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| 1 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 2 | Self-Powered Implantable Skin-Like Glucometer for Real-Time Detection of Blood Glucose Level In Vivo显示文摘Implantable bioelectronics for analyzing physiological biomarkers has recently been recognized as a promising technique in medical treatment or diagnostics. In this study, we developed a self-powered implantable skinlike glucometer for real-time detection of blood glucose level in vivo. Based on the piezo-enzymatic-reaction coupling effect of GOx@ZnO nanowire, the device under an applied deformation can actively output piezoelectric signal containing the glucose-detecting information. No external electricity power source or battery is needed for this device, and the outputting piezoelectric voltage acts as both the biosensing signal and electricity power. A practical application of the skin-like glucometer implanted in mouse body for detecting blood glucose level has been simply demonstrated. These results provide a new technique path for diabetes prophylaxis and treatment. | Wanglinhan Zhang Linlin Zhang Huiling Gao Wenyan Yang Shuai Wang Lili Xing Xinyu Xue | 2018 | Nano-Micro Letters2018，10，2： | 9 |
| 3 | Liraglutide alleviates cardiac fibrosis through inhibiting P4hα-1 expression in STZ-induced diabetic cardiomyopathy显示文摘Diabetic cardiomyopathy is an important contributor to morbidity and mortality of diabetic patients by causing heart failure.Interstitial and perivascular fibrosis plays a crucial role in diabetic cardiomyopathy.However,there is a lack of effective specific treatments available for diabetic cardiomyopathy.In the present study,we aim to explore the effects of Liraglutide,a GLP-1 analogue,on diabetic cardiomyopathy in STZ-induced diabetic rats fed with high-fat diet.A total of 60 male Wistar rats were randomly assigned to three groups,i.e.normal group,model group,and Liraglutide group,with 20 rats in each group.Serum levels of TC,TG,LDL-C,NEFA,and hydroxyproline were measured using commercial kits.Cardiac function was evaluated by QRS waves,LVEDd,LVESd,and LVEF.Myocardial fibrosis was measured by immunohistochemistry.Our results demonstrated that chronic administration of Liraglutide decreased the level of blood glucose and significantly alleviated lipid metabolic disturbance compared with the model group.Furthermore,Liraglutide was found to improve the damaged cardiac function.In line with this,we also found that the alleviation of cardiac dysfunction was associated with the decreased fibrosis in diabetic myocardial tissues,which was reflected by the decreased expressions of P4hα-1,COL-1,COL-3,MMP-1,and MMP-9.Our results thus suggest that Liraglutide might have a myocardial protective effect by inhibiting P4hα-1-mediated myocardial fibrosis. | Tong Zhao Huiqiang Chen Fei Xu Juan Wang Yusheng Liu Xiaowei Xing Linlin Guo Mingxiang Zhang Qinghua Lu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 9 |
| 4 | Activated carbon enhanced ozonation of oxalate attributed to HO·oxidation in bulk solution and surface oxidation: Effect of activated carbon dosage and pH显示文摘Ozonation of oxalate in aqueous phase was performed with a commercial activated carbon(AC)in this work. The effect of AC dosage and solution pH on the contribution of hydroxyl radicals(HOU) in bulk solution and oxidation on the AC surface to the removal of oxalate was studied. We found that the removal of oxalate was reduced by tert-butyl alcohol(tBA) with low dosages of AC,while it was hardly affected by tBA when the AC dosage was greater than 0.3 g/L. tBA also inhibited ozone decomposition when the AC dosage was no more than 0.05 g/L, but it did not work when the AC dosage was no less than 0.1 g/L. These observations indicate that HOUin bulk solution and oxidation on the AC surface both contribute to the removal of oxalate. HOU oxidation in bulk solution is significant when the dosage of AC is low, whereas surface oxidation is dominant when the dosage of AC is high. The oxalate removal decreased with increasing pH of the solution with an AC dosage of 0.5 g/L. The degradation of oxalate occurs mainly through surface oxidation in acid and neutral solution, but through HOUoxidation in basic bulk solution. A mechanism involving both HOUoxidation in bulk solution and surface oxidation was proposed for AC enhanced ozonation of oxalate. | Linlin Xing Yongbing Xie Daisuke Minakata Hongbin Cao Jiadong Xiao Yi Zhang John C. Crittenden | 2014 | Journal of Environmental Sciences2014，26，10： | 5 |
