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| 1 | Two Types of Flash Drought and Their Connections with Seasonal Drought显示文摘Flash drought is a rapidly intensifying drought with abnormally high temperature,which has greatly threatened crop yields and water supply,and aroused wide public concern in a warming climate.However,the preferable hydrometeorological conditions for flash drought and its association with conventional drought at longer time scales remain unclear.Here,we investigate two types of flash drought over China:one is high-temperature driven(Type Ⅰ),while the other is water-deficit driven(Type Ⅱ).Results show that the frequencies of the two types of flash drought averaged over China during the growing season are comparable.Type I flash drought tends to occur over southern China,where moisture supply is sufficient,while Type Ⅱ is more likely to occur over semi-arid regions such as northern China.Both types of flash drought increase significantly(p<0.01)during 1979–2010,with a doubled rise in Type Ⅰ as compared with Type Ⅱ.Composite analysis shows that high temperature quickly increases evapotranspiration(ET)and reduces soil moisture from two pentads before the onset of Type Ⅰ flash drought.In contrast,there are larger soil moisture deficits two pentads before the onset of Type Ⅱ flash drought,leading to a decrease in ET and increase in temperature.For flash drought associated with seasonal drought,there is a greater likelihood of occurrence during the onset and recovery phases of seasonal drought,suggesting perfect conditions for flash drought during transition periods.This study provides a basis for the early warning of flash drought by connecting multiscale drought phenomena. | Linying WANG Xing YUAN | 2018 | Advances in Atmospheric Sciences2018，35，12： | 16 |
| 2 | Cancer-associated fibroblasts in breast cancer:Challenges and opportunities显示文摘The tumor microenvironment is proposed to contribute substantially to the progression of cancers,including breast cancer.Cancer-associated fibroblasts(CAFs)are the most abundant components of the tumor microenvironment.Studies have revealed that CAFs in breast cancer originate from several types of cells and promote breast cancer malignancy by secreting factors,generating exosomes,releasing nutrients,reshaping the extracellular matrix,and suppressing the function of immune cells.CAFs are also becoming therapeutic targets for breast cancer due to their specific distribution in tumors and their unique biomarkers.Agents interrupting the effect of CAFs on surrounding cells have been developed and applied in clinical trials.Here,we reviewed studies examining the heterogeneity of CAFs in breast cancer and expression patterns of CAF markers in different subtypes of breast cancer.We hope that summarizing CAFrelated studies from a historical perspective will help to accelerate the development of CAF-targeted therapeutic strategies for breast cancer. | Dengdi Hu Zhaoqing Li Bin Zheng Xixi Lin Yuehong Pan Peirong Gong Wenying Zhuo Yujie Hu Cong Chen Lini Chen Jichun Zhou Linbo Wang | 2022 | Cancer Communications2022，42，5： | 9 |
| 3 | Diurnal and Seasonal Variations of CO2Fluxes and Their Climate Controlling Factors for a Subtropical Forest in Ningxiang显示文摘In this study, the diurnal and seasonal variations of CO2 fluxes in a subtropical mixed evergreen forest in Ningxiang of Hunan Province, part of the East Asian monsoon region, were quantified for the first time. The fluxes were based on eddy covariance measurements from a newly initiated flux tower. The relationship between the CO2 fluxes and climate factors was also analyzed. The results showed that the target ecosystem appeared to be a clear carbon sink in 2013, with integrated net ecosystem CO2exchange(NEE), ecosystem respiration(RE), and gross ecosystem productivity(GEP) of-428.8, 1534.8 and1963.6 g C m-2yr-1, respectively. The net carbon uptake(i.e. the-NEE), RE and GEP showed obvious seasonal variability,and were lower in winter and under drought conditions and higher in the growing season. The minimum NEE occurred on12 June(-7.4 g C m-2d-1), due mainly to strong radiation, adequate moisture, and moderate temperature; while a very low net CO2 uptake occurred in August(9 g C m-2month-1), attributable to extreme summer drought. In addition, the NEE and GEP showed obvious diurnal variability that changed with the seasons. In winter, solar radiation and temperature were the main controlling factors for GEP, while the soil water content and vapor pressure deficit were the controlling factors in summer. Furthermore, the daytime NEE was mainly limited by the water-stress effect under dry and warm atmospheric conditions, rather than by the direct temperature-stress effect. | JIA Binghao XIE Zhenghui ZENG Yujin WANG Linying WANG Yuanyuan XIE Jinbo XIE Zhipeng | 2015 | Advances in Atmospheric Sciences2015，32，4： | 9 |
