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| 1 | Treatment of solid tumors with chimeric antigen receptor-engineered T cells: current status and future prospects显示文摘Chimeric antigen receptors(CARs) are artificial recombinant receptors that generally combine the antigen-recognition domain of a monoclonal antibody with T cell activation domains. Recent years have seen great success in clinical trials employing CD19-specific CAR-T cell therapy for B cell leukemia. Nevertheless, solid tumors remain a major challenge for CAR-T cell therapy. This review summarizes the preclinical and clinical studies on the treatment of solid tumors with CAR-T cells. The major hurdles for the success of CAR-T and the novel strategies to address these hurdles have also been described and discussed. | Shengmeng Di Zonghai Li | 2016 | Science China(Life Sciences)2016，59，4： | 10 |
| 2 | Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic approaches显示文摘 | Min Yu Zonghai Li | 2017 | Frontiers of Medicine2017，11，4： | 5 |
| 3 | Identification and characterization of a novel peptide ligand of Tie2 for targeting gene therapy显示文摘有免疫球蛋白和表皮的生长因素相同 domain-2 (Tie2 ) 的酷氨酸 kinase 在稳固的肿瘤为基因治疗被看作了一个合理目标。以便为指向的基因治疗识别 Tie2 的新奇的肽 ligand,我们屏蔽了一个噬菌体显示肽图书馆并且识别了候选人肽 ligand NSLSNASEFRAPY (指明的 GA5 ) 。有约束力的试金和 Scatchard 分析表明 GA5 能明确地与 2.1 的一个分离常数绑在 Tie2 ?鷐 吗?? | Xianghua Wu Zonghai Li Ming Yao Huamao Wang Sumin Qu Xianlian Chen Jinjun Li Ye Sun Yuhong Xu Jianren Gu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，3： | 2 |
| 4 | Genetically engineered T cells for cancer immunotherapy显示文摘T cells in the immune system protect the human body from infection by pathogens and clear mutant cells through specific recognition by T cell receptors(TCRs).Cancer immunotherapy,by relying on this basic recognition method,boosts the antitumor efficacy of T cells by unleashing the inhibition of immune checkpoints and expands adaptive immunity by facilitating the adoptive transfer of genetically engineered T cells.T cells genetically equipped with chimeric antigen receptors(CARs)or TCRs have shown remarkable effectiveness in treating some hematological malignancies,although the efficacy of engineered T cells in treating solid tumors is far from satisfactory.In this review,we summarize the development of genetically engineered T cells,outline the most recent studies investigating genetically engineered T cells for cancer immunotherapy,and discuss strategies for improving the performance of these T cells in fighting cancers. | Dan Li Xue Li Wei-Lin Zhou Yong Huang Xiao Liang Lin Jiang Xiao Yang Jie Sun Zonghai Li Wei-Dong Han Wei Wang | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 2 |
| 5 | Centimeter-Deep NIR-II Fluorescence Imaging with Nontoxic AIE Probes in Nonhuman Primates显示文摘Fluorescence probes with aggregation-induced emission(AIE)characteristics are of great importance in biomedical imaging with superior spatial and temporal resolution.However,the lack of toxicity studies and deep tissue imaging in nonhuman primates hinders their clinical translation.Here,we report the blood chemistry and histological analysis in nonhuman primates treated with AIE probes over tenfold of an intravenous dose of clinically used indocyanine green(ICG)during a study period of 36 days to demonstrate AIE probes are nontoxic.Furthermore,through bright and nontoxic AIE probes and fluorescence imaging in the second window(NIR-II,1,000-1,700 nm),we achieve an unprecedented 1.5-centimeter-deep vascular imaging in nonhuman primates,breaking the current limitation of millimeter-deep NIR-II fluorescence imaging.Our important findings,i.e.,nontoxic features of AIE probes and centimeter-deep NIR-II vascular imaging in nonhuman primates,may facilitate successful translation of AIE probes in clinical trials. | Zonghai Sheng Yaxi Li Dehong Hu Tianliang Min Duyang Gao Jen-Shyang Ni Pengfei Zhang Yuenan Wang Xin Liu Kai Li Hairong Zheng Ben Zhong Tang | 2020 | Research2020，，1： | 1 |
