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| 1 | A Review on Pharmacological and Analytical Aspects of Naringenin显示文摘Flavonoids are a widely distributed group of phytochemicals having benzo-pyrone nucleus, and more than 4,000 different flavonoids have been described and categorized into flavonols, flavones, flavanones, isoflavones, catechins and anthocyanidins. Flavonoids occurs naturally in fruits, vegetables, nuts, and beverages such as coffee, tea, and red wine, as well as in medical herbs. Flavonoids are responsible for the different colors of plant parts and are important constituents of the human diet. Flavanoids have different pharmacological activities, such as antioxidant, anti-allergic, antibacterial, anti-inflammatory, antimutagenic and anticancer activity. Naringenin belongs to the flavanones and is mainly found in fruits(grapefruit and oranges) and vegetables. Pharmacologically, it has anticancer, antimutagenic, anti-inflammatory, antioxidant, antiproliferative and antiatherogenic activities. Naringenin is used for the treatments of osteoporosis, cancer and cardiovascular diseases, and showed lipid-lowering and insulin-like properties. In the present review, detailed pharmacological and analytical aspects of naringenin have been presented, which revealed the impressive pharmacological profile and the possible usefulness in the treatment of different types of diseases in the future. The information provided in this communication will act as an important source for development of effective medicines for the treatment of various disorders. | Kanika Patel Gireesh Kumar Singh Dinesh Kumar Patel | 2018 | Chinese Journal of Integrative Medicine2018，24，7： | 28 |
| 2 | Heteromeric and Homomeric Geranyl Diphosphate Synthases from Catharanthus roseus and Their Role in Monoterpene Indole Alkaloid Biosynthesis显示文摘Catharanthus roseus 是二很重要的 monoterpene 吲哚碱(MIA ) 的唯一的来源反癌症代理人:vinblastine 和长春新碱。MIA 拥有萜烯和分别地从 terpenoid 和 shikimate 小径导出的吲哚一半。Geranyl diphosphate (GPP ) ,入口点到萜烯一半的形成,由 GPP synthase (GPPS ) 是 isopentenyl diphosphate (IPP ) 和 dimethylallyl diphosphate (DMAPP ) 的冷凝作用的一个产品。这里,我们报导与顺序类似编码蛋白质到大子单元(CrGPPS.LSU ) 和 heteromeric GPPS,和 homomeric 的小子单元(CrGPPS.SSU ) 的三基因 GPPS。CrGPPS.LSU 是生产 GPP 和 geranyl geranyl diphosphate (GGPP ) 的 bifunctional 酶, CrGPPS.SSU 是不活跃的,而 CrGPPS 是形成 GPP 的 homomeric 酶。在 Escherichia coli 的两个子单元的合作表示与生产仅仅 GPP 的提高的活动导致了 heteromeric 酶。当 CrGPPS.LSU 和 CrGPPS 在更旧、更年轻的叶子显示出更高的表示时,分别地, CrGPPS.SSU 显示出一个增加的趋势并且逐渐地减少了。叶子的甲基 jasmonate (MeJA ) 处理显著地导致了仅仅 CrGPPS.SSU 的表示。而 CrGPPS 是 mitochondrial, GFP 本地化显示 CrGPPS.SSU 是 plastidial。在 C 的 AmGPPS.SSU 的短暂 overexpression。roseus 叶子导致了增加的 vindoline, vinblastine 和长春新碱的立即的 monomeric 先锋。尽管 C。roseus 有 heteromeric 和 homomeric GPPS 酶,我们的结果含有有为 MIA 生合成调整 GPP 流动的 CrGPPS.SSU 的仅仅 heteromeric GPPS 的参与。 | Avanish Rai Shachi S. Smita Anup Kumar Singh Karuna Shanker Dinesh A. Nagegowda | 2013 | Molecular Plant2013，6，5： | 20 |
| 3 | 舒芬太尼复合罗哌卡因用于硬膜外无痛分娩的临床观察显示文摘目的探讨舒芬太尼复合罗哌卡因用于连续硬膜外无痛分娩的效果和安全程度。方法将2018年12月至2019年4月期间昆明医科大学附属延安医院100例在产房正常待产的初产妇随机分为2组(n=50例),实验组常规于L2~3间隙行连续硬膜外穿刺,试验量后头侧置硬膜外管4cm接PCEA泵,协助产妇平卧位后给予舒芬太尼复合罗哌卡因的首剂量和维持剂量,对照组产妇实施常规阴道分娩。观察2组产妇硬膜外自控镇痛效果、产程时间、出血量和新生儿Apgar评分情况,记录是否需要助产和紧急更改剖宫产,是否出现产后出血和胎儿窘迫等不良事件。结果 2组产妇的年龄、身高、体重、孕周值比较差异无统计学意义(P>0.05),实验组产妇分娩镇痛效果的优良率明显高于对照组(P<0.05),2组产妇出血量和新生儿Apgar评分比较差异无统计学意义(P>0.05),实验组产妇第一产程和第二产程时间明显短于对照组(P<0.05),实验组产妇出现需要阴道助产、紧急更改剖宫产和产后出血的比例明显低于对照组(P<0.05)。结论舒芬太尼复合罗哌卡因用于连续硬膜外无痛分娩,镇痛效果显著,能够显著缩短产程时间,提高产妇自然分娩率,降低分娩过程中不良事件的发生率,可以安全有效地应用于临床。 | Dinesh Kumar Shrestha 刘萍 张富荣 | 2019 | 昆明医科大学学报2019，40，10： | 20 |
