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| 1 | Giant photonic spin Hall effect in momentum space in a structured metamaterial with spatially varying birefringence显示文摘The photonic spin Hall effect(SHE)in the reflection and refraction at an interface is very weak because of the weak spin-orbit interaction.Here,we report the observation of a giant photonic SHE in a dielectric-based metamaterial.The metamaterial is structured to create a coordinate-dependent,geometric Pancharatnam–Berry phase that results in an SHE with a spin-dependent splitting in momentum space.It is unlike the SHE that occurs in real space in the reflection and refraction at an interface,which results from the momentum-dependent gradient of the geometric Rytov–Vladimirskii–Berry phase.We theorize a unified description of the photonic SHE based on the two types of geometric phase gradient,and we experimentally measure the giant spin-dependent shift of the beam centroid produced by the metamaterial at a visible wavelength.Our results suggest that the structured metamaterial offers a potential method of manipulating spin-polarized photons and the orbital angular momentum of light and thus enables applications in spin-controlled nanophotonics. | Xiaohui Ling Xinxing Zhou Xunong Yi Weixing Shu Yachao Liu Shizhen Chen Hailu Luo Shuangchun Wen Dianyuan Fan | 2015 | Light(Science & Applications)2015，4，1： | 15 |
| 2 | Topology optimization of compliant adaptive wing leading edge with composite materials显示文摘An approach for designing the compliant adaptive wing leading edge with composite material is proposed based on the topology optimization. Firstly, an equivalent constitutive relationship of laminated glass fiber reinforced epoxy composite plates has been built based on the symmetric laminated plate theory. Then, an optimization objective function of compliant adaptive wing leading edge was used to minimize the least square error(LSE) between deformed curve and desired aerodynamics shape. After that, the topology structures of wing leading edge of different glass fiber ply-orientations were obtained by using the solid isotropic material with penalization(SIMP) model and sensitivity filtering technique. The desired aerodynamics shape of compliant adaptive wing leading edge was obtained based on the proposed approach. The topology structures of wing leading edge depend on the glass fiber ply-orientation. Finally, the corresponding morphing experiment of compliant wing leading edge with composite materials was implemented, which verified the morphing capability of topology structure and illustrated the feasibility for designing compliant wing leading edge. The present paper lays the basis of ply-orientation optimization for compliant adaptive wing leading edge in unmanned aerial vehicle(UAV) field. | Tong Xinxing Ge Wenjie Sun Chao Liu Xiaoyong | 2014 | Chinese Journal of Aeronautics2014，27，6： | 12 |
| 3 | Efficacy and safety of external application of Traditional Chinese Medicine for the treatment of acute gouty arthritis: a systematic review and Meta-analysis显示文摘OBJECTIVE:To evaluate the clinical efficacy and safety of external application of Traditional Chinese Medicine (EATCM) on acute gouty arthritis (AGA).METHODS:Six electronic data bases were retrieved from their inception to march 2017.15 randomized controlled clinical trials (RCTs) were included.The quality of the literatures was assessed according to Cochrane review criteria by using RevMan5.3 software;and related data was counted using Stata14.0 software.RESULTS:There was no significant difference in C-reactiveprotein (CRP) between experimental intervention group and control group [(WMD =1.093,95% C/(-2.514,4.701);P =0.553)].In terms of overall efficacy,the EATCM's treatment group was significantly superior to control group [(OR =3.692;95% CI (2.408,5.661);P <0.001)].The EATCM was better than western medicine treatments or other interventions in reducing the adverse reactions [(OR =0.135;95% CI (0.067,0.274);P < 0.001)].All these funnel plots showed unlikelihood of publishing bias.But due to excessive heterogeneity,the statistical results of serum uric acid and visual analogue scale and CRP between the two groups became uncertain.CONCLUSION:The results indicate that EATCM may have greater overall efficacy with fewer adverse drug reactions,although the evidence is weak owing to the low methodological quality and the small number of the included trials. | Huang Xinxing Zhu Zonghua Wu Guang-hui Min Peng Fei Peng Zhu Tao Wang Xuezong Xiao Lianbo | 2019 | Journal of Traditional Chinese Medicine2019，39，3： | 12 |
