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| 1 | Ginsenoside Rh2 inhibits proliferation and induces apoptosis in human leukemia cells via TNF-~ signaling pathway显示文摘人参皂甙 Rh2,从人参属人参提取的 triterpene saponin,对多重癌症的展览药理学活动。然而,人参皂甙 Rh2 的 anticancer 机制是不清楚的。在这研究,我们发现人参皂甙 Rh2 有效地禁止生长并且导致 HL-60 房间的 apoptosis。用 microarray 技术,我们发现了那个肿瘤坏死因素 --(TNF-) 清楚地是起来调整的。而且, anti-TNF- 抗体经由 caspase-8, caspase-9,和 caspase-3 激活的抑制减轻了导致 Rh2 的 HL-60 房间 apoptosis。另外, TNF- 起来规定也在另外的对待 Rh2 的癌症房间线被观察。这些结果证明 TNF- 在人参皂甙起一个关键作用导致 Rh2 的房间 apoptosis。 | Jingjia Huang Kunjian Peng Linghao Wang Bin Wen Lin Zhou Tiao Luo Min Su Jijia Li Zhiyong Luo | 2016 | Acta Biochimica et Biophysica Sinica2016，48，8： | 11 |
| 2 | Microbiota transplantation reveals beneficial impact of berberine on hepatotoxicity by improving gut homeostasis显示文摘Berberine has been shown to reduce acute liver injury although the underlying mechanism is not fully understood. Because of the anatomic connection, the liver is constantly exposed to gut-derived bacterial products and metabolites. In this study, we showed that berberine has beneficial effects on both hepatotoxicity and intestinal damage in a rat model of chronic or acute liver injury. Microbiota transplantation from the rats with chronic hepatotoxicity could aggravate acute hepatotoxicity in mice treated with diethylnitrosamine(DEN). In rat models with gut homeostasis disruption induced by penicillin or dextran sulfate sodium(DSS), their fecal microbiota could also cause an enhanced hepatotoxicity of recipient mice. When treated with berberine,the DSS-induced enteric dysbacteriosis could be mitigated and their fecal bacteria were able to reduce acute hepatotoxicity in recipient mice. This study indicates that berberine could improve intestinal dysbacteriosis, which reduces the hepatotoxicity caused by pathological or pharmacological intervention. Fecal microbiota transplantation might be a useful method to directly explore homeostatic alteration in gut microbiota. | Chenjie Qin Huilu Zhang Linghao Zhao Min Zeng Weijian Huang Gongbo Fu Weiping Zhou Hongyang Wang Hexin Yan | 2018 | Science China(Life Sciences)2018，61，12： | 8 |
| 3 | Adsorptive removal of nitrogen-containing compounds from fuel by metal-organic frameworks显示文摘The adsorptive denitrogenation from fuels over three metal-organic frameworks(MIL-96(Al),MIL-53(Al)and MIL-101(Cr))was studied by batch adsorption experiments.Four nitrogen-containing compounds(NCCs)pyridine,pyrrole,quinoline and indole were used as model NCCs in fuels to study the adsorption mechanism.The physicochemical properties of the adsorbents were characterized by XRD,N2physical adsorption,FT-IR spectrum and Hammett indicator method.The metal-organic frameworks(MOFs),especially the MIL-101(Cr)containing Lewis acid sites as well as high specific surface area,can adsorb large quantities of NCCs from fuels.In addition,the adsorptive capacity over MIL-101(Cr)will be different for NCCs with different basicity.The stronger basicity of the NCC is,the more it can be absorbed over MIL-101(Cr).Furthermore,pore size and shape also affect the adsorption capacity for a given adsorbate,which can be proved by the adsorption over MIL-53(Al)and MIL-96(Al).The pseudo-second-order kinetic model and Langmuir equation can be used to describe kinetics and thermodynamics of the adsorption process,respectively.Finally,the regeneration of the used adsorbent has been conducted successfully by just washing it with ethanol. | Zhaoyang Wang Zhiguo Sun Linghao Kong Gang Li | 2013 | Journal of Energy Chemistry2013，22，6： | 4 |
