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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | Focus on the gut-brain axis: multiple sclerosis, the intestinal barrier and the microbiome显示文摘The brain-gut axis serves as the bidirectional connection between the gut microbiome, the intestinal barrier and the immune system that might be relevant for the pathophysiology of inflammatory demyelinating diseases. People with multiple sclerosis have been shown to have an altered microbiome, increased intestinal permeability and changes in bile acid metabolism. Experimental evidence suggests that these changes can lead to profound alterations of peripheral and central nervous system immune regulation. Besides being of pathophysiological interest, the brain-gut axis could also open new avenues of therapeutic targets. Modification of the microbiome, the use of probiotics, fecal microbiota transplantation, supplementation with bile acids and intestinal barrier enhancers are all promising candidates. Hopefully, pre-clinical studies and clinical trials will soon yield significant results. | Carlos R Camara-Lemarroy Luanne M Metz V Wee Yong | 2018 | World Journal of Gastroenterology2018，24，37： | 6 |
| 3 | Osteopontin-CD44 Signaling in the Glioma Perivascular Niche Enhances Cancer Stem Cell Phenotypes and Promotes Aggressive Tumor Growth显示文摘 | Alexander Pietras Amanda M. Katz Elin J. Ekstr?m Boyoung Wee John J. Halliday Kenneth L. Pitter Jillian L. Werbeck Nduka M. Amankulor Jason T. Huse Eric C. Holland | 2014 | Cell Stem Cell2014，，3： | 3 |
| 4 | An integrated, multi-lot-size production inventory model for deteriorating item 显示文摘 | Yang P C Wee H M | 2003 | Computers and Operations Research2003，30，： | 1 |
| 5 | p53 Expression in hepatocellular carcinoma in a population in Singapore with endemic hepatitis B virus infections 显示文摘 | M The C Raju | 1995 | J Clin Pathol1995，48，： | 1 |
| 6 | An integrated multi-lot-size production inventory model for deteriorating item显示文摘 | WEE H M | 2003 | Computer & Operations research2003，30，： | 1 |
| 7 | Effects ofshape, size, and casting direction of specimens on stress-strain curves of high-strength Concrete显示文摘 | Chin M S Mansur M A Wee T H | 1997 | ACI Materials Journal1997，94，3： | 1 |
| 8 | Trade-off between carbon dioxide emissions and logistics costs based on multiobjective optimization显示文摘 | Kim N S Janic M Wee B | 2009 | Transportation Research Record2009，2139，： | 1 |
| 9 | A quick response production strategy to market demand显示文摘 | Yang P C Wee H M | 2001 | Product Planning Control2001，12，4： | 1 |
| 10 | Behavior of high-strength concrete I-beams with low shear reinforcement显示文摘 | Teoh B K Mansur M A Wee T H | 2002 | ACI Structural Journal2002，99，3： | 1 |
| 11 | Multi-product production quantity model with repair failure and partial backordering显示文摘 | ATA A T WEE H M SEYED J S | 2010 | Computers and Industrial Engineering2010，59，1： | 1 |
| 12 | Multiple-layer laser direct writing metal deposition in electrolyte solution显示文摘 | WEE L M LI L | 2005 | Applied Surface Science2005，247，1： | 1 |
| 13 | Design of a least-cost battery-supercapacitor energy storage system for realizing dispatchable wind power显示文摘 | Wee K W Choi S S Vilathgamuwa D M | 2013 | IEEE Transactions on Sustainable Energy2013，4，3： | 1 |
| 14 | An inventory model for a- meliorating and deteriorating items taking account of time value of money and finite planning horizon显示文摘 | WEE H M LOS T YU J | 2008 | International Journal of Systems Science2008，39，8： | 1 |
| 15 | Methane cracking over a bituminous coal char显示文摘 | SUN Z-Q WU J-H HAGHIGHI M BROMLY J NG E WEE H L WANG Y ZHANG D-K | 2007 | Energy Fuels2007，21，3： | 1 |
| 16 | Flexible chitin films as potential wound-dressing materials: wound model studies 显示文摘 | Yusof N L B M Wee A Lim L Y | 2003 | J Biomed Mater Res Part A2003，66，2： | 1 |
| 17 | Expression, isola- tion and properties of Fur( ferric up-take regulation) protein of Escherichia coli K12 显示文摘 | Wee S Neilands J B Bittner M L | 1988 | Biol Metals1988，，1： | 1 |
| 18 | Deposition of NiAl coating for improvement of oxidation resistance of cold-rolled Ni3Al foils显示文摘 | KIM S H OH M H KISHIDA K HIRANO T WEE D M | 2005 | Intermetallics2005，，13： | 1 |
| 19 | Improved biocompatibility of bicarbonate/lactate-buffered PDF is not related to pH显示文摘 | Zareie M Keuning ED ter Wee PM | 2006 | Nephrol Dial Transplant2006，21，1： | 1 |
| 20 | Design of a least-cost battery-supercapacitor energy storage system for realizing dispatchable wind power显示文摘 | WEE K W CHOI S S VILATHGAMUWA D M | 2013 | IEEE Transactions on Sustainable Energy2013，4，3： | 1 |
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