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| 1 | Temporal and spatial variations of the active layer along the Qinghai-Tibet Highway in a permafrost region显示文摘Using monitored active layer thickness(ALT) and environmental variables of 10 observation fields along the Qinghai-Tibet Highway in permafrost region of the Qinghai-Tibetan Plateau(QTP),a model for ALT estimation was developed.The temporal and spatial characteristics of the ALT were also analyzed.The results showed that in the past 30 years ALT in the study region increased at a rate of 1.33 cm a-1.Temperatures at the upper limit of permafrost and at 50 cm depth,along with soil cumulative temperature at 5 cm depth also exhibited a rising trend.Soil heat flux increased at a rate of 0.1 Wm-2 a-1.All the above changes demonstrated that the degradation of permafrost happened in the study region on the QTP.The initial thawing date of active layer was advanced,while the initial freezing date was delayed.The number of thawing days increased to a rate of 1.18 da-1.The variations of active layer were closely related to the permafrost type,altitude,underlying surface type and soil composition.The variations were more evident in cold permafrost region than in warm permafrost region,in high-altitude region than in low-altitude region,in alpine meadow region than in alpine steppe region;and in fine-grained soil region than in coarse-grained soil region. | LI Ren ZHAO Lin DING YongJian WU TongHua XIAO Yao DU ErJi LIU GuangYue QIAO YongPing | 2012 | Chinese Science Bulletin2012，57，35： | 51 |
| 2 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 3 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 4 | Probucol attenuates ethanol‐induced liver fibrosis in rats by inhibiting oxidative stress, extracellular matrix protein accumulation and cytokine production显示文摘 | Xuesong Su Yanqiu Wang Guangyu Zhou Xu Yang Rui Yu Yan Lin Changqing Zheng | 2014 | Clin Exp Pharmacol Physiol2014，，1： | 3 |
| 5 | Effects of antiviral therapy on hepatitis B virus reactivation and liver function after resection or chemoembolization for hepatocellular carcinoma显示文摘 | Xiang‐Ming Lao Guangyu Luo Liang‐Tao Ye Cheng Luo Ming Shi Dian Wang Rongping Guo Minshan Chen Shengping Li Xiaojun Lin Yunfei Yuan | 2013 | Liver Int2013，，4： | 3 |
| 6 | The influence of ^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography on the N-and M-staging and subsequent clinical management of intrahepatic cholangiocarcinoma显示文摘Background:Intrahepatic cholangiocarcinoma(ICC)is a highly metastatic cancer.^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography(^(18)F-FDG PET/CT)enables sensitive tumor and metastasis detection.Our aim is to evaluate the influence of pre-treatment PET/CT on the N-and M-staging and subsequent clinical management in ICC patients.Methods:Between August 2010 and August 2018,660 consecutive ICC patients,without prior anti-tumor treatments nor other malignancies,were enrolled.The diagnostic performance of PET/CT on the N-and M-staging was compared with conventional imaging,and the preoperative staging accuracy and treatment re-allocation by PET/CT were retrospectively calculated.Survival difference was compared between patients receiving PET/CT or not after propensity score matching.Results:Patients were divided into group A(n=291)and group B(n=369)according to whether PET/CT was performed.Among 291 patients with both PET/CT and conventional imaging for staging in group A,PET/CT showed significantly higher sensitivity(83.0%vs.70.5%,P=0.001),specificity(88.3%vs.74.9%,P<0.001)and accuracy(86.3%vs.73.2%,P<0.001)than conventional imaging in diagnosing regional lymph node metastasis,as well as higher sensitivity(87.8%vs.67.6%,P<0.001)and accuracy(93.5%vs.89.3%,P=0.023)in diagnosing distant metastasis.Overall,PET/CT improved