| 5 | Discovery of Marine-terrestrial Transitional Facies Shale Gas in Taiyuan Formation of Zhenjia 1 Well,Northern Shaanxi,Ordos basin显示文摘Objective At present,there is controversy regarding the existence of marine-terrestrial transitional facies that can act as a source of shale gas.This detailed study of CarboniferousPermian age geological data from the northern Shaanxi area(China)provides new insight for this type of shale gas.In addition,a new deposition and accumulation pattern for this type of shale gas is established.Thus,the objectives of this study were to identify high quality gasbearing shale intervals in the lithological column of | ZHANG Yongsheng ZHENG Mianping XING Enyuan LI Yangchi GUI Baoling SHI Lizhi HE Yongtao WANG Linlin PENG Yuan ZHAO Haitong | 2017 | Acta Geologica Sinica(English Edition)2017，91，3： | 1 |
| 6 | Simulation and optimization of micro power generation process by utilizing urban natural gas pipeline pressure energy显示文摘 | Xiaxi Li Hui Zhang Wendong Xu Linlin Xing Wei Duan | 2015 | Advances in engineering research2015，17，： | 1 |
| 7 | Simulation and optimization of micro power generation process by utilizing urban natural gas pipeline pressure energy显示文摘 | Xiaxi Li Hui Zhang Wendong Xu Linlin Xing Wei Duan | 2015 | Advances in engineering research2015，17，： | 1 |
| 8 | Bioaugmentation of Bromoamine Acid Degradation with Sphingomonas xenophaga QYY and DNA Fingerprint Analysis of Augmented Systems显示文摘 | Yuanyuan Qu Jiti Zhou Jing Wang Zhiyong Song Linlin Xing Xiang Fu | 2006 | Biodegradation2006，，1： | 1 |
| 9 | The siderophore-interacting protein is involved in iron acquisition and virulence of Riemerella anatipestifer strain CH3显示文摘 | Jing Tu Fengying Lu Shuang Miao Xintao Ni Pan Jiang Hui Yu Linlin Xing Shengqing Yu Chan Ding Qinghai Hu | 2013 | Veterinary Microbiology2013，，： | 1 |
| 10 | FastJoin,an improved neighbor-joining algorithm显示文摘 | WANG Juan GUO Maozu XING Linlin | | 0，，： | 1 |
| 11 | Propofol-fentanyl or remifentanil target-controlled intravenous anesthesia and inhalation anesthesia a comparison 显示文摘 | Geng Zhi words Song Linlin XU Xing | 2004 | China anesthesia2004，24，1： | 1 |
| 12 | Isotopic Geochemistry of Evaporite-Carbonate Sediments in Majiagou Formation Euxinic Systems with Implications for Evaluating Ordovician Northern Shaanxi Epicontinental Sea, Ordos Basin显示文摘Objective The Ordovician Shaanxi salt basin is located in the junction of the North China Sea and the Qilian Sea.In this basin the Majiagou Formation accumulated more than1000m thick evaporite-carbonate sediments,and this basin is divided into east and west saltern sags(ESS,WSS)according to the characteristics of geochemical analysis(Zhang Yongsheng et al.,2014).Isotope stratigraphy of evaporite sediments represents a fundamental tool | ZHAO Haitong ZHANG Yongsheng XING Enyuan WANG Linlin GUI Baoling SHANG Wenjun PENG Yuan SHI Lizhi | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 1 |
| 13 | Molecular Cloning and Bioinformatics Analysis of crp Gene in Vibrio alginolyticus显示文摘[Objectives]The crp gene in Vibrio alginolyticus was studied.[Methods]The crp gene of V.alginolyticus HY9901 was cloned and analyzed by bioinformatics.[Results]The ORF of the crp gene is 633 bp long and the predicted amino acid sequence encompasses 210 amino acid residues.The physicochemical property analysis indicated that the chemical formula of CRP is C_(1051)H_(1704)N_(290)O_(308)S_(10) with a molecular weight of 23.6514 kDa,and its theoretical pI is 7.74.Besides,the protein is stable and hydrophilic.The protein had three protein kinase C phosphorylation site,three casein kinase II phosphorylation site,one N-terminal myristoylation site.The BLAST analysis on the sequence revealed high homology with CRPs in other Vibrio species,and particularly the sequence shares about a homology of 99.52%with the CRP in V.parahaemolyticus.The SWISS-MODEL software simulated the subunit tertiary structural model of the CRP,and the similarity with template 3hif.1.A was 95.71%.[Conclusions]This study provides a reference for the search for efficient protective antigens against vibrosis. | Zhiqing WEI Weijie ZHANG Linlin YIN Haiyun FENG Junlin WANG Fuyuan ZENG Xing XIAO Huanying PANG | 2022 | Agricultural Biotechnology2022，11，2： | 0 |
