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| 1 | Liraglutide alleviates cardiac fibrosis through inhibiting P4hα-1 expression in STZ-induced diabetic cardiomyopathy显示文摘Diabetic cardiomyopathy is an important contributor to morbidity and mortality of diabetic patients by causing heart failure.Interstitial and perivascular fibrosis plays a crucial role in diabetic cardiomyopathy.However,there is a lack of effective specific treatments available for diabetic cardiomyopathy.In the present study,we aim to explore the effects of Liraglutide,a GLP-1 analogue,on diabetic cardiomyopathy in STZ-induced diabetic rats fed with high-fat diet.A total of 60 male Wistar rats were randomly assigned to three groups,i.e.normal group,model group,and Liraglutide group,with 20 rats in each group.Serum levels of TC,TG,LDL-C,NEFA,and hydroxyproline were measured using commercial kits.Cardiac function was evaluated by QRS waves,LVEDd,LVESd,and LVEF.Myocardial fibrosis was measured by immunohistochemistry.Our results demonstrated that chronic administration of Liraglutide decreased the level of blood glucose and significantly alleviated lipid metabolic disturbance compared with the model group.Furthermore,Liraglutide was found to improve the damaged cardiac function.In line with this,we also found that the alleviation of cardiac dysfunction was associated with the decreased fibrosis in diabetic myocardial tissues,which was reflected by the decreased expressions of P4hα-1,COL-1,COL-3,MMP-1,and MMP-9.Our results thus suggest that Liraglutide might have a myocardial protective effect by inhibiting P4hα-1-mediated myocardial fibrosis. | Tong Zhao Huiqiang Chen Fei Xu Juan Wang Yusheng Liu Xiaowei Xing Linlin Guo Mingxiang Zhang Qinghua Lu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 9 |
| 2 | Multi-omics analyses of 398 foxtail millet accessions reveal genomic regions associated with domestication,metabolite traits,and antiinflammatory effects显示文摘Foxtail millet(Setaria italica),which was domesticatedfromthewild speciesgreenfoxtail(Setaria viridis),isa richsource of phytonutrientsfor humans.To evaluate how breeding changed themetabolome offoxtail millet grains,we generated and analyzed the datasets encompassing the genomes,transcriptomes,metabolomes,and anti-inflammatory indices from 398 foxtail millet accessions.We identified hundreds of common variants that influence numerous secondary metabolites.We observed tremendous differences in natural variations of the metabolites and their underlying genetic architectures between distinct sub-groups of foxtail millet.Furthermore,we found that the selection of the gene alleles associated with yellow grains led to altered profiles of metabolites such as carotenoids and endogenous phytohormones.Using CRiSPR-mediated genome editing wevalidated the function of PHYTOENE SYNTHASE1(PSY1)gene in affecting milletgrain colorand quality.Interestingly,our in vitro cell inflammation assays showed that 83 metabolites in millet grains have anti-inflammatory effects.Taken together,ourmulti-omics study illustrates how the breeding history of foxtail millet has shaped its metabolite profile.The datasets we generated in this study also provide important resources for further understanding how millet grain quality is affected by different metabolites,laying the foundations for future millet genetic research and metabolome-assisted improvement. | Xukai Li Jianhua Gao Jingyi Song Kai Guo Siyu Hou Xingchun Wang Qiang He Yanyan Zhang Yakun Zhang Yulu Yang Jiaoyan Tang Hailang Wang Staffan Persson Mingquan Huang Lishuai Xu Linlin Zhong Dongqin Li Yongming Liu Hua Wu Xianmin Diao Peng Chen Xiaowen Wang Yuanhuai Han | 2022 | Molecular Plant2022，15，8： | 8 |
| 3 | Urban sprawl in provincial capital cities in China: evidence from multi-temporal urban land products using Landsat data显示文摘The onset of global urbanization has led to a population shift from rural to urban areas and the expansion of urban development [1-3]. Urban land areas are growing at faster rates than their populations in most parts of the world [4]. The urban sprawl process refers to dispersed land development characterized by low-density, unplanned, and uneven patter ns of growth duri ng urban expansion. This process can result in inefficient use of land resources contradictory to the principle of sustainable development [5]. Additionally, urban sprawl has various environmental, economic, and social consequences, including the following: loss of agricultural land, higher costs for transportation infrastructure, increased landscape fragmentation, degeneration of soil ecological functions, and reduced ecosystem resilience. It is crucial to understand the trends and patterns of urban sprawl to implement a framework for sustainable urban development in developing regions. | Linlin Lu Huadong Guo Christina Corbane Qingting Li | 2019 | Science Bulletin2019，64，14： | 8 |
