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| 1 | NLRP3-dependent pyroptosis is required for HIV-1 gp120- induced neuropathology显示文摘The human immunodeficiency virus-1(HIV-1)envelope protein gp120 is the major contributor to the pathogenesis of HIVassociated neurocognitive disorder(HAND).Neuroinflammation plays a pivotal role in gp120-induced neuropathology,but how gp120 triggers neuroinflammatory processes and subsequent neuronal death remains unknown.Here,we provide evidence that NLRP3 is required for gp120-induced neuroinflammation and neuropathy.Our results showed that gp120-induced NLRP3-dependent pyroptosis and IL-1βproduction in microglia.Inhibition of microglial NLRP3 inflammasome activation alleviated gp120-mediated neuroinflammatory factor release and neuronal injury.Importantly,we showed that chronic administration of MCC950,a novel selective NLRP3 inhibitor,to gp120 transgenic mice not only attenuated neuroinflammation and neuronal death but also promoted neuronal regeneration and restored the impaired neurocognitive function.In conclusion,our data revealed that the NLRP3 inflammasome is important for gp120-induced neuroinflammation and neuropathology and suggest that NLRP3 is a potential novel target for the treatment of HAND. | Xiaolong He Weijun Yang Zhijie Zeng Yi Wei Jie Gao Bao Zhang Li Li Liqun Liu Yu Wan Qing Zeng Zelong Gong Liting Liu Hanyun Zhang Yubin Li Shaojie Yang Tongtong Hu Lixian Wu Eliezer Masliah Shenghe Huang Hong Cao | 2020 | Cellular & Molecular Immunology2020，17，3： | 11 |
| 2 | Famitinib in combination with concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 1, open-label, dose-escalation Study显示文摘Background:Famitinib is a tyrosine kinase inhibitor against multiple targets,including vascular endothelial growth factor receptor 2/3,platelet-derived growth factor receptor,and stem cell factor receptor(c-kit).Previous studies have demonstrated anti-tumour activities of famitinib against a wide variety of advanced-stage solid cancers.We aimed to determine the safety and efficacy of famitinib with concurrent chemoradiotherapy(CCRT)in patients with locoregionally advanced nasopharyngeal carcinoma(NPC).We also evaluated the feasibility of contrast-enhanced ultrasound(D-CEUS)as a predictor of early tumour response to famitinib and to correlate functional parameters with clinical efficacy.Methods:The trial was conducted in subjects with stage III or IVa-b NPC using a 3+3 design of escalating fami-tinib doses.Briefly,subjects received 2 weeks of famitinib monotherapy followed by 7 weeks of famitinib plus CCRT.D-CEUS of the neck lymph nodes was performed at day 0,8 and 15 after famitinib was administered before starting concurrent chemoradiotherapy.End points included safety,tolerability and anti-tumour activity.Results:Twenty patients were enrolled(six each for 12.5,16.5 and 20 mg and two for 25 mg).Two patients in the 25 mg cohort developed dose-limiting toxicities,including grade 4 thrombocytopenia and grade 3 hypertension.The most common grade 3/4 adverse events were leukopenia,neutropenia and radiation mucositis.D-CEUS tests showed that more than 60%of patients achieved a perfusion parameter response after 2 weeks taking famitinib alone,and the parameter response was associated with disease improvement.In the famitinib monotherapy stage,three patients(15%)showed partial responses.The complete response rate was 65%at the completion of treatment and 95%3 months after the treatment ended.After a median follow-up of 44 months,the 3-year progression-free survival(PFS)and distant metastasis-free survival were 70%and 75%,respectively.Subjects with a decrease of perfusion parameter response,such as peak intensity decreased at least 30%after 1 week of famitinib treatment,had higher 3-year PFS(90.9%vs.44.4%,95%CI 73.7%-100%vs.11.9%-76.9%,P<0.001)than those with an increase or a reduction of less than 30%.Conclusions:The recommended famitinib dose for phase II trial is 20 mg with CCRT for patients with local advanced NPC.D-CEUS is a reliable and early measure of efficacy for famitinib therapies.Further investigation is required to confirm the effects of famitinib plus chemoradiotherapy. | Qiuyan Chen Linquan Tang Na Liu Feng Han Ling Guo Shanshan Guo Jianwei Wang Huai Liu Yanfang Ye Lu Zhang Liting Liu Pan Wang Yingqin Li Qingmei He Xiaoqun Yang Qingnan Tang Yang Li YuJing Liang XueSong Sun Chuanmiao Xie Yunxian Mo Ying Guo Rui Sun Haoyuan Mo Kajia Cao Xiang Guo Musheng Zeng Haiqiang Mai Jun Ma | 2018 | Cancer Communications2018，38，1： | 6 |