| 4 | Retrograde metamorphism of the eclogite in North Qaidam,western China:Constraints by joint ^(40)Ar/^(39)Ar in vacuo crushing and stepped heating显示文摘Two amphiboles and a syn-metamorphic quartz vein from the Yuka terrane,North Qaidam,western China,have been analyzed by joint ^(40)Ar/^(39)Ar crushing in vacuo and stepwise heating techniques.The crushing in vacuo results provide information to directly constrain the timing of fluid activity and the age of amphibolite-facies retrogression.The stepwise heating results could further be used to decipher the thermal history of the UHP rocks.Amphiboles from amphibolites and quartz vein within garnetamphibolite lens analyzed by in vacuo crushing yield similarly shaped age spectra and exhibit relatively flat age plateaus for the last several steps.The characteristics of gas release patterns and geochronological data testify to the presence of significant excess ^(40)Ar within the fluid inclusions.The age plateaux with weighted mean ages(WMA) ranges from 488 to 476 Ma for amphiboles and 403 Ma for quartz(2σ).These data points constitute amphibole WMA yielding excellent isochrons with isochron ages of 469 and 463 Ma with initial ^(40)Ar/^(36)Ar ratios of 520 and 334,respectively.The isochron ages are interpreted to represent initial amphibolite-facies retrogression.The data points constituting the quartz age plateaux give an isochron age of 405 Ma with initial ^(40)Ar/^(36)Ar ratio of 295,recording a significant aqueous fluid flow episode during the early Devonian.Age spectra obtained by stepwise heating of amphibole residues remaining after crushing experiments are characterized by younger and relatively complex age spectra,which are probably influenced by the combined effects of resetting argon and/or mineral inclusions.Nevertheless,we note that the spectra shapes have features in common:excluding the last two steps,minimum apparent ages are found at temperatures of around 500 ℃,corresponding to319 and 249 Ma,perhaps representing the time of isotopic resetting or resulting from release gas from mineral inclusions of,e.g.,biotite or feldspar.Maximum apparent ages are obtained at temperatures of around 800℃,corresponding to 418 and 413 Ma,which probably reflect mixed ages of radiogenic resetting and original amphibole.These results indicate that the Yuka eclogites and their retrogressed equivalents were overprinted by multiple thermal events in the Silurian and possibly as young as the Triassic. | Rongguo Hu Jan Wijbrans Fraukje Brouwer Linghao Zhao Min Wang Huaning Qiu | 2015 | Geoscience Frontiers2015，6，5： | 4 |
| 5 | Mantle Source Components and Magmatic Evolution for the Comei Large Igneous Province:Evidence from the Early Cretaceous Niangzhong Mafic Magmatism in Tethyan Himalaya显示文摘The Niangzhong diabase dikes,dated at 138.1±0.4 Ma,are located within the outcrop area of the Comei large igneous province(LIP).These diabase samples can be divided into two groups:samples in Group 1 show varying MgO(1.50 wt.%-10.25 wt.%)and TiO_(2)(0.85 wt.%-4.63 wt.%)contents,and enriched initial isotope compositions(^(87)Sr/^(86)Sr(t)=0.7056-0.7112,ε_(Nd)(t)=-0.3-+3.8),with OIB-like REEs and trace elements patterns,resulting from low degree melting of garnet-bearing lherzolite mantle sources;in contrast,samples in Group 2 show limited MgO(4.14 wt.%-7.75 wt.%)and TiO_(2)(0.98 wt.%-1.69 wt.%)contents,and depleted initial isotope compositions(^(87)Sr/^(86)Sr(t)=0.7075-0.7112,ε_(Nd)(t)=+5.5-+6.2),with N-MORB-like REEs and trace elements patterns,resulting from relatively high degree melting of spinel-bearing lherzolite mantle source.Combined with the published representative data about Comei LIP,we summarize that the source components for Comei LIP products include OIB end-member,enriched OIB end-member,and N-MORB end-member,respectively.Melts modeling suggests that magmas in the Comei LIP evolve in a relatively high oxygen fugacity condition,which influenced their fractionation sequences and led to systematic changes of TiO_(2)contents,Ti/Y and Ti/Ti*ratios.From the spatial and temporal distribution of above three end-member samples,deep process of Kerguelen plume during the Comei LIP formation can be interpreted as the interaction among the Kerguelen plume,the overlying lithospheric mantle,and the upwelling asthenosphere.The magmatism of Comei LIP began at~140 Ma and then lasted and peaked at~132 Ma with the progressively lithospheric thinning of eastern Gondwana upon the impact of Kerguelen plume. | Yaying Wang Lingsen Zeng Kejun Hou Li'e Gao Qian Wang Linghao Zhao Jiahao Gao Guangxu Li | 2022 | Journal of Earth Science2022，33，1： | 3 |
