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| 1 | Geochemical Characteristics and Sources of Ore-forming Fluids of the Mayuan Pb-Zn Deposit,Nanzheng,Shaanxi,China显示文摘The Mayuan stratabound Pb-Zn deposit in Nanzheng,Shaanxi Province,is located in the northern margin of the Yangtze Plate,in the southern margin of the Beiba Arch.The orebodies are stratiform and hosted in breciated dolostone of the Sinian Dengying Formation.The ore minerals are primarily sphalerite and galena,and the gangue minerals comprise of dolomite,quartz,barite,calcite and solid bitumen.Fluid inclusions from ore-stage quartz and calcite have homogenization tempreatures from 98 to 337℃ and salinities from 7.7 wt%to 22.2 wt%(NaCl equiv.).The vapor phase of the inclusions is mainly composed of CH_4 with minor CO_2 and H_2S.The δD_(fluid) values of fluid inclusions in quartz and calcite display a range from-68‰ to-113‰(SMOW),and the δ^(18)O_(fluid)values calculated from δ^(18)O_(quartz) and δ^(18)O_(calcite) values range from 4.5‰ to 16.7‰(SMOW).These data suggest that the ore-forming fluids may have been derived from evaporitic sea water that had reacted with organic matter.The δ^(13)C_(CH4) values of CH_4 in fluid inclusions range from-37.2‰ to-21.0‰(PDB),suggesting that the CH_4 in the ore-forming fluids was mainly derived from organic matter.This,together with the abundance of solid bitumen in the ores,suggest that organic matter played an important role in mineralization,and that the thermochemical sulfate reduction(TSR) was the main mechanism of sulfide precipitation.The Mayuan Pb-Zn deposit is a carbonate-hosted epigenetic deposit that may be classified as a Mississippi Valley type(MVT) deposit. | LIU Shuwen LI Ronxi CHI Guoxiang ZENG Rong LIU Lingfang SHI Shun | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 5 |
| 2 | 肝细胞中活化转录因子ATF6抑制SREBP1的转录活性显示文摘内质网膜定位的活化转录因子ATF6和SREBP1均是经过蛋白酶切水解激活,激活后的ATF6(N)和SREBP1(N)进入细胞核内,分别指导内质网膜未折叠蛋白聚集反应相关基因和脂肪酸合成相关基因的表达.研究发现,肝细胞内葡萄糖饥饿激活ATF6并抑制SREBP1的转录活性及其靶基因的表达.过表达ATF6(N)能够抑制SREBP1介导的转录及其下游基因的表达.免疫共沉淀实验显示,ATF6(N)在细胞核内结合SREBP1(N),这种结合在无糖状况下增强.不同功能区缺失分析表明,ATF6和SREBP1通过亮氨酸拉链(leucinezipper)功能区相互作用.在葡萄糖饥饿状况下,ATF6对SREBP1转录活性的抑制保证了细胞基本生命活动所需要的能量. | 李红玲 ZENG Lingfang 王保国 庞炜 朱毅 | 2005 | 中国生物化学与分子生物学报2005，21，4： | 4 |
| 3 | 组蛋白去乙酰化酶与血管重建显示文摘病理性的血管重建是一类由多种因子和多种细胞参与的复杂过程,在动脉粥样硬化、高血压等心血管疾病中普遍存在。组蛋白去乙酰化酶(HDACs)作为一类重要的染色体结构调节酶类,几乎参与所有的细胞生化过程。传统的HDACs研究主要集中在其抗肿瘤的作用上,但近来有大量报道表明,HDACs在血管重建中也起到重要的作用。本综述总结了HDACs与新生血管形成的关系,包括其对内皮细胞的增殖、迁移、生存和分化的影响。此外,HDACs的抑制剂具有较明显的抑制新生血管形成的作用,是一种全新的肿瘤治疗和抗血管增生途径。因此,探讨HDACs参与血管重建的机制将为动脉粥样硬化、高血压等心血管疾病的治疗提供新的方向。 | 杨俊瑶 王前 Zeng Lingfang | 2014 | 中华高血压杂志2014，22，5： | 2 |
| 4 | Nesiritide fails to reduce the mortality of patients with acute decompensated heart failure: An updated systematic review and cumulative meta-analysis显示文摘 | Bin Yan Liyuan Peng Xiaojing Zhao HsingChun Chung Lijun Li Lingfang Zeng HeanYee Ong Gang Wang | 2014 | International Journal of Cardiology2014，，： | 1 |
| 5 | Efficient Semi‑Transparent Wide‑Bandgap Perovskite Solar Cells Enabled by Pure‑Chloride 2D‑Perovskite Passivation显示文摘Wide-bandgap(WBG)perovskite solar cells suffer from severe non-radiative recombination and exhibit relatively large opencircuit voltage(V_(OC))deficits,limiting their photovoltaic performance.Here,we address these issues by in-situ forming a well-defined 2D perovskite(PMA)_(2)PbCl_(4)(phenmethylammonium is referred to as PMA)passivation layer on top of the WBG active layer.The 2D layer with highly pure dimensionality and halide components is realized by intentionally tailoring the side-chain substituent at the aryl ring of the post-treatment reagent.First-principle calculation and single-crystal X-ray diffraction results reveal that weak intermolecular interactions between bulky PMA cations and relatively low cation-halide hydrogen bonding strength are crucial in forming the well-defined 2D phase.The(PMA)_(2)PbCl_(4)forms improved type-I energy level alignment with the WBG perovskite,reducing the electron recombination at the perovskite/hole-transport-layer interface.Applying this strategy in fabricating semi-transparent WBG perovskite solar cells(indium tin oxide as the back electrode),the V_(OC)deficits can be reduced to 0.49 V,comparable with the reported state-of-the-art WBG perovskite solar cells using metal electrodes.Consequently,we obtain hysteresis-free 18.60%-efficient WBG perovskite solar cells with a high V_(OC)of 1.23 V. | Liu Yang Yongbin Jin Zheng Fang Jinyan Zhang Ziang Nan Lingfang Zheng Huihu Zhuang Qinghua Zeng Kaikai Liu Bingru Deng Huiping Feng Yujie Luo Chengbo Tian Changcai Cui Liqiang Xie Xipeng Xu Zhanhua Wei | 2023 | Nano-Micro Letters2023，15，8： | 1 |
| 6 | Endothelial NADPH oxidase-2 promotes interstitial cardiac fibrosis and diastolic dysfunction through pro-inflammatory effects and endothelial-mesenchymal transition显示文摘 | Colin E. Murdoch Sanjay Chaubey Lingfang Zeng Bin Yu Aleksander Ivetic Simon J. Walker Davy Vanhoutte Stephane Heymans David J. Grieve Alison C. Cave Alison C. Brewer Min Zhang Ajay M. Shah | 2014 | Journal of the American College of Cardiology2014，，： | 1 |
