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| 1 | Interaction between PCC Filler and Cellulosic Fiber in Fiber/Filler Co-refining System显示文摘Mineral fillers are important for conserving raw fiber materials and reducing production costs in the paper industry.However,the increase in filler content will inevitably result in strength reduction,which limits the adding amount of filler in paper production.In this study,we designed a cellulose fiber/filler co-refining approach to improve the strength and optical properties of paper;moreover,the synergistic interaction between fibers and precipitated calcium carbonate(PCC)fillers in the co-refining process was investigated.Results of fiber separation and PCC particle size analysis showed that,compared with conventional refining,the content of fines increased,whereas the PCC particle size decreased.More importantly,composites were formed between the PCC and fines,which promoted strength improvement of paper.Physical tests show that the tensile index of paper with 15%PCC content increased by 22%compared with that of the paper filled by conventional method,whereas the brightness and opacity of paper improved by fiber/filler co-refining for a specified filler content.These findings provide a basis for the further development of co-refining filling technology. | Sheng Qiang Shunxi Song Peiyao Wang Yujie Shi Linhao Li Haitang Liu | 2021 | Paper And Biomaterials2021，6，4： | 5 |
| 2 | Improving Low Bitrate Video Coding via Computation Incorporating A Priori Information显示文摘The growing number of mobile users, as well as the diversification in types of services have resulted in increasing demands for wireless network bandwidth in recent years. Although evolving transmission techniques are able to enlarge the network capacity to some degree, they still cannot satisfy the requirements of mobile users. Meanwhile, following Moore's Law, the data processing capabilities of mobile user terminals are continuously improving. In this paper, we explore possible methods of trading strong computational power at wireless terminals for transmission efficiency of communications. Taking the specific scenario of wireless video conversation, we propose a model-based video coding scheme by learning the structures in multimedia contents. Benefiting from both strong computing capability and pre-learned model priors, only low-dimensional parameters need to be transmitted; and the intact multimedia contents can also be reconstructed at the receivers in real-time. Experiment results indicate that, compared to conventional video codecs, the proposed scheme significantly reduces the data rate with the aid of computational capability at wireless terminals. | Tao Xiaoming Dong Linhao Li Shaoyang Li Yang Ge Ning Lu Jianhua | 2015 | China Communications2015，12，9： | 2 |
| 3 | Myristica fragrans promotes ABCA1 expression and cholesterol efflux in THP-1-derived macrophages显示文摘Myristica fragrans is a traditional herbal medicine and has been shown to alleviate the development of atherosclerosis.However,the anti-atherogenic mechanisms of M.fragrans are still to be addressed.In this study,we explored the effect of M.fragrans on lipid metabolism and inflammation and its mechanisms in THP-1-derived macrophages.The quantitative polymerase chain reaction and western blot analysis results showed that M.fragrans promotes cholesterol efflux from THP-1-derived macrophages and reduces intracellular total cholesterol,cholesterol ester,and free cholesterol contents in a dose-and a time-dependent manner.Further study found that liver X receptor alpha(LXRα)antagonist GGPP significantly blocked the upregulation of ABCA1 expression with M.fragrans treatment.In addition,chromatin immunoprecipitation assay confirmed that GATA binding protein 3(GATA3)can bind to the LXRαpromoter,and inhibition of GATA3 led to the downregulation of LXRαand ATP-binding cassette subfamily A member 1 expression.Furthermore,M.fragrans reduced lipid accumulation,followed by decreasing tumor necrosis factor-α,interleukin(IL)-6,and IL-1βand increasing IL-10 produced by THP-1-derived macrophages.Therefore,M.fragrans is identified as a valuable therapeutic medicine for atherosclerotic cardiovascular disease. | Shangming Liu Jiahui Gao Linhao He Zhenwang Zhao Gang Wang Jin Zou Li Zhou Xiangjun Wan Shilin Tang Chaoke Tang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，1： | 2 |