| 6 | Tomographic SAR imaging with large elevation aperture: a P-band small UAV demonstration显示文摘Elevation resolution is an important indicator in tomographic SAR imaging as it represents the ability to discriminate closed targets in elevation. In general, the elevation resolution is proportional to the length of the elevation aperture. However, as the elevation aperture increases, the geometric consistency of the image will undesirably deteriorate and hence fails the image coregistration approach required by the traditional super-resolution tomographic imaging. In this paper, a new super-resolution tomographic imaging method is proposed to overcome the inconsistency problem caused by the large elevation aperture. The core strategy is to get rid of two-dimensional image coregistration by applying a three-dimensional(3 D) back projection like imaging manner: the 3 D space is firstly divided into a 3 D imaging grid, each of which is individually imaged via compressive sensing for super-resolution. The effectiveness of the proposed approach is evaluated by both computer simulations and real P-band UAV SAR data. | Tao ZENG Minkun LIU Yan WANG Zegang DING Linghao LI Zhen WANG Yangkai WEI Jianping WANG | 2022 | Science China(Information Sciences)2022，65，3： | 2 |
| 7 | Multiple Phases of Mafic Magmatism in Gyangze-Kangma Area: Implications for the Tectonic Evolution of Eastern Tethyan Himalaya显示文摘A number of E-W trending subparallel mafic dikes of diabase composition occurred in Gyangze-Kangma area,eastern Tethyan Himalaya,southern Tibet.They intruded into the Tethyan Himalaya sedimentary sequence.Whether they belong to the^132 Ma Comei LIP(Zhu et al.,2009) | WANG Yaying ZENG Lingsen GAO Li-E ZHAO Linghao GAO Jiahao SHANG Zhen | 2016 | Acta Geologica Sinica(English Edition)2016，90，S1： | 1 |
| 8 | Spatial distribution, source identification and pollution assessment of metal content in the surface sediments of Nansi Lake, China 显示文摘 | WANG Longfeng YANG Liyuan KONG Linghao | 2014 | Journal of Geochemical Exploration2014，140，： | 1 |
| 9 | A periodic DFT study on adsorption of small molecules(CH4,CO,H2O,H2S,NH3)on the WO3(001) surface-supported Au显示文摘Gas molecules(such as CH4,CO,H2O,H2S,NH_3)adsorption on the pure and Au-doped WO3(001)surface have been studied by Density functional theory calculations with generalized gradient approximation.Based on the the calculation of adsorption energy,we found the most stable adsorption site for gas molecules by comparing the adsorption energies of different gas molecules on the WO3(001)surface.We have also compared the adsorption energy of five different gas molecules on the WO3(001)surface,our calculation results show that when the five kinds of gases are adsorbed on the pure WO3(001)surface,the order of the surface adsorption energy is CO>H2S>CH4>H2O>NH3.And the results show that NH3 is the most easily adsorbed gas among the other four gases adsorbed on the surface of pure WO3(001)surface.We also calculated the five different gases on the Au-doped WO3(001)surface.The order of adsorption energy was found to be different from the previous calculation:CO>CH4>H2S>H2O>NH3.These results provide a new route for the potential applications of Au-doped WO3 in gas molecules adsorption. | Long Lin Jingtao Huang Weiyang Yu Chaozheng He Hualong Tao Yonghao Xu Linghao Zhu Pengtao Wang Zhanying Zhang | 2020 | Communications in Theoretical Physics2020，72，3： | 1 |
