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| 1 | Ganoderic acid alleviates chemotherapy-induced fatigue in mice bearing colon tumor显示文摘Chemotherapy-related fatigue(CRF)is increasingly being recognized as one of the severe symptoms in patients undergoing chemotherapy,which not only largely reduces the quality of life in patients,but also diminishes their physical and social function.At present,there is no effective drug for preventing and treating CRF.Ganoderic acid(GA),isolated from traditional Chinese medicine Ganoderma lucidum,has shown a variety of pharmacological activities such as anti-tumor,anti-inflammation,immunoregulation,etc.In this study,we investigated whether GA possessed anti-fatigue activity against CRF.CT26 tumor-bearing mice were treated with 5-fluorouracil(5-FU,30 mg/kg)and GA(50 mg/kg)alone or in combination for 18 days.Peripheral and central fatigue-related behaviors,energy metabolism and inflammatory factors were assessed.We demonstrated that co-administration of GA ameliorated 5-FU-induced peripheral muscle fatigue-like behavior via improving muscle quality and mitochondria function,increasing glycogen content and ATP production,reducing lactic acid content and LDH activity,and inhibiting p-AMPK,IL-6 and TNF-αexpression in skeletal muscle.Co-administration of GA also retarded the 5-FU-induced central fatigue-like behavior accompanied by down-regulating the expression of IL-6,iNOS and COX2 in the hippocampus through inhibiting TLR4/Myd88/NF-κB pathway.These results suggest that GA could attenuate 5-FU-induced peripheral and central fatigue in tumor-bearing mice,which provides evidence for GA as a potential drug for treatment of CRF in clinic. | Abudumijiti Abulizi Ling Hu Ang Ma Fang-yu Shao Hui-ze Zhu Si-mei Lin Guang-ying Shao Yue Xu Jian-hua Ran Jing Li Hong Zhou Dong-mei Lin Lian-fu Wang Min Li Bao-xue Yang | 2021 | Acta Pharmacologica Sinica2021，42，10： | 5 |
| 2 | Clinical significance of HBME-1,Galectin-3,and CK19 expression and the status of BRAF mutation in papillary thyroid carcinoma显示文摘Objective The aim of this study was to explore the clinical significance of the expression of proteins human bone marrow endothelial cell markers(HBME-1), Galectin-3, and cytokeratin19(CK19), as well as the status of v-raf murine sarcoma viral oncogene homolog B1(BRAF) mutation in papillary thyroid carcinoma(PTC). Methods Immunohistochemical staining was performed in 82 specimens each of PTC and papillary benign lesions to detect the expression of HBME-1, Galectin-3, and CK19. Polymerase chain reaction(PCR) and gene sequencing were performed on 60 specimens each of PTC and papillary benign lesions to detect the status of BRAF mutation. Results The positive expression ratios of HBME-1, Galectin-3, and CK19 in PTC were 98.8%, 97.6% and 100% respectively, which were significantly higher than the expressions in papillary benign lesions(P < 0.05). No significant relationship was observed between the expression of these makers and the clinicopathological features of PTC. The sensitivity of co-expression of HBME-1 and CK19 or HBME-1 and Galectin-3 as diagnostic criteria of PTC was 99.9%, with a specificity of 95.4%. BRAF mutation was detected in 40 of 60 PTC(66.7%) specimens. There was a statistical difference in BRAF mutations between PTC and papillary benign lesions(P < 0.05); there were no associations between BRAF mutation and the clinicopathological features of PTC. Conclusion Combined immunohistochemical staining of HBME-1, Galectin-3, and CK19 can further improve the sensitivity and specificity of differential diagnosis of PTC. BRAF mutation is a significant genetic event, which may have diagnostic value for PTC. | Li Zheng Min Zhao Xiangyang Hu Jin Huang Ling Ang Hongguang Hu Qiang Zou Jin Wang Mingqiang Liu Yang Zhao | 2016 | Oncology and Translational Medicine2016，2，4： | 4 |
