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您的检索式：作者名="Kunjian Peng"
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| 1 | Ginsenoside Rh2 inhibits proliferation and induces apoptosis in human leukemia cells via TNF-~ signaling pathway显示文摘人参皂甙 Rh2,从人参属人参提取的 triterpene saponin,对多重癌症的展览药理学活动。然而,人参皂甙 Rh2 的 anticancer 机制是不清楚的。在这研究,我们发现人参皂甙 Rh2 有效地禁止生长并且导致 HL-60 房间的 apoptosis。用 microarray 技术,我们发现了那个肿瘤坏死因素 --(TNF-) 清楚地是起来调整的。而且, anti-TNF- 抗体经由 caspase-8, caspase-9,和 caspase-3 激活的抑制减轻了导致 Rh2 的 HL-60 房间 apoptosis。另外, TNF- 起来规定也在另外的对待 Rh2 的癌症房间线被观察。这些结果证明 TNF- 在人参皂甙起一个关键作用导致 Rh2 的房间 apoptosis。 | Jingjia Huang Kunjian Peng Linghao Wang Bin Wen Lin Zhou Tiao Luo Min Su Jijia Li Zhiyong Luo | 2016 | Acta Biochimica et Biophysica Sinica2016，48，8： | 11 |
| 2 | Ginsenoside Rh2 inhibits breast cancer cell growth via ERβ-TNFα pathway显示文摘Ginsenoside Rh2 is one of rare panaxidiols extracted from Panax ginseng and a potential estrogen receptor ligand that exhibits moderate estrogenic activity.However,the effect of Rh2 on growth inhibition and its underlying molecular mechanism in human breast cells are not fully understood.In this study,we tested cell viability by MTT and colony formation assays.Cell growth and cell cycle were determined to investigate the effect of ginsenoside Rh2 by flow cytometry.The expressions of estrogen receptors(ERs),TNFα,and apoptosis-related proteins were detected by qPCR and western blot analysis.The mechanisms of ERαand ERβaction were determined using transfection and inhibitors.Antitumor effect of ginsenoside Rh2 against MCF-7 cells was investigated in xenograft mice.Our results showed that ginsenoside Rh2 induced apoptosis and G1/S phase arrest in MCF-7 cells.Treatment of cells with ginsenoside Rh2 down-regulated protein levels of ERα,and up-regulated mRNA and protein levels of ERβand TNFα.We also found that ginsenoside Rh2-induced TNFαover-expression is through up-regulation of ERβinitiated by ginsenoside Rh2.Furthermore,ginsenoside Rh2 induced MCF-7 cell apoptosis via estrogen receptorβTNFαpathway in vivo.These results demonstrate that ginsenoside Rh2 promotes TNFα-induced apoptosis and G1/S phase arrest via regulation of ERβ. | Kunjian Peng Tiao Luo Jijia Li Jingjia Huang Zizeng Dong Jia Liu Chaoqiong Pi Zizeng Zou Qin Gu Ousheng Liu Jian-Ting Zhang Zhi-Yong Luo | 2022 | Acta Biochimica et Biophysica Sinica2022，54，5： | 1 |
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