| 4 | Variation in cis-regulation of a NAC transcription factor contributes to drought tolerance in wheat显示文摘Drought is a major environmental factor limiting wheat production worldwide,and developing drought-tolerant cultivars is a central challenge for wheat breeders globally.Therefore,it is important to identify genetic components determining drought tolerance in wheat.In this study,we identified a wheat NAC gene(TaNAC071-A)that is tightly associated with drought tolerance by a genome-wide association study.Knockdown of TaNAC071-A in wheat attenuated plant drought tolerance,whereas its overexpression significantly enhanced drought tolerance through improved water-use efficiency and increased expression of stress-responsive genes.This heightened water-saving mechanism mitigated the yield loss caused by water deficit.Further candidate gene association analysis showed that a 108-bp insertion in the promoter of TaNAC071-A alters its expression level and contributes to variation in drought tolerance among wheat accessions.This insertion contains two MYB cis-regulatory elements(CREs)that can be directly bound by the MYB transcription activator,TaMYBL1,thereby leading to increased TaNAC071-A expression and plant drought tolerance.Importantly,introgression of this 108-bp insertion allele,TaNAC071-AIn-693,into drought-sensitive cultivars could improve their drought tolerance,demonstrating that it is a valuable genetic resource for wheat breeding.Taken together,our findings highlight a major breakthrough in determining the genetic basis underlying phenotypic variation in wheat drought tolerance and showcase the potential of exploiting CRE-containing indels for improving important agronomical traits. | Hude Mao Shumin Li Bin Chen Chao Jian Fangming Mei Yifang Zhang Fangfang Li Nan Chen Tian Li Linying Du Li Ding Zhongxue Wang Xinxiu Cheng Xiaojing Wang Zhensheng Kang | 2022 | Molecular Plant2022，15，2： | 9 |
| 5 | Electroacupuncture diminishes P2X_2 and P2X_3 purinergic receptor expression in dorsal root ganglia of rats with visceral hypersensitivity显示文摘Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) can improve visceral hypersensitivity in rats. Colorectal distension was used to establish a rat model of chronic visceral hypersensitivity. Immunohistochemistry was used to detect P2X2 and P2X3 receptor expression in dorsal root ganglia from rats with chronic visceral hypersensitivity. Results demonstrated that abdominal withdrawal reflex scores obviously increased following establishment of the model, indicating visceral hypersensitivity. Simultaneously, P2X2 and P2X3 receptor expression increased in dorsal root ganglia. After bilateral electroacupuncture at Shangjuxu and Tianshu, abdominal withdrawal reflex scores and P2X2 and P2X3 receptor expression decreased in rats with visceral hypersensitivity. These results indicated that electroacupuncture treatment improved visceral hypersensitivity in rats with irritable bowel syndrome by reducing P2X2 and P2X3 receptor expression in dorsal root ganglia. | Zhijun Weng Luyi Wu Yuan Lu Lidong Wang Linying Tan Ming Dong Yuhu Xin | 2013 | Neural Regeneration Research2013，8，9： | 7 |