| 4 | A review on medicinal importance,pharmacological activity and bioanalytical aspects of beta-carboline alkaloid 'Harmine'显示文摘Harmine,a beta-carboline alkaloid,is widely distributed in the plants,marine creatures,insects, mammalians as well as in human tissues and body fluids.Harmine was originally isolated from seeds of Peganum harmal in 1847 having a core indole structure and a pyridine ring.Harmine has various types of pharmacological activities such as antimicrobial,antifungal,antitumor,cytotoxic, antiplasmodial,antioxidaant,antimutagenic,antigenotoxic and hallucinogenic properties.It acts on gamma-aminobutyric acid type A and monoamine oxidase A or B receptor,enhances insulin sensitivity and also produces vasorelaxant effect.Harmine prevents bone loss by suppressing osteoclastogenesis.The current review gives an overview on pharmacological activity and analytical techniques of harmine,which may be useful for researcheres to explore the hidden potential of harmine and and will also help in developing new drugs for the treatment of various diseases. | K Patel M Gadewar R Tripathi SK Prasad Dinesh Kumar Patel | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，8： | 17 |
| 5 | A review on synthesis of graphene,h-BN and MoS2 for energy storage applications:Recent progress and perspectives显示文摘The significance of graphene and its two-dimensional(2D)analogous inorganic layered materials especially as hexagonal boron nitride(h-BN)and molybdenum disulphide(MoS2)for“clean energy”applications became apparent over the last few years due to their extraordinary properties.In this review article we study the current progress and selected challenges in the syntheses of graphene,h-BN and MoS2 including energy storage applications as supercapacitors and batteries.Various substrates/catalysts(metals/insulator/semiconducting)have been used to obtain graphene,h-BN and MoS2 using different kinds of precursors.The most widespread methods for synthesis of graphene,h-BN and MoS2 layers are chemical vapor deposition(CVD),plasma-enhanced CVD,hydro/solvothermal methods,liquid phase exfoliation,physical methods etc.Current research has shown that graphene,h-BN and MoS2 layered materials modified with metal oxide can have an insightful influence on the performance of energy storage devices as supercapacitors and batteries.This review article also contains the discussion on the opportunities and perspectives of these materials(graphene,h-BN and MoS2)in the energy storage fields.We expect that this witen review article including recent research on energy storage will help in generating new insights for further development and practical applications of graphene,h-BN and MoS2 layers based materials. | Rajesh Kumar Sumanta Sahoo Ednan Joanni Rajesh Kumar Singh Ram Manohar Yadav Rajiv Kumar Verma Dinesh Pratap Singh Wai Kian Tan Angel Perez del Pino Stanislav A.Moshkalev Atsunori Matsuda | 2019 | Nano Research2019，12，11： | 12 |
| 6 | A Review on Pharmacological and Analytical Aspects of Diosmetin:A Concise Report显示文摘Plants have been used as a source for food material and natural remedies for the treatment of vast range of diseases.Nature provides us remedies for the treatment of various types of disorders ranging from simple ailments to complicated diseases.Plants are known to possess different pharmacological activities due to the presence of various phytoconstituents.Flavonoids are one of the main active phytoconstituents found in fruits,vegetables,wines,tea and cocoa.Flavonoids exhibit various pharmacological activities such as antioxidant,anti-inflammatory,anti-allergic,antibacterial,oestrogenic,cytotoxic antitumoural,hepatoprotective,antithrombotic