| 3 | Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation显示文摘Although monkeys and pigs can be infected with SARS-Co V-2,they generally have a long growth cycle and a large size that is difficult to handle in large quantities.However,the readily available rats and mice are not susceptible to SARSCo V-2 because of differences in ACE2(angiotensin-converting enzyme 2),the receptor mediating cell entry of SARSCo V-2[1].Thus,the key to establishing a mouse model of COVID-19 is to make the mice express human ACE2 protein,and therefore become SARS-Co V-2 susceptible.Recently reported COVID-19 mouse models using a random insertion transgene approach[2,3]or adenoviral approach to express h ACE2[4],lack the tissue-specificity of h ACE2 expression and might not replicate COVID-19 precisely,limiting their applications in certain studies. | Feng-Liang Liu Kaixin Wu Jiaoyang Sun Zilei Duan Xiongzhi Quan Junqi Kuang Shilong Chu Wei Pang Han Gao Ling Xu Ying-Chang Li Hai-Lin Zhang Xue-Hui ang Rong-Hua Luo Xiao-Li Feng Hans RScholer Xinwen Chen Duanqing Pei Guangming Wu Yong-Tang Zheng Jiekai Chen | 2021 | National Science Review2021，8，2： | 3 |
| 4 | Image Retrieval Based on Object's Orientation Spatial Relationalship显示文摘 | Zhou X M Ang C H Ling T W | 2001 | PRL2001，22，5： | 1 |
| 5 | A study of hot carrier degradation in nMOSFET' s by gate capacitance and charge pumping current 显示文摘 | LING C H TAN SE ANG D S | 1995 | IEEE Transactions on Electron Devices1995，42，7： | 1 |
| 6 | Dose,Plasma Level,and Treatment Outcome Among Methadone Patients in Shanghai,China显示文摘The purpose of this study was to investigate the blood levels of methadone in participants receiving methadone for the treatment of opioid dependence.After stabilization on methadone for four weeks,blood samples from 95 participants were collected between treatment weeks 4 and 12,before and after receiving doses of methadone,and its blood levels were measured.A multiple linear regression model was used to examine me association between methadone blood levels and the outcomes of methadone maintenance treatment(MMT).Outcome differences between participants who had high(>2) or low(<2) peak-to-trough ratios were also compared using an independent sample /-test.The blood level of methadone was not correlated with the clinical outcome of MMT with the moderate range of doses given.However,the retention of patients who had a free peak-to-trough ratio >2 was significantly poorer than those whose ratio was <2.Thus,monitoring plasma methadone levels is unlikely to be effective for guiding dosing decisions in situations where compliance with MMT is already very high or when the methadone dose is no longer the dominant factor in determining the clinical outcome.However,monitoring plasma methadone levels is still helpful for guiding the dosage for patients with a rapid metabolism. | Haifeng Jiang Maureen Hillhouse Jiang Du Shujun Pan Ang Alfonso Jun Wang Zhirong Zhou Weijun Yuan Walter Ling Min Zhao | 2016 | Neuroscience Bulletin2016，32，6： | 1 |
| 7 | Image retrieval based on object's orientation spatial relationalship显示文摘 | Zhou X M Ang C H Ling T W | 2001 | PRL2001，22，5： | 1 |
| 8 | Research progress on the ef- fective components of He6cium erinaceus and its pharmacological ac- tions显示文摘 | WANG X Y J]ANG Q Y LING P X | 2010 | Chin J Bioehem Pharm2010，1，： | 1 |
| 9 | A nosocomial outbreak of multiresistant Acinetobacter baumannii originating from an intensive care unit显示文摘 | Ling M L Ang A Wee M | 2001 | Infect Control Hosp Epidemiol2001，22，1： | 1 |
| 10 | A nosocomial outbreak of multiresistant Acinetobacter baumannii originating from an intensive care unit显示文摘 | Ling M L Ang A Wee M | 2001 | Infect Control Hosp Epidemio12001，，22： | 1 |
| 11 | Accuracy of 64-row multidetector computed tomography in detecting coronary artery disease in 134 symptomatic patients: Influence of calcification显示文摘 | Tiong Kiam Ong Sze Piaw Chin Chee Khoon Liew Wei Ling Chan M. Tobias Seyfarth Houng Bang Liew Annuar Rapaee Yean Yip Alan Fong Choon Kiat Ang Kui Hian Sim | 2006 | American Heart Journal2006，，6： | 1 |