| 6 | Electroacupuncture at Tianshu (ST 25) for diarrhea-predominant irritable bowel syndrome using positron emission tomography Changes in visceral sensation center显示文摘Previous studies have demonstrated that electroacupuncture therapy is effective in the treatment of irritable bowel syndrome. However, the precise mechanism of this therapy is unknown. The present study served to investigate the effects of electroacupuncture therapy on treatment of patients with diarrhea-predominant irritable bowel syndrome (IBS). We compared brain activation maps based on the changes of cerebral glucose metabolism obtained by 18-fluorodeoxyglucose positron emission tomography scanning under three conditions: resting, rectal balloon distension and rectal balloon distension plus electroacupuncture. Under the resting condition, compared with healthy controls, IBS patients displayed an increasing regional cerebral metabolic rate of glucose over a wide range: bilateral superior temporal gyrus, right middle occipital gyrus, superior frontal gyrus and bilateral middle frontal gyrus. However, there was no significant activity in the visceral pain center. Compared with the resting condition, under the rectal balloon distension condition, patients with IBS had a greater regional cerebral metabolic rate of glucose in the prefrontal cortex, left anterior cingulate cortex, postcentral gyrus, precentral gyrus and temporal gyrus. Under the rectal balloon distension plus electroacupuncture condition, stimulation by electroacupuncture at Tianshu (ST 25) manifested a decreased regional cerebral metabolic rate of glucose in the left cingulate gyrus, right insula, right caudate nucleus, fusiform gyrus and hippocampal gyrus. Electroacupuncture therapy relieved abdominal pain, distension or discomfort by decreasing glucose metabolism in the brain. | Huirong Liu Li Qi Xiaolong Wang Yihui Guan Chuantao Zuo Linying Tan Lingsong Yuan Xiaopeng Ma Xiaomei Wang Enhua Zhou Huangan Wu | 2010 | Neural Regeneration Research2010，5，16： | 6 |
| 7 | Copper-ceria sheets catalysts: Effect of copper species on catalytic activity in CO oxidation reaction显示文摘Copper-ceria sheets catalysts with different loadings of copper(2 wt.%, 5 wt.% and 10 wt.%) supported on ceria nanosheets were synthesized via a depositioneprecipitation(DP) method. The prepared catalysts were systematically characterized with various structural and textural detections including X-ray diffraction(XRD), Raman spectra, transmission electron microscopy(TEM), X-ray absorption fine structure(XAFS), and temperature-programmed reduction by hydrogen(H_2-TPR), and tested for the CO oxidation reaction. Notably, the sample containing 5 wt.% of Cu exhibited the best catalytic performance as a result of the highest number of active CuO species on the catalyst surface. Further increase of copper content strongly affects the dispersion of copper and thus leads to the formation of less active bulk CuO phase, which was verified by XRD and H_2-TPR analysis. Moreover, on the basis of in-situ diffuse reflectance infrared Fourier transform spectroscopy(in-situ DRIFTS) results, the surface Cu^+ species, which are derived from the reduction of Cu^(2+), are likely to play a crucial role in the catalyzing CO oxidation.Consequently, the superior catalytic performance of the copper-ceria sheets is mainly attributed to the highly dispersed CuO_x cluster rather than Cu-[O_x]-Ce structure, while the bulk CuO phase is adverse to the catalytic activity of CO oxidation. | Linying Du Weiwei Wang Han Yan Xu Wang Zhao Jin Qisheng Song Rui Si Chunjiang Jia | 2017 | Journal of Rare Earths2017，35，12： | 5 |
| 8 | In vitro assessment of thyroid hormone receptor activity of four organophosphate esters显示文摘Previous animal experiments have implied that organophosphate esters(OPEs) have a disruption effect on the thyroid endocrine system. However, knowledge of the toxicological mechanism remains limited. In this study, the activities of four OPEs have been characterized against the thyroid hormone(TH) nuclear receptor(TR) using two in vitro models, with the aim of evaluating their toxicity mechanisms towards the TR. The results of a TH-dependent cell proliferation assay showed that tris(2-chloro-1-(chloromethyl)ethyl)phosphate(TDCPP) could induce cell growth, while the other three OPEs had no effect. The results of a luciferase reporter gene assay revealed that all four of the OPEs tested in the current study showed agonistic activity towards TRβ, with TDCPP being the most potent one. Moreover, molecular docking revealed that all the tested OPEs could fit into the ligand binding pocket of TRβ, with TDCPP binding more effectively than the other three OPEs. Taken together, these data suggest that OPEs might disrupt the thyroid endocrine system via a mechanism involving the activation of TR. | Xiaomin Ren Linying Cao Yu Yang Bin Wan Sufang Wang Lianghong Guo | 2016 | Journal of Environmental Sciences2016，28，7： | 4 |