and antiviral activity.Diosmetin(3',5,7-trihydroxy-4'-methoxyflavone),the aglycone part of the flavonoid glycosides diosmin occurs naturally in citrus fruit.Although it is found in herbal medicines and plays an important role in the treatment of various ailments,only limited scientific researches have been conducted.The aim of this review is to collect all available scientific literature published on diosmetin and combine it into this paper.This review contains an overview of pharmacological activities,isolation techniques and analytical techniques for diosmetin.Thus,valuable information provided in the present review will help researchers in developing alternative methods for the treatment of diseases from diosmetin. | Kanika Patel Manoj Gadewar Vijay Tahilyani Dinesh Kumar Patel | 2013 | Chinese Journal of Integrative Medicine2013，19，10： | 11 |
| 7 | Antidiabetic activity of alcoholic leaves extract of Alangium lamarckii Thwaites on streptozotocin-nicotinamide induced type 2 diabetic rats显示文摘Objective:To investigate antidiabetic potential of alcoholic leaves extract of Alangium lamarekii (A.lamarckii) on streptozotocin-nicotinamide induced type 2 diabetic rats.Methods:Oral glucose tolerance test was done by inducing hyperglycemic state via administration of glucose in water(2 g/kg).Single dose of alcoholic leaves extract of.4.lamarckii(250 and 500 mg/kg,p.o.) were administered to normoglycemic,hyperglycemic rats.Type 2 diabetes was induced by single intraperitoneal injection of nicotinamide(110 mg/kg) followed by streptozotocin(65 mg/kg).The study also included estimations of blood plasma glucose,lipid profile,liver glycogen,body weight and antioxidant status in normal and diabetic rats.Results:Admistration of alcoholic extract of A.lamarekii at two dosage 250 and 500 rag/kg,p.o.did not showed any significant change in blood glucose level of normoglycemic rats(P>0.05).whereas,oral glucose tolerance test depicted reduction in blood glucose level(P<0.05).The streptozotocin-nicotinamide induced diabetic rats, significantly decreased the blood plasma glucose level(P<0.001) comparable to glibenclamide (10 mg/kg),restored the lipid profile and showed improvement in liver glycogen,body weight and antioxidant status in diabetic rats.Conclusions:Present finding demonstrated the significant antidiabetic activity of alcoholic leaves extract of.4.lamarekii. | Rajesh Kumar Dinesh Kumar Pate Satyendra Kuldip Prasad Kirshnamurthy Sairam Siva Hemalatha | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 8 |
| 8 | Antidiabetic activity of methanolic bark extract of Alhizia odoratissima Benth.in alloxan induced diabetic albino mice显示文摘Objective:To evaluate the antidiabetic potential of methanolic extract of Albizia odoratissima Benth.bark in alloxan induced diabetic mice.Methods:Group-Ⅰ(normal control) mice received only basal diet without any treatment.In Group-Ⅱ(Diabetic control) mice,diabetes was induced by alloxan(150 mg/kg i.p.) and received only Tween 80.5%v/v in normal saline. Group-Ⅲand Group-Ⅳmice received metformin(10 mg/kg) and gliclazide(10 mg/kg) as standard drugs.Group-ⅤandⅥmice received methanolic bark extract of Albizia odoratissima at doses of 250 and 500 mg/kg body weight p.o.,respectively.Results:The results of the study indicates that Albizia odoratissima bark extract significantly(P<0.01) reduced the blood sugar level.The bark extract also significantly reduced the levels of serum cholesterol,triglycerides, serum glutamic-oxaloacetic transaminase,serum glutamic-pyruvic transaminase,alkaline phosphatase and decreases level of total proteins in alloxan induced diabetic mice.Conclusions: Methanolic extract of Albizia odoratissima has protective effects on the protection of vital tissues(pancreas,kidney,liver,heart and spleen),thereby reducing the causation of diabetes in experimental animals. | Dinesh Kumar Sunil Kumar Sonia Kohli Renu Arya Jyoti Gupta | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 7 |