the accuracy of preoperative staging from 60.1%to 71.8%(P<0.001),and modified clinical treatment strategy in 5.8%(17/291)of ICC patients,with unique roles in different tumor-node-metastasis(TNM)stages.High tumor-to-non-tumor ratio(TNR)predicted poor overall survival[hazard ratio(HR)=2.17;95%confidence interval(CI):1.49-3.15;P<0.001].Furthermore,patients performing PET/CT had longer overall survival compared with those without PET/CT(HR=0.74;95%CI:0.58-0.93;P=0.011)after propensity score matching.Conclusions:PET/CT was valuable for diagnosing regional lymph node metastasis and distant metastasis in ICC patients,and facilitated accurate tumor staging and optimal treatment allocation. | Youpei Lin Huanhuan Chong Guohe Song Chenhao Zhang Liangqing Dong Ling Aye Fei Liang Shuaixi Yang Mengsu Zeng Guangyu Ding Shu Zhang Jieyi Shi Aiwu Ke Xiaoying Wang Jian Zhou Jia Fan Qiang Gao | 2022 | Hepatobiliary Surgery and Nutrition2022，11，5： | 3 |
| 7 | Giant Valley Coherence at Room Temperature in 3R WS_(2) with Broken Inversion Symmetry显示文摘Breaking the space-time symmetries in materials can markedly influence their electronic and optical properties.In 3R-stacked transition metal dichalcogenides,the explicitly broken inversion symmetry enables valley-contrasting Berry curvature and quantization of electronic angular momentum,providing an unprecedented platform for valleytronics.Here,we study the valley coherence of 3R WS_(2) large single-crystal with thicknesses ranging from monolayer to octalayer at room temperature.Our measurements demonstrate that both A and B excitons possess robust and thickness-independent valley coherence.The valley coherence of direct A(B)excitons can reach 0.742(0.653)with excitation conditions on resonance with it.Such giant and thickness-independent valley coherence of large single-crystal 3R WS_(2) at room temperature would provide a firm foundation for quantum manipulation of the valley degree of freedom and practical application of valleytronics. | Luojun Du Jian Tang Jing Liang Mengzhou Liao Zhiyan Jia Qinghua Zhang Yanchong Zhao Rong Yang Dongxia Shi Lin Gu Jianyong Xiang Kaihui Liu Zhipei Sun Guangyu Zhang | 2019 | Research2019，，1： | 2 |
| 8 | Comparison of six generalized linear models for occurrence of lightning-induced fires in northern Daxing'an Mountains,China显示文摘The occurrence of lightning-induced forest fires during a time period is count data featuring over-dispersion(i.e., variance is larger than mean) and a high frequency of zero counts. In this study, we used six generalized linear models to examine the relationship between the occurrence of lightning-induced forest fires and meteorological factors in the Northern Daxing'an Mountains of China. The six models included Poisson, negative binomial(NB), zeroinflated Poisson(ZIP), zero-inflated negative binomial(ZINB), Poisson hurdle(PH), and negative binomial hurdle(NBH) models. Goodness-of-fit was compared and tested among the six models using Akaike information criterion(AIC), sum of squared errors, likelihood ratio test, and Vuong test. The predictive performance of the models wasassessed and compared using independent validation data by the data-splitting method. Based on the model AIC, the ZINB model best fitted the fire occurrence data, followed by(in order of smaller AIC) NBH, ZIP, NB, PH, and Poisson models. The ZINB model was also best for predicting either zero counts or positive counts(C1). The two Hurdle models(PH and NBH) were better than ZIP,Poisson, and NB models for predicting positive counts, but worse than these three models for predicting zero counts.Thus, the ZINB model was the first choice for modeling the occurrence of lightning-induced forest fires in this study,which implied that the excessive zero counts of lightninginduced fires came from both structure and sampling zeros. | Futao Guo Guangyu Wang John L. Innes Zhihai Ma Aiqin Liu Yurui Lin | 2016 | Journal of Forestry Research2016，27，2： | 2 |