| 6 | Adaptive control method for nonlinear time-delay processes显示文摘Two complex properties,varying time-delay and block-oriented nonlinearity,are very common in chemical engineering processes and not easy to be controlled by routine control methods.Aimed at these two complex properties,a novel adaptive control algorithm the basis of nonlinear OFS (orthonormal functional series) model is proposed.First,the hybrid model which combines OFS and Volterra series is introduced.Then,a stable state feedback strategy is used to construct a nonlinear adaptive control algorithm that can guarantee the closed-loop stability and can track the set point curve without steady-state errors.Finally,control simulations and experiments on a nonlinear process with varying time-delay are presented.A number of experimental results validate the efficiency and superiority of this algorithm. | Chen Zonghai Zhang Haitao Li Ming Xiang Wei | 2007 | Journal of Systems Engineering and Electronics2007，18，3： | 1 |
| 7 | Dickkopf-1 autoantibody is a novel serological biomarker for non-small cell lung cancer显示文摘 | Xiao Yao Hua Jiang Cuizhen Zhang Huamao Wang Lin Yang Yongfeng Yu Junming Yu Bizhi Shi Zhijun Shen Huiping Gao Zhiwei Chen Shujun Tian Shun Lu Zonghai Li Jianren Gu | 2010 | Biomarkers2010，，2： | 1 |
| 8 | High-performance LiNi_(0.8)Mn_(0.1)Co_(0.1)O_(2) cathode by nanoscale lithium sulfide coating via atomic layer deposition显示文摘The commercialization of nickel-rich LiNi_(0.8)Mn_(0.1)Co_(0.1)O_(2)(NMC811) has been hindered by its continuous loss of practical capacity and reduction in average working voltage.To address these issues,surface modification has been well-recognized as an effective strategy.Different from the coatings reported in literature to date,in this work,we for the first time report a sulfide coating,amorphous Li_(2)S via atomic layer deposition (ALD).Our study revealed that the conformal nano-Li_(2)S coating shows exceptional protection over the NMC811 cathodes,accounting for the dramatically boosted capacity retention from~11.6%to~71%and the evidently mitigated voltage reduction from 0.39 to 0.18 V after 500 charge–discharge cycles.In addition,the Li_(2)S coating remarkably improved the rate capability of the NMC811 cathode.Our investigation further revealed that all these beneficial effects of the ALD-deposited nano-Li_(2)S coating lie in the following aspects:(i) maintain the mechanical integrity of the NMC811 electrode:(ii) stabilize the NMC electrode/electrolyte interface:and (iii) suppress the irreversible phase transition of NMC structure.Particularly,this study also has revealed that the nano-Li_(2)S coating has played some unique role not associated with traditional non-sulfide coatings such as oxides.In this regard,we disclosed that the Li_(2)S layer has reacted with the released O_(2) from the NMC lattices,and thereby has dramatically mitigated electrolyte oxidation and electrode corrosion.Thus,this study is significant and has demonstrated that sulfides may be an important class of coating materials to tackle the issues of NMCs and other layered cathodes in lithium batteries. | Xin Wang Jiyu Cai Yang Ren Mourad Benamara Xinwei Zhou Yan Li Zonghai Chen Hua Zhou Xianghui Xiao Yuzi Liu Xiangbo Meng | 2022 | Journal of Energy Chemistry2022，31，6： | 1 |