| 9 | Four-year dynamic observation and study on standardized management of elderly patients with type 2 diabetes in Beijing Yongding Road Community显示文摘Purpose:This study aimed to understand the joint standard of blood glucose,blood li-pids,and blood pressure in elderly patients>60 years of age with type 2 diabetes in the Beijing Yongding Road Community.Methods:One hundred ninety-two elderly patients>60 years of age who were diagnosed with type 2 diabetes in Yongding Road Community served as the investigation subjects,under-went standard management,and the dynamic changes in blood glucose,blood lipids,and blood pressure were monitored for 48 months.Results:At the end of the observation period,the standard rates of fasting blood glucose and postprandial blood glucose were 72.55%and 80.00%,respectively,which were increased compared with 55.73%and 56.08%at baseline(P<0.01).The standard rate of HbA1c was 59.81%,which was increased compared with 53.44%at baseline(P>0.05).The standard rates of TG and LDL-C were 76.71%and 60.38%,respectively,which were increased compared with 54.69%and 34.74%at base-line,and the standard rate of HDL-C was 13.64%,which was decreased compared with 40.10%at baseline(P<0.01).The standard rate of BP was 58.33%,which was increased compared with 38.54%at baseline(P<0.01).The optimal control rate of blood glucose for 48 months(the standard times of the total measurement times in 48 months≥75%)was higher;the fasting blood glucose was 52.17%,the 2-h postprandial blood glucose was 60.22%,and the HbA1c was 46.45%.The optimal control rate of blood lipids was lower;LDL-C was 17.49%and HDL-C was 13.59%.The optimal control rate of BP was 9.13%.At the end of the observation period,the levels of fasting blood glucose and postprandial blood glucose were decreased by 0.7 mmol/L and 1.48 mmol/L,respectively,compared with the base-line(P<0.01).The level of HbA1c was decreased by 0.18%compared with the baseline(P<0.05).The levels of LDL-C and HDL-C were decreased by 0.4 mmol/L and 0.23 mmol/L,respectively,compared with the baseline(P<0.01).The levels of SBP and DBP were decreased by 4 mmHg compared with the baseline(P<0.01).At the end of the observation period,the joint standard rate of the three indices of HbA1c,LDL-C,and BP was 24.72%,which was increased compared with 6.25%at baseline(P<0.01).Conclusion:Standardized management of elderly patients with diabetes in the Community can improve the joint standard rate of blood glucose,blood lipids,and blood pressure.The op-timal control rate and joint standard rate are the important indices for evaluating the quality of diabetes management. | Yue Li Dongyun Shen Wei Zhang Yimin Wang Hongmei Li Jie Geng Liying Yang Zhijun Xiao Yan Liu Zhigang Feng Linying Cao Yan Jin Lixia Shi | 2014 | Family Medicine and Community Health2014，2，2： | 4 |
| 10 | MICROSTRUCTURE OF INTERFACE BETWEEN HVOF SPRAYED WC-Co COATING AND SPRING STEEL SUBSTRATE显示文摘MICROSTRUCTUREOFINTERFACEBETWEENHVOFSPRAYEDWC-CoCOATINGANDSPRINGSTEELSUBSTRATE￥ShaoBeiling;LiuAnsheng;WangXiaohua;LiYonghong;... | Shao Beiling Liu Ansheng Wang Xiaohua Li Yonghong Zou Linying Wang Jing Zhang Jianguo Shi Changyong Zhou Yiru(General Research institute For Nonferrous Metals,Beijing 100088) | 1996 | 中国有色金属学会会刊:英文版1996，6，4： | 3 |
| 11 | High-strength porous alumina ceramics prepared from stable wet foams显示文摘Porous ceramics have been widely used in heat insulation,filtration,and as a catalyst carrier.Ceramics with high porosity and high strength are desired;however,this high porosity commonly results in low strength materials.In this study,porous alumina with high porosity and high strength was prepared by a popular direct foaming method based on particle-stabilized wet foam that used ammonium polyacrylate(PAA)and dodecyl trimethyl ammonium chloride(DTAC)as the dispersant and hydrophobic modifier,respectively.The effects of the dispersant and surfactant contents on the rheological properties of alumina slurries,stability of wet foams,and microstructure and mechanical properties of sintered ceramics were investigated.The microstructure of porous