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| 1 | Ubiquitination of Rheb governs growth factor-induced mTORC1 activation显示文摘Mechanistic target of rapamycin mTOR complex 1 (mTORC1)plays a key role in the integration of various environmental signals to regulate cell growth and metabolism,mTORC1 is recruited to the lysosome where it is activated by its interaction with GTP-bound Rheb GTPase.However,the regulatory mechanism of Rheb activity remains largely unknown.Here,we show that ubiquitination governs the nucleotide-bound status of Rheb.Lysosome-anchored E3 ligase RNF152 catalyzes Rheb ubiquitination and promotes its binding to the TSC complex.EGF enhances the deubiquitination of Rheb through AKT-dependent USP4 phosphorylation,leading to the release of Rheb from the TSC complex.Functionally,ubiquitination of Rheb is linked to mTORC1-mediated signaling and consequently regulates tumor growth.Thus,we propose a mechanistic model whereby Rheb-mediated mTORC1 activation is dictated by a dynamic opposing act between Rheb ubiquitination and deubiquitination that are catalyzed by RNF152 and USP4 respectively. | Lu Deng Lei Chen Linlin Zhao Yan Xu Xiaoping Peng Xinbo Wang Lin Ding Jiali Jin Hongqi Teng Yanming Wang Weijuan Pan Fei Yu Lujian Liao Li Li Xin Ge Ping Wang | 2019 | Cell Research2019，29，2： | 16 |
| 2 | Experimental Study and Model Analysis of the Performance of IPMC Membranes with Various Thickness显示文摘 | Qingsong He Min Yu Linlin Song Haitao Ding Xiaoqing Zhang Zhendong Dai | 2011 | Journal of Bionic Engineering2011，8，1： | 10 |
| 3 | Carboniferous Alaskan-type complex along the Sino–Mongolian boundary,southern margin of the Central Asian Orogenic Belt显示文摘We present zircon ages and geochemical data for the Hongshishan Carboniferous Alaskan-type mafic–ultramafic complex exposed in the Beishan area along the Sino–Mongolian boundary, southern margin of the Central Asian Orogenic Belt. This complex mainly consists of dunite,harzburgite, lherzolite, wehrlite, and gabbro, which intrudes Early Carboniferous volcanic rocks and reveals a zoned structure. Zircons of a gabbro sample yielded a 206Pb/238 U age of 357 ± 4 Ma, reflecting the time of Early Carboniferous magmatism. Zircon ages were also obtained for an andesite(322 ± 3 Ma) and a basaltic andesite(304 ± 2 Ma).High initial Nd isotope whole-rock values suggest that the Hongshishan gabbro [e_(Nd(t))= +9.6-+10.2] and basalt[eNd(t)= +10.0-+10.8] were derived from a depleted mantle source. Slightly lower eNd(t)values for the ultramafic rocks [eNd(t)= +8.5-+8.7] suggest some interaction of the parental magma with the continental crust. In contrast, the Late Carboniferous Quershan samples in this area represent subduction-related arc volcanic rocks with Adakite-like compositions. The early Carboniferous Hongshishan Alaskan-type complex was interpreted to represent the remnants of a magma chamber that crystallized at the base of a mature island arc, whereas the Quershan island arc volcanic rockssuggest the resurrection of the subduction process after arccontinent collision and uplift of the roots of the arc. | Yuruo Shi Linlin Li Alfred Kroner Jing Ding Wei Zhang Zengbao Huang Ping Jian | 2017 | Acta Geochimica2017，36，2： | 6 |
| 4 | Oxygen vacancy-engineered BaTiO_(3)nanoparticles for synergistic cancer photothermal,photodynamic,and catalytic therapy显示文摘With the rapid development of photo-responsive nanomaterials,photo-triggered therapeutic strategies such as photothermal therapy(PTT)and photodynamic therapy(PDT)have been new alternatives to current cancer therapeutic methods.Herein,we have fabricated oxygen vacancy-engineered BaTiO_(3)(BTO-Ov)nanoparticles(NPs)for near-infrared(NIR)light-triggered PTT,PDT,and catalytic therapy cooperatively for significantly improving cancer therapy.Compared to pristine BaTiO_(3)nanoparticles,BTO-Ov has stronger NIR light absorption and narrower band gap structure,which results in superior photothermal conversion and superoxide radical generation capabilities through PTT and PDT.Meanwhile,due to the existence of Ti^(3+),BTO-Ov also exhibits peroxidase(POD)-like activity to produce hydroxyl radical under tumor environment,which can be further improved under 808 nm light irradiation.Both in vitro and in vivo results demonstrate that such a multifunctional therapeutic nanoplatform can achieve a high therapeutic efficacy triggered by a single NIR light irradiation.The defect engineering strategy can be used as a general approach to fabricate multifunctional cancer therapeutic nanoplatform. | Yiming Ding Zhuo Wang Zeyu Zhang Yunchao Zhao Shangyu Yang Yalong Zhang Shuncheng Yao Shaobo Wang Tian Huang Yang Zhang Linlin Li | 2022 | Nano Research2022，15，8： | 3 |