| 4 | SUMOylation-modified Pelota-Hbs1 RNA surveillance complex restricts the infection of potyvirids in plants显示文摘RNA quality control nonsense-mediated decay is involved in viral restriction in both plants and animals.However,it is not known whether two other RNA quality control pathways,nonstop decay and no-go decay,are capable of restricting viruses in plants.Here,we show that the evolutionarily conserved Pelota–Hbs1 complex negatively regulates infection of plant viruses in the family Potyviridae(termed potyvirids),the largest group of plant RNA viruses that accounts for more than half of the viral crop damage worldwide.Pelota enables the recognition of the functional G1-2A6-7 motif in the P3 cistron,which is conserved in almost all potyvirids.This allows Pelota to target the virus and act as a viral restriction factor.Furthermore,Pelota interacts with the SUMO E2-conjugating enzyme SCE1 and is SUMOylated in planta.Blocking Pelota SUMOylation disrupts the ability to recruit Hbs1 and inhibits viral RNA degradation.These findings reveal the functional importance of Pelota SUMOylation during the infection of potyvirids in plants. | Linhao Ge Buwei Cao Rui Qiao Hongguang Cui Shaofang Li Hongying Shan Pan Gong Mingzhen Zhang Hao Li Aiming Wang Xueping Zhou Fangfang Li | 2023 | Molecular Plant2023，16，3： | 2 |
| 5 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 6 | Higher-order principal component pursuit via tensor approximation and convex optimization显示文摘Recovering the low-rank structure of data matrix from sparse errors arises in the principal component pursuit(PCP). This paper exploits the higher-order generalization of matrix recovery,named higher-order principal component pursuit(HOPCP), since it is critical in multi-way data analysis. Unlike the convexification(nuclear norm) for matrix rank function, the tensorial nuclear norm is still an open problem. While existing preliminary works on the tensor completion field provide a viable way to indicate the low complexity estimate of tensor, therefore, the paper focuses on the low multi-linear rank tensor and adopt its convex relaxation to formulate the convex optimization model of HOPCP. The paper further propose two algorithms for HOPCP based on alternative minimization scheme: the augmented Lagrangian alternating direction method(ALADM) and its truncated higher-order singular value decomposition(ALADM-THOSVD) version. The former can obtain a high accuracy solution while the latter is more efficient to handle the computationally intractable problems. Experimental results on both synthetic data and real magnetic resonance imaging data show the applicability of our algorithms in high-dimensional tensor data processing. | Sijia Cai Ping Wang Linhao Li Chuhan Zhang | 2014 | Journal of Systems Engineering and Electronics2014，25，3： | 1 |
| 7 | Surface modification of electrospun fibers with mechano-growth factor for mitigating the foreign-body reaction显示文摘The implantation of synthetic polymeric scaffolds induced foreign-body reaction(FBR)seriously influence the wound healing and impair functionality recovery.A novel short peptide,mechano-growth factor(MGF),was introduced in this study to modify an electrospun polycaprolactone(PCL)fibrous scaffold to direct the macrophage phenotype transition and mitigate the FBR.In vitro studies discovered the cell signal transduction mechanism of MGF regulates the macrophage polarization via the expression of related genes and proteins.We found that macrophages response the MGF stimuli via endocytosis,then MGF promotes the histone acetylation and upregulates the STAT6 expression to direct an anti-inflammatory phenotype transition.Subsequently,an immunoregulatory electrospun PCL fibrous scaffold was modified by silk fibroin(SF)single-component layer-by-layer assembly,and the SF was decorated with MGF via click chemistry.Macrophages seeded on scaffold to identify the function of MGF modified scaffold in directing macrophage polarization in vitro.Parallelly,rat subcutaneous implantation model and rat tendon adhesion model were performed to detect the immunomodulatory ability of the MGF-modified scaffold in vivo.The results demonstrate that MGF-modified scaffold is beneficial to the transformation of macrophages to M2 phenotype in vitro.More importantly,MGF-functionalized scaffold can inhibit the FBR at the subcutaneous tissue and prevent tissue adhesion. | Yang Song Linhao Li Weikang Zhao Yuna Qian Lili Dong Yunnan Fang Li Yang Yubo Fan | 2021 | Bioactive Materials2021，6，9： | 1 |