| 4 | Modeling and Trajectory Tracking Control for Flapping-Wing Micro Aerial Vehicles显示文摘This paper studies the trajectory tracking problem of flapping-wing micro aerial vehicles(FWMAVs)in the longitudinal plane.First of all,the kinematics and dynamics of the FWMAV are established,wherein the aerodynamic force and torque generated by flapping wings and the tail wing are explicitly formulated with respect to the flapping frequency of the wings and the degree of tail wing inclination.To achieve autonomous tracking,an adaptive control scheme is proposed under the hierarchical framework.Specifically,a bounded position controller with hyperbolic tangent functions is designed to produce the desired aerodynamic force,and a pitch command is extracted from the designed position controller.Next,an adaptive attitude controller is designed to track the extracted pitch command,where a radial basis function neural network is introduced to approximate the unknown aerodynamic perturbation torque.Finally,the flapping frequency of the wings and the degree of tail wing inclination are calculated from the designed position and attitude controllers,respectively.In terms of Lyapunov's direct method,it is shown that the tracking errors are bounded and ultimately converge to a small neighborhood around the origin.Simulations are carried out to verify the effectiveness of the proposed control scheme. | Wei He Xinxing Mu Liang Zhang Yao Zou | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，1： | 10 |
| 5 | Higher alcohol synthesis over Cu-Fe composite oxides with high selectivity to C_(2+)OH显示文摘Cu-Fe composite oxides were prepared by co-precipitation method and tested for higher alcohol synthesis from syngas. The selectivity to C2+OH and C6+OH in alcohol distribution was very high while the methane product fraction in hydrocarbon distribution was rather low, demonstrating a promising potential in higher alcohols synthesis from syngas. The distribution of alcohols and hydrocarbons approximately obeyed Anderson-Schulz-Flory distribution with similar chain growth probability, indicating alcohols and hydrocarbons derived from the same intermediates. The effects of Cu/Fe molar ratio, reaction temperature and gas hourly space velocity (GHSV) on catalytic performance were studied in detail. The sample with a Cu/Fe molar ratio of 10/1 exhibited the best catalytic performance. Higher reaction temperature accelerated water-gas-shift reaction and led to lower total alcohols selectivity. GHSV showed great effect on catalytic performance and higher GHSV increased the total alcohol selectivity, indicating there existed visible dehydration reaction of alcohol into hydrocarbon. | Zhenghong Bao Kang Xiao Xingzhen Qi Xinxing Wang Liangshu Zhong Kegong Fang Minggui Lin Yuhan Sun | 2013 | Journal of Energy Chemistry2013，22，1： | 10 |
| 6 | Study on Al2O3 Extraction From Activated Coal Gangue under Different Calcination Atmospheres显示文摘Coal gangue was calcinated under air, nitrogen, carbon dioxide, air-hydrogen, and hydrogen atmospheres. The effects of different calcination temperatures and atmospheres on the mineral composition of activated coal gangue were investigated by X-ray diffraction. Moreover, the acid leaching kinetics of aluminum oxide from coal gangue was investigated with sulfuric acid. It showed that the air atmosphere promoted kaolinite decomposition during coal gangue calcination. The hydrogen atmosphere promoted the activation and decomposition of kaolinite at reaction temperatures exceeding 650℃. The carbon dioxide atmosphere eliminated the influence of residual carbon on coal gangue. When the ratio of acid/coal gangue was 1.5 and reaction temperature was 650℃, the sulfuric acid leaching rate under air,air-hydrogen,carbon dioxide,hydrogen and nitrogen atmospheres were 93.66%,90.90%, 84.06%, 81.91% and 77.54% respectively. The acid leaching reaction process conformed to unreacted shrinking core model of particle unchanged, and was controlled by the interfacial chemical reaction. The reaction kinetic equation for the leaching process was 1-(1-x)1/3=kt with an apparent activation energy of 48.97 kJ/mol. | DONG Ling LIANG Xinxing SONG Qiang GAO Gewu SONG Lihua SHU Yuanfeng SHU Xinqian | 2017 | Journal of Thermal Science2017，26，6： | 7 |