| 5 | Surface Oxygen Injection in Tin Disulfide Nanosheets for Efficient CO_(2) Electroreduction to Formate and Syngas显示文摘Surface chemistry modification represents a promising strategy to tailor the adsorption and activation of reaction intermediates for enhancing activity.Herein,we designed a surface oxygen-injection strategy to tune the electronic structure of SnS_(2) nanosheets,which showed effectively enhanced electrocatalytic activity and selectivity of CO_(2) reduction to formate and syngas(CO and H_(2)).The oxygen-injection SnS_(2) nanosheets exhibit a remarkable Faradaic efficiency of 91.6%for carbonaceous products with a current density of 24.1 mA cm^(−2) at−0.9 V vs RHE,including 83.2%for formate production and 16.5%for syngas with the CO/H_(2) ratio of 1:1.By operando X-ray absorption spectroscopy,we unravel the in situ surface oxygen doping into the matrix during reaction,thereby optimizing the Sn local electronic states.Operando synchrotron radiation infrared spectroscopy along with theoretical calculations further reveals that the surface oxygen doping facilitated the CO_(2) activation and enhanced the affinity for HCOO*species.This result demonstrates the potential strategy of surface oxygen injection for the rational design of advanced catalysts for CO_(2) electroreduction. | Tao Chen Tong Liu Tao Ding Beibei Pang Lan Wang Xiaokang Liu Xinyi Shen Sicong Wang Dan Wu Dong Liu Linlin Cao Qiquan Luo Wei Zhang Wenkun Zhu Tao Yao | 2021 | Nano-Micro Letters2021，13，11： | 3 |
| 6 | Facile Synthesis of FePS3 Nanosheets@MXene Composite as a High-Performance Anode Material for Sodium Storage显示文摘Searching for advanced anode materials with excellent electrochemical properties in sodium-ion battery is essential and imperative for next-generation energy storage system to solve the energy shortage problem.In this work,two-dimensional(2D)ultrathin FePS3 nanosheets,a typical ternary metal phosphosulfide,are first prepared by ultrasonic exfoliation.The novel 2D/2D heterojunction of FePS3 nanosheets@MXene composite is then successfully synthesized by in situ mixing ultrathin MXene nanosheets with FePS3 nanosheets.The resultant FePS3 nanosheets@MXene hybrids can increase the electronic conductivity and specific surface area,assuring excellent surface and interfacial charge transfer abilities.Furthermore,the unique heterojunction endows FePS3 nanosheets@MXene composite to promote the diffusion of Na^+ and alleviate the drastic change in volume in the cyclic process,enhancing the sodium storage capability.Consequently,the few-layered FePS3 nanosheets uniformly coated by ultrathin MXene provide an exceptional reversible capacity of 676.1 mAh g^−1 at the current of 100 mA g^−1 after 90 cycles,which is equivalent to around 90.6% of the second-cycle capacity(746.4 mAh g^−1).This work provides an original protocol for constructing 2D/2D material and demonstrates the FePS3@MXene composite as a potential anode material with excellent property for sodium-ion batteries. | Yonghao Ding Yu Chen Na Xu Xintong Lian Linlin Li Yuxiang Hu Shengjie Peng | 2020 | Nano-Micro Letters2020，12，4： | 2 |
| 7 | Nanozymes for regulation of reactive oxygen species and disease therapy显示文摘With high catalytic activity and stability,nanozymes have huge advantage in generating or eliminating the reactive oxygen species(ROS)due to their intrinsic enzyme-mimicking abilities,therefore attracting wide attention in ROS-related disease therapy.To better design nanozyme-based platforms for ROSrelated biological application,we firstly illustrate the catalytic mechanism of different activities,and then introduce different strategies for using nanozymes to augment or reduce ROS level for the applications in cancer therapy,pathogen infection,neurodegeneration,etc.Finally,the challenges and future opportunities are proposed for the development and application of nanozymes. | Yujie Dai Yiming Ding Linlin Li | 2021 | Chinese Chemical Letters2021，32，9： | 2 |