| 4 | Comparative analysis between endometrial proteomes of pregnant and non-pregnant ewes during the peri-implantation period显示文摘Background:Early pregnancy failure has a profound impact on both human reproductive health and animal production.2/3 pregnancy failures occur during the peri-implantation period;however,the underlying mechanism(s)remains unclear.Well-organized modification of the endometrium to a receptive state is critical to establish pregnancy.Aberrant endometrial modification during implantation is thought to be largely responsible for early pregnancy loss.Result:In this study,using well-managed recipient ewes that received embryo transfer as model,we compared the endometrial proteome between pregnant and non-pregnant ewes during implantation period.After embryo transfer,recipients were assigned as pregnant or non-pregnant ewes according to the presence or absence of an elongated conceptus at Day 17 of pregnancy.By comparing the endometrial proteomic profiles between pregnant and non-pregnant ewes,we identified 94 and 257 differentially expressed proteins(DEPs) in the endometrial caruncular and intercaruncular areas,respectively.Functional analysis showed that the DEPs were mainly associated with immune response,nutrient transport and utilization,as well as proteasome-mediated proteolysis.Conclusion:These analysis imply that dysfunction of these biological processes or pathways of DEP in the endometrium is highly associated with early pregnancy loss.In addition,many proteins that are essential for the establishment of pregnancy showed dysregulation in the endometrium of non-pregnant ewes.These proteins,as potential candidates,may contribute to early pregnancy loss. | Haichao Zhao Linlin Sui Kai Miao Lei An Dong Wang Zhuocheng Hou Rui Wang Min Guo Zhilong Wang Jiqiang Xu Zhonghong Wu Jianhui Tian | 2015 | Journal of Animal Science and Biotechnology2015，6，3： | 8 |
| 5 | Contrasting Characteristics of the Surface Energy Balance between the Urban and Rural Areas of Beijing显示文摘A direct comparison of urban and rural surface energy balances, as well as a variety of other variables including incoming shortwave/longwave radiation and aerosol optical depth, is conducted for the Beijing metropolitan area. The results indicate that, overall, the urban area receives a smaller amount of incoming shortwave radiation but a larger amount of incoming longwave radiation. However, comparisons in the aerosol optical depth and cloud fraction at the two locations suggest that neither aerosol optical depth nor cloud fraction alone can explain the difference in the incoming shortwave radiation. The urban–rural differences in the incoming longwave radiation are unlikely to be caused by the presence of more abundant greenhouse gases over the urban area, as suggested by some previous studies, given that water vapor is the most dominant greenhouse gas and precipitable water is found to be less in urban areas. The higher incoming longwave radiation observed over the urban area is mostly likely due to the higher temperatures of the ambient air. The urban area is also found to always produce higher sensible heat fluxes and lower latent heat fluxes in the growing season. Furthermore, the urban area is associated with a larger amount of available energy(the sum of sensible and latent heat fluxes) than the rural area, except in May and October when evapotranspiration in the rural area significantly exceeds that in the urban area. This study provides observational evidence of urban–rural contrasts in relevant energy-balance components that plausibly arise from urban–rural differences in atmospheric and land-surface conditions. | WANG Linlin GAO Zhiqiu MIAO Shiguang GUO Xiaofeng SUN Ting Maofeng LIU Dan LI | 2015 | Advances in Atmospheric Sciences2015，32，4： | 7 |