| 7 | A Preliminary Review of Metallogenic Regularity of Molybdenum Deposits in China显示文摘Molybdenum is one of the dominant minerals in China because of its rich reserves.In recent years,outstanding breakthroughs have been made in molybdenum prospecting in China,and the distribution of molybdenum deposits in China is found to have a 'planar pattern'.In general,the molybdenum deposits are concentrated in eastern China,including the largest molybdenum reserves of Henan Province.In terms of the scale of molybdenum deposits,the identified resources of the superlarge deposits are the most important,which account for about 53% of the whole country,and those of the large deposits account for about 30%,those of the medium-sized deposits account for about 14%,those of the small-sized deposits,mine spots and mineralization account for about 3%.The molybdenum deposits are mainly classified as porphyry type,skarn type,hydrothermal(vein) type and sedimentary(metamorphic) type in genesis,and the identified resources of these types account for 85.75%,8.83%,2.79%and 2.63% of the total resources respectively.Based on the statistics of precise chronology data of molybdenites Re-Os,Mo-mineralization can be divided into 6 periods in Chinese geological history,which are Precambrian(>800 Ma),Cambrian-Silurian(540-415 Ma,Caledonian),Devonian-Permian(400-290 Ma,Hecynian),Triassic(260-200 Ma,Indosinian),Jurassic-Cretaceous(195-70 Ma,Yanshanian) and Paleogene-Neogene(65-10 Ma,Himalayan).Mo mineralization during the Yanshanian period is the strongest one,in which about 76.69% of the Chinese total identified resources was formed.The second is the Himalayan period.According to spatial-temporal distribution characteristics of molybdenum deposits,the metallogenic regularity of molybdenum deposits was preliminarily summarized,and 41 level-Ⅲ molybdenum-forming belts,13 level-Ⅱ molybdenum-forming provinces and 4 level-Ⅰ molybdenum-forming domains were ascertained in the mainland of China.There are 39 metallogenic series of and 60 sub-series of molybdenum deposits with molybdenum as the dominant metal and corresponding representative molybdenum deposits proposed.Metallogenic lineages of molybdenum deposits were also established.Spatial-temporal evolution of different types of molybdenum deposits,and the relationship between Mo-mineralization and tectonic evolution have been discussed in this paper.On this basis,the authors think that element Mo is an effective tracer for recording the crustal evolution history of China.At present,there are some problems in the exploration of Mo deposits in China,such as uneven exploration degrees in eastern and western China,shallow exploration depth,low and uneven grade,complex associated components,difficulty of mineral development and utilization,increasing costs of prospecting,and so on.According to successful experience of superficial and deep prospecting and considering also the discussion above,some suggestions are proposed for the prospecting of molybdenum deposits in the future. | HUANG Fan LIU Xinxing WANG Denghong WANG Chenghui | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 7 |
| 8 | 解析胃癌前病变及早期胃癌的单细胞转录组网络显示文摘文章简介本研究采集了一组处于胃癌前病变不同阶段及早期胃癌患者,这些患者还具有胃灼痛、大便干燥、舌苔黄或厚等若干中医'胃火'相关临床表现。通过解析单细胞网络,研究发现高表达MUC6的腺粘膜细胞随着疾病的进展出现了肠样干细胞表型,提示其可能是介导肿瘤发生的关键步骤。 | 张鹏 Mingran Yang Yiding Zhang Shuai Xiao Xinxing Lai Aidi Tan Shiyu Du 李梢 | 2020 | 科学新闻2020，，2： | 7 |
