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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | Protective effects of human umbilical cord mesenchymal stem cell-derived conditioned medium on ovarian damage显示文摘Chemotherapeutic agents are extensively used to treat malignancies.However,chemotherapy-induced ovarian damage and reduced fertility are severe side effects.Recently,stem cell transplantation has been reported to be an effective strategy for premature ovarian insufficiency(POI)treatment,but safety can still be an issue in stem cell-based therapy.Here,we show the protective effects of human umbilical cord mesenchymal stem cell-derived conditioned medium(hUCMSC-CM)on a cisplatin(Cs)-induced ovarian injury model.hUCMSC-CM can relieve Cs-induced depletion of follicles and preserve fertility.In addition,hUCMSC-CM can decrease apoptosis of oocytes and granulosa cells induced by Cs.RNA sequencing analysis reveals the differentially expressed genes of ovaries after Cs and hUCMSC-CM treatments,including genes involved in cell apoptosis.Furthermore,we show that the granulocyte colony-stimulating factor(G-CSF)/phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)pathway plays an important role in protecting granulosa cells from Cs-induced apoptosis.Together,we confirm the protective effects of hUCMSC-CM on ovarian reserve and fertility in mice treated with Cs,highlighting the remarkable therapeutic effects of hUCMSC-CM. | Liming Hong Long Yan Zhimin Xin Jie Hao Wenjing Liu Shuyu Wang Shujie Liao Hongmei Wang Xiaokui Yang | 2020 | Journal of Molecular Cell Biology2020，12，5： | 7 |
| 3 | The Quality Evaluation and Hydrocarbon Generation and Expulsion Characteristics of Permian Lucaogou Formation Source Rocks in Jimusar Sag,Junggar Basin显示文摘1 Introduction The exploration practice in the Junggar Basin revealed that tight oils were self-generated and self-preserved in the Lucaogou formation,Jimusar sag.Because of the tight reservoir and frequent source-reservoir interbedding,the hydrocarbon supplying ability of source rock is the | WU Luya PANG Xiongqi ZHOU Liming PANG Hong | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 6 |
| 4 | Inheritance of growth and survival in two 9-year-old, open-pollinated progenies of an advanced breeding population of Chinese firs in southeastern China显示文摘Tree growth traits(tree height,DBH and stem volume) and survival from two 9-year-old,open-pollinated progeny tests of Chinese fir were investigated for heritability,genotype 9 environment interaction,age-age genetic correlation and selection efficiency.The 97 and 79 families planted at two sites were collected from the thirdcycle seed orchard.Individual heritability was estimated between 0.05 and 0.21 for tree height,DBH,and volume and between 0.45 and 1.0 for survival.Family heritability was between 0.20 and 1.14.Significant genotype 9 environment interaction was observed for the three growth traits.Type B genetic correlation was between 0.41 and 0.67 with an increasing trend as tree grows.High age-age genetic correlation was observed with correlation reaching 0.9 after age 4 for height,DBH,and volume.The genetic gains were estimated at 3.26,3.39 and 5.98 % for tree height,DBH,and volume with 10 % selection intensity.The implication for advanced tree breeding in Chinese fir is discussed. | Renhua Zheng Zhou Hong Shunde Su Liming Bian Hui Xiao Jisen Shi Harry X. Wu | 2016 | Journal of Forestry Research2016，27，5： | 6 |
| 5 | Immune regulation of hydrogen sulfide in children with acute lymphoblastic leukemia显示文摘 | Du Shuxu Jia Yongrui Tang Hong Sun Yangling Wu Wanshui Sun Liming Du Junbao Geng Bin Tang Chaoshu Jin Hongfang | 2014 | Chinese Medical Journal2014，，21： | 5 |