| 6 | Heavy mineral assemblage characteristics and the Cenozoic paleogeographic evolution in southwestern Qaidam Basin显示文摘Based on the analysis of heavy mineral assemblages in Cenozoic southwestern Qaidam Basin, we found that different areas have variable heavy mineral assemblage characteristics, which suggested that there were two source areas—the Altyn Mountains and the Qimen Tagh-East Kunlun Mountains. In Ganchaigou-Shizigou-Huatugou(Area A), which was mainly source from the Altyn Mountains, its heavy minerals were mainly composed of zircon, Ti-oxides, and wollastonite in the Paleoceneearly Eocene and mainly of unstable minerals, especially amphibole, in the middle Eocene-Oligene. Since the late OligoceneMiocene, the heavy minerals were still mainly unstable minerals, but the content of epidote increased and the content of amphibole decreased. In Qigequan-Hongliuquan(Area B), which was the mixed source from the Altyn Mountains and the Qimen Tagh-East Kunlun Mountains, its heavy minerals were mainly garnet, epidote, and amphibole. The source of LücaotanDongchaishan-Kunbei(Area C) was mainly from the Qimen Tagh-East Kunlun Mountains, heavy minerals in the sediments in Area C were mainly zircon and Ti-oxides in Paleogene and garnet, epidote, and amphibole in Neogene. In Yuejin-Youshashan(Area D), where the stable minerals and unstable minerals were present simultaneously, the heavy mineral assemblages was controlled by multi-direction source. The variation of heavy mineral assemblages in southwestern Qaidam Basin shows that Altyn Mountains was of low-lying topographic relief in Paleocene-early Eocene, and the rapid uplift of Altyn Mountains started from the middle Eocene. In Paleogene, the Altyn Tagh Fault had a slow strike-slip velocity, but the strike-slip velocity increased greatly since the late Oligocene, leading to a strike-slip displacement above 300 km since Neogene. Meanwhile, the Qimen Tagh-East Kunlun fault zone was under a stable tectonic stage in Paleogene with the Qimen Tagh Mountain being lowlying hills; since the late Oligocene, the fault zone started to activate and the Qimen Tagh Mountain began to uplift rapidly. | LI LinLin GUO ZhaoJie GUAN ShuWei ZHOU SuPing WANG MingZhen FANG YaNan ZHANG ChenChen | 2015 | Science China Earth Sciences2015，58，6： | 6 |
| 7 | Seasonal and Interannual Variations of Carbon Exchange over a Rice–Wheat Rotation System on the North China Plain显示文摘Rice–wheat(R–W) rotation systems are ubiquitous in South and East Asia,and play an important role in modulating the carbon cycle and climate. Long-term,continuous flux measurements help in better understanding the seasonal and interannual variation of the carbon budget over R–W rotation systems. In this study,measurements of CO2 fluxes and meteorological variables over an R–W rotation system on the North China Plain from 2007 to 2010 were analyzed. To analyze the abiotic factors regulating Net Ecosystem Exchange(NEE),NEE was partitioned into gross primary production(GPP) and ecosystem respiration. Nighttime NEE or ecosystem respiration was controlled primarily by soil temperature,while daytime NEE was mainly determined by photosythetically active radiation(PAR). The responses of nighttime NEE to soil temperature and daytime NEE to light were closely associated with crop development and photosynthetic activity,respectively. Moreover,the interannual variation in GPP and NEE mainly depended on precipitation and PAR. Overall,NEE was negative on the annual scale and the rotation system behaved as a carbon sink of 982 g C m-2per year over the three years. The winter wheat field took up more CO2 than the rice paddy during the longer growing season,while the daily NEE for wheat and rice were-2.35and-3.96 g C m-2,respectively. After the grain harvest was subtracted from the NEE,the winter wheat field became a moderately strong carbon sink of 251–334 g C m-2per season,whereas the rice paddy switched to a weak carbon sink of107–132 per season. | CHEN Chen LI Dan GAO Zhiqiu Jianwu TANG GUO Xiaofeng WANG Linlin WAN Bingcheng | 2015 | Advances in Atmospheric Sciences2015，32，10： | 6 |
| 8 | Coronary heart disease: incidence, risk factors and interventions in Jiaozhou of Shandong province显示文摘 | Yu Hua Li Dan Chu Xianming An Yi Song Tongxun Feng Huixin Lin Peilin Wang Tao Jiang Shaoyan Guo Linlin Xu Fengqiang Liu Zhengke Yang Bin | 2014 | Chinese Medical Journal2014，，12： | 5 |
