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    题名 作者 年代 出处 被引量
12019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W 2020中华高血压杂志2020,28,3:516
2全颗粒饲料对奶牛生产性能的影响显示文摘饲料中的中性洗涤纤维(NDF)含量和饲料颗粒直径是影响瘤胃功能的重要因素。试验评估了以颗粒饲料为主的奶牛瘤胃健康情况、NDF消化率和生产性能。选取8头荷斯坦母牛(336±30 d,体重346±35 kg),随机分配到交叉重复试验组中,奶牛安置于牛栏,自由采食。试验期为3周,前两周是适应期,最后一周为数据收集期。各组饲粮原料相同,但物理形式不同,分为全混合日粮(TMR)和颗粒料(直径=8 mm)。两组间物理有效NDF(pe NDF)不同,TMR组为39.8%,颗粒料组为11.8%。在试验过程中,干物质采食量(DMI)、饮水量、瘤胃反刍时间、瘤胃温度和pH情况均记录。3周后收集粪样,确定潜在的可消化NDF总消化率(pdNDF)。每阶段结束后计算平均日增重和饲料转化率。颗粒料组的DMI、DMI/体重和饮水量更高。而两组间平均日增重和饲料转化率无显著差异。颗粒料组的瘤胃反刍时间为241 min·d-1低于TMR组的507 min·d-1。饲料的不同物理外形对瘤胃温度、瘤胃pH无显著影响。TMR组的pdNDF总消化率为90.25%高于颗粒料组的86.82%。试验结果表明,动物易接受完整的颗粒饲料,DMI较高,且反刍时间减少,但瘤胃pH无显著变化。TMR组的pdNDF消化率显著增加。尽管两组奶牛在DMI和纤维消化方面表现不同,但总体表现相似,两组饲料的保存时间与其物理形式有关。在短期内,提供能满足NDF需求的完全颗粒饲料可改善瘤胃健康状况和动物生产性能,而较长时间的数据则需要进一步试验。Wang J Yang M Cao M Lin Y Che L Q Duraipandiyan V Al-Dhabi N A Fang Z F Xu S Y Feng B Liu G Wu D Bonfante E Palmonari A Mammi L Canestrari G Fustini M Formigoni A 2016饲料博览2016,0,12:2
3胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 2017中华高血压杂志2017,25,9:2
4Noor Grafting of sodium carboxymethylcellulose (CMC) with glycidyl methacrylate and development of UV curable coatings from CMC-g-GMA induced by cationic photoinitiators显示文摘Lin Ong Hui Kumar R N Rozman H D 2005Carbohydrate Polymers2005,59,1:1
5Multiplicity of positive periodic solutions to second order differential equations 显示文摘CHU J F LIN X N JIANG D Q et 81 2006Bulletin of the Aus- tralian Mathematical Society2006,73,2:1
6Flexural streamwise vibration of gate plates under vortex action 显示文摘THANG N D LIN Q H NAUDASCHER E 1987Proc Int on Flow-Induced Vibrations1987,37,2:1
7CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney显示文摘Soos T J Sims T N Barisoni L Lin K Littman D R Dustin M L 2006Kidney lnt2006,70,:1
8Aheruative splicing in the vohage-gated sodium channel DmNav regulates activation, inactivation, and persistent cun'ent显示文摘LIN W H WRIGHT D E MURARO N I et ol 2009Journal of Neu- rophysiology2009,102,3:1
9HDAC inhibitor reduces cytokine storm and facilitates induction of chimerism that reverses lupus in anti-CD3 conditioning regimen显示文摘Li N Zhao D Kirschbaum M Zhang C Lin C L Todorov I 2008Proc Natl Acad Sci USA2008,105,:1
10Graphene field-effect tran- sistors with high on/off current ratio and large transport band gap at room temperature显示文摘Xia F N Farmer D B Lin Y M 2010Nano Lett2010,10,2:1
11Particle damage and exposure analysis in HPGR crushing of selected copper ores for column leaching显示文摘KODALI P DHAWAN N DEPCI T LIN C L MILLER J D 2011Minerals Engineering2011,24,13:1
12Allergic dysregulation and hyperimmunoglobulin emia E in Foxp3 mutant mice 显示文摘Lin W Truong N Grossman WJ Haribhai D Williams CB Wang J 2005J Allergy Clin Immunol2005,116,5:1
13Acute thoraeolumbar burst fractures: a new view of loading mechanisms 显示文摘Langrana N A Harten R D Lin D C 2002Spine2002,27,5:1
14Geometric design of roller gear cam reducers 显示文摘TSAY D M HUANG N J LIN B J 1999Transactions of the ASME1999,121,:1
15Microstructurerefinement of sintered alumina by a twostepsinteringtechnique显示文摘Lin F J T Jonghe L C D Rahaman M N 1997Journal of the American Ceramic Society1997,80,9:1
16Sorption of the herbicide terbuthylazine in two New Zealand forest soils amended with biosolids and bioehars 显示文摘Wang H L Lin K D Hou Z N 2010Journal of Soils and Sediments2010,10,2:1
17A dynamic core loss model for soft ferromagnetic and power ferrite materials in transient finite element analysis显示文摘LIN D ZHOU P FU W N 2004IEEE Transactions on Magnetics2004,40,2:1
18GA-optimized fuzzy logic control of a large-scale building forseismic loads显示文摘Shook D A Roschke P N Lin P Y 2008Engineering Structures2008,30,2:1
19Isolation of artemisinin (Qinghaosu) from Artemisia annua growing in the United States显示文摘Klayman D L Lin A J Acton N 1984J Nat Prod1984,47,40:1
20Sorption of the herbicide terbuthy-lazine in two New Zealand forest soils amended with biosolids andbiochars显示文摘Wang H L Lin K D Hou Z N 2010Journal of Soils and Sediments^2010,10,2:1
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