| 9 | Electronic structure of exfoliated millimeter-sized monolayer WSe2 on silicon wafer显示文摘The mono layer WSe2 is in teresting and important for future application in nanoelectronics,spintronics and valleytronics devices,because it has the largest spin splitting and Ion gest valley coherence time among all the known monolayer transition-metal dichalcogenides(TMDs).Toobtain the large-area monolayer TMDs'crystal is the first step to manu facture scalable and high-performance electronic devices.In this letter,we have successfully fabricated millimeter-sized mono layer WSe2 single crystals with very high quality,based on our improved mecha nicalexfoliation method.With such superior samples,using standard high resolution angle-resolved photoemission spectroscopy,we didcomprehe nsive electronic band structure measurements on our mono layer WSe2.The overall band features point it to be a 1.2 eV direct bandgap semico nductor.Its spin splitting of the valence band at K point is found as 460 meV,which is 30 meV less than the corresponding band splitting in its bulk counterpart.The effective hole masses of valence bands are determined as 2.344 me atГ,and 0.529 me as well as 0.532 meat K for the upper and lower branch of splitting ban ds,respectively.And screening effect from substrate is shown to substa ntially impact onthe electronic properties.Our results provide importa nt insights into band structure engineering in mono layer TMDs.Our mono layer WSe2 crystals may constitute a valuable device platform. | Wenjuan Zhao Yuan Huang Cheng Shen Cong Li Yongqing Cai Yu Xu Hongtao Rong Qiang Gao Yang Wang Lin Zhao Lihong Bao Qingyan Wang Guangyu Zhang Hongjun Gao Zuyan Xu Xingjiang Zhou Guodong Liu | 2019 | Nano Research2019，12，12： | 2 |
| 10 | Modeling liquid water effects in the gas diffusion and catalyst layers of the cathode of a PEM fuel cell 显示文摘 | Lin Guangyu He Wensheng Nguyen T V | 2004 | J Electrochem Soc2004，151，12： | 1 |
| 11 | The Application of Chaotic Oscillators to Weak Signal Dectection显示文摘 | WANG Guangyu CHEN Dajun LIN Jianya CHEN Xing | 1999 | IEEE Transactions on Industrial Electronics1999，46，2： | 1 |
| 12 | How G-quadruplex topology and loop sequences affect optical properties of DNA-templated silver nanoclusters显示文摘在模板 DNA 的银 nanoclusters (DNA-Ag NC ) 的制造的学习,模板怎么影响 nanoclusters 的荧光,仍然保持不清楚,并且它有是挑战理解在 DNA 模板和 Ag NC 的性质之间的关联。在这个方面,基于一系列在结构上的合理设计定义 intramolecular G 四倍,我们与 1:2 的定义 G-tetrad-to-silver 比率准备了 G-quadruplex-templated Ag NC。我们用圆形的二色性,和扑灭和排放光谱学在 DNA-Ag NC 的荧光上评估了 G 四倍的拓扑学和环序列的效果。有反平行的拓扑学的 G 四倍的模板被发现与平行、混合的配置相比与更强壮的荧光生产 Ag NC。邻近 G 四个的循环库在循环的中间与那些相比在 Ag NC 的荧光上有更重要的影响,与大部分展出是有害的改进效果和胸腺嘧啶的腺嘌。通常,在邻近 G 四个的环与腺嘌有反平行的拓扑学的 G 四倍将是为生产的好模板高度荧光灯 Ag NC。这是第一研究集中于在 G 四倍的拓扑学 / 顺序和 Ag NC 的光性质之间的关联。我们希望这研究的结果将便于在 G 四倍的模板和 Ag NC 之间的关联的更深入的理解,并且帮助理解并且利用他们的唯一的属性。 | Guangyu Tao Yang Chen Ruoyun Lin Jiang Zhou Xiaojing Pei Feng Liu Na Li | 2018 | Nano Research2018，11，4： | 1 |
| 13 | Determination ofHeavy Metal Ions in Chinese Herbal Medicine by Micro-wave Digestion and RP-HPLC with UV-Vis Detection显示文摘 | Yang Yaling Yan Guangyu Lin Qiang | 2004 | Microchimica Acta2004，144，4： | 1 |
| 14 | Determination of heavy metal in chinese herbal medicine by microwave digestion and RP-HPLC with uv-vis detection 显示文摘 | Yang Yaling Yang Guangyu Lin Qiang | 2004 | Microchirnica Aeta2004，144，4： | 1 |
| 15 | Follow-Up of High-Intensity Focused Ultrasound Treatment for Patients with Hepatocellular Carcinoma显示文摘 | Guoliang Xu Guangyu Luo Longjun He Jianjun Li Hongbo Shan Rong Zhang Yin Li Xiaoyan Gao Shiyong Lin Guobao Wang | 2011 | Ultrasound in Medicine & Biology2011，，12： | 1 |