| 9 | Evaluation of phytochemical and antioxidant activities of the different fractions of Hybanthus enneaspermus (Linn.) F.Muell. (Violaceae).显示文摘Objective:To investigate the naturally occurring antioxidant for the first time from the different solvent fractions of Hybanthus enneaspermus(H.enneaspermus) Linn F.Muell.family(Violaceae). Methods:Different fractions of H.enneaspermus were tested for total phenolic content,and in vitro antioxidant activity was measured by total antioxidant assay,DPPH assay,reducing power, nitric oxide(NO),hydrogen peroxide(H2O2) scavenging assays.Results:The ethyl acetate(EA) fraction was found to have high levels of phenolic content[(212.15±0.79) mg GAE/g].The EA fraction exhibited higher total antioxidant capacity,higher percentage of DPPH radical scavenging activity[(127.07±2.29) Fg/mL],nitric oxide[(245.16±1.44)μg/mLJ,hydrogen peroxide[(227.38±7.18)μg/mL],deoxyribose[(270.61±8.72)μg/mL]and higher reducing power.There was a significant correlation between total phenolic content and total antioxidant activity(r =0.972). Conclusions:These results reveal that EA fraction of H.enneaspermus has strong antioxidant potential compared with other fractions.Our further study has been extended to the isolation of the possible compound that is responsible for having antioxidant property. | Dinesh Kumar Patel Rajesh Kumar Damiki Laloo Siva Hemalatha | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，5： | 7 |
| 10 | Assessment of tumor markers CA 19-9,CEA,CA 125,and CA 242 for the early diagnosis and prognosis prediction of gallbladder cancer显示文摘BACKGROUND Gallbladder cancer(GBC)is one of the leading and aggressive cancers in this region of India.It is very difficult to diagnose in the early stage,as it lacks typical early signs and symptoms;thus,the diagnosis is often in the advanced stage,which ultimately leads to a poor 5-year survival outcome.Tumor markers including carbohydrate antigen 19-9(CA 19-9),carcinoembryonic antigen(CEA),CA 125,CA 242,and alpha fetoprotein are used as indicators in the diagnosis and prognosis of GBC.AIM To compare tumor marker levels between GBC and benign GB diseases(GBDs)and to assess the combined use of tumor markers to increase the diagnostic accuracy for GBC.METHODS Patients of either sex aged≥18 years,with suspected GBC(GB polyp,irregular thick GB wall,GB mass,porcelain GB)on the basis of radiological imaging were included in this study.GB wall thickness using ultrasonography and tumor markers CEA,CA 125,CA 19-9,and CA 242 in all patients were recorded.All cases after surgical intervention were divided into two groups,GBC and benign GBD,according to histopathological examination findings.The cases were followed up and clinical findings,radiological findings,and levels of tumor markers were assessed.RESULTS A total of 200 patients were included in this study,of whom 80 patients had GBC and 120 patients had benign GBD.The median(interquartile range)age was 52.0(41.0-60.0)years and the majority of patients(132,66.0%)were women.Tumor markers including CA 19-9,CA 125,CEA,and CA 242 were significantly elevated in patients with GBC(P<0.001).There was a significant reduction in tumor markers at 3 and 6 mo from baseline(P<0.001).The mean survival