| 10 | Spatial distribution, ecological risk assessment and source identification for heavy metals in surface sediments from Dongping Lake,Shandong, East China显示文摘 | WANG Yunqian YANG Liyuan KONG Linghao | 2015 | Catena2015，125，： | 1 |
| 11 | Clinical applications of neurolinguistics in neurosurgery显示文摘The protection of language function is one of the major challenges of brain surgery.Over the past century,neurosurgeons have attempted to seek the optimal strategy for the preoperative and intraoperative identification of language-related brain regions.Neurosurgeons have investigated the neural mechanism of language,developed neurolinguistics theory,and provided unique evidence to further understand the neural basis of language functions by using intraoperative cortical and subcortical electrical stimulation.With the emergence of modern neuroscience techniques and dramatic advances in language models over the last 25 years,novel language mapping methods have been applied in the neurosurgical practice to help neurosurgeons protect the brain and reduce morbidity.The rapid advancements in brain-computer interface have provided the perfect platform for the combination of neurosurgery and neurolinguistics.In this review,the history of neurolinguistics models,advancements in modern technology,role of neurosurgery in language mapping,and modern language mapping methods(including noninvasive neuroimaging techniques and invasive cortical electroencephalogram)are presented. | Peng Wang Zehao Zhao Linghao Bu Nijiati Kudulaiti Qiao Shan Yuyao Zhou N.U.Farrukh Hameed Yangming Zhu Lei Jin Jie Zhang Junfeng Lu Jinsong Wu | 2021 | Frontiers of Medicine2021，15，4： | 1 |
| 12 | Do rhizome severing and shoot defoliation affect clonal growth of Leymus chinensis at ramet population level显示文摘 | Wang Zhengwen Li Linghao Han Xingguo Dong Ming | 2004 | Acta Oecologica2004，26，： | 1 |
| 13 | The pattern between nitrogen mineralization and grazing intensities in an Inner Mongolian typical steppe显示文摘 | Xu Yuqing Li Linghao Wang Qibing | 2007 | Plant and Soil2007，300，6： | 1 |
| 14 | The pattern between nitrogen mineralization and grazing intensities in an Inner Mongolian typical steppe显示文摘 | Yuqing Xu Linghao Li Qibing Wang Quansheng Chen Weixin Cheng | 2007 | Plant and Soil (-)2007，，1： | 1 |
| 15 | miR?204-5p promotes the adipogenic differentiation of human adipose-derivedmesenchymal stem cells by modulating DVL3 expression and suppressing Wnt/β-cateninsignaling显示文摘 | Honghui He Ke Chen Fang Wang Liling Zhao Xinxing Wan Linghao Wang Zhaohui Mo | 2015 | International Journal of Molecular Medicine2015，，6： | 1 |
| 16 | Fluorofenidone Attenuates Tubulointerstitial Fibrosis by Inhibiting TGF-[beta]1-Induced Fibroblast Activation显示文摘 | Yuan Qiongjing Wang Rui Peng Yu Fu Xiao Wang Wei Wang Linghao Zhang Fangfang Peng Zhangzhe Ning Wangbin Hu Gaoyun Wang Zhaohe Tao Lijian | 2011 | EN2011，，2： | 1 |
| 17 | The pattern be- tween nitrogen mineralization and grazing intensities in an Inner Mongolian typical steppe显示文摘 | Xu Yuqing Li Linghao Wang Qibing | 2007 | Plant and Soil2007，300，12： | 1 |
| 18 | The pattern between ni-trogen mineralization and grazing intensities in Inner Mongoli-an typical steppe显示文摘 | Xu Yuqing Li Linghao Wang Qibing | 2007 | Plant and Soil2007，300，： | 1 |
| 19 | Do rhizome severing and shoot defoliation affect clonal growth of Leymus chinensis at ramet population level?显示文摘 | WANG Zhengwei LI Linghao HAN Xingguo | 2004 | Acta Oecologica2004，26，： | 1 |
| 20 | Changes in soil carbon storage due to over-grazing in Leymus chinensis steppe in the Xilin river basin of Inner Mongolia显示文摘 | Li Linghao Chen Zuozhong Wang Qibing | 1997 | Journal of Environmental science1997，9，4： | 1 |
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