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| 1 | Osthole inhibits proliferation of human breast cancer cells by inducing cell cycle arrest and apoptosis显示文摘Recent studies have revealed that osthole,an active constituent isolated from the fruit of Cnidium monnieri(L.) Cusson,a traditional Chinese medicine,possesses anticancer activity.However,its effect on breast cancer cells so far has not been elucidated clearly.In the present study,we evaluated the effects of osthole on the proliferation,cell cycle and apoptosis of human breast cancer cells MDA-MB 435.We demonstrated that osthole is effective in inhibiting the proliferation of MDA-MB 435 cells,The mitochondrion-mediated apoptotic pathway was involved in apoptosis induced by osthole,as indicated by activation of caspase-9 and caspase-3 followed by PARP degradation.The mechanism underlying its effect on the induction of G1 phase arrest was due to the up-regulation of p53 and p21 and down-regulation of Cdk2 and cyclin D1 expression.Were observed taken together,these findings suggest that the anticancer efficacy of osthole is mediated via induction of cell cycle arrest and apoptosis in human breast cancer cells and osthole may be a potential chemotherapeutic agent against human breast cancer. | Lintao Wang Yanyan Peng Kaikai Shi Haixiao Wang Jianlei Lu Yanli Li Changyan Ma | 2015 | The Journal of Biomedical Research2015，29，2： | 12 |
| 2 | Retrieval of the Change of Precipitable Water Vapor by GPS Technique显示文摘GPS 可降水蒸汽(PWV ) 的可行性基于相关系数是 0.94 的雷送和 GPS PWV 的比较被讨论, RMS 是 4.0 公里。在在 2004 的中国大陆的 PWV 变化是有在紧张的花键的 gridding 方法的 graphed,根据在中国的外壳监视器观测站网的 GPS 数据,与相关气象学信息结合了。根据在这个国家的降雨的年度数量的分发, PWV 的全部的趋势从东南沿海岸地区正在减少到西北内陆,这能被结束。PWV 到达它的最大值在期间 7 月和 8 月,和最小在 1 月和 2 月期间被到达。根据 PWV,从对 low 高,所有区域能作为东南沿海岸地区,内陆和台地被评价。 | WANG Yong LIU Yanping LIU Lintao XU Houze | 2007 | Geo-Spatial Information Science2007，10，4： | 8 |
| 3 | A new calculation model of cutterhead torque and investigation of its influencing factors显示文摘Cutterhead torque is a crucial parameter for the design and operation of earth pressure balance(EPB) shield tunneling machine.However,the traditional calculation models of cutterhead torque are too rough or exist gross errors under variable geological conditions.In order to improve the precision of the calculation model of cutterhead torque,dynamic operation parameters are considered and a new model is proposed.Experiment is carried out on a 1.8 m shield machine test rig and the calculating result with the new model is compared with the experimental data to verify the validity of the new model.The relative error of the new model is as low as 4% at smooth stage and is reduced to 5% at the end of trembling stage.Based on the results of the new model and the test data obtained from the 1.8 m test rig and the construction site,the inner relationships between several operation parameters and cutterhead torque are investigated and some quantitative conclusions are obtained. | WANG LinTao GONG GuoFang SHI Hu YANG HuaYong | 2012 | Science China(Technological Sciences)2012，55，6： | 6 |
| 4 | Design and test of soft-pot-tray automatic embedding system for light-economical pot seedling nursery machine显示文摘Most of the commercially-available pot seedling nursery machines are incompatible with soft-pot-trays and are labor-intensive and low in productivity.A soft-pot-tray automatic embedding system was developed in this study to achieve automatic embedding of the soft pot tray into the hard tray following sowing and covering with soil.A control system was constructed using the Arduino program development environment.An embedded-hard-tray automatic lowering mechanism and conveyor-belt-based pot-tray embedding system were designed.Dynamics analysis was conducted to derive an equation to describe the embedding process