| 8 | Pepino mosaic virus antagonizes plant m^(6)A modification by promoting the autophagic degradation of the m^(6)A writer HAKAI显示文摘Autophagy plays an active anti-viral role in plants.Increasing evidence suggests that viruses can inhibit or manipulate autophagy,thereby winning the arms race between plants and viruses.Here,we demonstrate that overexpression of an m^(6)A writer from Solanum lycopersicum,SlHAKAI,could negatively regulate pepino mosaic virus(PepMV)infection,inhibit viral RNA and protein accumulations by affecting viral m^(6)A levels in tomato plants and vice versa.The PepMV-encoded RNA-dependent RNA polymerase(RdRP)directly interacts with SlHAKAI and reduces its protein accumulation.The RdRP-mediated decreased protein accumulation of SlHAKAI is sensitive to the autophagy inhibitor 3-methyladenine and is compromised by knocking down a core autophagy gene.Furthermore,PepMV RdRP could interact with an essential autophagy-related protein,SlBeclin1.RdRP,SlHAKAI,and SlBeclin1 interaction complexes form bright granules in the cytoplasm.Silencing of Beclin1 in Nicotiana benthamiana plants abolishes the RdRP-mediated degradation of SlHAKAI,indicating the requirement of Beclin1 in this process.This study uncovers that the PepMV RdRP exploits the autophagy pathway by interacting with SlBeclin1 to promote the autophagic degradation of the SlHAKAI protein,thereby inhibiting the m^(6)A modification-mediated plant defense responses. | Hao He Linhao Ge Zhaolei Li Xueping Zhou Fangfang Li | 2023 | aBIOTECH2023，4，2： | 1 |
| 9 | Optimized high order product quantization for approximate nearest neighbors search显示文摘Product quantization is now considered as an effective approach to solve the approximate nearest neighbor(ANN)search.A collection of derivative algorithms have been developed.However,the current techniques ignore the intrinsic high order structures of data,which usually contain helpful information for improving the computational precision.In this paper,aiming at the complex structure of high order data,we design an optimized technique,called optimized high order product quantization(O-HOPQ)for ANN search.In O-HOPQ,we incorporate the high order structures of the data into the process of designing a more effective subspace decomposition way.As a result,spatial adjacent elements in the high order data space are grouped into the same subspace.Then,O-HOPQ generates its spatial structured codebook,by optimizing the quantization distortion.Starting from the structured codebook,the global optimum quantizers can be obtained effectively and efficiently.Experimental results show that appropriate utilization of the potential information that exists in the complex structure of high order data will result in significant improvements to the performance of the product quantizers.Besides,the high order structure based approaches are effective to the scenario where the data have intrinsic complex structures. | Linhao LI Qinghua HU | 2020 | Frontiers of Computer Science2020，14，2： | 1 |
| 10 | m^(6)A modification of plant virus enables host recognition by NMD factors in plants显示文摘N^(6)-methyladenosine(m^(6)A)is the most abundant eukaryotic mRNA modification and is involved in various biological processes.Increasing evidence has implicated that m^(6)Amodification is an important anti-viral defense mechanism in mammals and plants,but it is largely unknown how m^(6)Aregulates viral infection in plants.Here we report the dynamic changes and functional anatomy of m^(6)Ain Nicotiana benthamiana and Solanum lycopersicum during Pepino mosaic virus(PepMV)infection.m^(6)Amodification in the PepMV RNA genome is conserved in these two species.Overexpression of the m^(6)Awriters,mRNA adenosine methylase A(MTA),and HAKAI inhibit the PepMV RNA accumulation accompanied by increased viral m^(6)Amodifications,whereas deficiency of these writers decreases the viral RNA m^(6)Alevels but enhances virus infection.Further study reveals that the cytoplasmic YTH-domain family