| 9 | Influence of Magnet Shape on the Cogging Torque of a Surface-mounted Permanent Magnet Motor显示文摘The influence of bread-loaf shaped magnet poles under parallel magnetization on the cogging torque of surface-mounted permanent magnet(SPM)motors is studied.For the SPM motors having magnetic poles with eccentricity and sine harmonic compensation,the electromagnetic performances of integer and fractional slot motors are compared.It is found that the cogging torque and torque ripple of the integer and fractional slot motors can be reduced with the same eccentric magnet pole.The cogging torque and torque ripple of a fractional slot motor can be decreased by sine harmonic compensation,however,the same sine harmonic compensation has a small influence in integer slot motors.By varying the magnetic poles,the contribution of the field harmonics(k=(2n+1)p),which are a direct result of magnet magnetization,to the cogging torque also changes.The electromagnetic performance of a 3 kW prototype is tested,and it is found that the experimental results validate the theoretical investigation. | Min Zhou Xinxing Zhang Wenxiang Zhao Jinghua Ji Jingning Hu | 2019 | Chinese Journal of Electrical Engineering2019，5，4： | 7 |
| 10 | FOUR-PARAMETER AUTOMATIC TRANSMISSION TECHNOLOGY FOR CONSTRUCTION VEHICLE BASED ON ELMAN RECURSIVE NEURAL NETWORK显示文摘From the viewpoint of energy saving and improving transmission efficiency,the ZL50E wheel loader is taken as the study object. And the system model is analyzed based on the transmission system of the construction vehicle. A new four-parameter shift schedule is presented,which can keep the torque converter working in the high efficiency area. The control algorithm based on the Elman recursive neural network is applied,and four-parameter control system is developed which is based on industrial computer. The system is used to collect data accurately and control 4D180 power-shift gearbox of ZL50E wheel loader shift timely. An experiment is done on automatic transmission test-bed,and the result indicates that the control system could reliably and safely work and improve the efficiency of hydraulic torque converter. Four-parameter shift strategy that takes into account the power consuming of the working pump has important operating significance and reflects the actual working status of construction vehicle. | ZHANG Hongyan ZHAO Dingxuan TANG Xinxing Ding Chunfeng | 2008 | Chinese Journal of Mechanical Engineering2008，21，1： | 6 |
| 11 | Policy iteration based Q-learning for linear nonzero-sum quadratic differential games显示文摘In this paper, a policy iteration-based Q-learning algorithm is proposed to solve infinite horizon linear nonzero-sum quadratic differential games with completely unknown dynamics. The Q-learning algorithm, which employs off-policy reinforcement learning(RL), can learn the Nash equilibrium and the corresponding value functions online, using the data sets generated by behavior policies. First, we prove equivalence between the proposed off-policy Q-learning algorithm and an offline PI algorithm by selecting specific initially admissible polices that can be learned online. Then, the convergence of the off-policy Qlearning algorithm is proved under a mild rank condition that can be easily met by injecting appropriate probing noises into behavior policies. The generated data sets can be repeatedly used during the learning process, which is computationally effective. The simulation results demonstrate the effectiveness of the proposed Q-learning algorithm. | Xinxing LI Zhihong PENG Li LIANG Wenzhong ZHA | 2019 | Science China(Information Sciences)2019，62，5： | 6 |
| 12 | The YDA-MKK4/MKK5-MPK3/MPK6 Cascade Functions Downstream of the RGF1-RGI Ligand-Receptor Pair in Regulating Mitotic Activity in Root Apical Meristem显示文摘The mitotic activity of root apical meristem(RAM)is critical to primary root growth and development.Previous studies have identified the roles of ROOT GROWTH FACTOR 1(RGF1),a peptide ligand,and its receptors,RGF1 INSENSITIVEs(RGIs),a clade of five leucine-rich-repeat receptor-like kinases,in promoting cell division in the RAM,which determines the primary root length.However,the downstream signaling components remain elusive.In this study,we identify a complete mitogen-activated protein kinase(MAPK or