| 8 | Fibronectin and asialoglyprotein receptor mediate hepatitis B surface antigen binding to the cell surface显示文摘 | Jing Yang Feng Wang Linlin Tian Jing Su Xiangqian Zhu Li Lin Xiaoran Ding Xuejun Wang Shengqi Wang | 2010 | Archives of Virology2010，，6： | 1 |
| 9 | Breaking the linear correlations for enhanced electrochemical nitrogen reduction by carbon-encapsulated mixed-valence Fe_(7)(PO_(4))_(6)显示文摘Electrochemical nitrogen reduction(NRR)is deemed as a consummate answer for the traditional Haber–Bosch technology.Breaking the linear correlations between adsorption and transition-state energies of intermediates is vital to improve the kinetics of ammonia synthesis and obtain a less energy-intensive process.Herein,carbon-encapsulated mixed-valence Fe_(7)(PO_(4))_(6) was prepared and applied as an electrocatalyst for high-efficiency NRR.A dramatic faradaic efficiency(FE)of 36.93%and an NH_(3) production rate of 13.1μg h^(-1) mg_(cat)^(-1) were obtained at-0.3 V versus RHE,superior to nearly all Fe-based catalysts.Experiments and DFT calculations revealed that the superior performance was ascribed to the synergistic effect of mixed-valence iron pair,which braked the linear correlations to improve the kinetics of ammonia from collaborative hydrogenation and*NH_(3) separation.This work proves the feasibility of mixedvalence catalysts for nitrogen reduction and thus opening a new avenue towards artificial nitrogenfixation catalysts. | Lehui Ma Fanfan Xu Linlin Zhang Zhongfen Nie Kai Xia Mingxia Guo Mingzhu Li Xin Ding | 2022 | Journal of Energy Chemistry2022，31，8： | 1 |
| 10 | The siderophore-interacting protein is involved in iron acquisition and virulence of Riemerella anatipestifer strain CH3显示文摘 | Jing Tu Fengying Lu Shuang Miao Xintao Ni Pan Jiang Hui Yu Linlin Xing Shengqing Yu Chan Ding Qinghai Hu | 2013 | Veterinary Microbiology2013，，： | 1 |
| 11 | Continuous pro- duction of liquid reclaimed rubber from ground tire rubber and its application as reactive polymeric plasticizer显示文摘 | SHI Jinwei ZOU Hua DING Linlin | 2014 | Polymer Degradation and Stability2014，99，1： | 1 |
| 12 | Unified control and detection framework and its applications: a review, some new results, and future perspectives显示文摘Initiated three decades ago,integrated design of controllers and fault detectors has continuously attracted research attention.The recent development of the unified control and detection framework with an observer-based residual generator in its core gives a more general form of the previous works.Its applications to residual centred modelling of uncertain control systems,fault detection in feedback control systems with uncertainties,fault-tolerant control(FTC)as well as control performance degradation monitoring,detection and recovery are introduced.In conclusion,some future perspectives are proposed. | DING Steven Xianchuan LI Linlin JIANG Bin | 2021 | Journal of Systems Engineering and Electronics2021，32，5： | 1 |
| 13 | Efficient User Preferences-Based Top-k Skyline Using MapReduce显示文摘 | Linlin Ding Xiao Zhang Mingxin Sun Aili Liu Baoyan Song | 2018 | 国际计算机前沿大会会议论文集2018，，1： | 1 |
| 14 | Lignin dissolution in dialkylimidazolium-based ionic liquid–water mixtures显示文摘 | Yantao Wang Ligang Wei Kunlan Li Yingchong Ma Ningning Ma Shan Ding Linlin Wang Deyang Zhao Bing Yan Wenying Wan Qian Zhang Xin Wang Junmei Wang Hui Li | 2014 | Bioresource Technology2014，，： | 1 |
| 15 | Continuous production of liquid reclaimed rubber from ground tire rubber and its application as reactive polymeric plasticizer显示文摘 | Jinwei Shi Hua Zou Linlin Ding Xiaolin Li Kuan Jiang Tung Chen Xiaodan Zhang Liqun Zhang Dongyun Ren | 2013 | Polymer Degradation and Stability2013，，： | 1 |