of the soft pot tray into the embedded hard tray.A prototype of the soft-pot-tray automatic embedding system was manufactured and tested.The analytical equation suggested that a minimum linear velocity of 0.86 m/s was required for a complete embedding process.The experimental results showed that the embedded-hard-tray automatic lowering mechanism was reliable and stable as the tray placement success rate was greater than 99%.The successful tray embedding rate was 100%and the seed exposure rate was less than 1%with a linear velocity of the conveyor belt of 0.92 m/s.The experiment findings agreed well with the analytical results.The proposed soft-pot-tray automatic embedding system satisfied the technical specifications for a light-economical pot seedling nursery machine. | Lintao Chen Xu Ma Cong Wang Hongwei Li Zehua Li Xueshen Chen Tao Chen | 2020 | International Journal of Agricultural and Biological Engineering2020，13，1： | 4 |
| 5 | High-performance all-polymer solar cells enabled by a novel low bandgap non-fully conjugated polymer acceptor显示文摘The non-fully conjugated polymer as a new class of acceptor materials has shown some advantages over its small molecular counterpart when used in photoactive layers for all-polymer solar cells(all-PSCs),despite a low power conversion efficiency(PCE)caused by its narrow absorption spectra.Herein,a novel non-fully conjugated polymer acceptor PFY-2TS with a low bandgap of~1.40 eV was developed,via polymerizing a largeπ-fused small molecule acceptor(SMA)building block(namely YBO)with a non-conjugated thioalkyl linkage.Compared with its precursor YBO,PFY-2TS retains a similar low bandgap but a higher LUMO level.Moreover,compared with the structural analog of YBO-based fully conjugated polymer acceptor PFY-DTC,PFY-2TS shows a similar absorption spectrum and electron mobility,but significantly different molecular crystallinity and aggregation properties,which results in optimal blend morphology with a polymer donor PBDB-T and physical processes of the device in all-PSCs.As a result,PFY-2TS-based all-PSCs achieved a PCE of 12.31%with a small energy loss of 0.56 eV enabled by the reduced non-radiative energy loss(0.24 eV),which is better than that of 11.08%for the PFY-DTC-based ones.Our work clearly demonstrated that non-fully conjugated polymers as a new class of acceptor materials are very promising for the development of high-performance all-PSCs. | Qunping Fan Ruijie Ma Tao Liu Jianwei Yu Yiqun Xiao Wenyan Su Guilong Cai Yuxiang Li Wenhong Peng Tao Guo Zhenghui Luo Huiliang Sun Lintao Hou Weiguo Zhu Xinhui Lu Feng Gao Ellen Moons Donghong Yu He Yan Ergang Wang | 2021 | Science China Chemistry2021，64，8： | 3 |
| 6 | Study on the surface cracking in hot-rolled plates of Fe-23Mn-2Al-V austenitic steel显示文摘The study introduces the chemical composition,mechanical properties,physical properties and production processes of the Fe-23Mn-2Al-V austenitic steel.Investigations were made into the formation of cracks in the hot-rolled Fe-23Mn-2Al-V steel plates,with optical microscopy (OM),scanning electron microscopy (SEM) and energy dispersive spectrum (EDS).The results have shown that intergranular oxidation in the reheating furnace is the main cause of the cracks on the surface of the hot-rolled steel plates.The surface cracking can be largely avoided by controlling the remaining oxygen content in the reheating furnace and improving continuous casting (CC) processes to increase the thickness of fine equiaxed grain layer of the steel slabs. | LIAO Hongjun MAO Zhengdong WANG Lintao ZHU Jun LI Yuan ZHANG Heng | 2011 | Baosteel Technical Research2011，5，1： | 2 |