| 9 | Controllable synthesis of highly crystallized mesoporous TiO2/WO3 heterojunctions for acetone gas sensing显示文摘Mesoporous semiconducting metal oxides(SMOs)heterojunctions are appealing sensors for gas detecting.However,due to the different hydrolysis and condensation mechanism of every metal precursor and the contradiction between high crystallinity and high surface area,the synthesis of mesoporous SMOs heterojunctions with highly o rdered mesostructures,highly crystallized frameworks,and high surface area remains a huge challenge.In this work,we develop a novel'acid-base pair'adjusted solvent evaporation induced self-assembly(EISA)strategy to prepare highly crystallized ordered mesoporous TiO2/WO3(OM-TiO2/WO3)heterojunctions.The WCl6 and titanium isopropoxide(TIPO)are used as the precursors,respectively,which function as the'acid-base pair',enabling the coassembly with the structure directing agent(PEO-b-PS)into highly ordered meso structures.In addition,PEO-b-PS can be converted to rigid carbon which can protect the meso structures from collapse during the crystallization process.The resultant OM-TiO2/WO3 heterojunctions possess primitive cubic mesostructures,large pore size(~21.1 nm),highly crystalline frameworks and surface area(~98 m2/g).As a sensor for acetone,the obtained OM-TiO2/WO3 show excellent re sponse/recovery perfo rmance(3 s/5 s),good linear dependence,repeatability,selectivity,and long-term stability(35 days). | Changyao Wang Yuhui Li Pengpeng Qiu Linlin Duan Wei Bi Yan Chen Dingyi Guo Yupu Liu Wei Luo Yonghui Deng | 2020 | Chinese Chemical Letters2020，31，5： | 4 |
| 10 | COVID-19 epidemic prediction and the impact of public health interventions: A review of COVID-19 epidemic models显示文摘The coronavirus disease outbreak of 2019(COVID-19)has been spreading rapidly to all corners of the word,in a very complex manner.A key research focus is in predicting the development trend of COVID-19 scientifically through mathematical modelling.We conducted a systematic review of epidemic prediction models of COVID-19 and the public health intervention strategies by searching the Web of Science database.55 studies of the COVID-19 epidemic model were reviewed systematically.It was found that the COVID-19 epidemic models were different in the model type,acquisition method,hypothesis and distribution of key input parameters.Most studies used the gamma distribution to describe the key time period of COVID-19 infection,and some studies used the lognormal distribution,the Erlang distribution,and theWeibull distribution.The setting ranges of the incubation period,serial interval,infectious period and generation time were 4.9-7 days,4.41-8.4 days,2.3-10 days and 4.4-7.5 days,respectively,and more than half of the incubation periods were set to 5.1 or 5.2 days.Most models assumed that the latent period was consistent with the incubation period.Some models assumed that asymptomatic infections were infectious or pre-symptomatic transmission was possible,which overestimated the value of R0.For the prediction differences under different public health strategies,the most significant effect was in travel restrictions.There were different studies on the impact of contact tracking and social isolation,but it was considered that improving the quarantine rate and reporting rate,and the use of protective face mask were essential for epidemic prevention and control.The input epidemiological parameters of the prediction models had significant differences in the prediction of the severity of the epidemic spread.Therefore,prevention and control institutions should be cautious when formulating public health strategies by based on the prediction results of mathematical models. | Yue Xiang Yonghong Jia Linlin Chen Lei Guo Bizhen Shu Enshen Long | 2021 | Infectious Disease Modelling2021，6，1： | 3 |
| 11 | A titanium dioxide nanorod array as a high-affinity nano-bio interface of a microfluidic device for efficient capture of circulating tumor cells显示文摘处理临床的问题的 Nanomaterials 表演答应机会(例如传播肿瘤房间的不够的俘获;CTC ) 经由为生物房间的高表面 area-to-volume 比率和高亲密关系。然而,怎么与高特性遗体为有效 CTC 俘获在一台 microfluidic 设备作为一个 nano 简历接口使用这些 nanomaterials 挑战。在现在的工作,我们首先发现那钛二氧化物(能方便地在底层的多重类型上被准备的 TiO 2) nanorod 数组为肿瘤房间有高亲密关系。然后, TiO 2 nanorod 数组在有经由热水的反应的六角形地有图案的 Si micropillars 的 microchannel 的表面上是垂直地成年的,层次地形成 micro-nano 3D 的一种新类型结构化的 microfluidic 设备。当这 3D 的一个敏感 nano 简历接口层次地组织了 microfluidic 设备,垂直地成年的 TiO 2 nanorod 数组被使用,哪个显示出 CTC 俘获的高效率(76.7% 潩獮 ? 畯 ? 牰灯獯摥栠杩 ? 数晲牯慭据 ? 潍 ? ??? 猯'T ￣楢獯湥潳獲挠湡搠瑥捥 ?? 卐? 潣据湥牴瑡潩吗?? | Jichuan Qiu Kun Zhao Linlin Li Xin Yu Weibo Guo Shu Wang Xiaodi Zhang Caofeng Pan Zhong Lin Wang Hong Liu | 2017 | Nano Research2017，10，3： | 3 |