| 16 | Interface construction of NiCo LDH/NiCoS based on the 2D ultrathin nanosheet towards oxygen evolution reaction显示文摘Carbon-free hydrogen as a promising clean energy source can be produced with electrocatalysts via water electrolysis.Oxygen evolution reaction(OER)as anodic reaction determines the overall efficiency of water electrolysis due to sluggish OER kinetics.Thus,it’s much desirable to explore the efficient and earth-abundant transition-metal-based OER electrocatalysts with high current density and superior stability for industrial alkaline electrolyzers.Herein,we demonstrate a significant enhancement of OER kinetics with the hybrid electrocatalyst arrays in alkaline via judiciously combining earth-abundant and ultrathin NiCo-based layered double hydroxide(NiCo LDH)nanosheets with nickel cobalt sulfides(NiCoS)with a facile metal-organic framework(MOF)-template-involved surface sulfidation process.The obtained NiCo LDH/NiCoS hybrid arrays exhibits an extremely low OER overpotential of 308 mV at 100 mA·cm^(−2),378 mV at 200 mA·cm^(−2)and 472 mV at 400 mA·cm^(−2)in 1 M KOH solution,respectively.A much low Tafel slope of 48 mV·dec^(−1)can be achieved.Meanwhile,with the current density from 50 to 250 mA·cm^(−2),the NiCo-LDH/NiCoS hybrid arrays can run for 25 h without any degradation.Our results demonstrate that the construction of hybrid arrays with abundant interfaces of NiCo LDH/NiCoS can facilitate OER kinetics via possible modulation of binding energy of O-containing intermediates in alkaline media.The present work would pave the way for the development of lowcost and efficient OER catalysts and industrial application of water alkaline electrolyzers. | Jiahui Li Lili Wang Haojia He Yiquan Chen Zirui Gao Na Ma Bing Wang Linlin Zheng Rulin Li Yujia Wei Junqing Xu Yao Xu Bowen Cheng Zhen Yin Ding Ma | 2022 | Nano Research2022，15，6： | 0 |
| 17 | Efficient k-dominant skyline query over incomplete data using MapReduce显示文摘Skyline queries are extensively incorporated in various real-life applications by filtering uninteresting data objects.Sometimes,a skyline query may return so many results because it cannot control the retrieval conditions especially for highdimensional datasets.As an extension of skyline query,the kdominant skyline query reduces the control of the dimension by controlling the value of the parameter k to achieve the purpose of reducing the retrieval objects.In addition,with the continuous promotion of Bigdata applications,the data we acquired may not have the entire content that people wanted for some practically reasons of delivery failure,no power of battery,accidental loss,so that the data might be incomplete with missing values in some attributes.Obviously,the k-dominant skyline query algorithms of incomplete data depend on the user definition in some degree and the results cannot be shared.Meanwhile,the existing algorithms are unsuitable for directly used to the incomplete big data.Based on the above situations,this paper mainly studies k-dominant skyline query problem over incomplete dataset and combines this problem with the distributed structure like MapReduce environment.First,we propose an index structure over incomplete data,named incomplete data index based on dominate hierarchical tree(ID-DHT).Applying the bucket strategy,the incomplete data is divided into different buckets according to the dimensions of missing attributes.Second,we also put forward query algorithm for incomplete data in MapReduce environment,named MapReduce incomplete data based on dominant hierarchical tree algorithm(MR-ID-DHTA).The data in the bucket is allocated to the subspace according to the dominant condition by Map function.Reduce function controls the data according to the key value and returns the k-dominant skyline query result.The effective experiments demonstrate the validity and usability of our index structure and the algorithm. | Linlin DING Shu WANG Baoyan SONG | 2021 | Frontiers of Computer Science2021，15，4： | 0 |