| 7 | IMCI: an efficient fingerprint retrieval approach based on 3D stacked memory显示文摘Dear editor,Data deduplication (Dedup for short) as a type of redundant data elimination technology,can effectively reduce the impact of redundant data on storage costs,which consequently alleviates the problems and pressures caused by massive data storage,management,and backup. | Wen CHENG Ran CAI Lingfang ZENG Dan FENG Andre BRINKMANN Yang WANG | 2020 | Science China(Information Sciences)2020，63，7： | 1 |
| 8 | Effects of all-trans retinoic acid on proliferation of human aorta smooth muscle cells显示文摘The primary cultured human aorta smooth muscle cells(SMCs)were characterized and theeffects of all—trans retinoic acid(atRA)on these cells were analysed.It is found that atRA could slowdown the growth rate of SMCs,and decrease the expression Ievels of cyclinDl,CDK4,c-myc at39%。38%and 43.6%respectively,while atRA had no effects on the expression of c^-actin which isspecific for SMCs.Results demonstrated that atRA inhibited cell growth of SMCs but did not induce celIdifferentiation.These effects may be clue to the decreased translation Ievels of cyclinDl.CDK4 andtranscription Ievel of c-myc.The fact that ati tA inhibited SMCs proIiferation may become one of thetheoretic basis for the cIinicaI use of atRA in the trea㈣t of SMCs proliferative diseases such asatherosclerosis. | Guoxia Liu Cunxi Li Lingfang Zeng Yongchao Wang | 1999 | Chinese Science Bulletin1999，44，5： | 0 |
| 9 | Exploiting flash memory characteristics to improve performance of RAIS storage systems显示文摘Redundant array of independent SSDs (RAIS) is generally based on the traditional RAID design and implementation. The random small write problem is a serious challenge of RAIS. Random small writes in parity-based RAIS systems generate significantly more pre-reads and writes which can degrade RAIS performance and shorten SSD lifetime. In order to overcome the well-known write-penalty problem in the parity-based RAID5 storage systems, several logging techniques such as Parity Logging and Data Logging have been put forward. However, these techniques are originally based on mechanical characteristics of the HDDs, which ignore the properties of the flash memory. In this article, we firstly propose RAISL, a flash-aware logging method that improves the small write performance of RAIS storage systems. RAISL writes new data instead of new data and pre-read data to the log SSD by making full use of the invalid pages on the SSD of RAIS. RAISL does not need to perform the pre-read operations so that the original characteristics of workloads are kept. Secondly, we propose AGCRL on the basis of RAISL to further boost performance. AGCRL combines RAISL with access characteristic to guide read and write cost regulation to improve the performance of RAIS storage systems. Our experiments demonstrate that the RAISL significantly improves write performance and AGCRL improves both of write performance and read performance. AGCRL on average outperforms RAIS5 and RAISL by 39.15% and 16.59% respectively. | Linjun MEI Dan FENG Lingfang ZENG Jianxi CHEN Jingning LIU | 2019 | Frontiers of Computer Science2019，13，5： | 0 |
| 10 | Fiber-specific increase of carotenoid content promotes cotton fiber elongation by increasing abscisic acid and ethylene biosynthesis显示文摘Cotton fiber is a raw material for the global textile industry and fiber quality is essential to its industrial application.Carotenoids are plant secondary metabolites that may serve as dietary components,regulate light harvesting,and scavenge reactive oxygen species.Although carotenoids accumulate predominantly in rapidly elongating cotton fibers,their roles in cotton fiber development remain poorly understood.In this study,a fiber-specific promoter proSCFP was applied to drive the expression of GhOR1Del,a positive regulator of carotenoid accumulation,to upregulate the carotenoid level in cotton fiber in planta.Fiber length,strength,and fineness were increased in proSCFP:GhOR1Del transgenic cotton and abscisic acid(ABA)and ethylene contents were increased in elongating fibers.The ABA downstream regulator GhbZIP27a stimulated the expression of the ethylene synthase gene GhACO3 by binding to its promoter,suggesting that ABA promoted fiber elongation by increasing ethylene production.These findings suggest the involvement of carotenoids and ABA signaling in promoting cotton fiber elongation and provide a strategy for improving cotton fiber quality. | Jianyan Zeng Dan Yao Ming Luo Lingli Ding Yi Wang Xingying Yan Shu’e Ye Chuannan Wang Yiping Wu Jingyi Zhang Yaohua Li Lingfang Ran Yonglu Dai Yang Chen Fanlong Wang Hanyan Lai Nian Liu Nianjuan Fang Yan Pei Yuehua Xiao | 2023 | The Crop Journal2023，11，3： | 0 |
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