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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities显示文摘Aim:To clarify the mechanism of the therapeutic action of icariin on erectlile dysfunction(ED).Methods:PDE5 was isolated from the human platelet and PDE4 form the rat liver tissue using the FPLC system (Pharmacia,Milton Keynes,UK)and the Mono Q column.The inhibitory effects of icariin on PDE5 and PDE4 activities were investigated by the two-step radioisotope procedure with [^3H]-c GMP/[^3H]-cAMP.Papaverine served as the control drug.Results:Icariin and papaverine showed dose-dependent inhibitory effects on PDE5 and PDE4 activities.The IC50 of Icariin and papaverine on PDE5 were 0.432μ mol/L and 0.680μmol/L,respectively and those on PDE4,73.50μmol/L and 3.07μmol/L,respectively.The potencies of selectivity of icariin and papaverine on PDE5(PDE4/PDE5 of IC50)were 167.67 times and 4.54 times,respectively.Conclusion:Icariin is a cGMP-specific PDE5 inhibitor that may be developed into an oral effective agent for the treatment of ED. | ZC Xin EK Kim CS Lin WJ Liu L Tian YM Yuan J Fu | 2003 | Asian Journal of Andrology2003，5，1： | 38 |
| 3 | Secondary structural formation of alpha-synuclein amyloids as revealed by g-factor of solid-state circular dichroism.显示文摘 | Lin XJ Zhang F Xie YY Bao WJ He JH Hu HY | 2006 | 中国生物学文摘2006，20，9： | 2 |
| 4 | The role of STAT5a and STAT5b in signaling by IL-2 family cytokines显示文摘 | Lin JX Leonard WJ | 2000 | Oncogene2000，19，21： | 1 |
| 5 | Synergistic effect of a recombinant N-terminal fragment of bactericidal/permeability-increasing protein and cefamandole in treatment of rabbit Gram-negative sepsis显示文摘 | Lin Y Leach WJ Ammons W S | 1996 | Antimicrob Agents Chemother1996，40，1： | 1 |
| 6 | Effects of different preproendothelin-1 mRNA anti-sense oligodeoxynucleotides on ischemic arrhythmias in rats 显示文摘 | Lin L Yuan WJ | 2002 | Cardiovasc Pharmacol2002，39，4： | 1 |
| 7 | Visfatin-induced expression of inflammatory mediators in human endothelial cells through the NF-kappa B pathway显示文摘 | Lee WJ Wu CS Lin H | | 0，，： | 1 |
| 8 | Antioxidant ability and mechanism of rhizoma atractylodes macrocephala显示文摘 | Li XC Lin J Han WJ | 2012 | Molecules2012，17，13： | 1 |
| 9 | Induction of G1 arrest and apoptosis in human jurkat T cells by pentagalloylglucose through inhibiting proteasome activity and elevating IO27 Kipl, p21Cipl/WAF1, and Bax proteins 显示文摘 | Chen WJ Lin JK | 2004 | J Biol Chem2004，279，13： | 1 |
| 10 | Melatonin and its metaholites aecu- mulate in the human epidermis in vivo and inhibit proliferation and ty- rosinase activity in epidermal melanacytes in vitro显示文摘 | Kim TK Lin Z Tidwell WJ et at | 2014 | Mol Cell Endo- crinol2014，404，： | 1 |
| 11 | Characterization of polyethylene glycol-modified proteins by semi-aqueous capillary electrophoresis显示文摘 | LI WJ ZHONG Y LIN BC | 2001 | J Chromatogr A2001，905，12： | 1 |
| 12 | Lactobacillus effects on cholesterol:in vitro and in vivo results显示文摘 | Lin SY Ayres JW Winkler WJ | 1989 | Journal of Dairy Science1989，72，11： | 1 |
| 13 | Serum immunoglobu- lin levels in patients with primary by pogamma globu- linemia experience from a tertiary hospital in Taiwan 显示文摘 | Tsai WJ Lin JY Yang YH | 2009 | J Microbiol Immunol Infect2009，42，3： | 1 |
| 14 | In situ gelling of algi nate / pluronic solutions for opthalmic delivery of pilo carpine显示文摘 | Lin HR Sung KC Vong WJ | 2004 | Biomaeromolecules2004，5，23： | 1 |
| 15 | Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy 显示文摘 | Liao W Lin JX Leonard WJ | 2013 | Immunity2013，38，1： | 1 |
| 16 | Androgen receptor roles in the development of benign prostate hyperplasia显示文摘 | Izumi K Mizokami A Lin WJ | | 0，，： | 1 |
| 17 | Cardiac risk factors in patients with diabetes mellitus and major depression显示文摘 | Katon WJ Lin EH Russo J | 2004 | J Gen Intern Med2004，19，12： | 1 |
| 18 | Allergic dysregulation and hyperimmunoglobulin emia E in Foxp3 mutant mice 显示文摘 | Lin W Truong N Grossman WJ Haribhai D Williams CB Wang J | 2005 | J Allergy Clin Immunol2005，116，5： | 1 |
| 19 | Mechanobiology of MG63 osteo- blast-like ceils adaptation to static magnetic forces显示文摘 | Lin SL Chang WJ Chiu KH | 2008 | Electromagn Biol Med2008，27，1： | 1 |
| 20 | Factorial analysis of variables influencing mechanical characteristics of a single tooth implant placed in the maxilla using finite element analysis and the statistics-based Taguchi method 显示文摘 | Lin CL Chang SH Chang WJ | 2007 | Eur J Oral Sci2007，115，5： | 1 |
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