MPK)cascade,composed of YDA,MKK4/MKK5,and MPK3/MPK6,that functions downstream of the RGF1-RGI ligand-receptor pair.Similar to the rgi1/2/3/4/5 quintuple mutant,loss-of-function mutants of MPK3 and MPK6,MKK4 and MKK5,or YDA show a short-root phenotype,which is associated with reduced mitotic activity and lower expression of PLETHORA 1(PLT1)/PLT2 in the RAM.Furthermore,MPK3/MPK6 activation in response to exogenous RGF1 treatment is impaired in the rgi1/2/3/4/5 quintuple,yda single,and mkk4 m kk5 double mutants.Epistatic analyses demonstrated that the expression of constitutively active MKK4,MKK5,or YDA driven by the RGI2 promoter can rescue the short-root phenotype of the rgi1/2/3/4/5 mutant.Taken together,these results suggest that the YDA-MKK4/MKK5-MPK3/MPK6 cascade functions downstream of the RGF1-RGI ligand-receptor pair and upstream of PLT1/PLT2 to modulate the stem cell population and primary root growth in Arabidopsis. | Yiming Shao Xinxing Yu Xuwen Xu Yong Li Wenxin Yuan Yan Xu Chuanzao Mao Shuqun Zhang Juan Xu | 2020 | Molecular Plant2020，13，11： | 6 |
| 13 | Rod-shape inorganic biomimetic mutual-reinforcing MnO2-Au nanozymes for catalysis-enhanced hypoxic tumor therapy显示文摘Biomimetic nanozymes possessing natural enzyme-mimetic activities have been extensively applied in nanocatalytic tumor therapy.However,engineering hybrid biomimetic nanozymes to achieve superior nanozyme activity remained to be an intractable challenge in hypoxic tumors.Herein,a rod-like biomimetic hybrid inorganic MnO2-Au nanozymes are developed,where MnO2 and ultrasmall Au nanoparticles(NPs)are successively deposited on the mesoporous silica nanorod to cooperatively improve the O2 content and thermal sensitivity of hypoxic solid tumors guided by multi-modal imaging.Under the catalyzing of MnO2,the intratumoral H2O2 is decomposed to greatly accelerate O2 generation,which could boost the curative effect of radiation therapy(RT)and further enhance the Au-catalyzed glucose oxidation.Mutually,the Au NPs can steadily and efficiently catalyze the oxidation of glucose in harsh tumor microenvironment,thus sensitizing tumor cells to thermal ablation for mild photothermal therapy and further promoting the catalytic efficiency of MnO2 with the self-supplied H2O2/H+.As a result,this mutual-reinforcing cycle can endow the nanoplatform with accelerated O2 generation,thus alleviating hypoxic environment and further boosting RT effect.Furthermore,acute glucose consuming can induce downregulation expression of heat shock protein(HSP),achieving starvation-promoted mild photothermal therapy.This synthesized hybrid nanozymes proves to be a versatile theranostic agent for nanocatalytic cancer therapy. | Lifang Yang Chuchu Ren Min Xu Yilin Song Qianglan Lu Yule Wang Yan Zhu Xinxing Wang Nan Li | 2020 | Nano Research2020，13，8： | 5 |
| 14 | Dynamic analysis of spinning solar sails at deployment process显示文摘The spinning deployment process of solar sails is analyzed in this study. A simplified model is established by considering the out-of-plane and in-plane motions of solar sails. The influences of structure parameters, initial conditions, and feedback control parameters are also analyzed.A method to build the geometric model of a solar sail is presented by analyzing the folding process of solar sails. The finite element model of solar sails is then established, which contains continuous cables and sail membranes. The dynamics of the second-stage deployment of solar sails are simulated by using ABAQUS software. The influences of the rotational speed and out-of-plane movement of the hub are analyzed by different tip masses, initial velocities, and control parameters.Compared with the results from theoretical models, simulation results show good agreements. | Xinxing ZHANG Chunyan ZHOU | 2017 | Chinese Journal of Aeronautics2017，30，5： | 5 |