| 12 | 甲状腺相关性眼病伴眼外肌肌腱受累1例(英文)显示文摘目的:报告1例甲状腺相关性眼病的非典型CT扫描表现。方法:一位64岁的中国女性出现复视3mo,无视力模糊。14a前她曾患甲状腺功能亢进症伴多结节甲状腺肿并行甲状腺切除术。眼科检查发现双眼下斜视并向上注视受限。左眼red desaturation并Ⅰ级相对性瞳孔传入障碍。T3,T4和促甲状腺激素(thyroid stimulating hormone,TSH)正常。TSH受体、抗体水平高,与Graves'病一致。磁共振成像(magnetic resonance imaging,MRI)显示双下直肌弥漫性增大,肌腱受累。结果:给予几周期静脉注射甲基强的松龙继之以口服强的松后视力无提高,反之继续下降。行左眼眼眶减压术,术后其左眼视力有所改善。结论:有肌腱受累的眼外肌增大不能排除甲状腺相关性眼眶病(thyroid assciated orbitopathy,TAO)的可能。 | Ng Guan Fook Dinesh Kumar Ang Ee Ling Liza-Sharmini AT | 2012 | 国际眼科杂志2012，12，3： | 1 |
| 13 | A nosocomial outbreak of muhiresistant Acinetobacter banmannii originating from an intensive care unit 显示文摘 | LING ML Ang A Wee M | 2001 | Infection Control and Hospital Epidemiology2001，22，1： | 1 |
| 14 | 查看详情显示文摘 | Molton J. S Tambyah P. A Ang B. S Ling M.L.Fisher D.A.Clin | | 0，，09： | 1 |
| 15 | A nosocomal outbreak ofmultiresistant Acinetobacter baumannii originating from an intensivecare unit显示文摘 | Ling ML Ang A Wee M | 2001 | Infect Control Hosp Epidemiol2001，22，1： | 1 |
| 16 | Study on Toxicity of 9 Biocontrol Microbial Products to Adult Population of Tobacco Beetle,Lasioderrma serricorne(Fabricius)显示文摘[Objectives]The paper was to study the toxicity of 9 biocontrol microbial products to adult population of Lasioderrma serricorne.[Methods]Nine biocontrol microbes were used as test materials to study their toxicity to the experimental population of L.serricorne adults.[Results]The toxicities of these biocontrol microbes from low to high at 5 d post spraying were:Luhai Beauveria bassiana powder(LC_(50)=462.752×10^(8) spores/L),Meichongzhi B.bassiana powder(LC_(50)=9713.157×10^(8) spores/L),Yiqiang Bio B.bassiana powder(LC_(50)=11203.321×10^(8)spores/L),Nongbao Bio B.bassiana powder(LC_(50)=12188.866×10^(8) spores/L),Yeshengwang B.bassiana powder(LC_(50)=21685.532×10^(8) spores/L);Fatu Bacillus thuringiensis suspension(LC_(50)=1.0844×10^(8) IU/L),Laojite B.thuringiensis suspension(LC_(50)=2.056×10^(8) IU/L),Lujinwa B.thuringiensis powder(LC_(50)=2.273×10^(8) IU/L),Nongbao Bio B.thuringiensis powder(LC_(50)=18.399×10^(8) spores/L).The toxicities of these biocontrol microbes from low to high at 10 d post spraying were:Nongbao Bio B.bassiana powder(LC_(50)=0.072×10^(8) spores/L),Yiqiang Bio B.bassiana powder(LC_(50)=2.484×10^(8) spores/L),Luhai B.bassiana powder(LC_(50)=44.551×10^(8) spores/L),Meichongzhi B.bassiana powder(LC_(50)=96.447×10^(8) spores/L),Yeshengwang B.bassiana powder(LC_(50)=723.347×10^(8) spores/L);Lujinwa B.thuringiensis powder(LC_(50)=0.0001×10^(8) IU/L),Fatu B.thuringiensis suspension(LC_(50)=0.045×10^(8) IU/L),Laojite B.thuringiensis suspension(LC_(50)=0.0644×10^(8) IU/L),Nongbao Bio B.thuringiensis powder(LC_(50)=1.899×10^(8) spores/L).The toxicities of these biocontrol microbes from low to high at 15 d post spraying were:Meichongzhi B.bassiana powder(LC_(50)=0.001×10^(8) spores/L),Nongbao Bio B.bassiana powder(LC_(50)=0.01×10^(8) spores/L),Yiqiang Bio B.bassiana powder(LC_(50)=0.084×10^(8) spores/L),Luhai B.bassiana powder(LC_(50)=2.370×10^(8) spores/L),Yeshengwang B.bassiana powder(LC_(50)=8.915×10^(8)spores/L);Lujinwa B.thuringiensis powder(LC_(50)=0.16×10^(4) IU/L),Laojite B.thuringiensis suspension(LC_(50)=0.185×10^(4) IU/L),Fatu B.thuringiensis suspension(LC_(50)=32.211×10^(4) IU/L),Nongbao Bio B.thuringiensis powder(LC_(50)=1590×10^(4) spores/L).[Conclusions]According to the three stages of tube rubbing,it is found that the control effects of Lujinwa B.thuringiensis powder and Meichongzhi B.bassiana powder are the best,and the results will provide technical support for the biological control of L.serricorne adults. | Zijun ZHAO Yingjie JIANG Ang LI Chaojun LUO Pengchao CHEN Xueqin ZHANG Ling LU Yongan REN Fei XU Shunxian LIANG | 2022 | Plant Diseases and Pests2022，13，2： | 0 |
