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| 1 | A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients显示文摘AIM To investigate the interference ofmethionine.free parenteral nutrition plus 5-Fu(-MetTPN+5-Fu)in gastric cancer cell kineticsand the side effects of the regimen.METHODS Fifteen patients with advancedgastric cancer were randomly divided into twogroups,7 patients were given preoperatively aseven-day course of standard parenteralnutrition in combination with a five-day courseof chemotherapy(sTPN+5-Fu),while the other8 patients were given methionine-deprivedparenteral nutrition and 5-Fu(-MetTPN+5-Fu).Cell cycles of gastric cancer and normal mucosawere studied by flow cytometry(FCM).Bloodsamples were taken to measure the serumprotein,methionine(Met)and cysteine(Cys)levels,and liver and kidney functions.RESULTS As compared with the resultsobtained before the treatment,the percentage ofG0/G1 tumor cells increased and that of S phasedecreased in the-MetTPN+5-Fu group,while thecontrary was observed in the sTPN+5-Fu group.Except that the ALT,AST and AKP levels wereslightly increased in a few cases receiving-MetTPN+5-Fu,all the other biochemicalparameters were within normal limits.Serum Cys level decreased slightly after the treatmentin both groups.Serum Met level of patientsreceiving sTPN+5-Fu was somewhat higher aftertreatment than that before treatment;however,no significant change occurred in the -MetTPN+5-Fu group,nor operative complications in bothgroups.CONCLUSION -MetTPN+5-Fu exerted asuppressive effect on cancer cell proliferation,probably through a double mechanism ofcreating a state of'Met starvation'adverse tothe tumor cell cycle,and by allowing 5-Fu to killspecifically cells in S phase.Preoperative short-term administration of -MetTPN+5-Fu had littleundesirable effect on host metabolism. | Cao WX Cheng QM Fei XF Li SF Yin HR Lin YZ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Preparation of macroporous biodegradable PLGA scaffolds for cell attachment with the use of mixed salts as porogen additives显示文摘 | Lin HR Kuo CJ Yang CY | 2002 | J Biomed Mater Res2002，63，3： | 1 |
| 3 | Genetic polymorphism of cyto chrome P4502C19 in Mexican Americans:Across- ethnic comparative study 显示文摘 | Luo HR Poland RE Lin KM | 2006 | Clin Pharmacol Ther2006，80，： | 1 |
| 4 | Characterization of pilocarpine-loaded chitosan/carbopol nanoparticles显示文摘 | Kao HJ Lin HR Lo YL | 2006 | J Pharm Pharmacol2006，58，2： | 1 |
| 5 | Perceived uncertainty, social sup- port and psychological adjustment in older patients with cancer being treated with surgery显示文摘 | Lien CY Lin HR Kuo IT | 2009 | J Clin Nurs2009，18，16： | 1 |
| 6 | Levels of organochlorine pesticides in human milk from central Taiwan显示文摘 | Wang SL Lin TC | 2006 | Chemosphere2006，62，11： | 1 |
| 7 | Carbopol/plurnic phase change solutions for ophthalmic drug delivery显示文摘 | Lin HR Sung KC | 2000 | J Control Release2000，69，： | 1 |
| 8 | In situ gelling of algi nate / pluronic solutions for opthalmic delivery of pilo carpine显示文摘 | Lin HR Sung KC Vong WJ | 2004 | Biomaeromolecules2004，5，23： | 1 |
| 9 | Triterpenes fi'om Alisma orientalis act as farnesoid X re- ceptor agonists显示文摘 | LIN HR | 2012 | Bioorg Med Chem Lett2012，22，14： | 1 |
| 10 | IRE1 signaling affects cell fate during the unfolded protein response 显示文摘 | Lin JH Li H Yasumura D Cohen HR | 2007 | Science2007，318，5852： | 1 |
| 11 | Ultrasound sonication with microbubbles disrupts blood vessels and enhances tumor treatments of anticancer nanodrug显示文摘 | Lin CY Tseng HC Shiu HR | | 0，，： | 1 |
| 12 | UV Disinfection induces a VBNC state in Escherichia coli and Pseudomoras aeruginosa显示文摘 | Zhang SH Ye CS Lin HR | 2015 | Environ Sci Techol2015，49，3： | 1 |
| 13 | Livin abrogates apoptosis of SPC-AI cell by regulating JNKI signaling pathway显示文摘 | Chen YS Li HR Lin M | 2010 | Mol Biol Rep2010，37，5： | 1 |
| 14 | Burnout, iob satisfaction, and medical malpractice among physicians 显示文摘 | Chen KY Yang CM Lien CH Chiou HY Lin MR Chang HR Chiu WT | 2013 | Inter J bled Sci2013，10，11： | 1 |
| 15 | Detection of acid-labile conjugates of ketamine and its metaholites in urine samples collected from pub participants显示文摘 | Lin HR Lau AC | 2004 | J Anal Toxicol2004，28，3： | 1 |
| 16 | Cell cycle arrest and inhibition of anoikis by galcetin-3 in human breast epithelial cells 显示文摘 | Kim HR Lin HM Biliran H | 1999 | Cancer Res1999，59，16： | 1 |
| 17 | Genetic polymorphism of cytochrome P450 2C19 in Mexican Americans:a cross-ethnic comparative study显示文摘 | Luo HR Poland RE Lin KM | 2006 | Clin Pharmacol Ther2006，80，1： | 1 |
| 18 | A rapid and sensitive ESI-MS screening procedure for ketamine and norketamine in urine samples显示文摘 | Lua AC Lin HR | 2004 | J Anal Toxicol2004，28，8： | 1 |
| 19 | Paeoniflorin acts as a liver X receptor agonist显示文摘 | Lin HR | | 0，，01： | 1 |
| 20 | Detection of acid-labile conjugates of ketamine and its metabolites in urine samples collected from Pub participants 显示文摘 | Lin HR Lua AC | 2004 | Journal of Analytical Toxicology2004，28，： | 1 |
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