| 3 | AFAP1-AS1: a rising star among oncogenic long non-coding RNAs显示文摘Long non-coding RNAs(lncRNAs)have become a hotspot in biomedical research.This interest reflects their extensive involvement in the regulation of the expression of other genes,and their influence on the occurrence and development of a variety of human diseases.Actin filament associated protein 1-Antisense RNA 1(AFAP1-AS1)is a recently discovered oncogenic lncRNA.It is highly expressed in a variety of solid tumors,and regulates the expression of downstream genes and signaling pathways through adsorption and competing microRNAs,or by the direct binding to other proteins.Ultimately,AFAP1-AS1 promotes proliferation,chemotherapy resistance,and resistance to apoptosis,maintains stemness,and enhances invasion and migration of tumor cells.This paper summarizes the research concerning AFAP1-AS1 in malignant tumors,including the clinical application prospects of AFAP1-AS1 as a potential molecular marker and therapeutic target of malignant tumors.We also discuss the limitations in the knowledge of AFAP1-AS1 and directions of further research.AFAP1-AS1 is expected to provide an example for studies of other lncRNA molecules. | Fang Xiong Kunjie Zhu Su Deng Hongbin Huang Liting Yang Zhaojian Gong Lei Shi Yi He Yanyan Tang Qianjin Liao Jianjun Yu Xiaoling Li Yong Li Guiyuan Li Zhaoyang Zeng Wei Xiong Shanshan Zhang Can Guo | 2021 | Science China(Life Sciences)2021，64，10： | 4 |
| 4 | A comparative study on the air-side performance of wavy fin-and-tube heat exchanger with punched delta winglets in staggered and in-line arrangements显示文摘 | Tian Liting He Yaling Tao Yubing | 2009 | International Journal of Thermal Science2009，48，9： | 1 |
| 5 | Interfering with cellular signaling pathways enhances sensitization to combined sodium butyrate and GCV treatment in EBV-positive tumor cells显示文摘 | Yuwen He Shaohui Cai Ge Zhang Xiaoqing Li Liting Pan Jun Du | 2008 | Virus Research2008，，1： | 1 |
| 6 | Hydrodynamics and heat transfer characteristics of a novel heat exchanger with delta-winglet vortex generators 显示文摘 | Yonggang Lei Yaling He Liting Tian | 2010 | Chemical Engineering Science2010，65，5： | 1 |
| 7 | A Com- parative Study on the Air-Side Performance of Wavy Fin- and-~be Heat Exchanger With Punched Delta Winglets in Staggered and in-Line Arrangements 显示文摘 | TIAN Liting HE Yaling TAO Yubing | 2009 | International Journal of Thermal Sciences2009，48，17： | 1 |
| 8 | Hydrodynamics and heat transfer characteristics of a novel heat exchanger with delta-winglet vortex generators显示文摘 | LEI Yonggang HE Yaling TIAN Liting | 2010 | Chemical Engineering Science2010，65，5： | 1 |
| 9 | Interfering with cellular signaling pathways enhances sensitization to combined sodium butyrate and GCV treatment in EBV-positive tumor cells显示文摘 | Yuwen He Shaohui Cai Ge Zhang Xiaoqing Li Liting Pan Jun Du | 2008 | Virus Research2008，，1： | 1 |
| 10 | A comparative study on the air-side performance of wavy fin-and-tube heat exchanger with punched delta winglets in staggered and in-line arrangements显示文摘 | Liting Tian Yaling He Yubing Tao Wenquan Tao | 2009 | International Journal of Thermal Sciences2009，，9： | 1 |
| 11 | A comparative study on the air-side performance of wavy fin-and-tube heat exchanger with punched delta winglets in staggered and in-line arrangements 显示文摘 | Tian Liting He Yaling Tao Yubing | 2009 | International Journal of Thermal Sciences2009，48，9： | 1 |