| 6 | Abnormal Adipokines Associated with Various Types of Obesity in Chinese Children and Adolescents显示文摘Objective To explore the role of adipokines including insulin, resistin, leptin, adiponectin, acylation stimulating protein (ASP) and complement C3 (C3) in various types of obesity (peripheral obesity, abdominal obesity and mixed obesity) in Chinese children and adolescents, and their relationships with body size and pubertal development. Methods Children and adolescents (n=3 508) aged 6 to 18 years, with 1 788 boys and 1 720 girls were assessed for body mass index, waist circumference, pubertal development, blood insulin, resistin, leptin, adiponectin, ASP and C3 levels. Three types of obesity [peripheral obesity (n=43), abdominal obesity (n=473), mixed obesity (n=1 187)] and non‐obese control (n=1 805) were defined with combined use of Chinese body mass index and waist circumference criteria. Results Serum resistin, leptin and adiponectin levels were higher in girls than those in boys (all P<0.01). Insulin and leptin increased and adiponectin decreased across five Tanner stages in both girls and boys (all P<0.001), while ASP changed only in girls (P<0.001) and C3 only in boys (P<0.001). Insulin, leptin and ASP were higher, but adiponectin was lower in all three types of obesity vs. the non‐obese control (all P<0.05). The greatest abnormalities of all six adipokines were found in the mixed obesity group. With inclusion of body mass index and waist circumference in simultaneous regression analyses, both body size indices were independently and significantly correlated with insulin, leptin and adiponectin after age and gender adjustment. Compared with waist circumference, the body mass index was stronger in interpreting insulin, leptin, adiponectin and ASP levels, whereas it was weaker in explaining variance of plasma C3. Conclusions Obese children have a worse metabolic profile with high insulin, resistin, leptin, ASP and C3, and low adiponectin levels. The adipokine profile in mixed obesity is worse than that in peripheral or abdominal obesity. Identification of obese subjects with a malignant adipokine profile using a combination of body mass index and waist circumference is important for the prevention of obesity‐related disease. | ZHANG MeiXian ZHAO XiaoYuan LIMing CHENG Hong HOU DongQing WEN Yu Katherine CIANFLONE MI Jie | 2011 | Biomedical and Environmental Sciences2011，24，1： | 4 |
| 7 | Changes of sulfur dioxide, nuclear factor-κB, and interleukin-8 levels in pediatric acute lymphoblastic leukemia with bacterial inflammation显示文摘 | Wu Wanshui Jia Yongrui Du Shuxu Tang Hong Sun Yangling Sun Liming | 2014 | Chinese Medical Journal2014，，23： | 4 |
| 8 | Using nuclear genes to reconstruct angiosperm phylogeny at the species level: A case study with Brassicaceae species显示文摘被子植物发展史用 organellar 序列广泛地被调查了;用原子基因的最近的努力也在重建是成功的在家庭或更深的层次的被子植物发展史。然而,原子基因是否在在一个类理解在种之间的关系也是有效的,不是清楚的。这里我们在场在有原子基因的通用、特定的层次的发展史的案例研究,把 Brassicaceae taxa 用作例子。Brassicaceae 包括各种各样的庄稼和模型植物 Arabidopsis thaliana。最近的研究证明原子基因能在 Brassicaceae 提供在部落和更大的系之间的解决得好的关系,但是很少种类在任何给定的类被包括。我们在场有在每在为 65 taxa 的一个总数的 Brassicaceae 以内的五个类的多重种类的发展史用三编码蛋白质的原子基因, MLH1, SMC2,和 MCM5,与约多达 10, 200 基于对(在 exons 和 introns ) 。最大的可能性的和分开的基因区域和联合数据的贝叶斯的分析在各种各样的种系发生的深度揭示高分辨率。在这里的类之间的关系与以前的结果大部分适合,与在种水平的进一步的分辨率。另外,我们第一次与部落 Camelineae 报导 Cardamine rockii 的亲密关系而不是另外的 Cardamine 成员。另外,我们报导在三点的顺序分叉铺平:越过被子植物,在 Brassicaceae 种类之中,并且在 Arabidopsis 生态型之间。我们的结果为很多个 Brassicaceae 成员提供柔韧的种类级的发展史并且为相对最近的 clades 在保存原子数据的种系发生的用途上支持一个乐观观点。 | Liming Cai Hong Ma | 2016 | Journal of Systematics and Evolution2016，54，4： | 3 |
| 9 | Genome-wide identification and cold stress-induced expression analysis of the CBF gene family in Liriodendron chinense显示文摘Cold-resistance pathways that operate in model plants such as Arabidopsis thaliana and Oryza sativa have been studied extensively.It has been found that CBF genes play an important role in plant cold resistance.Liriodendron chinense,a tree known for its graceful tree shape and widely spread in south China,has weak cold tolerance.However,little is known about its response to cold.To further study the function of L.chinense CBF gene family,we started by characterizing all members of this gene family in the L.chinense genome and their expression profiling.Phylogenetic analysis found that 14 CBF genes in L.chinense are more closely related to their homologues in woody plants and A.thaliana than those in O.sativa.Cis-acting elements and GO analysis showed that some LcCBF genes participated in the biological process of cold stress response.The transcriptomic and RT-qPCR data showed that most of LcCBF genes displayed an initially increasing and subsequently decreasing trend during cold stress course and the expression profile of each member was different.Some LcCBF genes exhibited a different abundance in callus,root,stem and leaf tissues.The structure and expression characteristics of LcCBF genes imply that they may have similar and different functions in response to cold stress conditions.The identification and analysis of LcCBF gene family have laid the foundation for future studies into L.chinense cold stress mechanisms and for the cultivation of cold-resistance cultivars. | Yuanlin Guan Siqin Liu Weihuang Wu Kaiyue Hong Rongxue Li Liming Zhu Yang Liu Ye Lu Jinhui Chen Liming Yang Jisen Shi | 2021 | Journal of Forestry Research2021，32，6： | 3 |