| 7 | Novel Mg-Bi-Mn wrought alloys:The effects of extrusion temperature and Mn addition on their microstructures and mechanical properties显示文摘Designing and developing the Mg alloys with low cost and high performance is of the great significance.Novel Mg-1Bi-xMn(x=0,1and 2 wt.%)extruded alloys,in this work,were fabricated at different extrusion temperatures(220,250 and 300℃).The effects of extrusion temperature and Mn addition on the microstructures and mechanical properties of extruded alloys at room temperature were investigated.The results showed that decreasing the extrusion temperature could refine the average grain size,weaken the basal fiber texture intensity and improve the microstructural homogeneity of extruded alloys.When the Mn element was added to the Mg-1Bi alloy,the average grain size further reduced.Simultaneously,the number fraction of low angle grain boundaries(LAGBs)increased,along with the occurrence of regions without dynamic recrystallization(unDRX).The combined effects of grain refinement and coarse unDRXed structure made the textures of the extruded Mg-1Bi-xMn alloys never obviously change.Besides few large size un-dissolved second phases,fine Mg_(3)Bi_(2) and α-Mn phases were precipitated in the extruded Mg-1Bi-xMn alloys and partial nano-scaleα-Mn particles pined at grain boundaries(GBs)to effectively impede the migration of GBs for grain refinement.Microstructural variations determined the extruded Mg-1Bi-2Mn alloy to exhibit the highest yield strength of~319.2 MPa with the appropriate elongation-to-failure of~13%at the extrusion temperature of 220℃,and they enabled the extruded Mg-1Bi-1Mn alloy to show the highest elongation-to-failure of~26%without the obvious loss of yield strength of~252.1 MPa. | Qinghang Wang Haowei Zhai Lintao Liu Hongbo Xia Bin Jiang Jun Zhao Daolun Chen Fusheng Pan | 2022 | Journal of Magnesium and Alloys2022，10，9： | 2 |
| 8 | Temperature field analysis and its application in hot continuous rolling of Inconel 718 superalloy显示文摘A coupled thermo-mechanical model containing metal flow and temperature field for calculating temperature variation has been developed on fourteen-pass hot continu-ous rolling of round rod for Inconel 718 alloy using 3D elastic-plastic finite element method(FEM).The temperature of characteristic analysis points in the intermedi-ate cross-section of the workpiece has been simulated at initial temperature ranging from 960 to 1000 °C and initial velocity in range of 0.15-0.55 m·s-1.Based on fi-nite element analysis and microstructural observation in cylindrical hot compression experiments,the appropriate hot continuous rolling technologies have been designed for rod products with different diameters.For a real rolling practice,the simulated surface temperature was examined and is in good agreement with the measured one. | Fengli SUI Liqing CHEN Xianghua LIU Lintao WANG Wei LI | 2009 | Acta Metallurgica Sinica(English Letters)2009，22，2： | 2 |
| 9 | Modeling and analysis of thrust force for EPB shield tunneling machine显示文摘 | WANG Lintao GONG Guofang SHI Hu | 2012 | Automation in Construction2012，27，： | 1 |
| 10 | Modeling and analysis of thrust force for EPB shield tunneling machine显示文摘 | Lintao Wang Guofang Gong Hu Shi Huayong Yang | 2012 | Automation in Construction2012，，： | 1 |
| 11 | Determination of the cutterhead torque for EPB shield tunneling machine显示文摘 | Hu Shi Huayong Yang Guofang Gong Lintao Wang | 2011 | Automation in Construction2011，，8： | 1 |
| 12 | The Development of a high-speed segment erec- ting system for shield tunneling machine显示文摘 | WANG Lintao GONG Guofang YANG Huayong | 2013 | IEEE/ ASME Transactions on Mechatronies2013，18，6： | 1 |
| 13 | Side- chain architectures of 2, 7-earbazole and quinoxaline-based polymers for efficient polymer solar cells 显示文摘 | Wang Ergang Hou Lintao Wang Zhongqiang | 2011 | Macromole- cules2011，44，： | 1 |
