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| 1 | The steady-state level of CDK4 protein ms regulated by antagonistic actions between PAQR4 and SKP2 and involved in tumorigenesis显示文摘 | Lin Wang RuiZhang Xue You Huanhuan Zhang Siying Wei Tingting Cheng Qianqian Gao ZhenzhenWang Yan Chen | 2017 | Journal of Molecular Cell Biology2017，9，5： | 4 |
| 2 | Engineered neutrophil apoptotic bodies ameliorate myocardial infarction by promoting macrophage efferocytosis and inflammation resolution显示文摘Inflammatory response plays a critical role in myocardial infarction(MI)repair.The neutrophil apoptosis and subsequent macrophage ingestion can result in inflammation resolution and initiate regeneration,while the therapeutic strategy that simulates and enhances this natural process has not been established.Here,we constructed engineered neutrophil apoptotic bodies(eNABs)to simulate natural neutrophil apoptosis,which regulated inflammation response and enhanced MI repair.The eNABs were fabricated by combining natural neutrophil apoptotic body membrane which has excellent inflammation-tropism and immunoregulatory properties,and mesoporous silica nanoparticles loaded with hexyl 5-aminolevulinate hydrochloride(HAL).The eNABs actively targeted to macrophages and the encapsulated HAL simultaneously initiated the biosynthesis pathway of heme to produce anti-inflammatory bilirubin after intracellular release,thereby further enhancing the anti-inflammation effects.In in vivo studies,the eNABs efficiently modulated inflammation responses in the infarcted region to ameliorate cardiac function.This study demonstrates an effective biomimetic construction strategy to regulate macrophage functions for MI repair. | Lili Bao Geng Dou Ran Tian Yajie Lv Feng Ding Siying Liu Ruifeng Zhao Lu Zhao Jun Zhou Lin Weng Yan Dong Bei Li Shiyu Liu Xin Chen Yan Jin | 2022 | Bioactive Materials2022，7，3： | 3 |
| 3 | Environmental Lead Pollution and Elevated Blood Lead Levels Among Children in a Rural Area of China显示文摘 | Lin Sihao Wang Xiaorong Yu Ignatius Tak Sun Tang Wenjuan Miao Jianying Li Jin Wu Siying Lin Xing | 2011 | American Journal of Public Health2011，，： | 1 |
| 4 | Constructing Pd-N interactions in Pd/g-C_(3)N_(4)to improve the charge dynamics for efficient photocatalytic hydrogen evolution显示文摘The formation of chemical bonds between metal ions and their supports is an effective strategy to achieve good catalytic activity.However,both the synthesis of active metal species on a support and control of their coordination environment are still challenging.Here,we show the use of an organic compound to produce tubular carbon nitride(TCN)as a support for Pd nanoparticles(NPs),creating a composite material(NP-Pd-TCN).It was found that Pd ions preferentially bind with the electron-rich N atoms of TCN,leading to strong metal-support interactions that benefit charge transfer from g-C_(3)N_(4)to Pd.X-ray absorption spectroscopy further revealed that the metal-support interactions resulted in the formation of Pd-N bonds,which are responsible for the improvement in the charge dynamics as evidenced by the results from various techniques including photoluminescence(PL)spectroscopy,photocurrent measurements,and electrochemical impedance spectroscopy(EIS).Owing to the good dynamical properties,NP-Pd-TCN was used for photocatalytic hydrogen evolution under visible-light irradiation(λ>420 nm)and an excellent evolution rate of~381μmol·h^(-1)(0.02 g of the photocatalyst)was attained.This work aims to promote a strategy to synthesize efficient photocatalysts for hydrogen production by controllably introducing metal nanoparticles on a support and in the meantime forming chemical bonds to achieve intimate metal-support contact. | Xudong Xiao Siying Lin Liping Zhang Huiyuan Meng Jing Zhou Qi Li Jianan Liu Panzhe Qiao Baojiang Jiang Honggang Fu | 2022 | Nano Research2022，15，4： | 1 |
| 5 | miR-124 Represses ROCK1 Expression to Promote Neurite Elongation Through Activation of the PI3K/Akt Signal Pathway显示文摘 | Xi Gu Siying Meng Shuhu Liu Chunhong Jia Yingying Fang Shuji Li Congcong Fu Qiancheng Song Lifang Lin Xuemin Wang | 2014 | Journal of Molecular Neuroscience2014，，1： | 1 |
| 6 | Novel mutations in PDE6A and CDHR1 cause retinitis pigmentosa in Pakistani families显示文摘AIM:To investigate the genetic basis of autosomal recessive retinitis pigmentosa(arRP)in two consanguineous/endogamous Pakistani families.METHODS:Whole exome sequencing(WES)was performed on genomic DNA samples of patients with arRP to identify disease causing mutations.Sanger sequencing was performed to confirm familial segregation of identified mutations,and potential pathogenicity was determined by predictions of the mutations’functions.RESULTS:A novel homozygous frameshift mutation[NM_000440.2:c.1054delG,p.(Gln352Argfs*4);Chr5:g.149286886del(GRCh37)]in the PDE6A gene in an endogamous family and a novel homozygous splice site mutation[NM_033100.3:c.1168-1G>A,Chr10:g.85968484G>A(GRCh37)]in the CDHR1 gene in a consanguineous family were identified.The PDE6A variant p.(Gln352Argfs*4)was predicted to be deleterious or pathogenic,whilst the CDHR1 variant c.1168-1G>A was predicted to result in potential alteration of splicing.CONCLUSION:This study expands the spectrum of genetic variants for arRP in Pakistani families. | Muhammad Dawood Siying Lin Taj Ud Din Irfan Ullah Shah Niamat Khan Abid Jan Muhammad Marwan Komal Sultan Maha Nowshid Raheel Tahir Asif Naveed Ahmed Muhammad Yasin Emma LBaple Andrew HCrosby Shamim Saleha | 2021 | International Journal of Ophthalmology(English edition)2021，14，12： | 0 |