of patients with normal and elevated levels of tumor markers CA 125,CA 19-9,and CEA was comparable;however lymph node metastasis and CA 242 expression level were independent prognostic factors.CONCLUSION Serum levels of tumor markers including CA 19-9,CA 125,CEA,and CA 242 were significantly associated with GBC.However,no significant association was observed between the presence of elevated levels of any tumor marker with respect to survival.Tumor marker assessment during follow-up may represent a treatment response. | Seema Rani Sinha Prem Prakash Rakesh Kumar Singh Dinesh Kumar Sinha | 2022 | World Journal of Gastrointestinal Surgery2022，14，11： | 5 |
| 11 | Nanostructured porous polyaniline(PANI)coated carbon cloth(CC)as electrodes for flexible supercapacitor device显示文摘Nanostructured porous polyaniline(PANI)has been synthesized and coated simultaneously on a highly flexible and conductive carbon cloth(CC)substrate using a simple in-situ chemical oxidative polymerization technique.PANI coated CC(PANI-CC)based flexible electrodes were further used for the fabrication of flexible supercapacitor devices.For the comparison purpose,pure PANI has also been synthesized and tested for its electrochemical performance.The energy storage capacity of PANI and PANI–CC composite was investigated using electrochemical techniques like CV,GCD,and EIS in a potential range from 0 to 0.8 V in 1 M H_(2)SO_(4)electrolyte.PANI-CC flexible electrodes exhibited the highest specific capacitance of 691 F/g;whereas,pure PANI could only achieve 575 F/g of specific capacitance at 1 A/g.Composite also exhibited outstanding cyclic stability by recollecting 94%of its initial capacitance after 2000 GCD cycles.For actual implementation,a flexible supercapacitor device has been fabricated using stainless steel sheets and PANI-CC flexile electrodes.The energy storage performance of the PANI-CC flexible supercapacitor device was tested at several bending angles,which resulted in 72%of capacitance retention at a maximum bending angle of 140°compared to the capacitance obtained at an angle 0°(flat state).PANI-CC exhibited improved electrochemical performance than pure PANI due to the synergistic effect between PANI and CC.Here,CC helped in enhancing the conductivity and stability;whereas,PANI boosted the capacitance owing to its excellent porosity and fast pseudocapacitive charge storage response. | Dinesh J.Ahirrao Ajay Kumar Pal Vikalp Singh Neetu Jha | 2021 | Journal of Materials Science & Technology2021，，29： | 5 |
| 12 | Inhibitory effect of two Indian medicinal plants on aldose reductase of rat lens in vitro显示文摘Objective:To assesse the inhibitor) effect of alcoholic extract of two Indian medicinal plants namely Ceasalpinia digyna Rottler and.Alangium lamarckii Thwaits on aldose reductase(AR) of rat lens.Methods:Rats lens were enucleated through posterior approach and their homogenate was prepared and centrifuged to obtain a clear supernatant for the determination of AR activity and protein content.Results:The alcoholic extract of Ceasalpirda digyna and Alangium lamarckii had a potent inhibitory effect on the lens AR enzyme.The IC50 values of alcoholic extract of the selected plants were calculated and were(46.29±11.17) and(106.00±5.11)μg/mL,respectively. Quercetin was used as a positive control and its IC50 value was(2.95±1.53)μg/mL.Conclusions:Thus,it is concluded that alcoholic extracts of the selected plant exhibit significant inhibitory effects on AR in the rat lens in vitro. | Rajesh Kumar Dinesh Kumar Patel Damiki Laloo Krishnamurthy Sairam Siva Hemalatha | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，9： | 4 |