protein NbECT2A/2B/2C as m^(6)Areaders are involved in anti-viral immunity.Protein-protein interactions indicate that NbECT2A/2B/2C interact with nonsense-mediated mRNA decay(NMD)-related proteins,including NbUPF3 and NbSMG7,but not with NbUPF1.m^(6)Amodification-mediated restriction to PepMV infection is dependent on NMD-related factors.These findings provide new insights into the functionality of m^(6)Aanti-viral activity and reveal a distinct immune response that NMD factors recognize the m^(6)Areaders-viral m^(6)ARNA complex for viral RNA degradation to limit virus infection in plants. | Hao He Linhao Ge Yalin Chen Siwen Zhao Zhaolei Li Xueping Zhou Fangfang Li | 2024 | Science China(Life Sciences)2024，67，1： | 0 |
| 11 | Plant and animal positive-sense single-stranded RNA viruses encode small proteins important for viral infection in their negative-sense strand显示文摘Positive-sense single-stranded RNA(+ssRNA)viruses,the most abundant viruses of eukaryotes in nature,require the synthesis of negative-sense RNA(-RNA)using their genomic(positive-sense)RNA(+RNA)as a template for replication.Based on current evidence,viral proteins are translated via viral+RNAs,whereas-RNA is considered to be a viral replication intermediate without coding capacity.Here,we report that plant and animal+ssRNA viruses contain small open reading frames(ORFs)in their-RNA(reverse ORFs[rORFs]).Using turnip mosaic virus(TuMV)as a model for plant+ssRNA viruses,we demonstrate that small proteins encoded by rORFs display specific subcellularlocalizations,and confirm the presence of rORF2 in infected cells through mass spectrometry analysis.The protein encoded by TuMV rORF2 forms punctuate granules that are localized in the perinuclear region and co-localized with viral replication complexes.The rORF2 protein can directly interact with the viral RNA-dependent RNA polymerase,and mutation of rORF2 completely abolishes virus infection,whereas ectopic expression of rORF2 rescues the mutant virus.Furthermore,we show that several rORFs in the-RNA of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have the ability to suppress type l interferon production and facilitate the infection of ve-sicular stomatitis virus.In addition,we provide evidence that TuMV might utilize internal ribosome entry sites to translate these small rORFs.Taken together,these findings indicate that the-RNA of+ssRNA vi-ruses can also have the coding capacity and that small proteins encoded therein play critical roles in viral infection,revealing a viral proteome larger than previously thought. | Pan Gong Qingtang Shen Mingzhen Zhang Rui Qiao Jing Jiang Lili Su Siwen Zhao Shuai Fu Yu Ma Linhao Ge Yaqin Wang Rosa Lozano-Durán Aiming Wang Fangfang Li Xueping Zhou | 2023 | Molecular Plant2023，16，11： | 0 |
| 12 | Detector development at the Back-n white neutron source显示文摘Purpose Back-n is a white neutron beamline at China spallation neutron source,which was established in the year of 2018.It is a powerful facility for nuclear data measurement,neutron detector calibration,and radiation effect research.Method A series of detectors were built for different experiments,including beam monitoring,beam profile measurement,neutron induced secondaries(fission fragments,light charged particles and gamma)cross section measurement,and neutron resonance radiography,etc.A common digitization electronics and a cluster-based DAQ were developed for these detector systems.Most detectors have been employed at Back-n and serviced for experiments from the beginning of the beamline running.Results and conclusion As an overview of detectors of Back-n,the details of the detector design and the experiment performing are described in this paper.Some developing systems,e.g.,MTPC and B-MCP,are also included. | Fan Ruirui Li Qiang Bao Jie Li Yang Liu Rong Jiang Wei Ren Jie Zhang Qiwei Cao Ping Gu Minhao Ren Zhizhou Yi Han Tang Jingyu An Qi Bai Haofan Bai Jiangbo Chen Qiping Chen Yonghao Chen Zhen Cui Zengqi Fan Anchuan Feng Changqing Feng Fanzhen Gao Keqing Han Changcai Han Zijie He Guozhu He Yongcheng Hong Yang Hu Yiwei Huang Hanxiong Jia Weihua Jiang Haoyu Jiang Zhijie Jin Zhengyao Kang Ling Li Bo Li Chao Li Gong Li Jiawen Li Xiao Liu Jie Liu Shubin Luan Guangyuan Ning Changjun Qi Binbin Ruan Xichao Song Zhaohui Sun Kang Tan Zhixin Tang Shengda Wang Pengcheng Wang Zhaohui Wen Zhongwei Wu Xiaoguang Wu Xuan Xie Likun Yang Yiwei Yu Yongji Zhang Guohui Zhang Linhao Zhang Mohan Zhang Xianpeng Zhang Yuliang Zhang Yue Zhang Zhiyong Zhao Maoyuan Zhou Luping Zhou Zhihao Zhu Kejun The CSNS Back-n Collaboration | 2023 | Radiation Detection Technology and Methods2023，7，2： | 0 |
