|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 3 | Study and Application of Polarographic Catalytic Wave of Chlordiazepoxide in the Presence of Persulfate显示文摘Polarographic catalytic wave of chlordiazepoxide in the presence of K2S2O8 was studied in aqueous and DMF/H2O mixed solutions,The results showed that a single reduction wave in alkaline medium was the reduction of the N=C bond in 1,2-position of chlordiazepoxide via an intermediate free radical in two one-electron successive additions,When K2S2O8 was present,the free radical of the N=C bond was oxidized to regenerate the original,producing a parallel catalytic wave of chlordiazepoxide,It was determined that the apparent rate constant kf of the oxidation reaction was 3.2×10^3 mol^-1.L.s^-1,Using the catalytic wave the trace of chlordiazepoxide can be determined by linear-potential scan polarography,In NH3/NH4Cl(pH 10.2±0.1,0.12mol/L)/K2S2O8(0.016mol/L)supporting electrolyte,the second-order derivative peak current of the catalytic wave was rectilinear to chlordiazepoxide concentration in the range of 3.20×10^-8-1.60×10^-7,1.60×10^-7-1.44×10^-6 and 1.44×10^-6-1.44×10^-5mol/L,respectively.The limit of detection was 9.0×10^-9mol/L. | Guo, W Lin, H Liu, LM Guo, ZA Song, JF | 2002 | Chinese Journal of Chemistry2002，20，5： | 3 |
| 4 | Purification and Partial Characterization of Immobilization Antigens from Ichthyophthirius multifiliis 显示文摘 | Lin Tian-Long Dickerson H W | 1992 | J Protozoal1992，39，4： | 2 |
| 5 | Passive Immunization of Channel Catfish (Ictalurus punctatus) against the Ciliated Protozoan Parasite Ichthyophthirius multifiliis by Use of Murine Monoclonal Antibodies显示文摘 | Lin Tian-Long Clark T G Dickerson H W | 1996 | Infection and Immunity1996，64，10： | 2 |
| 6 | The study of supercritical carbon dioxide extraction for Ganoderma lucidum显示文摘 | Hsu R C Lin B H Chen C W | 2001 | Ind Eng Chem Res2001，40，： | 2 |
| 7 | Cerebral oxygen extraction fraction and cerebral venous blood volume measurements using MRI: effects of magnetic field variation显示文摘 | An H Lin W | 2002 | Magn Reson Med2002，47，5： | 2 |
| 8 | Generation of nematic liquid crystal alignment with polyimides exposed to linearly polarized light of long wavelength显示文摘 | Y H Wang Y Z Chen Z W Lin H. D. Sun J. S. Fan | | 0，，： | 2 |
| 9 | 查看详情显示文摘 | Y H Wang Y Z Chen Z W Lin H. D. Sun | | 0，，： | 2 |
| 10 | Fine mapping and characterization of quantitative trait loci Hd4 and Hd5 controlling heading date in rice显示文摘 | LIN H X LIANG Z W SASAKI T | 2003 | Breeding Science2003，53，： | 1 |
| 11 | Adaptive multiple fault detection and alarm processing for loop system with probabilistic network显示文摘 | Lin W M Lin C H Sun Z C | 2004 | IEEE Transactions on Power Delivery2004，19，1： | 1 |
| 12 | Strategic shotgun proteomics approach for efficient construction of an expression map of targeted protein families in hepatoma cell lines显示文摘 | Lee C L Hsiao H H Lin C W | 2003 | Proteomics2003，3，12： | 1 |
| 13 | Non-stationary random seismic responses of multi-support structuresin evolutionary inhomogeneous random fields显示文摘 | Li J J Zhang W S | 1997 | Earthquake Engineering and Structural Dynamics1997，26，： | 1 |
| 14 | The effect of excess Zn on mineral nutrition and antioxidative response in rapeseed seedlings显示文摘 | WANG CH ZHANG S H WANG P F HOU J ZHANG W J LI W LIN ZH P | 2009 | Chemosphere2009，75，： | 1 |
| 15 | Immunopathological effects of porcine circovims type 2 (PCV2) on swine alveolar macrophages by in vitro inoculation 显示文摘 | Chang H W Jeng C R Lin TL | 2006 | Veterinary Immunology and Immunopathology2006，110，34： | 1 |
| 16 | A mesh reconstruction algorithm driven by an intrinsic property of a point cloud显示文摘 | Lin H W Tai C L Wang G J | 2004 | Computer-Aided Design2004，36，1： | 1 |
| 17 | Evaluation of the ability of an artificial neural net work model to assess the variation of groundwater quality in an area of black foot disease in Taiwan 显示文摘 | Kuo Y M Liu C W Lin K H | 2004 | Water Research2004，38，1： | 1 |
| 18 | Label-free colorimetric assay for methyltransferase activity based on a novel methylation-responsive DNAzyme strategy显示文摘 | Li W Liu Z Lin H | 2010 | Anal Chern2010，82，5： | 1 |
| 19 | The wealth effects of CEO turnover on Taiwanese listed electronic com- panies 显示文摘 | Wang Y H Lin C T Lin W R | 2007 | Journal of Financial Economics2007，19，20： | 1 |
| 20 | Idiopathic hypereosinophilia syn-drome with loeffler endocarditis,embolic cerebral infarction,and left hy-dranencephaly:a case report显示文摘 | Lin C H Chang W N Chua S | 2009 | Acta Neurol Taiwan2009，18，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员