| 13 | 含笑属植物所含化学成分与其生物活性的综述(英文)显示文摘属木兰科的含笑属植物大约有80多个种类,它们大都分布在南亚国家。这些植物被当地人用于治疗各种疾病,如发烧、绞痛、麻风病、眼疾、炎症以及解蝎子毒。从9种含笑属植物中分离出94种化合物,例如倍半萜烯、类固醇、黄酮类、阿扑啡类、苯酚、酯类、生物碱和苯环型化合物等,它们具有抗菌、抗癌以及抗疟原虫活性。本文详细地论述了含笑属植物所含化学成分的生物及化学性能。 | Dinesh Kumar Sunil Kumar Seema Taprial Deepak Kashyap Ajay Kumar Om Prakash | 2012 | 中西医结合学报2012，10，12： | 4 |
| 14 | A novel approach for part family formation using K-means algorithm显示文摘The reconfigurable manufacturing system(RMS) is the next step in manufacturing,allowing the production of any quantity of highly customized and complex parts together with the benefits of mass production.In RMSs,parts are grouped into families,each of which requires a specific system configuration.Initially system is configured to produce the first family of parts.Once it is finished,the system will be reconfigured in order to produce the second family,and so forth.The effectiveness of a RMS depends on the formation of the optimum set of part families addressing various reconfigurability issues.The aim of this work is to establish a methodology for grouping parts into families for effective working of RMS.The methodology carried out in two phases. In the first phase,the correlation matrix is used as similarity coefficient matrix.In the second phase,agglomerative hierarchical K-means algorithm is used for the parts family formation resulting in an optimum set of part families for reconfigurable manufacturing system. | Ashutosh Gupta P.K.Jain Dinesh Kumar | 2013 | Advances in Manufacturing2013，1，3： | 4 |
| 15 | A review on pharmacological and analytical aspects of diosgenin:a concise report显示文摘Diosgenin is a steroidal sapogenin found in plants such as Dioscorea nipponoca,Solanum incanum,Solanum xanthocarpum and Trigonella foenum graecum.Diosgenin,biologically active phytochemicals have been used for the treatment of various types of disorder such as leukemia,inflammation,hypercholesterolemia and cancer.It is also able to prevent bone loss to the same extent as that of oestrogen.It is a typical initial intermediate for synthesis of steroidal compounds,oral contraceptives and sex hormones.Dioscorea,Costus and Trigonella are mainly used for the production of diosgenin.On the basis of literature survey it divulges that diosgenin has very impressive pharmacological profile and could be used as a medicine for the treatment of different types of disorders in the future.Thus,the present work aims to provide collective information in concern with its pharmacological activity and phytoanalytical techniques.This review will be beneficial to researches for the development of an alternative method for the treatment of innumerable diseases from diosgenin. | Kanika PATEL Manoj GADEWAR Vijay TAHILYANI Dinesh Kumar PATEL | 2012 | Natural Products and Bioprospecting2012，2，2： | 4 |
| 16 | Evaluation of antihyperglycemic and antioxidant activities of Saraca asoca (Roxb.) De Wild leaves in streptozotocin induced diabetic mice显示文摘 | Sunil Kumar Smita Narwal Dinesh Kumar Gurvirender Singh Sumit Narwal Renu Arya | 2012 | Asian Pacific Journal of Tropical Disease2012，，3： | 3 |
| 17 | 吸入型糖皮质激素用于哮喘患者的效果研究显示文摘目的借助于哮喘控制测试(ACT),论证使用吸入型糖皮质激素作为控制哮喘患者病情的临床疗效,与未使用任何药物控制哮喘症状或疾病发作的患者进行数据比较。方法在2012年7月,总共60名哮喘患者被要求做ACT问卷,其中32名患者作为对照组(n=32)未使用任何控制药物;28名患者作为观察组(n=28)使用吸入型糖皮质激素;并对两组的ACT结果进行了比较。结果所有患者都进行了ACT,并得到了相应的ACT分值。在对照组中,所有男性(n=13)患者的哮喘病情都控制不佳,19名女性中只有2名(10.53%)患者的病情得到了轻微的控制,其余的17名女性患者(89.47%)哮喘病情都控制不佳。在观察组中,男性患者(n=13)有6名(46.15%)患者哮喘病情未得到控制,女性患者(n=15)中,只有3名(20%)患者哮喘病情未得到控制。总体来说,ACT分值高于19的情况下,11名(39.29%)患者的哮喘得到了良好控制。结论使用吸入型糖皮质激素的哮喘控制物,例如倍氯米松和去炎松在维持哮喘的良好控制方面取得较好结果 ,ACT分值结果展示了这一点。使用吸入型糖皮质激素与未使用任何控制物相比,ACT分值得到了显著改变。 | Bhanu Siva Kumar Sileveru Dinesh Babu Abbadasari Neelesh Taticherala 冯宇峰 | 2013 | 中国实用医药2013，8，29： | 3 |