ceramics was regulated using wet foams to achieve high strength.For a given PAA content,the wet foams exhibited increasing stability with increasing DTAC content.The most stable wet foam was successfully obtained with 0.40 wt%PAA and 0.02 wt%DTAC.The corresponding porous alumina ceramics had a porosity of 82%,an average grain size of 0.7μm,and a compressive strength of 39 MPa.However,for a given DTAC content,the wet foams had decreasing stability with increasing PAA content.A possible mechanism to explain these results is analyzed. | Linying WANG Liqiong AN Jin ZHAO Shunzo SHIMAI Xiaojian MAO Jian ZHANG Juan LIU Shiwei WANG | 2021 | Journal of Advanced Ceramics2021，10，4： | 3 |
| 12 | Electrochemical properties of MmNi 3.8 Co 0.75 Mn 0.4 Al 0.2 hydrogen storage alloy modified with nanocrystalline nickel显示文摘 | Xiangyu Zhao Yi Ding Liqun Ma Linying Wang Meng Yang Xiaodong Shen | 2008 | International Journal of Hydrogen Energy2008，，22： | 2 |
| 13 | Overexpression of miR-431 attenuates hypoxia/reoxygenation-induced myocardial damage via autophagy-related 3显示文摘Myocardial injury is still a serious condition damaging the public health. Clinically, myocardial injury often leads to cardiac dysfunction and, in severe cases, death. Reperfusion of the ischemic myocardial tissues can minimize acute myocardial infarction (AMI)-induced damage. MicroRNAs are commonly recognized in diverse diseases and are often involved in the development of myocardial ischemia/reperfusion injury. However, the role of miR-431 remains unclear in myocardial injury. In this study, we investigated the underlying mechanisms of miR-431 in the cell apoptosis and autophagy of human cardiomyocytes in hypoxia/reoxygenation (H/R). H/R treatment reduced cell viability, promoted cell apoptotic rate, and down-regulated the expression of miR-431 in human cardiomyocytes. The down-regulation of miR-431 by its inhibitor reduced cell viability and induced cell apoptosis in the human cardiomyocytes. Moreover, miR-431 down-regulated the expression of autophagy-related 3 (ATG3) via targeting the 3ʹ-untranslated region of ATG3. Up-regulated expression of ATG3 by pcDNA3.1-ATG3 reversed the protective role of the overexpression of miR-431 on cell viability and cell apoptosis in H/R-treated human cardiomyocytes. More importantly, H/R treatments promoted autophagy in the human cardiomyocytes, and this effect was greatly alleviated via miR-431-mimic transfection. Our results suggested that miR-431 overexpression attenuated the H/R-induced myocardial damage at least partly through regulating the expression of ATG3. | Kang Zhou Yan Xu Qiong Wang Lini Dong | 2021 | Acta Biochimica et Biophysica Sinica2021，53，2： | 2 |
| 14 | Electrochemical properties of MmNi 3.8 Co 0.75 Mn 0.4 Al 0.2 hydrogen storage alloy modified with nanocrystalline nickel显示文摘 | Xiangyu Zhao Yi Ding Liqun Ma Linying Wang Meng Yang Xiaodong Shen | 2008 | International Journal of Hydrogen Energy2008，，22： | 2 |
| 15 | The abnormal variation of earth temperature before the Tangshan and Haicheng earthquakes 显示文摘 | Wang Linying Zhu Chuanzhen | 1984 | Journal of Seismological Research1984，7，6： | 1 |
| 16 | Highly Effective Inactivation of Pseudomonas sp HB1 in Water By Atmospheric Pressure Microplasma Jet Array显示文摘 | Xianhui Zhang Dongping Liu Hongzhe Wang Linying Liu Songbai Wang Si-ze Yang | 2012 | Plasma Chemistry and Plasma Processing2012，，： | 1 |
| 17 | A Facile stratcgy for constructing boron-rich nanoparticles via boronic acidrelated reaction显示文摘 | Zhang LZ LinY Wang J | | 0，，06： | 1 |
| 18 | Single-cell transcriptomic analysis reveals a systemic immune dysregulation in COVID-19-associated pediatric encephalopathy显示文摘Unraveling the molecular mechanisms for COVID-19-associated encephalopathy and its immunopathology is crucial for developing effective treatments.Here,we utilized single-cell transcriptomic analysis and integrated clinical observations and laboratory examination to dissect the host immune responses and reveal pathological mechanisms in COVID-19-associated pediatric encephalopathy.We found that lymphopenia was a prominent characteristic of immune perturbation in COVID-19 patients with encephalopathy,especially those with acute necrotizing encephalopathy(AE).This was characterized a marked