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| 1 | Improving Low Bitrate Video Coding via Computation Incorporating A Priori Information显示文摘The growing number of mobile users, as well as the diversification in types of services have resulted in increasing demands for wireless network bandwidth in recent years. Although evolving transmission techniques are able to enlarge the network capacity to some degree, they still cannot satisfy the requirements of mobile users. Meanwhile, following Moore's Law, the data processing capabilities of mobile user terminals are continuously improving. In this paper, we explore possible methods of trading strong computational power at wireless terminals for transmission efficiency of communications. Taking the specific scenario of wireless video conversation, we propose a model-based video coding scheme by learning the structures in multimedia contents. Benefiting from both strong computing capability and pre-learned model priors, only low-dimensional parameters need to be transmitted; and the intact multimedia contents can also be reconstructed at the receivers in real-time. Experiment results indicate that, compared to conventional video codecs, the proposed scheme significantly reduces the data rate with the aid of computational capability at wireless terminals. | Tao Xiaoming Dong Linhao Li Shaoyang Li Yang Ge Ning Lu Jianhua | 2015 | China Communications2015，12，9： | 2 |
| 2 | Surface modification of electrospun fibers with mechano-growth factor for mitigating the foreign-body reaction显示文摘The implantation of synthetic polymeric scaffolds induced foreign-body reaction(FBR)seriously influence the wound healing and impair functionality recovery.A novel short peptide,mechano-growth factor(MGF),was introduced in this study to modify an electrospun polycaprolactone(PCL)fibrous scaffold to direct the macrophage phenotype transition and mitigate the FBR.In vitro studies discovered the cell signal transduction mechanism of MGF regulates the macrophage polarization via the expression of related genes and proteins.We found that macrophages response the MGF stimuli via endocytosis,then MGF promotes the histone acetylation and upregulates the STAT6 expression to direct an anti-inflammatory phenotype transition.Subsequently,an immunoregulatory electrospun PCL fibrous scaffold was modified by silk fibroin(SF)single-component layer-by-layer assembly,and the SF was decorated with MGF via click chemistry.Macrophages seeded on scaffold to identify the function of MGF modified scaffold in directing macrophage polarization in vitro.Parallelly,rat subcutaneous implantation model and rat tendon adhesion model were performed to detect the immunomodulatory ability of the MGF-modified scaffold in vivo.The results demonstrate that MGF-modified scaffold is beneficial to the transformation of macrophages to M2 phenotype in vitro.More importantly,MGF-functionalized scaffold can inhibit the FBR at the subcutaneous tissue and prevent tissue adhesion. | Yang Song Linhao Li Weikang Zhao Yuna Qian Lili Dong Yunnan Fang Li Yang Yubo Fan | 2021 | Bioactive Materials2021，6，9： | 1 |
| 3 | Mechanogrowth Factor Promotes Mechanical Response in Ligament Fibroblasts of Knee Osteoarthritis via Activating ATF-2显示文摘Background&Objective Knee osteoarthritis(OA)is a degenerative disease,which not only induces superficial cartilage defects and full-thickness cartilage defects,but also exacerbates the microenvironment of the knee joint and affects the mechano-chemical responses of the organ.As a growth/repair factor,mechanical growth factor(MGF)has the function of preventing OA,promoting cartilage regeneration and repairing damaged ligaments.activating transcription factor 2(ATF-2),a transcription factor,has the property of binding to cytokines,which makes it involved in the transcriptional regulation of various pathways in response to cellular stress,inflammatory cytokine and growth factors.At present,little is known about the effect of MGF on human osteoarthritis ligament fibroblasts(OA-LFs),and whether the approach can promote OA-LFs timely response to the mechanical injury and initiate signaling pathway for cell survival.Therefore,the purpose of this study is to investigate whether MGF promotes mechanical response to ligament fibroblasts in osteoarthritis knee cavity via ATF-2.Methods OA-LFs were seeded onto six-cell BioFlex plates and suffered from 12%static mechanical stretch[60 cycles/minute(1 Hz)]for 12 hours to mimic mechanical force mediated ligament injury.Meanwhile,OA-LFs were treated with MGF before and during mechanical stretch.Intracellular reactive oxygen species(ROS)and GRP78 mRNA expression were investigated to detect the cellular stress response of OA-LFs.The scratch test was performed to detect the migration ability of cells,gelatin zymography was used to examine the effect of MGF on the activity of matrix metalloproteinase 2(MMP-2)in OA-LFs,and cell deformation was detected by phalloidin-FITC staining after stretching.Quantitative real-time polymerase chain reaction(qRT-PCR)was used to screen the messenger RNA(mRNA)expression of ATF family members after OALFs treatment with MGF.Western blotting further proved that MGF is capable to activate the p-ATF-2.Results OA delays LFs response to mechanical injury,while MGF pretreatment can promote cells timely feedback the mechanically stimuli by inducing cellular stress.MGF treatment can alleviate the decline in cell migration ability caused by mechanical injury and further promote cell migration.In addition,MGF can reduce the activity of MM P-5 and alleviate the stretch-induced deformation of OA-LFs.Furthermore,the mRNA expression of ATF-2 up-regulated in a dose-dependent manner upon MGF treatment compared with control,while the expression of ATF-5 gene was down-regulated in a dose-dependent.Protein levels showed that the expression of p-ATF-2 increased with increasing MGF concentration.Conclusions Our study shows that MGF pretreatment of OA-LFs can respond quickly to mechanical damage and accelerate the ligament injury repair by promoting cell migration,decreasing the MMP-2 activity,and remitting the cell deformation.Therefore,MGF has potential as a therapeutic for OA patients. | Yu Ma Yang Song Linhao Li Lili Dong Li Yang | 2019 | 医用生物力学2019，34，A01： | 0 |
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