| 18 | Pedalium murex Linn.:An overview of its phytopharmacological aspects显示文摘Pedalium murex Linn(family:Pedaliaceae)(P.murex) commonly known as Large Caltrops and Gokhru(India) is a shrub found in the Southern part.Deccan region of India and in some parts of Ceylon.Different parts of the plant are used to treat various ailments like,cough,cold and as an antiseptic.Interestingly.P.murex is reported traditionally to have an excellent cure in patients with reproductive disorders which are mainly impotency in men.nocturnal emissions,gonorrhoea as well as leucorrhoea in women.The plant has also benifiled in complications like urinary track disorder as well as gastro intestinal tract disorders.Phytochemically the plant is popular for the presence of a considerable amount of diosgenin and vanillin which are regarded as an important source and useful starting materials for synthesizing steroidal contraceptive drugs and isatin alkaloids.Other phytochemicals reported in the plant includes quercetin.ursolic acid,caffeic acid,amino acids(glycine,histidine,tyrosine,threonine,aspartie acid and glutamic acid) and various classes of fatty acids(triacontanoic acid,nonacosane.tritriacontane.tetratriacontanyl and heptatriacontan-4-one).Pharmacologically,the plant have been investigated for antiulcerogenic. nephroprotective.hypolipidemic,aphrodisiac,antioxidant,antimicrobial and insecticidal activities.From all these reports it can be concluded that the plant were found to have a better profile with potential natural source for the treatment of various range of either acute or chronic disease.The overall database of our review article was collected from the scientific sources in regards with all the information ol the research article for P.murex published so far. | Dinesh Kumar Patel Damiki Laloo Rajesh Kumar Siva Hemalatha | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，9： | 3 |
| 19 | 鲍曼不动杆菌分子特征及其在替加环素压力下外排泵表达的变化显示文摘目的鲍曼不动杆菌是医院内感染常见的细菌。文中旨在分析其分子流行特征,检测外排泵和调节蛋白基因的携带率,并研究替加环素对外排泵和调节蛋白基因表达的影响。方法选取2017年5月至2019年3月江苏大学附属医院住院患者183株鲍曼不动杆菌。分为耐药组(一类及以上抗菌药物耐药的菌株,139株),敏感组(药敏试验中的药物均为非耐药的菌株,44株)。应用重复序列PCR作菌株的同源性分析,并以脉冲场凝胶电泳(PFGE)为同源性分析的金标准对部分菌株进行验证和比较。PCR检测耐药相关基因。依据同源性分析、外排泵携带率检测及药敏试验结果,选取6株外排泵基因全携带但耐药表型不同的临床菌株作为实验株,包括敏感株(SAB)、多药耐药株(MDRAB)、广泛耐药株(XDRAB),进行替加环素体外诱导,诱导后的菌株为诱导组,以不含替加环素LB培养的相同菌株为对照组。检测AdeB、TetB等外排泵基因及AdeS、BaeS等调节蛋白的基因表达变化。结果同源性分析显示,183株临床分离株包含有45个克隆群。耐药组AdeB、TetB基因(97.84%、98.56%)检出率均高于敏感组(63.64%、20.45%),CraA、AbeM等基因亦高于敏感组(P<0.05)。替加环素诱导前MDRAB、XDRAB中AdeB(4.17±0.94、6.86±3.23)、TetB(13.06±0.38、13.96±0.63)表达较SAB(0.00±3.70、0.00±0.70)升高(P<0.05),MDRAB菌株中MacB、BaeS表达较SAB菌株亦升高(P<0.05)。MDRAB、XDRAB菌株中AbaQ表达较SAB菌株降低(P<0.05)。诱导组AdeB、TetB在各菌株的表达较对照组明显升高(P<0.01);除SAB1菌株外,AbaQ、AbeM在其余菌株中的表达较对照组明显升高(P<0.05);AdeS在SAB1、SAB2、MDRAB1、XDRAB2菌株中的表达较对照组升高(P<0.05);负调节蛋白SoxR在SAB1、XDRAB1菌株中表达较对照组降低(P<0.05)。结论AdeB、TetB、AbeS、AdeS、BaeS在临床鲍曼不动杆菌多药耐药过程中发挥着重要的作用,其中AdeB和TetB在菌株对替加环素耐药过程中的作用尤为明显,可能是替加环素耐药的优势外排泵基因。 | 程建军 Kesavan Dinesh Kumar 阴晴 王慧璇 蔡伟 陈建国 苏兆亮 许化溪 | 2020 | 医学研究生学报2020，33，1： | 3 |
| 20 | 焊接参数对搅拌摩擦焊接AA2219-T87材料韧性、洋葱圆环的断裂行为的影响(英文)显示文摘与熔焊相比,搅拌摩擦焊可以更好地保持材料的韧性和塑性,提高焊接的抗裂稳定性。本研究旨在提高焊接接头的延性和强度。刀具廓形在保持延性、分析金属流动行为和确定断裂起始点等方面起着重要作用。分析了洋葱圆环不同区域的微观结构,得出了洋葱圆环强度与金属流型的关系。结果表明,洋葱圆环强化了焊缝熔核。肩部和锥形螺纹型线刀具具有优异的力学性能。显微硬度数据表明,断口经过热影响区和热机械影响区等低硬度区。扫描电镜图像显示了细长的晶粒和韧窝,证实了断裂为韧性断裂。 | Dinesh KUMAR R S MUTHUKUMARAN Vincent XAVIER T VENKATESWARAN D SIVAKUMAR | 2019 | Journal of Central South University2019，26，9： | 2 |
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