| 10 | Reversible Al^(3+) storage mechanism in anatase TiO_(2) cathode material for ionic liquid electrolyte-based aluminum-ion batteries显示文摘Rechargeable aluminum ion battery(AIB) with high theoretical specific capacity, abundant elements and low cost engages considerable attention as a promising next generation energy storage and conversion system. Nevertheless, to date, one of the major barriers to pursuit better AIB is the limited applicable cathode materials with the ability to store aluminum highly reversibly. Herein, a highly reversible AIB is proposed using mesoporous TiO2 microparticles(M-TiO2) as the cathode material. The improved performance of Ti O2/Al battery is ascribed to the high ionic conductivity and material stability, which is caused by the stable architecture with a mesoporous microstructure and no random aggregation of secondary particles. In addition, we conducted detailed characterization to gain deeper understanding of the Al^(3+) storage mechanism in anatase Ti O2 for AIB. Our findings demonstrate clearly that Al^(3+)can be reversibly stored in anatase TiO2 by intercalation reactions based on ionic liquid electrolyte. Especially, DFT calculations were used to investigate the accurate insertion sites of aluminum ions in M-Ti O2 and the volume changes of M-TiO2 cells during discharging. As for the controversial side reactions in AIBs, in this work, by normalized calculation, we confirm that M-Ti O2 alone participate in the redox reaction. Moreover, cyclic voltammetry(CV) test was performed to investigate the pseudocapacitive behavior. | Na Zhu Feng Wu Zhaohua Wang Liming Ling Haoyi Yang Yaning Gao Shuainan Guo liumin Suo Hong Li Huajie Xu Ying Bai Chuan Wu | 2020 | Journal of Energy Chemistry2020，29，12： | 3 |
| 11 | Retrieval of aerosol size distribution using improved quantum-behaved particle swarm optimization on spectral extinction measurements显示文摘 | Zhenzong He Hong Qi Qin Chen Liming Ruan | 2016 | Particuology2016，14，5： | 2 |
| 12 | Prediction of the coupled heat radiation and conduction parameters and boundary condition using the unscented Kalman filter显示文摘The boundary emissivity, thermal conductivity, and boundary time-varying heat flux in the participating media are retrieved in this work. In the forward model, the coupled radiation-conduction heat transfer in the participating medium is resolved by the finite volume method combined with discrete ordinates method. The inverse model utilizes the temperature signals at the appropriate position of the medium as the known information and uses the unscented Kalman filter(UKF) as an optimization tool to reconstruct the boundary emissivity, thermal conductivity, and boundary time-varying heat flux. It is found that when the emissivity, thermal conductivity, and boundary time-varying heat flux are reconstructed simultaneously, only the temperature information of two locations is required. The influence of the measurement noise, sampling interval, absorption coefficient,process noise covariance, measurement noise covariance on the accuracy and stability of the retrieval results is investigated in detail. All the reconstruction results indicate that the UKF technique is effective and robust for estimating the photothermal parameters and boundary condition of the radiation-conduction heat transfer problems. | WEN Shuang QI Hong WANG YiFei REN YaTao WEI LinYang RUAN LiMing | 2020 | Science China(Technological Sciences)2020，63，3： | 2 |
| 13 | An effective inversion algorithm for retrieving bimodal aerosol particle size distribution from spectral extinction data显示文摘 | Zhenzong He Hong Qi Yuchen Yao Liming Ruan | 2014 | Journal of Quantitative Spectroscopy and Radiative Transfer2014，，： | 2 |