| 13 | Mechanism of the Greenland-Scotland Ridge overflow variation under different atmospheric CO_2 scenarios显示文摘Baroclinic transport and the barotropic effect are two different viewpoints for understanding the mechanism of the Greenland-Scotland Ridge overflow. The mechanism of this overflow, being an important deep branch of thermohaline circulation, deserves research discussion, especially against the background of global warming. Using the newly developed ECHAM5/MPI-OM, of the Max Planck Institute for Meteorology, which is an advanced atmospheresea iceocean coupled climate model, the mechanism of the Greenland-Scotland Ridge overflow variation under different atmospheric CO2 scenarios is studied. First, a control experiment is forced by a fixed CO2 concentration of 280 ppmv, which is the pre-industrial level before 1860. Three sensitive experiments are carried out under different scenarios of increased atmospheric CO2 concentrations, which are listed in the Intergovernmental Panel on Climate Change (IPCC) assessment report (B1, A1B and A2). In the control run, more water with higher salinity intruding into the Greenland-Icelandic-Norwegian Seas results in greater barotropic transport and greater overflow because of the baroclinic effect. Therefore, the barotropic effect and baroclinic effect on the overflow are unified. Under the atmospheric CO2 scenarios, the strength of overflow across the Faro-Bank Channel is controlled by the baroclinic effect and the increase in Denmark Strait overflow is attributed to the barotropic effect. | MU Lin SONG Jun ZHONG LinHao WANG LanNing LI Huan LI Yan | 2011 | Chinese Science Bulletin2011，56，24： | 0 |
| 14 | Frequent central Pacific La Nina events may accelerate Arctic warming since the 1980s显示文摘Including significant warming trend,Arctic climate changes also exhibit strong interannual variations in various fields,which is suggested to be related to El Nino and Southern Oscillation(ENSO)events.Previous studies have demonstrated the different impacts on the Arctic of central Pacific(CP)and eastern Pacific(EP)ENSO events,and suggested these impacts are largely of opposite sign for ENSO warm and cold phases.Our results illustrate asymmetrical changes for the cold and warm ENSO events,especially for the La Nina events.Compared to the past frequent basin-wide cooling La Nina events,since the 1980 s the cooling center for the La Nina event has strengthened and moved westward along with the increasing frequency for the canonical and CP La Nina events.Contrary to the basin-wide cooling and canonical La Nina events,the frequent CP La Nina events induce significant warming from the Beaufort Sea to Greenland via the convection center moving northward over the western Pacific.Observation analysis and numerical experiments both suggest that the changes in La Nina type may also accelerate Arctic warming. | Jing Li Lin Mu Linhao Zhong | 2021 | Acta Oceanologica Sinica2021，40，11： | 0 |
| 15 | Multi-functionalized nanofibers with reactive oxygen species scavenging capability and fibrocartilage inductivity for tendon-bone integration显示文摘The presence of excessive reactive oxygen species(ROS)after injuries to the enthesis could lead to cellular oxidative damage,high inflammatory response,chronic inflammation,and limited fibrochondral inductivity,making tissue repair and functional recovery difficult.Here,a multifunctional silk fibroin nanofiber modified with polydopamine and kartogenin was designed and fabricated to not only effectively reduce inflammation by scavenging ROS in the early stage of the enthesis healing but also enhance fibrocartilage formation with fibrochondrogenic induction in the later stages.The in vitro results confirmed the antioxidant capability and the fibrochondral inductivity of the functionalized nanofibers.In vivo studies showed that the multifunctional nanofiber can significantly improve the integration of tendon-bone and accelerate the regeneration of interface tissue,resulting in an excellent biomechanical property.Thus,the incorporation of antioxidant and bio-active molecules into extracellular matrix-like biomaterials in interface tissue engineering provides an integrative approach that facilitates damaged tissue regeneration and functional recovery,thereby improving the clinical outcome of the engineered tissue. | Peixing Chen Sixiang Wang Zhi Huang Yan Gao Yu Zhang Chunli Wang Tingting Xia Linhao Li Wanqian Liu Li Yang | 2021 | Journal of Materials Science & Technology2021，，11： | 0 |