| 12 | Numerical study of fluid flow and heat transfer in a flatplate channel with longitudinal vortex generators by applying filed synergy principle analysis显示文摘 | Tian Liting He Yaling Lei Yonggang | 2009 | International Communications in Heat Mass Transfer2009，36，2： | 1 |
| 13 | Lipase-catalyzed modification of lard to produce human milk fat substitutes显示文摘 | Tiankui Yang Xuebing Xu Chuan He Lite Li | 2002 | Food Chemistry2002，，4： | 1 |
| 14 | Numerical study of fluid flow and heat transfer in a fiat-plate channel with longitudinal vortex generators by applying field synergy principle analysis 显示文摘 | Tian Liting He Yaling Lei Yonggang | 2009 | International Communication in Heat and Mass Transfer2009，36，2： | 1 |
| 15 | A comparative study on the air-side performance of wavy fin-and-tube heat exchanger with punched delta winglets in staggered and in-line arrangements显示文摘 | Tian Liting He Yaling Tao Yubing | 2009 | International Journal of Thermal Sciences2009，48，9： | 1 |
| 16 | A comparative study on the air-side performance of wavy fin-and-tube heat exchanger with punched delta winglets in staggered and in-line arrangements 显示文摘 | Tian Liting He Yaling Tao Yubing | 2009 | International Journal of Thermal Sciences2009，48，9： | 1 |
| 17 | Hydrodynamics and heat transfer characteristics of a novel heat exchanger with delta-winglet vortex generators显示文摘 | Lei Yonggang He Yaling Tian Liting | 2010 | Chemical EngineeringScience2010，65，5： | 1 |
| 18 | Long non-coding RNA AFAP1-AS1 accelerates lung cancer cells migration and invasion by interacting with SNIP1 to upregulate c-Myc显示文摘Actin filament associated protein 1 antisense RNA 1(named AFAP1-AS1)is a long non-coding RNA and overexpressed in many cancers.This study aimed to identify the role and mechanism of AFAP1-AS1 in lung cancer.The AFAP1-AS1 expression was firstly assessed in 187 paraffin-embedded lung cancer and 36 normal lung epithelial tissues by in situ hybridization.The migration and invasion abilities of AFAP1-AS1 were investigated in lung cancer cells.To uncover the molecular mechanism about AFAP1-AS1 function in lung cancer,we screened proteins that interact with AFAP1-AS1 by RNA pull down and the mass spectrometry analyses.AFAP1-AS1 was highly expressed in lung cancer clinical tissues and its expression was positively correlated with lung cancer patients'poor prognosis.In vivo experiments confirmed that AFAP1-AS1 could promote lung cancer metastasis.AFAP1-AS1 promoted lung cancer cells migration and invasion through interacting with Smad nuclear interacting protein 1(named SNIP1),which inhibited ubiquitination and degradation of c-Myc protein.Upregulation of c-Myc molecule in turn promoted the expression of ZEB1,ZEB2,and SNAIL gene,which ultimately enhanced epithelial to mesenchymal transition(EMT)and lung cancer metastasis.Understanding the molecular mechanism by which AFAP1-AS1 promotes lung cancer's migration and invasion may provide novel therapeutic targets for lung cancer patients'early diagnosis and therapy. | Yu Zhong Liting Yang Fang Xiong Yi He Yanyan Tang Lei Shi Songqing Fan Zheng Li Shanshan Zhang Zhaojian Gong Can Guo Qianjin Liao Yujuan Zhou Ming Zhou Bo Xiang Xiaoling Li Yong Li Zhaoyang Zeng Guiyuan Li Wei Xiong | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 1 |
| 19 | The effect of electrolyzed water on decontamination, germination and γ-aminobutyric acid accumulation of brown rice显示文摘 | Rui Liu Xiangli He Jiaqi Shi Satoru Nirasawa Eizo Tatsumi Lite Li Haijie Liu | 2013 | Food Control2013，，1： | 1 |
| 20 | Numerical study of fluid flow and heat transfer in a flat-plate channel with longitudinal vortex generators by applying field synergy principle analysis显示文摘 | Tian Liting He Yaling Lei Yonggang | 2009 | International Communications in Heat and Mass Transfer2009，36，2： | 1 |
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