng Sha Hao Jianfeng Zhou Ping Zhu Tao Cheng | 2021 | Science China(Life Sciences)2021，64，10： | 3 |
| 15 | Experimental Study on Thermal Management of Cylindrical Li-ion Battery with Flexible Microchannel Plates显示文摘A novel thermal management system of cylindrical Li-ion battery with the liquid cooling in flexible microchannel plate was established in the study. The experiments were conducted with R141 b in flexible microchannel plates. The cooling system with the flexible aluminum microchannels can effectively transfer heat from battery to the cooling refrigerant R141 b based on flow boiling. A battery module with five cells along flow channel was chosen to study the effects of contact surface area and mass flux on the thermal performance and electrochemical characteristics in the experiments. Three types of structure with different contact areas were studied and their performances were compared with the experiments without cooling structures. The experiments were carried out at the same discharge rate with the inlet mass flow rates of 0–10 kg/h. For the inlet mass flow rate of 5.98 kg/h, the surface temperature and temperature uniformity of battery were the best, and the output voltage and capacity of batteries were higher than those under other mass flow rates. With given inlet mass flow rates, the five series cells exhibited different electrochemical performances, including output voltage and discharge capacity, due to the different refrigerant flow states in the microchannels. Finally, an optimal design was presented with thermal performances, macroscopic electrochemical characteristics, inlet mass flow rates and cooling performance taken into consideration. | WEI Liting JIA Li AN Zhoujian DANG Chao | 2020 | Journal of Thermal Science2020，29，4： | 3 |
| 16 | Iodine biofortification of vegetable plants-An innovative method for iodine supplementation显示文摘To elevate the iodine level in edible plants has been shown to be an excellent approach to correct iodine deficiency.We have proposed an innovative approach to produce iodine supplementation by growing vegetables on soils with algal-based iodized organic fertilizer.Ten species of vegetables were tested.The biological absorption and migration of the iodine within the vegetable plants were revealed using microscopy with silver iodide precipitation technique.The results show that the absorption of iodine by the vegetable increases with increasing amount of the algal-based iodized organic fertilizer in general.And the uptake of iodine by leaf vegetable is significantly greater than that by fruit vegetable.Distribution of iodine in various plant organs shows a trend of decreasing iodine concentration from root,leaf,stalk,to fruit.A similar of decreasing concentration can also be found in various cells(cytoplasm>cytoderm>organelles).The exploration of the iodine uptake and biogeochemistry migration mechanisms provides an important scientific foundation for establishing a new method of producing a natural iodine supplementation by iodine biofortification of vegetables. | WENG HuanXin HONG ChunLai XIA TianHong BAO LiTing LIU HuiPing LI DeWang | 2013 | Chinese Science Bulletin2013，58，18： | 3 |
| 17 | Electrochemical Surface Restructuring of Phosphorus-Doped Carbon@MoP Electrocatalysts for Hydrogen Evolution显示文摘The hydrogen evolution reaction(HER) through electrocatalysis is promising for the production of clean hydrogen fuel. However,designing the structure of catalysts,controlling their electronic properties,and manipulating their catalytic sites are a significant challenge in this field. Here,we propose an electrochemical surface restructuring strategy to design synergistically interactive phosphorus-doped carbon@MoP electrocatalysts for the HER. A simple electrochemical cycling method is developed to tune the thickness of the carbon layers that cover on MoP core,which significantly influences HER performance. Experimental investigations and theoretical calculations indicate that the inactive surface carbon layers can be removed through electrochemical cycling,leading to a close bond between the MoP and a few layers of coated graphene. The electronsdonated by the MoP core enhance the adhesion and electronegativity of the carbon layers;the negatively charged carbon layers act as an active surface. The electrochemically induced optimization of the surface/interface electronic structures in the electrocatalysts significantly promotes the HER. Using this strategy endows the catalyst with excellent activity in terms of the HER in both acidic and alkaline environments(current density of 10 mA cm^(-2) at low overpotentials,of 68 mV in 0.5 M H_(2)SO_(4) and 67 mV in 1.0 M KOH). | Huimin Jiang Liting Yan Shuo Zhang Yanchao Zhao Xue Yang Yameng Wang Jianxing Shen Xuebo Zhao Lianzhou Wang | 2021 | Nano-Micro Letters2021，13，12： | 3 |
| 18 | Guanling Biota: A Rare Biota in Sea Early Late Triassic显示文摘Guanling biota has been found at the bottom of Wayao Formation of Upper Triassic (Carnic stage) near Xinpu town, Guanling County, Guizhou Province, China. There are a lot of crinoids and marine reptiles, which is a characteristic of Guanling biota, including ammonites, bivalve, brachiopod, fish, conodont and plant. These fossils are featured not only with the large quantity, but also with their extraordinary perfect forms. This paper explores the meaning, geological background, present situation of study and scientific significance of Guanling biota. | Wang Shangyan The State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002 Guizhou Geological Survey, Guiyang, 550004 Wang Yangeng Wang Liting Yin Gongzheng Guizhou Geological Survey, Guiyang 550004 | 2002 | Journal of China University of Geosciences2002，13，3： | 3 |
| 19 | Mitochondrial homeostasis in Parkinson's disease-a triumvirate rule?显示文摘Mitochondrial dysfunction in Parkinson’s disease:Mitochondria are the primary energy generator of the cell and they are important for cell survival and apoptosis.Defective mitochondrial homeostasis is frequently reported in human diseases especially those affecting the brain. | Chee-Hoe Ng Liting Hang Kah-Leong Lim | 2017 | Neural Regeneration Research2017，12，8： | 2 |
| 20 | Outcome of aggressive B-cell lymphoma with TP53 alterations administered with CAR T-cell cocktail alone or in combination with ASCT显示文摘TP53 gene alteration confers inferior prognosis in refractory/relapse aggressive B-cell non-Hodgkin lymphoma(r/r B-NHL).From September 2016 to September 2020,257 r/r B-NHL patients were assessed for eligibility for two trials in our center,assessing anti-CD19 and anti-CD22 chimeric antigen receptor(CAR19/22)T-cell cocktail treatment alone or in combination with autologous stem cell transplantation(ASCT).TP53 alterations were screened in 123 enrolled patients and confirmed in 60.CAR19/22 T-cell administration resulted in best objective(ORR)and complete(CRR)response rate of 87.1%and 45.2%in patients with TP53 alterations. | Jia Wei Min Xiao Zekai Mao Na Wang Yang Cao Yi Xiao Fankai Meng Weimin Sun Ying Wang Xingcheng Yang Liting Chen Yicheng Zhang Haichuan Zhu Shangkun Zhang Tongcun Zhang Jianfeng Zhou Liang Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 2 |
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