| 14 | Effects of Flexible Conjugation-Break Spacers of Non-Conjugated Polymer Acceptors on Photovoltaic and Mechanical Properties of All-Polymer Solar Cells显示文摘All-polymer solar cells(all-PSCs)possess attractive merits including superior thermal stability and mechanical flexibility for large-area roll-to-roll processing.Introducing flexible conjugation-break spacers(FCBSs)into backbones of polymer donor(P_(D))or polymer acceptor(P_(A))has been demonstrated as an efficient approach to enhance both the photovoltaic(PV)and mechanical properties of the all-PSCs.However,length dependency of FCBS on certain all-PSC related properties has not been systematically explored.In this regard,we report a series of new non-conjugated P_(A)s by incorporating FCBS with various lengths(2,4,and 8 carbon atoms in thioalkyl segments).Unlike com-mon studies on so-called side-chain engineering,where longer side chains would lead to better solubility of those resulting polymers,in this work,we observe that the solubilities and the resulting photovoltaic/mechanical properties are optimized by a proper FCBS length(i.e.,C2)in P_(A) named PYTS-C2.Its all-PSC achieves a high efficiency of 11.37%,and excellent mechanical robustness with a crack onset strain of 12.39%,significantly superior to those of the other P_(A)s.These results firstly demonstrate the effects of FCBS lengths on the PV performance and mechanical properties of the all-PSCs,providing an effective strategy to fine-tune the structures of P_(A)s for highly efficient and mechanically robust PSCs. | Qiaonan Chen Yung Hee Han Leandro R.Franco Cleber F.N.Marchiori Zewdneh Genene CMoyses Araujo Jin-Woo Lee Tan Ngoc-Lan Phan Jingnan Wu Donghong Yu Dong Jun Kim Taek-Soo Kim Lintao Hou Bumjoon J.Kim Ergang Wang | 2022 | Nano-Micro Letters2022，14，10： | 1 |
| 15 | Determination of the cutterhead torque for EPB shield tunneling machine显示文摘 | Hu Shi Huayong Yang Guofang Gong Lintao Wang | 2011 | Automation in Construction2011，，8： | 1 |
| 16 | Revealing HOC1 burst from endoplasmic reticulum in cisplatin-treated cells via a ratiometric fluorescent probe显示文摘The reactive oxygen species(ROS) are tightly associated with endoplasmic reticulum(ER) stress.Thus,the deep and visual insight of aberrant ROS fluctuations in the ER can help us better investigate the ER stress-associated pathology.In this work,a fluorescent probe ERC for HOCI detection in the ER based on phenothiazine-derived coumarin platform was developed.In the presence of HOCI,ERC exhibited an emission change from 609 nm to 503 nm within seconds.It also showed high sensitivity(0.44 μmol/L)and superb photostability.Significantly,ERC displayed low cytotoxicity,good cell membrane permeability,and appreciable ER-targetability.Ultimately,the probe was successfully utilized to image exogenous and endogenous HOCl in living cells and reveal the HOCI burst in cisplatin-treated cancer cells. | Shan Wang Beitong Zhu Bingya Wang Xinhua Cao Lei Zhu Ji-Ting Hou Lintao Zeng | 2021 | Chinese Chemical Letters2021，32，5： | 1 |
| 17 | Protection Performance of Plasma Sprayed Al_(2)O_(3)-13 wt%TiO_(2) Coating Sealed with an Organic-inorganic Hybrid Agent显示文摘An organic-inorganic hybrid sealing agent was fabricated and used in the plasma sprayed Al_(2)O_(3)-13 wt%TiO_(2)coating,and conventional silicone agent was also used for comparison.Protection performance of the coatings was comprehensively evaluated based on both anti-corrosion and anti-biofouling properties.The results reveal that the sealing treatment is remarkably useful to decrease the porosity of the coating,and the porosity of the coating sealed with the hybrid agent is only 0.035%.Immersion corrosion test and Tafel polarization test reveal that the sealed coating with the hybrid agent exhibits a better corrosion resistance by compared with the coating sealed with silicone agent.The corrosion current