| 12 | Friction and Wear Properties of TiAl and Ti_2AlN/TiAl Composites at High Temperature显示文摘The high-temperature friction and wear properties of TiAl alloys and Ti2 AlN/TiAl composites(TTC) in contact with nickel-based superalloy were studied.The results showed that,at 800 and 1 000 ℃,the coefficient of the friction(COF) decreased with the increase of sliding velocity and the wear loss of the TTC decreased with the increase of volume fraction of Ti2 AlN.The wear mechanisms of the pairs are adhesive wear and the wear debris mainly comes from the contacting nickel-based superalloy.The intergranular fracture and the cracking of the phase boundary in the lamellar structure are the wear mode of TiAl alloy.The wear mode of TTC is phase boundary fracture and adhesive spalling.The abrasive resistance of TTC is slightly higher than that of TiAl alloy. | 孙东立 SUN Tao WANG Qing HAN Xiuli GUO Linlin | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，5： | 3 |
| 13 | Changes in dendritic cells and dendritic cell subpopulations in peripheral blood of recipients during acute rejection after kidney transplantation显示文摘 | Ma Linlin Liu Yong Wu Junjie Xu Xiuhong Liu Fen Feng Lang Xie Zelin Tang Yawang Sun Wen Guo Hongbo Zhang Lei Lin Jun Tian Ye | 2014 | Chinese Medical Journal2014，，8： | 3 |
| 14 | Phase group synchronization between any signals and its physical characteristics显示文摘The phase group synchronization between any signals is further revealed,which is based on proposing the new concepts of the greatest common factor frequency,the least common multiple period,quantized phase shift resolution,equivalent phase comparison frequency and so on.Then the problem of phase comparison and processing between different frequency signals is solved and shown in detail.Using the basic principle and the variation law of group phase difference,the frequency stability better than 10-14/s can be easily obtained in the time&frequency measurement and control domain,and experimental results also show the phase relations between atomic energy level transition signal and the locked crystal oscillator signal in an active hydrogen atomic clock are strict phase group synchronization,and locked precision with 10-13/s can be reached based on phase group synchronization.The phase group synchronization can provide technical support to frequency linking among radio frequency,microwave and light frequency. | DU BaoQiang SHI LinLin CHEN YaoMing DONG ShaoFeng YANG ZhiGang CAO LingZhi GUO ShuTing | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，4： | 2 |
| 15 | miR-7/TGF-β2 axis sustains acidic tumor microenvironment-induced lung cancer metastasis显示文摘Acidosis,regardless of hypoxia involvement,is recognized as a chronic and harsh tumor microenvironment(TME)that educates malignant cells to thrive and metastasize.Although overwhelming evidence supports an acidic environment as a driver or ubiquitous hallmark of cancer progression,the unrevealed core mechanisms underlying the direct effect of acidification on tumorigenesis have hindered the discovery of novel therapeutic targets and clinical therapy.Here,chemical-induced and transgenic mouse models for colon,liver and lung cancer were established,respectively.miR-7 and TGF-β2 expressions were examined in clinical tissues(n=184).RNA-seq,miRNA-seq,proteomics,biosynthesis analyses and functional studies were performed to validate the mechanisms involved in the acidic TME-induced lung cancer metastasis.Our data show that lung cancer is sensitive to the increased acidification of TME,and acidic TME-induced lung cancer metastasis via inhibition of miR-7-5 p.TGF-β2 is a direct target of miR-7-5 p.The reduced expression of miR-7-5 p subsequently increases the expression of TGF-β2 which enhances the metastatic potential of the lung cancer.Indeed,overexpression of miR-7-5 p reduces the acidic p H-enhanced lung cancer metastasis.Furthermore,the human lung tumor samples also show a reduced miR-7-5 p expression but an elevated level of activated TGF-β2;the expressions of both miR-7-5 p and TGF-β2 are correlated with patients’survival.We are the first to identify the role of the miR-7/TGF-β2 axis in acidic p H-enhanced lung cancer metastasis.Our study not only delineates how acidification directly affects tumorigenesis,but also suggests miR-7 is a novel reliable biomarker for acidic TME and a novel therapeutic target for non-small cell lung cancer(NSCLC)treatment.Our study opens an avenue to explore the p H-sensitive subcellular components as novel therapeutic targets for cancer treatment. | Tao Su Suchao Huang Yanmin Zhang Yajuan Guo Shuwei Zhang Jiaji Guan Mingjing Meng Linxin Liu Caiyan Wang Dihua Yu Hiu-Yee Kwan Zhiying Huang Qiuju Huang Elaine Lai-Han Leung Ming Hu Ying Wang Zhongqiu Liu Linlin Lu | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 16 | Comparative population genomics dissects the genetic basis of seven domestication