| 9 | Evolution of the Raman spectrum of graphene grown on copper upon oxidation of the substrate显示文摘在在一部铜电影上种的单个层的 graphene 的拉曼光谱的重要变化在发生在周围的条件下面的内在的底层的自发的氧化以后被观察。graphene G 和 2D 拉曼模式的频率被发现经历红移动,当二个乐队的紧张由超过一个数量级变化时。为了理解这些的起源,完成,我们进一步由扫描通道描绘了样品显微镜学(STM ) ,扫描通道光谱学(圣) ,和原子力量显微镜学(AFM ) 。没有破坏 graphene overlayer 的水晶的顺序或改变做水平的搬运人,底层的氧化在底层生产了可估计的折皱。我们以 graphene 层的折皱导致的张力的紧张解释拉曼频率的红移动。在有氧化的拉曼紧张的变化从对在散布过程的拉曼结合 graphene 层的光的效率的薄亚铜的氧化物电影的影响产生。 | XiuliYin Yilei Li Fen Ke Chenfang Lin Huabo Zhao Lin Gan Zhengtang Luo Ruguang Zhao Tony F. Heinz Zonghai Hu | 2014 | Nano Research2014，7，11： | 1 |
| 10 | Production Situation and Development Trends of Hydrogen Peroxide in China | Wu Guoquan, Li Cheng, Liu Shimei, Wu Qiujun, Wang Qingji, Liu Zonghai, Song Shuli, from Qingdao Soda Ash Industrial Co., Ltd. | 2009 | China Chemical Reporter2009，，16： | 0 |
| 11 | Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12显示文摘Colorectal cancer (CRC) is a common malignant tumor in the digestive tract, and 30%—85% of CRCs express epidermal growth factor receptors (EGFRs). Recently, treatments using cetuximab, also named C225, an anti-EGFR monoclonal antibody, for CRC have been demonstrated to cause an S492R mutation in EGFR. However, little is known about the biological function of S492R EGFR. Therefore, we attempted to elucidate its biological function in CRC cells and explore new treatment strategies for this mutant form. Our study indicated that EGFR and S492R EGFR accelerate the growth of CRC cells in vitro and in vivo and monoclonal antibody CH12, which specifically recognizes an EGFR tumor-specific epitope, can bind efficiently to S492R EGFR. Furthermore, mAb CH12 showed significantly stronger growth suppression activities and induced a more potent antibody-dependent cellular cytotoxicity effect on CRC cells bearing S492R EGFR than mAb C225.mAb CH12 obviously suppressed the growth of CRC xenografts with S492R EGFR mutations in vivo. Thus, mAb CH12 may be a promising therapeutic agent in treating patients with CRC bearing an S492R EGFR mutation. | Qiongna Dong Bizhi Shi Min Zhou Huiping Gao Xiaoying Luo Zonghai Li Hua Jiang | 2019 | Frontiers of Medicine2019，13，1： | 0 |
| 12 | Battery Full Life Cycle Management and Health Prognosis Based on Cloud Service and Broad Learning显示文摘Dear editor,This letter presents battery full life cycle management and health prognosis based on cloud service and broad learning.Specifically,a cloud-based framework for battery full life cycle management is presented.Then,the broad learning method is proposed for battery state-of-health(SOH)prediction. | Yujie Wang Kaiquan Li Zonghai Chen | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，8： | 0 |
| 13 | Unveiling the parasitic-reaction-driven surface reconstruction in Ni-rich cathode and the electrochemical role of Li_(2)CO_(3)显示文摘Nickel-rich transition-metal oxides are widely regarded as promising cathode materials for high-energydensity lithium-ion batteries for emerging electric vehicles. However, achieving high energy density in Ni-rich cathodes is accompanied by substantial safety and cycle-life obstacles. The major issues of Ni-rich cathodes at high working potentials are originated from the unstable cathode-electrolyte interface, while the underlying mechanism of parasitic reactions towards surface reconstructions of cathode materials is not well understood. In this work, we controlled the Li_(2)CO_(3) impurity content on LiNi_(0.83)Mn_(0.1)Co_(0.07)O_(2) cathodes using air, tank-air, and O_(2) synthesis environments. Home-built high-precision leakage current and on-line electrochemical mass spectroscopy experiments verify that Li_(2)CO_(3) impurity is a significant promoter of parasitic reactions on Ni-rich cathodes. The rate of parasitic reactions is strongly correlated to Li_(2)CO_(3) content and severe performance deterioration of Ni83 cathodes.The post-mortem characterizations via high-resolution