| 16 | Prediction of forest fire occurrence in China under climate change scenarios显示文摘Climate change has an impact on forest fire patterns.In the context of global warming,it is important to study the possible effects of climate change on forest fires,carbon emission reductions,carbon sink effects,forest fire management,and sustainable development of forest ecosystems.This study is based on MODIS active fire data from 2001-2020 and the influence of climate,topography,vegetation,and social factors were integrated.Temperature and precipitation information from different scenarios of the BCC-CSM2-MR climate model were used as future climate data.Under climate change scenarios of a sustainable low development path and a high conventional development path,the extreme gradient boosting model predicted the spatial distribution of forest fire occurrence in China in the 2030s(2021-2040),2050s(2041-2060),2070s(2061-2080),and2090s(2081-2100).Probability maps were generated and tested using ROC curves.The results show that:(1)the area under the ROC curve of training data(70%)and validation data(30%)were 0.8465 and 0.8171,respectively,indicating that the model can reasonably predict the occurrence of forest fire in the study area;(2)temperature,elevation,and precipitation were strongly correlated with fire occurrence,while land type,slope,distance from settlements and roads,and slope direction were less strongly correlated;and,(3)based on future climate change scenarios,the probability of forest fire occurrence will tend to shift from the south to the center of the country.Compared with the current climate(2001-2020),the occurrence of forest fires in 2021-2040,2041-2060,2061-2080,and 2081-2100 will increase significantly in Henan Province(Luoyang,Nanyang,S anmenxia),Shaanxi Province(Shangluo,Ankang),Sichuan Province(Mianyang,Guangyuan,Ganzi),Tibet Autonomous Region(Shannan,Linzhi,Changdu),Liaoning Province(Liaoyang,Fushun,Dandong). | Yakui Shao Guangpeng Fan Zhongke Feng Linhao Sun Xuanhan Yang Tiantian Ma XuSheng Li Hening Fu Aiai Wang | 2023 | Journal of Forestry Research2023，34，5： | 0 |
| 17 | High-consistency proton exchange membrane fuel cells enabled by oxygen-electron mixed-pathway electrodes via digitalization design显示文摘Proton exchange membrane(PEM)fuel cell has been regarded as a promising approach to the decarbonization and diversification of energy sources.In recent years,durability and cost issues of PEM fuel cells are increasingly significant with the rapid increase of power density.However,the failure to maintain the cell consistency,as one major cause of the above issue,has attracted little attention.Therefore,this study intends to figure out the underlying cause of cell inconsistency and provide solutions to it from the perspective of multi-physics transport coupled with electrochemical reactions.The PEM fuel cells with electrodes under two compression modes are firstly discussed to fully explain the relationship of cell performance and consistency to electrode structure and multi-physics transport.The result indicates that one main cause of cell inconsistency is the intrinsic conflict between the separated transport and cooperated consumption of oxygen and electron throughout the active area.Then,a mixed-pathway electrode design is proposed to reduce the cell inconsistency by enhancing the mixed transport of oxygen and electron in the electrode.It is found that the mixing of pathways in electrodes at under-rib region is more effective than that at the under-channel region,and can achieve an up to 40%reduction of the cell inconsistency with little(3.3%)sacrificed performance.In addition,all the investigations are implemented based on a self-developed digitalization platform that reconstructs the complex physical–chemical system of PEM fuel cells.The fully observable physical information of the digitalized cells provides strong support to the related analysis. | Zhiming Bao Biao Xie Weizhuo Li Shenghui Zhong Linhao Fan Chasen Tongsh Fei Gao Qing Du Mohamed Benbouzid Kui Jiao | 2023 | Science Bulletin2023，，3： | 0 |