| 18 | Insights into electrolyte effects on photoactivities of dye-sensitized photoelectrochemical cells for water splitting显示文摘Dye-sensitized photoelectrochemical cell(DS-PEC) is an especially attractive method to generate hydrogen via visible light driven water splitting. Electrolyte, an essential component of DS-PEC, plays a great role in determining the photoactivities of devices for water splitting. When using phosphate buffer(pH = 6.4)as electrolyte, the DS-PEC displayed much higher photoactivity than using 0.1 M Na_2SO_4(pH = 6.4) as electrolyte. The insight is phosphate anion gathers together to form a negative electrostatic field on TiO_2 surface, which increases the resistance in the TiO_2/catalyst and electrolyte interface and validly reduces the charge recombination from TiO_2 to the oxidized catalyst. | Xin Ding Linlin Zhang Yan Gao | 2017 | Journal of Energy Chemistry2017，26，3： | 0 |
| 19 | Characterization of Swirling Inflow Effects on Turbine Performance under Pulsating Flows显示文摘The present study focuses on the influence of the swirling flows on flow behaviors and performance of a radial-flow turbocharger turbine under pulsating inflow condition.To characterize the effects of swirling flow,three sets of simulations of the turbine were carried out,which are an unsteady simulation under pulsating swirling inflow,an unsteady simulation under equivalent pulsating uniform inflow,and quasi-steady simulations under uniform inflow.Results proved that swirling flow has a considerable negative influence on turbine instantaneous performance and lead to 2.5%cycle-averaged efficiency reduction under pulsating flow condition.Swirling inflow would lead to significant losses in both the volute and the rotor,while the pulsating inflow leads to higher losses in the rotor and shows little influence on the losses in the volute.The instantaneous efficiency reduction of the turbine could be correlated with the time-varying inlet swirl strength.Under the influence of unsteady inlet swirls,the volute flow field is highly distorted and the free vortex relation is no longer valid.The swirling flow has strong interactions with the wake flow of the volute tongue,leading to additional losses.Relative flow angle at rotor inlet is remarkably reduced and its distribution is significantly distorted.Strong separation flows and passage vortices would appear in the rotor because of the swirling inflow,leading to inferior rotor performance. | DING Zhanming WANG Cuicui ZHANG Junyue LIU Ying HOU Linlin ZHUGE Weilin ZHANG Yangjun | 2022 | Journal of Thermal Science2022，31，5： | 0 |
| 20 | Urban Land Use Efficiency and Contributing Factors in the Yangtze River Delta Under Increasing Environmental Restrictions in China显示文摘Evaluating urban land use efficiency(ULUE) provides insights into the interactions between land use systems and their external environment. Specifically, changes in ULUE are important for monitoring urban transformation in developing countries. In this study, using a traditional input-output index model, we incorporated slack-based measurements and undesirable outputs into a SBM-UN(slack-based measure-undesirable) model to investigate ULUE within the context of increasing environmental restrictions in China. The model was used to estimate the ULUE of 26 cities in the highly developed urban agglomeration of the Yangtze River Delta from 2000 to2018. The average ULUE in the Yangtze River Delta was relatively low compared to that of developed city regions in the European Union(EU) and North America and exhibited a U-shaped curve over the study period. Incorporating undesirable outputs, such as environmental pollution, into the model reduced ULUE by 19.06%. ULUE varied spatially, with the kernel density estimation exhibiting a bimodal distribution. Efficiency decomposition analysis showed that scale efficiency made a greater contribution to ULUE than pure technical efficiency. Based on our findings, recommended approaches to improve ULUE include optimizing factor allocation, reducing undesirable outputs, and increasing the effective output per land unit. The study suggests that ULUE and the SBM-UN model are useful planning tools for sustainable urban development. | YANG Qingke WANG Lei QIN Xianhong FAN Yeting WANG Yazhu DING Linlin | 2022 | Chinese Geographical Science2022，32，5： | 0 |
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