transition electron microscope and X-ray photoelectron spectroscopy depth profiles reveal that parasitic reactions promote more Ni reduction and O deficiency and even rock-salt phase transformation at the surface of cathode materials. Our observation suggests that surface reconstructions have a strong affiliation to parasitic reactions that create chemically acidic environment to etch away the lattice oxygen and offer the electrical charge to reduce the valence state of transition metal. Thus, this study advances our understanding on surface reconstructions of Nirich cathodes and prepares us for searching for rational strategies. | Jiyu Cai Zhenzhen Yang Xinwei Zhou Bingning Wang Ana Suzana Jianming Bai Chen Liao Yuzi Liu Yanbin Chen Shunlin Song Xuequan Zhang Li Wang Xiangming He Xiangbo Meng Niloofar Karami Baasit Ali Shaik Sulaiman Natasha A.Chernova Shailesh Upreti Brad Prevel Feng Wang Zonghai Chen | 2023 | Journal of Energy Chemistry2023，，10： | 0 |
| 14 | Combined local therapy and CAR-GPC3 T-cell therapy in advanced hepatocellular carcinoma:a proof-of-concept treatment strategy显示文摘Dear Editor,Available evidence regarding the most suitable treatment strategies for hepatocellular carcinoma(HCC)with inferior vena cava tumor thrombus(IVCTT)is extremely limited,and the median overall survival time for these patients after liver resection is only 17.76 months[1].Other local or systemic treatments for HCC with IVCTT result in a median overall survival time ranging from 5.88 to 15.36 months[1–3].Thus,new therapeutic strategies are urgently needed to improve the survival of HCC patients with IVCTT.Chimeric antigen receptor(CAR)T-cell therapy has seen success in treating B-cell neoplasms with impressive outcomes[4].However,this therapy alone has shown limited efficacy on solid tumors,such as HCC[5]. | Yaoping Shi Donghua Shi Jiachang Chi Dan Cui Xiaoyin Tang Yan Lin Siying Wang Zonghai Li Haojie Jin Bo Zhai | 2023 | Cancer Communications2023，43，9： | 0 |
| 15 | Magneto-mechanical effect of magnetic microhydrogel for improvement of magnetic neuro-stimulation显示文摘Superparamagnetic iron oxide(SPIO)nanoparticles play an important role in mediating precise and effective magnetic neurostimulation and can help overcome limitations related to penetration depth and spatial resolution.However,nanoparticles readily diffuse in vivo,decreasing the spatial resolution and activation efficiency.In this study,we employed a microfluidic means to fabricate injectable microhydrogels encapsulated with SPIO nanoparticles,which significantly improved the stability of nanoparticles,increased the magnetic properties,reinforced the stimulation effectivity.The fabricated magnetic microhydrogels were highly uniform in size and sphericity,enabling minimally invasive injection into brain tissue.The long-term residency in the cortex up to 22 weeks and the safety of brain tissue were shown using a mouse model.In addition,we quantitatively determined the magneto-mechanical force yielded by only one magnetic microhydrogel using a video-based method.The force was found to be within 7–8 pN under 10 Hz magnetic stimulation by both theoretical simulation and experimental measurement.Lastly,electrophysiological measurement of brain slices showed that the magnetic microhydrogels offer significant advantages in terms of neural activation relative to dissociative SPIO nanoparticles.A universal strategy is thus offered for performing magnetic neuro-stimulation with an improved prospect for biomedical translation. | Le Xue Qing Ye Linyuan Wu Dong Li Siyuan Bao Qingbo Lu Sha Liu Dongke Sun Zonghai Sheng Zhijun Zhang Ning Gu Jianfei Sun | 2023 | Nano Research2023，16，5： | 0 |
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