| 14 | Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy显示文摘Mitochondria as a signaling platform play crucial roles in deciding cell fate.Many classic anticancer agents are known to trigger cell death through induction of mitochondrial damage.Mitophagy,one selective autophagy,is the key mitochondrial quality control that effectively removes damaged mitochondria.However,the precise roles of mitophagy in tumorigenesis and anticancer agent treatment remain largely unclear.Here,we examined the functional implication of mitophagy in the anticancer properties of magnolol,a natural product isolated from herbal Magnolia officinalis.First,we found that magnolol induces mitochondrial depolarization,causes excessive mitochondrial fragmentation,and increases mitochondrial reactive oxygen species(mtROS).Second,magnolol induces PTEN-induced putative kinase protein 1(PINK1)-Parkin-mediated mitophagy through regulating two positive feedforward amplification loops.Third,magnolol triggers cancer cell death and inhibits neuroblastoma tumor growth via the intrinsic apoptosis pathway.Moreover,magnolol prolongs the survival time of tumor-bearing mice.Finally,inhibition of mitophagy by PINK1/Parkin knockdown or using inhibitors targeting different autophagy/mitophagy stages significantly promotes magnolol-induced cell death and enhances magnolol's anticancer efficacy,both in vitro and in vivo.Altogether,our study demonstrates that magnolol can induce autophagy/mitophagy and apoptosis,whereas blockage of autophagy/mitophagy remarkably enhances the anticancer efficacy of magnolol,suggesting that targeting mitophagy may be a promising strategy to overcome chemoresistance and improve anticancer therapy. | Yancheng Tang Liming Wang Tao Yi Jun Xu Jigang Wang Jiang-Jiang Qin Qilei Chen Ka-Man Yip Yihang Pan Peng Hong Yingying Lu Han-Ming Shen Hu-Biao Chen | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 2 |
| 15 | Blade-coated organic solar cells from non-halogenated solvent offer 17%efficiency显示文摘Organic solar cell(OSC)has attracted great interests due to its potential applications[1-9].To date,18%power conversion efficiency(PCE)has been achieved in single-junction OSC[10−13],indicating the feasibility of commercialization.This photovoltaic technology currently faces the performance gap between laboratory cells and large-area modules. | Wei Guan Dong Yuan Juntao Wu Xiaobo Zhou Hong Zhao Fei Guo Lianjie Zhang Ke Zhou Wei Ma Wanzhu Cai Junwu Chen Liming Ding Lintao Hou | 2021 | Journal of Semiconductors2021，42，3： | 2 |
| 16 | A novel ejector-absorption eombined refrigeration cycle 显示文摘 | Hong Daliang Chen Guangming Tang Liming | 2011 | lnterantional Journal of Refrigeration2011，34，7： | 1 |
| 17 | The origin and genetic differentiation of native breeds of pigs in southwest China: An approach from mitochondrial DNA polymorphism显示文摘 | Hong Lan Liming Shi | 1993 | Biochemical Genetics (-)1993，，1： | 1 |
| 18 | High cycle fatigue failure with radial cracks in gears of aero-engines显示文摘The gears in aero-engines perform energy and motion transfer between the HighPressure Rotor(HPR)and accessories.Firstly,an occurred fault with radial cracks in the driven gear disk was diagnosed as High Cycle Fatigue(HCF)failure through necessary examinations.Analysis of fault tree and test signals indicated that the fracture was relevant to the swing vibration of the driven gear excited by the unbalance excitation on HPR.Secondly,a corresponding mechanism model was established,in which the gear meshing effect was considered,with lateral and swing vibration mode.The Governing Equations(GEs)and the Finite Element Model(FEM)were established and verified.Then,the modal shapes,harmonic response,and transient response were analyzed,indicating that the swing vibration of the driven gear could be significantly excited by the unbalance on HPR,which induced the cracks in the driven gear disk to extend radially.Furthermore,influences of factors on the unbalance response were obtained,in which the unbalance response appeared local minimum points and maximum points.Meanwhile,1#and 2#bearing stiffness had rather significant influences on the response.Thus it is efficient to modify them to achieve vibration control. | Jie HONG Liming JIANG Xiru XU Yanhong MA | 2020 | Chinese Journal of Aeronautics2020，33，10： | 1 |
| 19 | Automated reticulocyte counting using the SysmexRAM-1显示文摘 | PENG Liming YANG Hui JIANG Hong | 2001 | Clin Lab Haem2001，23，： | 1 |
| 20 | Automated reticulocyte counting using the Sysmex RAM-1显示文摘 | LIMING PENG HUI YANG HONG JIANG | 2001 | Clin Lab Haem2001，23，： | 1 |
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