| 18 | The Regulatory Effect of Braided Silk Fiber Skeletons with Differential Porosities on In Vivo Vascular Tissue Regeneration and Long-Term Patency显示文摘The development of small-diameter vascular grafts that can meet the long-term patency required for implementation in clinical practice presents a key challenge to the research field.Although techniques such as the braiding of scaffolds can offer a tunable platform for fabricating vascular grafts,the effects of braided silk fiber skeletons on the porosity,remodeling,and patency in vivo have not been thoroughly investigated. | Xili Ding Weirong Zhang Peng Xu Wentao Feng Xiaokai Tang Xianda Yang Lizhen Wang Linhao Li Yan Huang Jing Ji Diansheng Chen Haifeng Liu Yubo Fan | 2023 | Research2023，，2： | 0 |
| 19 | Applications of protein engineering in the microbial synthesis of plant triterpenoids显示文摘Triterpenoids are a class of natural products widely used in fields related to medicine and health due to their biological activities such as hepatoprotection,anti-inflammation,anti-viral,and anti-tumor.With the advancement in biotechnology,microorganisms have been used as cell factories to produce diverse natural products.Despite the significant progress that has been made in the construction of microbial cell factories for the heterogeneous biosynthesis of triterpenoids,the industrial production of triterpenoids employing microorganisms has been stymied due to the shortage of efficient enzymes as well as the low expression and low catalytic activity of heterologous proteins in microbes.Protein engineering has been demonstrated as an effective way for improving the specificity,catalytic activity,and stability of the enzyme,which can be employed to overcome these challenges.This review summarizes the current progress in the studies of Oxidosqualene cyclases(OSCs),cytochrome P450s(P450s),and UDP-glycosyltransferases(UGTs),the key enzymes in the triterpenoids synthetic pathway.The main obstacles restricting the efficient catalysis of these key enzymes are analyzed,the applications of protein engineering for the three key enzymes in the microbial synthesis of triterpenoids are systematically reviewed,and the challenges and prospects of protein engineering are also discussed. | Yan Luo Yaozhu Jiang Linhao Chen Chun Li Ying Wang | 2023 | Synthetic and Systems Biotechnology2023，8，1： | 0 |
| 20 | Differences in root stress and strain distribution in buccal and lingual orthodontics: A finite element analysis study显示文摘Orthodontic forces can cause stress and strain concentration and microcracks on tooth root surfaces.This study aimed to analyze whether a lingual orthodontic appliance was more likely to cause root stress concentration and root resorption than the traditional buccal appliance.A finite element model of the root of the maxillary central incisor with straight,buccal,and lingual curvatures was established.A load perpendicular to the tooth surface on the buccal and lingual surfaces of the central incisor was applied,and the stress and strain concentration at the root apex was compared.The stress and strain at the root apex of the lingual cingulum group were lesser than those of the buccal group;little difference was observed between the lingual and buccal clinical crown central augmentation groups.The stress and strain at the root apex of the lingual direction movement group were greater than those of the buccal direction movement group.The direction of the root curvature also influenced the amount of stress and strain at the root apex.The difference in the risk of root resorption between lingual and buccal orthodontics is dependent on the height of the bracket placement.The loading direction of the orthodontic force and direction of the root curvature also affect the stress and strain at the root apex. | Shengzhao Xiao Xiangfei Kong Jie Yao Jinlin Liu Linhao Li Tianyun Jiang Lizhen Wang Yubo Fan | 2022 | Medicine in Novel Technology and Devices2022，，2： | 0 |
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