| 15 | Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc显示文摘Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity,but the underlying molecular mechanisms remain incompletely understood.In this study,Sin1,a key component of mTOR complex 2(mTORC2),specifically regulates B cell growth and metabolism.Genetic ablation of Sin1 in B cells reduces the cell size at either the transitional stage or upon antigen stimulation and severely impairs metabolism.Sin1 deficiency also severely impairs B-cell proliferation,antibody responses,and anti-viral immunity.At the molecular level,Sin1 controls the expression and stability of the c-Myc protein and maintains the activity of mTORC1 through the Akt-dependent inactivation of GSK3 and TSC1/2,respectively.Therefore,our study reveals a novel and specific role for Sin1 in coordinating the activation of mTORC2 and mTORC1 to control B cell growth and metabolism. | Man Li Adam S.Lazorchak Xinxing Ouyang Huihui Zhang Hongzhi Liu Omotooke A.Arojo Lichong Yan Jingsi Jin Yuheng Han Guojun Qu Yuhong Fu Xiaocao Xu Xiaobo Liu Wenqian Zhang Zhengfeng Yang Chuan Ruan Qijun Wang Dou Liu Chuanxin Huang Lu Lu Shibo Jiang Fubin Li Bing Su | 2019 | Cellular & Molecular Immunology2019，16，9： | 4 |
| 16 | Online adaptive Q-learning method for fully cooperative linear quadratic dynamic games显示文摘A model-based offline policy iteration(PI) algorithm and a model-free online Q-learning algorithm are proposed for solving fully cooperative linear quadratic dynamic games. The PI-based adaptive Q-learning method can learn the feedback Nash equilibrium online using the state samples generated by behavior policies, without sending inquiries to the system model. Unlike the existing Q-learning methods, this novel Q-learning algorithm executes both policy evaluation and policy improvement in an adaptive manner.We prove the convergence of the offline PI algorithm by proving its equivalence to Newton’s method while solving the game algebraic Riccati equation(GARE). Furthermore, we prove that the proposed Q-learning method will converge to the Nash equilibrium under a small learning rate if the method satisfies certain persistence of excitation conditions, which can be easily met by suitable behavior policies. Our simulation results demonstrate the good performance of the proposed online adaptive Q-learning algorithm. | Xinxing LI Zhihong PENG Lei JIAO Lele XI Junqi CAI | 2019 | Science China(Information Sciences)2019，62，12： | 4 |
| 17 | Short-working-distance optical imaging system and method for surface detection of underwater structures显示文摘In the surface imaging of underwater structures, long working distance will reduce image quality due to the turbidity of water. To acquire high definition and large field of view(FOV) images for surface detection, a short-working-distance underwater imaging system is proposed based on camera array. A multi-view calibration and rectification method is developed. A look-up table(LUT) method and a multi-resolution spline(MRS) method are applied to stitch array images real-time and seamlessly.Experiments both in the air and in the water are conducted. Strength and weakness of the LUT and MRS methods are discussed.Based on the results, the effectiveness in surface detection of underwater structures is verified. | LIU Cong WANG ChengFei XU YingJun LI Xu LUO ChunHao DAI MeiLing SHAO XinXing HE XiaoYuan | 2018 | Science China(Technological Sciences)2018，61，5： | 4 |
| 18 | Controllable photonic spin Hall effect with phase function construction显示文摘Photonic spin Hall efect(SHE)provides new opportunities for achieving spin-based photonics applications.However,flexibly manipulating the spin-dependent sltting(SDS)of photonic SHE and imposing extra phase modulation on the two spin components are always a challenge.Here,a controllable SHE mechanism based on phase function construction is reported.It is conduded that the phases with specific functional structures performing a coordinate translation are equivalent to integrating a gradient phase to the original phases.Hence,the original phase can be used for independent phase modulation,and the gradient phase originating from the co-ordinate translation is capable of manipulating the SDS.A metasurface with Pancharatnam-Berry phase that can impose conjugate phases to the two spin components of light is fabricated to verify this mechanism.By shifing the light position,the SDS is continuously manipulated in the visible region,which is successfully used for detecting the polarization llipticity.The extra phase modulation is also performed with the original phase and thus enables measuring singular beams.It is anticipated that the controllable SHE manipulation method may open new avenues in the fields of spin photonics,optical sensing,optical communications,etc. | YANLIANG HE ZHIQIANG XIE BO YANG XUEYU CHEN JUNMIN LIU HUAPENG YE XINXING ZHOU YING LI SHUQING CHEN DIANYUAN FAN | 2020 | Photonics Research2020，8，6： | 3 |