| 16 | Optimization of Ultrasonic Extraction Process of Oenanthe benghalensis Polysaccharide by Orthogonal Test显示文摘[Objectives] The research aimed to explore extraction method of Oenanthe benghalensis polysaccharide,and determine the optimal process of its ultrasonic extraction by orthogonal test. [Methods] Phenol-sulfuric acid method was used to determine polysaccharide's content. Based on single-factor experiment and orthogonal test,the influences of solid-liquid ratio( A),ultrasonic extraction temperature( B),ultrasonic power( C) and ultrasonic time( D) on extraction rate of O. benghalensis polysaccharide were studied,and the optimal process of ultrasonic extraction was selected. [Results] The influence order of solid-liquid ratio( A),ultrasonic extraction temperature( B),ultrasonic power( C) and ultrasonic time( D) on extraction rate of O. benghalensis polysaccharide was A > D > B > C. Via the orthogonal test,it was determined that the optimal extraction condition of O. benghalensis polysaccharide was as below: solid-liquid ratio 1∶ 25( g/mL),extraction temperature 60℃,extraction power 80 W,extraction time 40 min. Under the condition,extraction rate of O. benghalensis polysaccharide was9. 80%. [Conclusions] The process could provide the reference basis for extracting and producing O. benghalensis polysaccharides. | Liufu LU Aiyue LUO Bingyang LIN Zhenlian XIE Guangyu GAN Xiuzhen HUANG Zhidong LEI Shimei CHEN Suoyi HUANG | 2018 | Medicinal Plant2018，9，5： | 1 |
| 17 | In-situ growth of ZnO particles on bamboo pulp fabric and its anti-UV property显示文摘 | Guangyu Zhang Hong Lin Hideaki Morikawa Mikihiko Miura | 2013 | Fibers and Polymers2013，，： | 1 |
| 18 | Performance Evaluation of an Anti-Lock Braking System for Electric Vehicles with a Fuzzy Sliding Mode Controller显示文摘 | Jingang Guo Xiaoping Jian Guangyu Lin | 2014 | Energies2014，7，： | 1 |
| 19 | The Application of Chaotic Oscillators to Weak Signal Detection显示文摘 | Wang Guangyu Chen Dajun Lin Jiangya | 1999 | IEEE Trans on Industrial Electronics1999，46，2： | 1 |
| 20 | The Establishment and Application of Mobile Electronic Surveillance System for Infectious Diseases with the Help of China—Sierra Leone,2016-Present显示文摘Introduction:Infectious disease surveillance has long been a challenge for low-income countries like Sierra Leone.Traditional approaches based on paper and Short Message Service(SMS)were subject to severe delays in obtaining,transmitting,and analyzing information.Methods:During the China aid operation for fighting Ebola since the end of 2014,a mobile electronic surveillance system for infectious diseases(MESSID)was developed in collaboration with the Republic of Sierra Leone Armed Forces(RSLAF),which comprised an Android-based reporting system and a complementary web-based program designed by Active Server Page.NET(ASP.NET)with the main functions including surveillance,real-time reporting,and risk assessment of infectious diseases.Results:MESSID was successfully registered in June 2016 and had been used by all medical and health institutions in RSLAF.From June 1,2016 to July 5,2021,34,419 cases were diagnosed with 47 infectious diseases of 5 categories,with a total of 42 clinical symptoms.Compared to traditional approaches based on paper and SMS,the MESSID showed flexibility,high efficiency,convenience,and acceptability.Discussion:MESSID is an accessible tool for surveillance of infectious diseases in Sierra Leone and possibly in other African countries with similar needs,capable of improving timeliness of disease reporting,thus rendering a timely outbreak detection and response. | Guangyu Zhao Haorong Chen Yanfeng Yan Jiafu Jiang Lei Lin Baogui Jiang Foday Sahr Stephen Sevalie Qiang Xu Jinjin Chen Henry Saidu Bangura Kandeh Bassie Kargbo Yajun Song Wei Liu Liqun Fang Yansong Sun | 2021 | China CDC weekly2021，3，36： | 1 |
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