| 17 | Acquisition of a novel conjugative multidrug-resistant hypervirulent plasmid leads to hypervirulence in clinical carbapenem-resistant Klebsiella pneumoniae strains显示文摘The co-occurrence of plasmid-mediated multidrug resistance and hypervirulence in epidemic carbapenem-resistant Klebsiella pneumoniae has emerged as a global public health issue.In this study,an ST23 carbapenem-resistant hyper-virulent K.pneumoniae(CR-HvKP)strain VH1-2 was identified from cucumber in China and harbored a novel hybrid plasmid pVH1-2-VIR.The plasmid pVH1-2-VIR carrying both virulence and multidrug-resistance(MDR)genes was likely generated through the recombination of a virulence plasmid and an IncFIIK conjugative MDR plasmid in clinical ST2318622 isolated from a sputum sample.The plasmid pVH1-2-VIR exhibited the capacity for transfer to the clinical ST11 carbapenem-resistant K.pneumoniae(CRKP)strain via conjugation assay.Acquisition of pVH1-2-VIR plasmid directly converted a CRKP into CR-HvKP strain characterized by hypermucoviscosity,heightened virulence for Galleria mellonella larvae,and increased colonization ability in the mouse intestine.The emergence of such a hybrid plasmid may expedite the spread of CR-HvKP strains,posing a significant risk to human health. | Gong Li Ling Jia Lei Wan Lijuan Xia Ang Gao Runshi Yang Ruanyang Sun Minge Wang Juan Du Xinlei Lian Rongmin Zhang Liangxing Fang Xiaoping Liao Yahong Liu Bao-Tao Liu Jian Sun | 2023 | mLife2023，2，3： | 0 |
| 18 | Knock out Fall Incidence显示文摘 | Magdalene Ng Kim Choo Juweita Bte Arba'in Heng Lili Joline NurJannah Zhong Tan Sue Ching Mardielene Cunanan Mercado Nur Amelia Binte Azman Jayanthi d/o Sivam Pillay Israel Jimenez Bernal Connie Besas Oepulango Chong Lai Ling Ang Shin Yuh | 2014 | Journal of Health Science2014，2，9： | 0 |
| 19 | Hypoxia and the developing brain: factors underlying cell damage显示文摘 | Charanjit Kaur Ling Eng Ang | 2009 | 解剖学杂志2009，32，3： | 0 |
| 20 | Submerged fermentation improves bioactivity of mulberry fruits and leaves显示文摘Objective:Mulberry(Morus spp.)fruits and leaves have been proven to possess nutraceutical properties.Due to its fast and easy growing characteristics,mulberry fruits(MF)and leaves(ML)potentially emerge as a great source of functional foods.This study aims to enhance bioactivities(antioxidant,antiinflammation,and hypoglycemic activity)of MF and ML via submerged fermentation using bacteria(Lactobacillus plantarum TAR 4),yeast(Baker’s yeast and red yeast)and fungi(Tempeh and Tapai starter).Methods:In this study,25%(mass to volume ratio)of MF and ML were fermented(48 h)with 1%(mass to volume ratio)of different microbial cultures,respectively.Effects of different fermentations on MF and ML were determined based on the changes of total phenolics(TPC),flavonoids(TFC),anthocyanins,total sugar,DPPH activity,ferric reducing antioxidant power(FRAP),albumin denaturation inhibition activity(ADI),anti-lipoxygenase activity and a-amylase inhibition activity(AI).Results:Generally,ML had higher AI than MF.However,MF exhibited higher DPPH,FRAP and antilipoxygenase activity than ML.After all forms of fermentation,DPPH and AI activity of MF and ML were increased significantly(P<0.05).However,the effects of fermentation on TPC,FRAP,ADI and antilipoxygenase activity of MF were in contrast with ML.TPC,FRAP and anti-lipoxygenase activity of ML were enhanced,but reduced in MF after fermentation.Although the effects exerted by different microorganisms in MF and ML fermentation were different,the bioactivities of MF and ML were generally improved after fermentation.Fermentation by Tempeh starter enhanced TPC(by 2-fold),FRAP(by 2.3-fold),AI(at 10%increment)and anti-lipoxygenase activity(by 5-fold)of ML,whereas Tapai fermentation effectively enhanced the DPPH(at 17%increment)and ADI(by 2-fold)activity of MF.Conclusion:Findings of this study provide an insight into the future process design of MF and ML processing into novel functional foods. | Hui Qian Chuah Pei Ling Tang Ni Jing Ang Hui Yin Tan | 2021 | Chinese Herbal Medicines2021，13，4： | 0 |
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