| 14 | Erysipeloid and Erysipelothrix rhusiopathiae Bacteremia Secondary to a Crab Stab Wound:A Case Report and Literature Review显示文摘Erysipelothrix rhusiopathiae is a facultative anaerobic,nonmotile,nonspore-forming,gram-positive bacillus.It is a zoonotic pathogen that rarely infects humans but causes swine erysipelas.The disease caused by E.rhusiopathiae canmanifest in the following threemain forms:erysipeloid,diffuse cutaneous infections,and bacteremia with or without endocarditis.In this article,we present the case study of a healthy Chinese man who developed erysipeloid and an E.rhusiopathiae bloodstream infection after being stabbed by a crab.Additionally,we conducted a thorough review of the available literature on E.rhusiopathiae bacteremia within the past two decades and provided a summary of the key findings.Early diagnosis and proper treatment are crucial in mitigating recurrence risk and avoiding sepsis.Understanding the risk factors for death from E.rhusiopathiae bacteremia is essential,and appropriate personal protective equipment should be used to prevent occupational exposure to this bacterium. | Chaowen Deng Xin Li Defu Liu Linlin Sun Haiyan Ye Fanfan Xing | 2023 | Infectious Microbes & Diseases2023，5，4： | 0 |
| 15 | Observation on the Effect of Integrated Medical and Nursing Care in Patients with Pulmonary Tuberculosis Combined with Lung Cancer显示文摘Objective:To explore the effect of integrated medical and nursing care in patients with pulmonary tuberculosis combined with lung cancer.Methods:From August 2021 to August 2022,60 patients with pulmonary tuberculosis combined with lung cancer were admitted.All patients were diagnosed with pulmonary tuberculosis according to the Guidelines for the Diagnosis and Treatment of Pulmonary Tuberculosis and with lung cancer by pathology.The patients were randomly divided into two groups,with 30 cases in each group.The control group received daily nursing care,whereas the study group received integrated medical and nursing care.The sputum conversion rate,tumor remission rate,and quality of life of patients were observed and analyzed.Results:The item function score and symptom function score of the observation group were higher than those of the control group(P<0.05);the total effective rate of the observation group was significantly higher than that of the control group(P<0.05);the sputum conversion rate of the observation group was significantly higher than that of the control group(P<0.05).Conclusion:For patients with pulmonary tuberculosis combined with lung cancer,the application of integrated medical and nursing care can help consolidate the treatment effect and improve the quality of life of patients;thus,it is worthy of promotion and application. | Wei Yuan Yuanyuan Lu Mi Zhang Min Zheng Xing Luan Yanling Feng Linlin Chai | 2023 | Proceedings of Anticancer Research2023，7，3： | 0 |
| 16 | New Understanding of Lithium Isotopic Evolution from Source to Deposit——A Case Study of the Qaidam Basin显示文摘Objective The lithium-rich deep brine of the western Qaidam Basin is the successor of the lithium-rich salt lake on the surface.The identification of the lithium source has been a topic of intense interest among geologists.The dissolved lithium in lithium-rich protoliths transported to the basin through surface river water is considered as an important source of lithium in deep brine.The geochemical characteristics of lithium isotopes as they move from | WANG Linlin ZHANG Yongsheng XING Enyuan MENG Qingqiang YU Dongdong | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 0 |
| 17 | Identification and prioritization of differentially expressed genes for time-series gene expression data显示文摘 | Linlin XING Maozu GUO Xiaoyan LIU Chunyu WANG | 2018 | Frontiers of Computer Science2018，12，4： | 0 |