reduction of various lymphocytes(e.g.,CD8^(+)T and CD4^(+)T cells)and significant increases in other inflammatory cells(e.g.,monocytes).Further analysis revealed activation of multiple cell apoptosis pathways(e.g.,granzyme/perforin-,FAS-and TNF-induced apoptosis)may be responsible for lymphopenia.A systemic S100A12 upregulation,primarily from classical monocytes,may have contributed to cytokine storms in patients with AE.A dysregulated type I interferon(IFN)response was observed which may have further exacerbated the S100A12-driven inflammation in patients with AE.In COVID-19 patients with AE,myeloid cells(e.g.,monocytic myeloid-derived suppressor cells)were the likely contributors to immune paralysis.Finally,the immune landscape in COVID-19 patients with encephalopathy,especially for AE,were also characterized by NK and T cells with widespread exhaustion,higher cytotoxic scores and inflammatory response as well as a dysregulated B cell-mediated humoral immune response.Taken together,this comprehensive data provides a detailed resource for elucidating immunopathogenesis and will aid development of effective COVID-19-associated pediatric encephalopathy treatments,especially for those with AE. | Yi Wang Laurence Don Wai Luu Shuang Liu Xiong Zhu Siyuan Huang Fang Li Xiaolan Huang Linying Guo Jin Zhang Haiyan Ge Yuanyuan Sun Yi Hui Yanning Qu Huicong Wang Xiaoxia Wang Weilan Na Juan Zhou Dong Qu Jun Tai | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
| 19 | Ir-Catalyzed Asymmetric Hydrogenation of Unprotected Indoles:Scope Investigations and Mechanistic Studies显示文摘Transition metal-catalyzed asymmetric hydrogenation(AH)of unprotected indoles has mainly been applied to alkyl substituted unprotected indoles.However,the challenging aryl substituted unprotected indoles with poor reactivity and enantioselectivity(≤42%ee)could not be hydrogenated well.In this work,a highly efficient Ir/bisphosphine-thiourea ligand ZhaoPhos catalytic system for the AH of challenging aryl substituted unprotected indoles has been successfully developed for the first time with high reactivity and excellent stereoselective control.Moreover,a series of 2-alkyl-substituted and 2,3-disubstituted unprotected indoles were also well tolerated in this catalytic system.A wide variety of chiral indoline derivatives were obtained in good to high yields with excellent stereoselectivities(75–99%yields,>20:1 dr,and 86–99%ee).The anion-binding activation strategy played an important role in accessing both high reactivity and excellent stereoselectivity,which was formed between the catalyst and unprotected indoles in situ-generating iminium ion with the assistance of Brønsted acid.A possible catalytic mechanism was proposed for this Ir-catalyzed AH according to density functional theory calculations and control experiment results.Readily available substrates,a broad range of substrate tolerance,an efficient chiral catalytic system,and a gram-scale protocol further demonstrated the potential practicality of this methodology. | Gongyi Liu Lini Zheng Kui Tian Haifeng Wang Lung Wa Chung Xumu Zhang Xiu-Qin Dong | 2023 | CCS Chemistry2023，5，6： | 0 |
| 20 | An Approach to Obtain the Correct Shock Speed for Euler Equations with Stiff Detonation显示文摘Incorrect propagation speed of discontinuities may occur by straightforward application of standard dissipative schemes for problems that contain stiff source terms for underresolved grids even for time steps within the CFL condition.By examining the dissipative discretized counterpart of the Euler equations for a detonation problem that consists of a single reaction,detailed analysis on the spurious wave pattern is presented employing the fractional stepmethod,which utilizes the Strang splitting.With the help of physical arguments,a threshold values method(TVM),which can be extended to more complicated stiff problems,is developed to eliminate the wrong shock speed phenomena.Several single reaction detonations as well as multispecies and multi-reaction detonation test cases with strong stiffness are examined to illustrate the performance of the TVM approach. | Bin Yu Linying Li Bin Zhang Jianhang Wang | 2017 | Communications in Computational Physics2017，22，6： | 0 |
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