| 19 | Review of the Metallogenic Regularity of Magnesite Deposits in China显示文摘China has abundant reserves of magnesite, making it the world's leading source of this strategic mineral.Sparry magnesite is the main type of magnesite deposit, and is easy to exploit.It occurs mainly as the sedimentary-metamorphic type.Production is centred on eastern Liaoning Province, where a world-class large to super large magnesite ore processing and production facility has been developed.Hydrothermal metasomatic deposits, associated with ultramafic complexes and eluvial deposits produced by weathering, are two other important types found in China.The Western section of the Bangonghu-Nujiang metallogenic belt is an important target region for prospecting lake-sedimentary magnesite deposits.Based on a systematic analysis of material from 62 magnesite production areas, this study investigated the metallogeny of magnesite and delineated 13 magnesite metallogenic belts.Maps were produced showing metallogenic regularities in magnesite deposits, the metallogenic system of the magnesite deposits, and the distribution of the metallogenic belts of Chinese magnesite deposits.It provides a theoretical basis for forecasting the location of potential magnesite resources in China.Finally, it explores some key scientific issues, including the formation processes of ultra magnesite ore-concentrated areas, and their sources of magnesium. | ZHAO Zheng CUI Xiaolin WANG Denghong CHEN Yuchuan BAI Ge LI Jiankang LIU Xinxing | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 3 |
| 20 | The effect of carbon nanotubes on osteogenic functions of adipose-derived mesenchymal stem cells in vitro and bone formation in vivo compared with that of nano-hydroxyapatite and the possible mechanism显示文摘It has been well recognized that the development and use of artificial materials with high osteogenic ability is one of the most promising means to replace bone grafting that has exhibited various negative effects.The biomimetic features and unique physiochemical properties of nanomaterials play important roles in stimulating cellular functions and guiding tissue regeneration.But efficacy degree of some nanomaterials to promote specific tissue formation is still not clear.We hereby comparatively studied the osteogenic ability of our treated multiwalled carbon nanotubes(MCNTs)and the main inorganic mineral component of natural bone,nano-hydroxyapatite(nHA)in the same system,and tried to tell the related mechanism.In vitro culture of human adiposederived mesenchymal stem cells(HASCs)on the MCNTs and nHA demonstrated that although there was no significant difference in the cell adhesion amount between on the MCNTs and nHA,the cell attachment strength and proliferation on the MCNTs were better.Most importantly,the MCNTs could induce osteogenic differentiation of the HASCs better than the nHA,the possible mechanism of which was found to be that the MCNTs could activate Notch involved signaling pathways by concentrating more proteins,including specific bone-inducing ones.Moreover,the MCNTs could induce ectopic bone formation in vivo while the nHA could not,which might be because MCNTs could stimulate inducible cells in tissues to form inductive bone better than nHA by concentrating more proteins including specific bone-inducing ones secreted from M2 macrophages.Therefore,MCNTs might be more effective materials for accelerating bone formation even than nHA. | Zhipo Du Xinxing Feng Guangxiu Cao Zhending She Rongwei Tan Katerina E.Aifantis Ruihong Zhang Xiaoming Li | 2021 | Bioactive Materials2021，6，2： | 3 |
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