| 18 | Mineralization of phenol by ozone combined with activated carbon:Performance and mechanism under different pH levels显示文摘The degradation of phenol using ozone with activated carbon(O_(3)/AC system)was investigated in this study.The O_(3)/AC system was also compared with the single O_(3) and AC systems.The total organic carbon(TOC)removal efficiency in the O_(3)/AC system was roughly 26%and 30%higher than the single AC and O_(3) systems,respectively.It was demonstrated that the phenol degradation rate and TOC removal efficiency were significantly affected by the ozone concentration,AC dosage,and solution pH.The pseudo-first-order and pseudo-second-order kinetic models were fitted to identify the mechanisms of the phenol removal process.The results of Scanning Electron Microscopy,Brunauer-Emmett-Teller,and Fourier-transform infrared spectroscopy of raw and used AC indicated that the surface morphology,microstructure,and functional group properties had been changed during the reaction process.The possible O_(3)/AC system mineralization mechanism for phenol removal was tentatively proposed using scavenging active species such as·OH,O_(2)^(·-),and H_(2)O_(2).The transformation byproducts generated during the application of the O_(3)/AC system were identified by High Performance Liquid Chromatography and Gas Chromatography-Mass Spectrometry analyses.Therefore,the mineralization pathway of phenol in detail was proposed in acidic(pH 3.0)and alkaline(pH 11.0)conditions.This study provided a more systematic explanation of the mineralization mechanism for phenol in the O_(3)/AC system. | Wei Xiong Weihua Cui Rui Li Chuanping Feng Yang Liu Ningping Ma Jian Deng Linlin Xing Yu Gao Nan Chen | 2020 | Environmental Science and Ecotechnology2020，，1： | 0 |
| 19 | A physics-based electromigration reliability model for interconnects lifetime prediction显示文摘Dear editor,When the technology node scales down to 14 nm, the backend-of-line(BEOL) in IC design faces the more serious challenges [1, 2]. The high-density integration induced by the technology innovation increases the number of interconnecting layers and reduces the metal pitch, making the placement and routing of BEOL more difficult. Meanwhile, due to the size effects, the maximum tolerable current density in narrow dimensions of metal lines can no longer meet the requirements of driving current density in interconnects. | Linlin CAI Wangyong CHEN Jinfeng KANG Gang DU Xiaoyan LIU Xing ZHANG | 2021 | Science China(Information Sciences)2021，64，11： | 0 |
| 20 | Upconversion luminescence Ca-Mg-Si bioactive glasses synthesized using the containerless processing technique显示文摘In this study,a series of Er^3+/Yb^3+co-doped Ca-Mg-Si glasses were prepared via the containerless processing.Phase composition and luminescent properties of the prepared materials were investigated through XRD and spectrometry,and bioactivity,biocompatibility and cytotoxicity were evaluated.The XRD patterns indicated that akermanite(AKT)ceramic powders were completely transformed into the glassy phase(AKT-G,EYA)through the containerless processing,which exhibit upconversion luminescence,and the luminescence intensity increased with the increase of the doping amount of Er^3+ and Yb^3+.High amount of Yb^3+doping and existence of Ca^2+in glasses resulted in more intensive red-light emission.The SEM observation,combined with EDS analysis,and cell culture experiments showed that the as-prepared glasses were nontoxic,biocompatible and bioactive.All these results demonstrated that the containerless processing is a facile method for preparing homogeneous luminescent bioactive glasses.Furthermore,this luminescent Ca-Mg-Si glasses may be used as bone implant materials to study the in vivo distribution of degradation products of bone implants,which may be of great significance for the development and clinical application of new bone grafting materials. | Qin LI Min XING Lan CHANG Linlin MA Zhi CHEN Jianrong QIU Jianding YU Jiang CHANG | 2019 | Frontiers of Materials Science2019，13，4： | 0 |
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