traits in jujube显示文摘Jujube(Ziziphus jujuba Mill.)is an important perennial fruit tree with a range of interesting horticultural traits.It was domesticated from wild jujube(Ziziphus acidojujuba),but the genomic variation dynamics and genetic changes underlying its horticultural traits during domestication are poorly understood.Here,we report a comprehensive genome variation map based on the resequencing of 350 accessions,including wild,semi-wild and cultivated jujube plants,at a>15×depth.Using the combination of a genome-wide association study(GWAS)and selective sweep analysis,we identified several candidate genes potentially involved in regulating seven domestication traits in jujube.For fruit shape and kernel shape,we integrated the GWAS approach with transcriptome profiling data,expression analysis and the transgenic validation of a candidate gene to identify a causal gene,ZjFS3,which encodes an ethyleneresponsive transcription factor.Similarly,we identified a candidate gene for bearing-shoot length and the number of leaves per bearing shoot and two candidate genes for the seed-setting rate using GWAS.In the selective sweep analysis,we also discovered several putative genes for the presence of prickles on bearing shoots and the postharvest shelf life of fleshy fruits.This study outlines the genetic basis of jujube domestication and evolution and provides a rich genomic resource for mining other horticulturally important genes in jujube. | Mingxin Guo Zhongren Zhang Yanwei Cheng Sunan Li Peiyin Shao Qiang Yu Junjie Wang Gan Xu Xiaotian Zhang Jiajia Liu Linlin Hou Hanxiao Liu Xusheng Zhao | 2020 | Horticulture Research2020，7，1： | 2 |
| 17 | Experimental demonstration of λ/8 DFB semiconductor laser array for 1.3 μm CWDM system显示文摘In this article,we report the first experimental demonstration of an eight-wavelength λ/8 phased-shifted laser array based on the REC technique in the 1.3 μm wavelength domain.Measurement results exhibit good linearity of lasing wavelength with+/-0.35 nm wavelength residual.The SLM property was ensured with SMSRs all larger than 38 dB.Moreover,the directmodulation performance was also tested.The experimental results show that the modulation bandwidth can reach up to 13GHz even at the small injection current of 40 mA and the measured spurious-free dynamic range(SFDR)is up to 87 dB/Hz2/3,which shows good linearity.These measurements show that REC-based λ/8 phased-shifted laser array has good modulation performance and it may find potential application in actual fiber-optic systems. | LU LinLin HUANG Long SHI YueChun GUO RenJia LIU Rui LI LianYan LI SiMin CHEN XiangFei | 2014 | Science China(Technological Sciences)2014，57，9： | 2 |
| 18 | Estimation of Fracture Geometry Parameters and Characterization of Rock Mass Structure for the Beishan Area,China显示文摘The accurate estimation of fracture geometry parameters and the characterization of rock mass structure are two important topics in the geological disposal system of high-level radioactive waste(HLW).The Beishan area,as the current preselected area for China’s HLW disposal,has three subareas considered to be the key survey area at the stage of site selection.In this paper,a comprehensive survey method conducted on the outcrop is developed to estimate fracture geometry parameters.Results show that fracture occurrence obeys a Fisher distribution,fracture trace length obeys a normal distribution,and the distribution of spacing obeys a negative exponential distribution.An evaluation index,Rock Mass Structure Rating(RMSR),is proposed to characterize rock mass structure for the three subareas.The results show that the Xinchang area is more suitable to act as China’s HLW disposal repository site.At the same time,the index can also be applied to characterize surface rock mass structure and rock mass integrity at the site selection phase of HLW disposal. | WEI Xiang GUO Ying CHENG Hanlie WEI Jianfei ZHANG Linlin HUO Liang HOU Zhenkun | 2020 | Acta Geologica Sinica(English Edition)2020，94，5： | 1 |
| 19 | Phar- macokinetics of a new ivermectin/praziquantel oil suspen- sion after intramuscular administration in pigs 显示文摘 | TANG Shusheng CHEN Linlin GUO Zhaoxu | 2012 | Vet Parasitol2012，185，234： | 1 |
| 20 | An investigation of the dispersion of CuCl on γ-Al2O3 surface and the adsorption of ethylene on CuC1 / y -Al2O3 and other supported transition metal salts显示文摘 | Gui Linlin Guo Qinlin Xie Youchang | 1984 | Scientia Sinica(series B)1984，27，5： | 1 |
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