| 7 | Acidic Electrocatalytic Semihydrogenation of Alkynols to Alkenols on Copper Phosphide at Industrial-Level Current Density显示文摘Alkenols are important intermediates for the industrial manufacture of various commodities and fine chemicals.At present,alkenols are produced via thermocatalytic semihydrogenation of corresponding alkynols using precious metal Pd-based catalysts in pressurized hydrogen atmosphere.In this work,we highlight an efficient electrocatalytic strategy for selectively reducing alkynols to alkenols under ambient conditions.Using 2-methyl-3-butyn-2-ol as a model alkynol,Cu3P nanoarrays anchored on Cu foam remarkably deliver an industrial-level partial current density of 0.79 A·cm^(-2) and a specific selectivity of 98%for 2-methyl-3-buten-2-ol in acidic solution.Over a 40-runs stability test,Cu3P nanoarrays maintain 90%alkynol conversion and 90%alkenol selectivity.Even in a large two-electrode flow electrolyser,the single-pass alkynol conversion and alkenol selectivity of Cu3P nanoarrays exceed 90%.Moreover,this selective electrocatalytic hydrogenation approach is broadly feasible for the production of various water-soluble alkenols.Electrochemical analyses,theoretical simulation and electrochemical in-situ infrared investigations together reveal that exothermic alkynol hydrogenation,facile alkenol desorption and formation of active H on Cu3P surfaces account for the excellent electrocatalytic performance. | Sanyin Yang Jun Bu Rui Bai Jin Lin Siying An Yafei Wu Ying Guo Jie Gao Jian Zhang | 2023 | Chinese Journal of Chemistry2023，41，24： | 0 |
| 8 | ARF-mediated SUMOylation of Apak antagonizes ubiquitylation and promotes its nucleolar accumulation to inhibit 47S pre-rRNA synthesis显示文摘Ribosomes are among the most fundamental molecular machines in all cells,as they are required for protein synthesis.Most structural rRNA components are generated in the nucleolus and assembled into pre-ribosomal particles.Here we show Apak,a previously identified p53 inhibitor,as a novel ribosomal stress response protein.In unstressed cells,Apak is bound to the deSUMOylase SENP1 in the nucleoplasm and targeted for proteasomal degradation by MDM2 ubiquitin ligase.Upon ribosomal stress,SENP1 dissociates fromApak and the tumor suppressor protein ARF couplesUbc9 with Apak to promote Apak SUMOylation on zinc fingers.This results in Apak protein stabilization and translocation to the nucleolus,where Apak inhibits the pre-rRNA synthesis.These findings provide a molecular mechanism whereby ARF coordinates Apak to regulate ribosome biogenesis upon cellular stress. | Shan Wang Siying Wang Lihua Yang Hua Guo Xue Kong Lin Yuan Guichun Xing Fuchu He Lingqiang Zhang | 2015 | Journal of Molecular Cell Biology2015，7，2： | 0 |
| 9 | Combined local therapy and CAR-GPC3 T-cell therapy in advanced hepatocellular carcinoma:a proof-of-concept treatment strategy显示文摘Dear Editor,Available evidence regarding the most suitable treatment strategies for hepatocellular carcinoma(HCC)with inferior vena cava tumor thrombus(IVCTT)is extremely limited,and the median overall survival time for these patients after liver resection is only 17.76 months[1].Other local or systemic treatments for HCC with IVCTT result in a median overall survival time ranging from 5.88 to 15.36 months[1–3].Thus,new therapeutic strategies are urgently needed to improve the survival of HCC patients with IVCTT.Chimeric antigen receptor(CAR)T-cell therapy has seen success in treating B-cell neoplasms with impressive outcomes[4].However,this therapy alone has shown limited efficacy on solid tumors,such as HCC[5]. | Yaoping Shi Donghua Shi Jiachang Chi Dan Cui Xiaoyin Tang Yan Lin Siying Wang Zonghai Li Haojie Jin Bo Zhai | 2023 | Cancer Communications2023，43，9： | 0 |
| 10 | Historical Contributions and Innovative Development of China's Inclusive Culture显示文摘Inclusive culture is a dynamic pattern of cultural integration and innovative development formed in the interactions between man and nature, man and society, and man and others. Chinese culture is among the sources of inclusive culture. Being inheritable, open, assimilative, innovative and self–driven, this inclusive culture significantly contributes to China's ideological evolution, ethnic integration, religious development, economic openness, literature and art prosperity, as well as political wisdom in building a community with a shared future for mankind. Inclusiveness is key to the lasting and sustainable development of traditional Chinese culture. During China's construction of a great modern socialist country, the CPC's leadership over cultural innovation and development must be strengthened; a strong cultural confidence must always be maintained; the prosperity of socialist culture with Chinese characteristics must be further enhanced; the sustainable and integrated development of socialist culture with Chinese characteristics must be promoted; people's need for an enriched cultural life must be satisfied; and more efforts must be made to build a community with a shared future for mankind. Only in this way can the light of China's inclusive culture illuminate the future of globalization. | Zhang Zhancang Mou Hong Lin Siying Liu Xiaolong Xu Qingtong | 2018 | Contemporary Social Sciences2018，3，4： | 0 |
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