density i_(corr) of the hybrid agent sealed coating is only 0.7×10^(-6)A·cm^(-2).Moreover,anti-biofouling tests both in the outdoor analogue hydraulic environment and in the natural marine environment prove that the mentioned novel coating presents a better combination of corrosion resistance and anti-biofouling property by compared with the other coatings,and it could be used as a protection of metal components in the marine environment. | 张凯城 周泽华 DENG Yong WANG Guangyu WANG Zehua WU Lintao YANG Guangheng | 2022 | Journal of Wuhan University of Technology(Materials Science)2022，37，3： | 1 |
| 18 | Path Planning and Navigation of Oceanic Autonomous Sailboats and Vessels: A Survey显示文摘Oceanic autonomous surface vehicles(ASVs) are one kind of autonomous marine robots that have advantages of energy saving and is flexible to use. Nowadays, ASVs are playing an important role in marine science, maritime industry, and national defense. It could improve the efficiency of oceanic data collection, ensure marine transportation safety, and protect national security. One of the core challenges for ASVs is how to plan a safe navigation autonomously under the complicated ocean environment. Based on the type of marine vehicles, ASVs could be divided into two categories: autonomous sailboats and autonomous vessels. In this article, we review the challenges and related solutions of ASVs' autonomous navigation, including modeling analysis, path planning and implementation. Finally, we make a summary of all of those in four tables and discuss about the future research directions. | JING Wei LIU Chao LI Ting RAHMAN A B M Mohaimenur XIAN Lintao WANG Xi WANG Yu GUO Zhongwen BRENDA Gumede TENDAI Wachi Kelvin | 2020 | Journal of Ocean University of China2020，19，3： | 1 |
| 19 | Rising trends of global precipitable water vapor and its correlation with flood frequency显示文摘Using 4 global reanalysis data sets, significant upward trends of precipitable water vapor(PWV) were found in the 3 time periods of 1958-2020, 1979-2020, and 2000-2020. During 1958-2020, the global PWV trends obtained using the ERA5 and JRA55 data sets are 0.19 ± 0.01 mm per decade(1.15 ± 0.31%)and 0.23 ± 0.01 mm per decade(1.45 ± 0.32%), respectively. The PWV trends obtained using the ERA5,JRA55, NCEP-NCAR, and NCEP-DOE data sets are 0.22 ± 0.01 mm per decade(1.18 ± 0.54%),0.21 ± 0.00 mm per decade(1.76 ± 0.56%), 0.27 ± 0.01 mm per decade(2.20 ± 0.70%) and 0.28 ± 0.01 mm per decade(2.19 ± 0.70%) for the period 1979-2020. During 2000-2020, the PWV trends obtained using ERA5, JRA55, NCEP-DOE, and NCEP-NCAR data sets are 0.40 ± 0.25 mm per decade(2.66 ± 1.51%),0.37 ± 0.24 mm per decade(2.19 ± 1.54%), 0.40 ± 0.26 mm per decade(1.96 ± 1.53%) and 0.36 ± 0.25 mm per decade(2.47 ± 1.72%), respectively. Rising PWV has a positive impact on changes in precipitation,increasing the probability of extreme precipitation and then changing the frequency of flood disasters.Therefore, exploring the relationship between PWV(derived from ERA5 and JRA55) change and flood disaster frequency from 1958 to 2020 revealed a significant positive correlation between them, with correlation coefficients of 0.68 and 0.79, respectively, which explains the effect of climate change on the increase in flood disaster frequency to a certain extent. The study can provide a reference for assessing the evolution of flood disasters and predicting their frequency trends. | Dong Ren Yong Wang Guocheng Wang Lintao Liu | 2023 | Geodesy and Geodynamics2023，14，4： | 0 |
| 20 | Experimental Studies of Radionuclide Imaging of Receptor: CD-IRES2-hSSTR Transgenes显示文摘 | Guoquan Li Jing Wang Lintao Jia Zhe Wang Rui Zhang Angang Yang Jinglan Deng | 2006 | Journal of US-China Medical Science2006，3，3： | 0 |
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